Faculty

Institution

Unit

Venue

Joan Mecsas

Professor

Tufts University

Affiliations

Graduate School of Biomedical Sciences

Immunology

Molecular Microbiology

School of Medicine

Molecular Biology and Microbiology

Joan Mecsas is currently serving as a Graduate School Of Biomedical Sciences Professor at Tufts University.

Honors

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Experiences

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Education

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Joan Mecsas

Tufts University

Professor

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infectious diseases clinical microbiology immunology microbial pathogenesis microbiology genetics veterinary medicine pathogens pathogenic bacteria infection control virology immune responses veterinary microbiology respiratory medicine viral pathogenesis pathogen transmission host response applied microbiology tuberculosis antimicrobial resistance molecular microbiology medical microbiology innate immune system bacteriology medical mycology mammalian biology emerging infectious diseases virulence factors yop translocation antimicrobial agents cell death virus-host interactions antibiotic resistance virus research medicinal research experimental medicine venereology klebsiella pneumoniae experimental pathology disease transmission clinical infection viral persistence antimicrobial chemotherapy pathogen characterization host-microbe interactions adaptive immune system professional phagocytes plo biology laboratory medicine general virology experimental biology mutagenesis clinical mycology microbial genetics antimicrobial susceptibility pathway analysis pulmonary diseases vaccine research apoptosis signature-tagged mutagenesis host cells mesenteric lymph nodes yersinia pseudotuberculosis bacterial secretion systems pharmacotherapy 3d reconstruction 3d bioprinting bacterial resistance nadph oxidase activation vivo aids systemic infection gi colonization candida albicans bacterial pool bacterial infections orogastric infection

Notable Scholarly Works

Notable Federal Grants

Collaborators

Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus Pneumoniae. Aging Cell (2026)

experimental gerontologylongevitypathogenesisclinical microbiologyinfectious diseaseshost responselung microbiomeageingimmune mediatorsbiogerontologyinnate immune systemimmune responseshost agingmicrobial pathogenesisaging cellaltered transcriptional responseshost-microbe interactionsimmunologysenescent‐like phenotypemicrobiology

Neutrophil Degranulation and Extracellular Ros Production Are Inactivated by Yersinia Pseudotuberculosis Yope Through a Skap2 Independent Pathway. bioRxiv (Cold Spring Harbor Laboratory) (2026)

antimicrobial agentsmicrobial pathogenesispathogenesismolecular microbiologyhost responseclinical microbiologyneutrophil degranulationskap2 independent pathwaypathogenic bacteriavirulence factorsinfectious diseasesmedical microbiologyyersinia pseudotuberculosis yopemicrobiology

Blocking Hxa 3 -Mediated Neutrophil Elastase Release During S. Pneumoniae Lung Infection Limits Pulmonary Epithelial Barrier Disruption and Bacteremia. mBio (2024)

Shuying XuShumin TanPatricia RomanosJennifer L. ReedyYihan ZhangMichael K. MansourJatin M. VyasJoan MecsasHongmei MouJohn M. Leong

immunologypulmonary diseasesinfection controlneutrophil elastase releaseclinical microbiologyinfectious respiratory diseasedrug resistancepathogenic bacteriaimmune responsesrespiratory medicineinfectious diseasesmicrobiology

Blocking Hxa 3 -Mediated Neutrophil Elastase Release During S. Pneumoniae Lung Infection Limits Pulmonary Epithelial Barrier Disruption and Bacteremia. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Shuying XuShumin TanPatricia RomanosJennifer L. ReedyYihan ZhangMichael K. MansourJatin M. VyasJoan MecsasHongmei MouJohn M. Leong

respiratory infectionsclinical microbiologyapplied microbiologytoxicologyinfectious diseasesphagocytesinfectious respiratory diseasehost factorsimmune responsesinflammationmicrobial pathogenesisveterinary medicineimmunologyenzyme inhibitionpharmacologyinfection controlneutrophil elastase releasehost specificityrespiratory medicine

Critical Role of Growth Medium for Detecting Drug Interactions in Gram-Negative Bacteria That Model in Vivo Responses. mBio (2024)

Kathleen P. DavisYoelkys MoralesRachel J. EndeRyan PetersAnne L. McCabeJoan MecsasBree B. Aldridge

drug interactionspharmacologygrowth mediumclinical microbiologymodeling and simulationgram-negative bacteria

Massively Parallel Combination Screen Reveals Small Molecule Sensitization of Antibiotic-Resistant Gram-Negative Eskape Pathogens. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Megan W. TseMeilin ZhuBenjamin PetersEfrat HamamiJulie ChenKathleen P. DavisSamuel NitzJuliane WellerThulasi WarrierDiana K. HuntYoelkys MoralesTomohiko KawateJeffrey L. GaulinJon H. ComeJuan Hernandez-BirdWenwen HuoIsabelle NeisewanderLaura L. KiesslingDeborah T. HungJoan MecsasBree B. AldridgeRalph R. IsbergPaul C. Blainey

immunologyantimicrobial resistanceantibiotic resistancemolecular microbiologyepidemiologyclinical microbiologyapplied microbiologyinfectious diseases

Non-Canonical Autophosphorylation of Ripk1 Drives Timely Pyroptosis to Control Yersinia Infection. Cell Reports (2024)

David JettonHayley I MuendleinWilson M ConnollyZoie MagriIrina SmirnovaRebecca BatorskyJoan MecsasAlexei DegterevAlexander Poltorak

immunologypharmacologyimmune responsesinfectious diseasesnon-canonical autophosphorylation

Yersinia Pseudotuberculosis Yope Prevents Uptake by M Cells and Instigates M Cell Extrusion in Human Ileal Enteroid-Derived Monolayers. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Alyssa C. FascianoGaya S. DasanayakeMary K. EstesNicholas C. ZachosDavid T. BreaultRalph R. IsbergShumin TanJoan Mecsas

pathogensmicrobial pathogenesismolecular microbiologyclinical microbiologygeneticsveterinary medicinepathogenic bacteriamembrane biologyinfectious diseasesmicrobiology

Neutrophils Require Skap2 for Reactive Oxygen Species Production Following C-Type Lectin and Candida Stimulation. iScience (2021)

Giang T. NguyenShuying XuWalter AdamsJohn M. LeongStephen C. BunnellMichael K. MansourDavid B. SykesJoan Mecsas

immunologypharmacologyfree radical biologyhost responsec-type lectinoxidative stressneuroscience

Role of the Yersinia Pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes. EcoSal Plus (2021)

James B. BliskaIgor E. BrodskyJoan Mecsas

immunologymicrobial pathogenesispathogen-phagocyte interactionsclinical microbiologygeneticsveterinary medicinepathogenic bacteriamesenteric lymph nodespathologyveterinary microbiology

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Joan Mecsas

Professor

Tufts University

Affiliations

Graduate School of Biomedical Sciences

Immunology

Molecular Microbiology

School of Medicine

Molecular Biology and Microbiology

Joan Mecsas is currently serving as a Graduate School Of Biomedical Sciences Professor at Tufts University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Joan Mecsas

Tufts University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus Pneumoniae. Aging Cell (2026)

Neutrophil Degranulation and Extracellular Ros Production Are Inactivated by Yersinia Pseudotuberculosis Yope Through a Skap2 Independent Pathway. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Blocking Hxa 3 -Mediated Neutrophil Elastase Release During S. Pneumoniae Lung Infection Limits Pulmonary Epithelial Barrier Disruption and Bacteremia. mBio (2024)

Shuying XuShumin TanPatricia RomanosJennifer L. ReedyYihan ZhangMichael K. MansourJatin M. VyasJoan MecsasHongmei MouJohn M. Leong

Critical Role of Growth Medium for Detecting Drug Interactions in Gram-Negative Bacteria That Model in Vivo Responses. mBio (2024)

Kathleen P. DavisYoelkys MoralesRachel J. EndeRyan PetersAnne L. McCabeJoan MecsasBree B. Aldridge

drug interactionspharmacologygrowth mediumclinical microbiologymodeling and simulationgram-negative bacteria

Massively Parallel Combination Screen Reveals Small Molecule Sensitization of Antibiotic-Resistant Gram-Negative Eskape Pathogens. bioRxiv (Cold Spring Harbor Laboratory) (2024)

immunologyantimicrobial resistanceantibiotic resistancemolecular microbiologyepidemiologyclinical microbiologyapplied microbiologyinfectious diseases

Non-Canonical Autophosphorylation of Ripk1 Drives Timely Pyroptosis to Control Yersinia Infection. Cell Reports (2024)

David JettonHayley I MuendleinWilson M ConnollyZoie MagriIrina SmirnovaRebecca BatorskyJoan MecsasAlexei DegterevAlexander Poltorak

immunologypharmacologyimmune responsesinfectious diseasesnon-canonical autophosphorylation

Yersinia Pseudotuberculosis Yope Prevents Uptake by M Cells and Instigates M Cell Extrusion in Human Ileal Enteroid-Derived Monolayers. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Alyssa C. FascianoGaya S. DasanayakeMary K. EstesNicholas C. ZachosDavid T. BreaultRalph R. IsbergShumin TanJoan Mecsas

pathogensmicrobial pathogenesismolecular microbiologyclinical microbiologygeneticsveterinary medicinepathogenic bacteriamembrane biologyinfectious diseasesmicrobiology

Neutrophils Require Skap2 for Reactive Oxygen Species Production Following C-Type Lectin and Candida Stimulation. iScience (2021)

Giang T. NguyenShuying XuWalter AdamsJohn M. LeongStephen C. BunnellMichael K. MansourDavid B. SykesJoan Mecsas

immunologypharmacologyfree radical biologyhost responsec-type lectinoxidative stressneuroscience

Role of the Yersinia Pseudotuberculosis Virulence Plasmid in Pathogen-Phagocyte Interactions in Mesenteric Lymph Nodes. EcoSal Plus (2021)

James B. BliskaIgor E. BrodskyJoan Mecsas

immunologymicrobial pathogenesispathogen-phagocyte interactionsclinical microbiologygeneticsveterinary medicinepathogenic bacteriamesenteric lymph nodespathologyveterinary microbiology

1
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11
10 / page

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