Faculty

Institution

Unit

Venue

Justin Legleiter

Professor

West Virginia University

Affiliations

Eberly College of Arts and Sciences

C. Eugene Bennett Department of Chemistry

School of Medicine

Neuroscience

Justin Legleiter is currently serving as a C. Eugene Chemistry Professor at West Virginia University.

Honors

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Experiences

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Education

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Justin Legleiter

West Virginia University

Professor

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biophysics neuroscience membrane biology molecular biology structural biology protein science biochemistry biomolecular interactions lipid membranes experimental biophysics protein function proteinlipid interaction alzheimer's disease microscopy membranes protein structure neurodegenerative diseases biological chemistry molecular physiology protein chemistry lipid bilayers surface science molecular science membrane science atomic force microscopy huntingtin aggregation biochemical sciences structural molecular biology lipid science molecular neurobiology lipoprotein metabolism interface science molecular neurodegeneration lipid binding mechanical changes mammalian biology plo biology redox biology vascular biology experimental gerontology molecular aggregate neurochemistry peptides medical genetics integrative biology biological inorganic chemistry nanoscale science colloid chemistry interface chemistry colloidal systems interfacial studies membrane transport protein mass spectrometry mutagenesis neuroprotection mutant huntingtin fragment polyglutamine aggregation point mutations lipid systems mutant huntingtin fragments in vitro toxicology phytotoxicity hepatotoxicity biomedical modeling x-ray diffraction receptor (biochemistry) molecular research neural science oligonucleotides immunochemistry antibody engineering astrocyte-secreted apoe huntingtin misfolding functional deficits gel phase dmpc polyglutamine protein species degenerative pathology huntington's disease protein misfolding systems biology

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Divalent Cations Promote Huntingtin Fibril Formation on Endoplasmic Reticulum Derived and Model Membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes (2024)

Adam SkeensJordyn M. MarkleGabriella PetipasShelli L. FreyJustin Legleiter

biophysicsphysiologyendoplasmic reticulumneurosciencedivalent cationsmembrane biologymodel membranes

Structure Characterization of a Disordered Peptide Using In-Droplet Hydrogen Deuterium Exchange Mass Spectrometry and Molecular Dynamics. (2024)

Mohammad RahmanMst Nigar SultanaDaud SharifSultan MahmudPeng LiJustin LegleiterBlake MertzStephen Valentine

biophysicsmolecular dynamicsstructure characterizationstructural biologymaterials sciencedisordered peptide

The Polyglutamine Domain is the Primary Driver of Seeding in Huntingtin Aggregation. PLoS ONE (2024)

Adam SkeensChathuranga SiriwardhanaSophia E. MassinopleMichelle M. WunderZachary L. EllisKaitlyn M. KeithTyler GirmanShelli L. FreyJustin Legleiter

plo biologyprotein sciencepolyglutamine domainimmunologyneurosciencehuntingtin aggregationprimary driverstructural biologygenetics

Blocking Huntingtin Oligomers From Binding Lipid Membranes Improves Phenotype in a C. Elegans Model of Huntington's Disease. Biophysical Journal (2023)

Chathuranga SiriwardhanaJustin A. Legleiter

biophysicshuntington's diseasemedical biophysicsbiophysical aspecthuntingtin oligomersbiophysical reviewprotein functionneurosciencemolecular biophysicsmembrane biologymolecular biologybiophysical modelingbiomolecular interactionsbiophysical chemistrystructural biology

Charge Within Nt17 Peptides Modulates Huntingtin Aggregation and Initial Lipid Binding Events. Biophysical Chemistry (2023)

Alyssa R. StonebrakerRachel HankinKathryn L. KappPeng LiStephen J. ValentineJustin Legleiter

biophysicsphysiologyprotein functionneurosciencemolecular biophysicspeptidesmembrane biologyexperimental biophysicsbiophysical chemistry

Cholesterol Impacts the Formation of Huntingtin/Lipid Complexes and Subsequent Aggregation. Protein Science (2023)

Alyssa R. StonebrakerMaryssa BeasleySophia MassinopleMichelle WunderPeng LiStephen J. ValentineJustin Legleiter

protein sciencelipoprotein metabolismneurosciencebiochemistrymolecular biologymolecular aggregatestructural biology

Controlling Htt Protein Aggregation to Assess Toxicity in Caenorhabditis Elegans. Biophysical Journal (2023)

Ephraim C. EzeigboJustin A. Legleiter

biophysicscaenorhabditis elegans

Oligomerization Enhances Huntingtin Membrane Activity but is Suppressed by Covalent Crosslinking. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Faezeh SedighiAdam SkeensAdewale AdegbuyiroJohn BardChathuranga SiriwardhanaEmily DonleyWerner J. GeldenhuysJustin Legleiter

biophysicscovalent crosslinkingcell biologyneurosciencemembrane biology

Polyglutamine Core is the Primary Driver of Seeded Huntingtin Aggregation. Biophysical Journal (2023)

Adam SkeensJustin A. Legleiter

biophysicscell biologyneurosciencepolyglutamine coreseeded huntingtin aggregationprimary driverbiophysical chemistry

Probing the Morphological and Mechanical Changes in a C. Elegans Model of Huntington's Disease. Biophysical Journal (2023)

Zachary L. EllisChathuranga C. SiriwardhanaJustin A. Legleiter

biophysicshuntington's diseasemechanical changesnematologydevelopmental biologymorphology (biology)biophysical modelingmorphogenesis

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Justin Legleiter

Professor

West Virginia University

Affiliations

Eberly College of Arts and Sciences

C. Eugene Bennett Department of Chemistry

School of Medicine

Neuroscience

Justin Legleiter is currently serving as a C. Eugene Chemistry Professor at West Virginia University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Justin Legleiter

West Virginia University

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Divalent Cations Promote Huntingtin Fibril Formation on Endoplasmic Reticulum Derived and Model Membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes (2024)

Adam SkeensJordyn M. MarkleGabriella PetipasShelli L. FreyJustin Legleiter

biophysicsphysiologyendoplasmic reticulumneurosciencedivalent cationsmembrane biologymodel membranes

Structure Characterization of a Disordered Peptide Using In-Droplet Hydrogen Deuterium Exchange Mass Spectrometry and Molecular Dynamics. (2024)

Mohammad RahmanMst Nigar SultanaDaud SharifSultan MahmudPeng LiJustin LegleiterBlake MertzStephen Valentine

biophysicsmolecular dynamicsstructure characterizationstructural biologymaterials sciencedisordered peptide

The Polyglutamine Domain is the Primary Driver of Seeding in Huntingtin Aggregation. PLoS ONE (2024)

Adam SkeensChathuranga SiriwardhanaSophia E. MassinopleMichelle M. WunderZachary L. EllisKaitlyn M. KeithTyler GirmanShelli L. FreyJustin Legleiter

plo biologyprotein sciencepolyglutamine domainimmunologyneurosciencehuntingtin aggregationprimary driverstructural biologygenetics

Blocking Huntingtin Oligomers From Binding Lipid Membranes Improves Phenotype in a C. Elegans Model of Huntington's Disease. Biophysical Journal (2023)

Chathuranga SiriwardhanaJustin A. Legleiter

Charge Within Nt17 Peptides Modulates Huntingtin Aggregation and Initial Lipid Binding Events. Biophysical Chemistry (2023)

Alyssa R. StonebrakerRachel HankinKathryn L. KappPeng LiStephen J. ValentineJustin Legleiter

biophysicsphysiologyprotein functionneurosciencemolecular biophysicspeptidesmembrane biologyexperimental biophysicsbiophysical chemistry

Cholesterol Impacts the Formation of Huntingtin/Lipid Complexes and Subsequent Aggregation. Protein Science (2023)

Alyssa R. StonebrakerMaryssa BeasleySophia MassinopleMichelle WunderPeng LiStephen J. ValentineJustin Legleiter

protein sciencelipoprotein metabolismneurosciencebiochemistrymolecular biologymolecular aggregatestructural biology

Controlling Htt Protein Aggregation to Assess Toxicity in Caenorhabditis Elegans. Biophysical Journal (2023)

Ephraim C. EzeigboJustin A. Legleiter

biophysicscaenorhabditis elegans

Oligomerization Enhances Huntingtin Membrane Activity but is Suppressed by Covalent Crosslinking. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Faezeh SedighiAdam SkeensAdewale AdegbuyiroJohn BardChathuranga SiriwardhanaEmily DonleyWerner J. GeldenhuysJustin Legleiter

biophysicscovalent crosslinkingcell biologyneurosciencemembrane biology

Polyglutamine Core is the Primary Driver of Seeded Huntingtin Aggregation. Biophysical Journal (2023)

Adam SkeensJustin A. Legleiter

biophysicscell biologyneurosciencepolyglutamine coreseeded huntingtin aggregationprimary driverbiophysical chemistry

Probing the Morphological and Mechanical Changes in a C. Elegans Model of Huntington's Disease. Biophysical Journal (2023)

Zachary L. EllisChathuranga C. SiriwardhanaJustin A. Legleiter

biophysicshuntington's diseasemechanical changesnematologydevelopmental biologymorphology (biology)biophysical modelingmorphogenesis

1
2
3
4
5
12
10 / page

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