Faculty

Institution

Unit

Venue

Kevin Lynch

Professor and Vice Chair Pharmacology

University of Virginia

Affiliations

School of Medicine

Department of Pharmacology

Kevin Lynch is currently serving as a Pharmacology Professor and Vice Chair Pharmacology at University of Virginia.

Honors

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Experiences

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Education

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Kevin Lynch

University of Virginia

Professor and Vice Chair Pharmacology

You can click a keyword to filter the displayed items

pharmacology receptors molecular physiology cell biology molecular pharmacology biochemistry receptor (biochemistry) cell signaling g protein-coupled receptor signal transduction cellular biochemistry pharmacological research immunology vascular biology medicinal research drug discovery cellular physiology inflammation enzyme inhibition biological chemistry immune responses therapeutic targets vascular pharmacology mechanisms of action protein phosphorylation renal pathophysiology kidney research molecular cell biology cancer cells proteinlipid interaction signaling pathways pharmaceutical chemistry endothelial dysfunction neuropsychopharmacology molecular cancer renal function cell death molecular neurobiology angiogenesis cytokines cellular pharmacology sphingosine kinase 2 pharmacotherapy cell transplantation cellular immune responses anti-cancer agents drug development immunologic mechanisms experimental pharmacology functional selectivity drug targets inflammatory diseases sphingosine kinase cell research receptor tyrosine kinases cell physiology rational drug design chronic inflammation reperfusion injury non-peptide ligand ischemia-reperfusion injury lysophosphatidic acid immune dysregulation neuropeptide receptors biological evaluation lpa receptors renin gene immune system cell lines tumor growth molecular cloning g protein dnas g protein pertussis toxin lysophospholipid receptor nomenclature renin mrna

Notable Scholarly Works

Notable Federal Grants

Collaborators

Assessment of Spinster Homologue 2 (Spns2)‐Dependent Transport of Sphingosine‐1‐Phosphate as a Therapeutic Target. British Journal of Pharmacology (2025)

Yugesh KharelTao HuangKyle DunnavantDaniel FosterGeorge M. P. R. SouzaKatherine E. NimchukAndrea R. MerchakCaitlin M. PavelecZuzanna J. JuskiewiczSimon S. AlexanderAlban GaultierStephen B. G. AbbottJung‐Bum ShinBrant E. IsaksonWehao XuNorbert LeitingerWebster L. SantosKevin R. Lynch

pharmacological researchpharmacologyprotein transport

Targeted Immunotherapy With Sphingosine-1-Phosphate Improves Myocardial Contractility and Mitochondrial Function in a Novel Murine Ex Vivo Perfusion and Transplantation Model. Journal of Thoracic and Cardiovascular Surgery (2025)

John IguidbashianJack ZakrzewskiLi LuAnastacia M GarciaLudmila KhailovaXinsheng DengRobert PlenterFrancisco La RosaStephanie NakanoKevin LynchJames JaggersJesse DavidsonMatthew L Stone

vascular biologycardiologythoracic surgeryimmunosuppressionimmunologycell transplantationmedicinal researchimmunotherapyimmunomodulationbiomedical engineeringimmune responsesimmunity (medicine)novel murine eximmunosuppressive therapytransplantation modelcardiac pathologiesbiomolecular engineeringtransplantation medicine

Assessing Spns2-Dependent S1P Transport as a Prospective Therapeutic Target. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Y KharelT HuangK DunnavantD FosterGMPR SouzaKE NimchukAR MerchakCM PavelecZJ JuskiewiczA GaultierSBG AbbottJ-B ShinBE IsaksonW XuN LeitingerWL SantosKR Lynch

biomarker targetprospective therapeutic targetbiochemistryprotein transportmolecular biologytherapeutic targetssystems biology

Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry (2024)

Daniel J. FosterKyle DunnavantChristopher W. ShraderMarion LoPrestiSarah SeayYugesh KharelAnne M. BrownTao HuangKevin R. LynchWebster L. Santos

drug deliverypharmaceutical chemistrylead identificationmedicinal chemistrypharmacologydrug discovery

2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry (2023)

Ariel L. BurgioChristopher W. ShraderYugesh KharelTao HuangJoseph M. SalamounKevin R. LynchWebster L. Santos

pharmaceutical chemistrymedicinal chemistrypharmacologydrug discoverypotent inhibitors

Analogs of Fty720 Inhibit Trpm7 but Not S1Prs and Exert Multimodal Anti-Inflammatory Effects. The Journal of General Physiology (2023)

Gregory W. BuseyMohan C. ManjegowdaTao HuangWesley H. IobstShardul S. NaphadeJoel A. KennedyCatherine A. DoylePhilip V. SeegrenKevin R. LynchBimal N. Desai

physiological researchinflammationanti-inflammatoryphysiologychronic inflammationmedicinal researchpharmacologyhuman physiology

Assay of Sphingosine 1-Phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors. SLAS DISCOVERY (2023)

Yugesh KharelTao HuangWebster L. SantosKevin R. Lynch

neurologyneuropharmacologymedicinal chemistrymembrane biologymolecular biologypharmacologymolecular pharmacologydrug discoveryenzyme inhibition

CORRECTION: Mechanism of Sphingosine 1-Phosphate Clearance From Blood. Biochemical Journal (2023)

Yugesh KharelTao HuangAnita SalamonThurl E. HarrisWebster L. SantosKevin R. Lynch

physiologyhepatologybiochemistrymembrane biologybiochemical sciencespharmacology

Imidazole-Based Sphingosine-1-Phosphate Transporter Spns2 Inhibitors. Bioorganic & Medicinal Chemistry Letters (2023)

Christopher W. ShraderDaniel FosterYugesh KharelTao HuangKevin R. LynchWebster L. Santos

drug deliverymedicinal chemistrybioorganic chemistrymedicinepharmacologydrug discoveryenzyme inhibition

Novel Trpm7 Inhibitors With Potent Anti-Inflammatory Effects in Vivo. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Gregory W. BuseyMohan C. ManjegowdaTao HuangWesley H. IobstShardul S. NaphadeJoel A. KennedyCatherine A. DoylePhilip V. SeegrenKevin R. LynchBimal N. Desai

inflammationanti-inflammatorydrug targetingmolecular medicinemedicinal researchneurosciencemedicinal chemistrymolecular biologypharmacologytranslational pharmacologydrug discoverypharmacotherapycytokines

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Kevin Lynch

Professor and Vice Chair Pharmacology

University of Virginia

Affiliations

School of Medicine

Department of Pharmacology

Kevin Lynch is currently serving as a Pharmacology Professor and Vice Chair Pharmacology at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Kevin Lynch

University of Virginia

Professor and Vice Chair Pharmacology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Assessment of Spinster Homologue 2 (Spns2)‐Dependent Transport of Sphingosine‐1‐Phosphate as a Therapeutic Target. British Journal of Pharmacology (2025)

pharmacological researchpharmacologyprotein transport

John IguidbashianJack ZakrzewskiLi LuAnastacia M GarciaLudmila KhailovaXinsheng DengRobert PlenterFrancisco La RosaStephanie NakanoKevin LynchJames JaggersJesse DavidsonMatthew L Stone

Assessing Spns2-Dependent S1P Transport as a Prospective Therapeutic Target. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Y KharelT HuangK DunnavantD FosterGMPR SouzaKE NimchukAR MerchakCM PavelecZJ JuskiewiczA GaultierSBG AbbottJ-B ShinBE IsaksonW XuN LeitingerWL SantosKR Lynch

biomarker targetprospective therapeutic targetbiochemistryprotein transportmolecular biologytherapeutic targetssystems biology

Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry (2024)

Daniel J. FosterKyle DunnavantChristopher W. ShraderMarion LoPrestiSarah SeayYugesh KharelAnne M. BrownTao HuangKevin R. LynchWebster L. Santos

drug deliverypharmaceutical chemistrylead identificationmedicinal chemistrypharmacologydrug discovery

2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry (2023)

Ariel L. BurgioChristopher W. ShraderYugesh KharelTao HuangJoseph M. SalamounKevin R. LynchWebster L. Santos

pharmaceutical chemistrymedicinal chemistrypharmacologydrug discoverypotent inhibitors

Analogs of Fty720 Inhibit Trpm7 but Not S1Prs and Exert Multimodal Anti-Inflammatory Effects. The Journal of General Physiology (2023)

Gregory W. BuseyMohan C. ManjegowdaTao HuangWesley H. IobstShardul S. NaphadeJoel A. KennedyCatherine A. DoylePhilip V. SeegrenKevin R. LynchBimal N. Desai

physiological researchinflammationanti-inflammatoryphysiologychronic inflammationmedicinal researchpharmacologyhuman physiology

Assay of Sphingosine 1-Phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors. SLAS DISCOVERY (2023)

Yugesh KharelTao HuangWebster L. SantosKevin R. Lynch

neurologyneuropharmacologymedicinal chemistrymembrane biologymolecular biologypharmacologymolecular pharmacologydrug discoveryenzyme inhibition

CORRECTION: Mechanism of Sphingosine 1-Phosphate Clearance From Blood. Biochemical Journal (2023)

Yugesh KharelTao HuangAnita SalamonThurl E. HarrisWebster L. SantosKevin R. Lynch

physiologyhepatologybiochemistrymembrane biologybiochemical sciencespharmacology

Imidazole-Based Sphingosine-1-Phosphate Transporter Spns2 Inhibitors. Bioorganic & Medicinal Chemistry Letters (2023)

Christopher W. ShraderDaniel FosterYugesh KharelTao HuangKevin R. LynchWebster L. Santos

drug deliverymedicinal chemistrybioorganic chemistrymedicinepharmacologydrug discoveryenzyme inhibition

Novel Trpm7 Inhibitors With Potent Anti-Inflammatory Effects in Vivo. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Gregory W. BuseyMohan C. ManjegowdaTao HuangWesley H. IobstShardul S. NaphadeJoel A. KennedyCatherine A. DoylePhilip V. SeegrenKevin R. LynchBimal N. Desai

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