Faculty

Institution

Unit

Venue

Ralph Isberg

Professor

Tufts University

Affiliations

Graduate School of Biomedical Sciences

Genetics, Molecular and Cellular Biology

Immunology

Molecular Microbiology

School of Medicine

Molecular Biology and Microbiology

Ralph Isberg is currently serving as a Genetics, Molecular And Cellular Biology Professor at Tufts University.

Honors

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Experiences

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Education

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Ralph Isberg

Tufts University

Professor

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microbiology microbial pathogenesis infectious diseases immunology pathogens clinical microbiology pathogenic bacteria molecular biology bacteria infection control pathogenesis molecular microbiology bacteriology immune responses host-microbe interactions applied microbiology virulence factors gene expression medical microbiology legionella pneumophila immunity (medicine) molecular cell biology pathogen transmission biological chemistry intracellular trafficking structural molecular biology innate immune system mammalian biology insect molecular biology phagocytes protein science host specificity veterinary microbiology cellular biology pathogen characterization microbial genetics host response intracellular growth yersinia pseudotuberculosis environmental microbiology microbial physiology protein secretion antibiotic resistance integrin receptors vascular biology virus research diagnostic microbiology viral pathogenesis adaptive immune system microbial disease cellular immune responses dictyostelium discoideum general virology experimental medicine evolutionary microbiology cell culture zoonotic diseases cell adhesion pathogen detection mammalian cells acinetobacter baumannii host-pathogen interactions communicable diseases biological invasions infectious respiratory disease specific resistance endocytic pathway disease transmission cultured mammalian cells bacterial internalization host cells single genetic locus bacterial uptake bacterial pathogens drosophila cells mouse macrophages

Notable Scholarly Works

Notable Federal Grants

Collaborators

Host Cd59 Potentiates the Type III Secretion System in Yersinia Pseudotuberculosis. bioRxiv (Cold Spring Harbor Laboratory) (2026)

pathogenic bacteriapathogensmicrobiologymicrobial pathogenesisinfectious diseasesprotein secretionpathogenesisvirulence factorsbacteriastructural molecular biologymedical microbiologyhost cd59clinical microbiology

Rna Quality Control Enables Antibiotic Tolerance. bioRxiv (Cold Spring Harbor Laboratory) (2026)

antimicrobial agentsmicrobiologyrna biologydrug resistanceapplied microbiologyantimicrobial resistancenucleic acidsmolecular biologyantibiotic resistancetranscriptomerna processingtranscription (biology)clinical microbiology

The Transcriptional Response of Yersinia Pseudotuberculosis to Macrophage-Released Chemicals During Growth Within Synthetic Microcolonies. bioRxiv (Cold Spring Harbor Laboratory) (2026)

biofilmsbacteriologymicrobiologysynthetic biologymicrobial pathogenesissynthetic microcoloniesapplied microbiologymolecular microbiologytranscriptional responsemacrophage-released chemicalsmolecular biologybacteriamicrobial cell factorybiological macromoleculesbiotechnologymedical microbiologymicroorganismsbiomolecules

Resistance, Heteroresistance, and Fitness Costs Drive Colistin Treatment Failure During Acinetobacter Baumannii Pneumonia. Proceedings of the National Academy of Sciences (2025)

antimicrobial agentsbiofilmsinfection controlmicrobiologyinfectious diseaseshospital infectionsdrug resistanceantimicrobial resistanceantibiotic resistanceantimicrobial resistance genesfitness costscolistin treatment failureantimicrobial susceptibilityclinical microbiology

A Random Mutagenesis Screen Enriched for Missense Mutations in Bacterial Effector Proteins. G3 Genes Genomes Genetics (2024)

Malene L UrbanusThomas M ZhengAnna N KhusnutdinovaDoreen BanhHarley O’Connor MountAlind GuptaPeter J StogiosAlexei SavchenkoRalph R IsbergAlexander F YakuninAlexander W Ensminger

geneticsmissense mutationsmutagenesisrandom mutagenesis screengenomicsbacterial effector proteins

Genetic Evidence for a Regulated Cysteine Protease Catalytic Triad in Lega7, a Legionella Pneumophila Protein That Impinges on a Stress Response Pathway. mSphere (2024)

Dar HershkovitzEmy J. ChenAlexander W. EnsmingerAisling S. DuganKaleigh T. ConwayAlex C. JoyceGil SegalRalph R. Isberg

geneticsmicrobiologymicrobial pathogenesisstress response pathwaymolecular biologygenetic evidence

Identification of Determinants That Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter Baumannii. mBio (2024)

Efrat HamamiWenwen HuoJuan Hernandez-BirdArnold CastanedaJinna BaiSapna SyalJuan C. Ortiz-MarquezTim van OpijnenEdward GeisingerRalph R. Isberg

pathogenic bacteriaantimicrobial agentsinfection controlbacteriologymicrobiologymicrobial pathogenesisinfectious diseasesspecific resistancedrug resistancehigh-level fluoroquinolone resistanceapplied microbiologyantimicrobial resistanceantibiotic resistancemolecular biologybacteriaantimicrobial resistance genesantimicrobial susceptibilityclinical microbiology

Integrin-Activating Yersinia Protein Invasin Sustains Long-Term Expansion of Primary Epithelial Cells as 2D Organoid Sheets. Proceedings of the National Academy of Sciences (2024)

Joost J.A.P.M. WijnakkerGijs J.F. van SonDaniel KruegerWilline J. van de WeteringCarmen Lopez-IglesiasRobin SchreursFenna van RijtSangho LimLin LinPeter J. PetersRalph R. IsbergClaudia Y. JandaWim de LauHans Clevers

primary epithelial cellsorganoid sheetscellular differentiationdevelopmental biologymolecular biologycell biologyintracellular trafficking

Streptococcus Pneumoniae Favors Tolerance via Metabolic Adaptation Over Resistance to Circumvent Fluoroquinolones. mBio (2024)

Tina H. DaoHaley EchlinAbigail McKnightEnolia S. MarrJulia JunkerQidong JiaRandall HaydenTim van OpijnenRalph R. IsbergVaughn S. CooperJason W. Rosch

microbiologyclinical microbiologydisease preventionmetabolic adaptationantimicrobial resistanceveterinary medicinepublic healthepidemiology

Loss of Essential Outer Membrane Functions Causes Drug Hypersensitization in Acinetobacter Baumannii Overexpressing Multidrug Efflux Pumps. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Efrat HamamiWenwen HuoKatherine NealIsabelle NeisewanderEdward GeisingerRalph R. Isberg

pharmacologyessential genesbacteriologymolecular microbiologybacteriamolecular biologyveterinary medicineglobal healthclinical microbiology

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Ralph Isberg

Professor

Tufts University

Affiliations

Graduate School of Biomedical Sciences

Genetics, Molecular and Cellular Biology

Immunology

Molecular Microbiology

School of Medicine

Molecular Biology and Microbiology

Ralph Isberg is currently serving as a Genetics, Molecular And Cellular Biology Professor at Tufts University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ralph Isberg

Tufts University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Host Cd59 Potentiates the Type III Secretion System in Yersinia Pseudotuberculosis. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Rna Quality Control Enables Antibiotic Tolerance. bioRxiv (Cold Spring Harbor Laboratory) (2026)

The Transcriptional Response of Yersinia Pseudotuberculosis to Macrophage-Released Chemicals During Growth Within Synthetic Microcolonies. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Resistance, Heteroresistance, and Fitness Costs Drive Colistin Treatment Failure During Acinetobacter Baumannii Pneumonia. Proceedings of the National Academy of Sciences (2025)

A Random Mutagenesis Screen Enriched for Missense Mutations in Bacterial Effector Proteins. G3 Genes Genomes Genetics (2024)

Malene L UrbanusThomas M ZhengAnna N KhusnutdinovaDoreen BanhHarley O’Connor MountAlind GuptaPeter J StogiosAlexei SavchenkoRalph R IsbergAlexander F YakuninAlexander W Ensminger

geneticsmissense mutationsmutagenesisrandom mutagenesis screengenomicsbacterial effector proteins

Genetic Evidence for a Regulated Cysteine Protease Catalytic Triad in Lega7, a Legionella Pneumophila Protein That Impinges on a Stress Response Pathway. mSphere (2024)

Dar HershkovitzEmy J. ChenAlexander W. EnsmingerAisling S. DuganKaleigh T. ConwayAlex C. JoyceGil SegalRalph R. Isberg

geneticsmicrobiologymicrobial pathogenesisstress response pathwaymolecular biologygenetic evidence

Identification of Determinants That Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter Baumannii. mBio (2024)

Efrat HamamiWenwen HuoJuan Hernandez-BirdArnold CastanedaJinna BaiSapna SyalJuan C. Ortiz-MarquezTim van OpijnenEdward GeisingerRalph R. Isberg

Integrin-Activating Yersinia Protein Invasin Sustains Long-Term Expansion of Primary Epithelial Cells as 2D Organoid Sheets. Proceedings of the National Academy of Sciences (2024)

primary epithelial cellsorganoid sheetscellular differentiationdevelopmental biologymolecular biologycell biologyintracellular trafficking

Streptococcus Pneumoniae Favors Tolerance via Metabolic Adaptation Over Resistance to Circumvent Fluoroquinolones. mBio (2024)

Tina H. DaoHaley EchlinAbigail McKnightEnolia S. MarrJulia JunkerQidong JiaRandall HaydenTim van OpijnenRalph R. IsbergVaughn S. CooperJason W. Rosch

microbiologyclinical microbiologydisease preventionmetabolic adaptationantimicrobial resistanceveterinary medicinepublic healthepidemiology

Loss of Essential Outer Membrane Functions Causes Drug Hypersensitization in Acinetobacter Baumannii Overexpressing Multidrug Efflux Pumps. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Efrat HamamiWenwen HuoKatherine NealIsabelle NeisewanderEdward GeisingerRalph R. Isberg

pharmacologyessential genesbacteriologymolecular microbiologybacteriamolecular biologyveterinary medicineglobal healthclinical microbiology

1
2
3
4
5
25
10 / page

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