Faculty

Institution

Unit

Venue

Kent S. Gates

Schlundt Distinguished Professor of Chemistry

University of Missouri

Affiliations

College of Arts & Science

Chemistry

Kent S. Gates is currently serving as a Chemistry Schlundt Distinguished Professor of Chemistry at University of Missouri.

Honors

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Experiences

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Education

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Kent S. Gates

University of Missouri

Schlundt Distinguished Professor of Chemistry

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molecular biology biochemistry pharmacology chemistry medicinal chemistry chemical biology toxicology enzymes dna repair biological chemistry organic chemistry structural biology redox biology nucleic acids enzyme inhibition protein science bioorganic chemistry abasic sites duplex dna nucleic acid chemistry free radical biology molecular science genome biology enzyme catalysis redox chemistry anti-cancer agents rna biology abasic site chemical sciences clinical chemistry dna analysis dna nanotechnology crystal structures protein tyrosine phosphatases analytical toxicology biomolecular structure redox signaling protein chemistry hypoxia (medicine) molecular cancer molecular structure molecular diagnostics biological inorganic chemistry biocatalysis aldehyde dehydrogenase dna sequencing nanobiotechnology redox regulation dna damage interstrand dna-dna cross-links interstrand cross-links structural molecular biology radical (chemistry) experimental toxicology heterocyclic cancer biology enzymatic modification cellular dna dna cleavage dna strand cleavage covalent modification genome structure molecular basis damage mechanism genome instability tumor targeting clinical toxicology chemical biotechnology surface reactivity oligonucleotides pharmaceutical chemistry nanometrology adenine residues molecular oxygen antitumor antibiotic leinamycin natural product leinamycin base excision repair systems biology toxicogenomics toxicological mechanism molecular informatics

Notable Scholarly Works

Notable Federal Grants

Collaborators

Formation and Properties of Dna Adducts Generated by Reactions of Abasic Sites With 1,2-Aminothiols Including Cysteamine, Cysteine Methyl Ester, and Peptides Containing N -Terminal Cysteine Residues. Chemical Research in Toxicology (2024)

Anuoluwapo GominaTanhaul IslamGaram ShimZhentian LeiKent S. Gates

chemistrycysteine methyl esterchemical biologybiological chemistrybiochemistrymolecular biologyabasic sitesdna adducts

Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of N -Propargylglycine. Biochemistry (2024)

John J. TannerJuan JiAlexandra N. BognerGary K. ScottSagar M. PatelJavier SeravalliKent S. GatesChristopher C. BenzDonald F. Becker

enzymesbiomolecular engineeringnoncovalent inhibitionenzyme catalysisproline dehydrogenasepeptide sciencebiochemistryenzymatic modificationmolecular biologyenzyme inhibitioncovalent inactivation

Novel Processes Associated With the Repair of Interstrand Cross-Links Derived From Abasic Sites in Duplex Dna: Roles for the Base Excision Repair Glycosylase Neil3 and the Srap Protein Hmces. Chemical Research in Toxicology (2024)

Nathan E. PriceKent S. Gates

genome instabilityprotein scienceprotein structurepharmacologyabasic sitesnucleic acid amplificationenzymesduplex dnaprotein misfoldingdna repairchemical biologyin vitro toxicologycellular enzymologybiochemistryenzymatic modificationgenome biologytoxicologynovel processesnucleic acidssrap protein hmcesinterstrand cross-linksmolecular biologyenzyme inhibition

Repurposing the Antihypertensive Agent Hydralazine as an Inhibitor of the Base Excision Repair Enzyme Ape1. Chemical Research in Toxicology (2024)

Tanhaul IslamVenkatrao NunnaDon Pivithuru LiyanarachchiDouglas MeltonCalvin D. LewisKent S. Gates

antihypertensive agent hydralazineenzymesbase excision repairchemical biologybiochemistryantihypertensive therapyenzyme inhibitiontoxicology

The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in Dna. Chemical Research in Toxicology (2024)

Tanhaul IslamSaosan Binth Md AminKent S. Gates

intercalator ethidium bromidebiochemistrytoxicologycovalent adducts

Ultrafast Reaction of the Drug Hydralazine With Apurinic/Apyrimidinic Sites in Dna Gives Rise to a Stable Triazolo[3,4- a ]Phthalazine Adduct. Chemical Research in Toxicology (2024)

Tanhaul IslamGaram ShimDouglas MeltonCalvin D. LewisZhentian LeiKent S. Gates

catalyst preparationchemistryclinical chemistrynucleic acidsnucleic acid chemistrydrug hydralazinemedicinal chemistrybiochemistrypharmacologyultrafast reactiondrug discoverytoxicology

Effects of Local Sequence, Reaction Conditions, and Various Additives on the Formation and Stability of Interstrand Cross-Links Derived From the Reaction of an Abasic Site With an Adenine Residue in Duplex Dna. ACS Omega (2022)

Saosan Binth Md. AminTanhaul IslamNathan E. PriceAmanda WallaceXu GuoAnuoluwapo GominaMarjan HeidariKevin M. JohnsonCalvin D. LewisZhiyu YangKent S. Gates

molecular geneticsmolecular chemistrymolecular engineeringlocal sequencenanotechnologygenome editingreaction conditionsduplex dnanucleic acid chemistrybiological chemistryadenine residuemolecular structuregenome biologydna nanotechnologystructural biologybiomolecular engineeringsurface reactivitydna sequencingmolecular sciencebiological engineeringbiomolecular structureinterstrand cross-linksmolecular biology

N -Methyl- N -Nitrosourea Induced 3′-Glutathionylated Dna-Cleavage Products in Mammalian Cells. Analytical Chemistry (2022)

Jiekai YinKent S. GatesYinsheng Wang

geneticscell biologydrug analysisbiochemistrymammalian cellsgene expressionanalytical chemistry

Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in Dna: New Insights From a Biomimetic Nucleoside Model System. Chemical Research in Toxicology (2022)

Jay S. JhaChristopher NelTuhin HaldarDaniel PetersKurt HoushKent S. Gates

biomolecular engineeringnucleic acidsbiocatalysischemical engineeringmolecular catalysisbiological engineeringenzyme catalysisamine-catalyzed strand cleavagedna analysistoxicologycatalytic synthesisdrug discoverycatalysis

Reconsidering the Chemical Nature of Strand Breaks Derived From Abasic Sites in Cellular Dna: Evidence for 3′-Glutathionylation. Journal of the American Chemical Society (2022)

Jay S. JhaJiekai YinTuhin HaldarZhiyu YangYinsheng WangKent S. Gates

bioconjugationchemical sciencesmolecular engineeringcellular dnaabasic sitesnucleic acid chemistrystrand breaksbiological chemistrychemical biologychemical naturebiochemistrybiophysical chemistrystructural biologychemical kineticsbiomolecular engineeringnucleic acidsmolecular sciencebiomolecular structuremolecular biologymolecular research

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Kent S. Gates

Schlundt Distinguished Professor of Chemistry

University of Missouri

Affiliations

College of Arts & Science

Chemistry

Kent S. Gates is currently serving as a Chemistry Schlundt Distinguished Professor of Chemistry at University of Missouri.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Kent S. Gates

University of Missouri

Schlundt Distinguished Professor of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anuoluwapo GominaTanhaul IslamGaram ShimZhentian LeiKent S. Gates

chemistrycysteine methyl esterchemical biologybiological chemistrybiochemistrymolecular biologyabasic sitesdna adducts

Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of N -Propargylglycine. Biochemistry (2024)

John J. TannerJuan JiAlexandra N. BognerGary K. ScottSagar M. PatelJavier SeravalliKent S. GatesChristopher C. BenzDonald F. Becker

enzymesbiomolecular engineeringnoncovalent inhibitionenzyme catalysisproline dehydrogenasepeptide sciencebiochemistryenzymatic modificationmolecular biologyenzyme inhibitioncovalent inactivation

Nathan E. PriceKent S. Gates

Repurposing the Antihypertensive Agent Hydralazine as an Inhibitor of the Base Excision Repair Enzyme Ape1. Chemical Research in Toxicology (2024)

Tanhaul IslamVenkatrao NunnaDon Pivithuru LiyanarachchiDouglas MeltonCalvin D. LewisKent S. Gates

antihypertensive agent hydralazineenzymesbase excision repairchemical biologybiochemistryantihypertensive therapyenzyme inhibitiontoxicology

The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in Dna. Chemical Research in Toxicology (2024)

Tanhaul IslamSaosan Binth Md AminKent S. Gates

intercalator ethidium bromidebiochemistrytoxicologycovalent adducts

Ultrafast Reaction of the Drug Hydralazine With Apurinic/Apyrimidinic Sites in Dna Gives Rise to a Stable Triazolo[3,4- a ]Phthalazine Adduct. Chemical Research in Toxicology (2024)

Tanhaul IslamGaram ShimDouglas MeltonCalvin D. LewisZhentian LeiKent S. Gates

catalyst preparationchemistryclinical chemistrynucleic acidsnucleic acid chemistrydrug hydralazinemedicinal chemistrybiochemistrypharmacologyultrafast reactiondrug discoverytoxicology

Saosan Binth Md. AminTanhaul IslamNathan E. PriceAmanda WallaceXu GuoAnuoluwapo GominaMarjan HeidariKevin M. JohnsonCalvin D. LewisZhiyu YangKent S. Gates

N -Methyl- N -Nitrosourea Induced 3′-Glutathionylated Dna-Cleavage Products in Mammalian Cells. Analytical Chemistry (2022)

Jiekai YinKent S. GatesYinsheng Wang

geneticscell biologydrug analysisbiochemistrymammalian cellsgene expressionanalytical chemistry

Products Generated by Amine-Catalyzed Strand Cleavage at Apurinic/Apyrimidinic Sites in Dna: New Insights From a Biomimetic Nucleoside Model System. Chemical Research in Toxicology (2022)

Jay S. JhaChristopher NelTuhin HaldarDaniel PetersKurt HoushKent S. Gates

Reconsidering the Chemical Nature of Strand Breaks Derived From Abasic Sites in Cellular Dna: Evidence for 3′-Glutathionylation. Journal of the American Chemical Society (2022)

Jay S. JhaJiekai YinTuhin HaldarZhiyu YangYinsheng WangKent S. Gates

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