Joan Curcio

Senior Research Scientist

Health Research, Inc

Affiliations

Biomedical Sciences

Joan Curcio is currently serving as a Biomedical Sciences Senior Research Scientist at Health Research, Inc.

Honors

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Education

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Joan Curcio

Health Research, Inc

Senior Research Scientist

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molecular cell biology genetics genome biology molecular biology nucleic acids transcription (biology) molecular genetics gene expression yeast molecular and cellular biology transcription factors genomic mechanisms transcription regulation cell biology gene regulation genome instability rna processing dna repair biological chemistry ty1 retrotransposition structural molecular biology general virology rna biology cell signaling fungal genetics chromosomal rearrangements chromatin remodeling genome structure human retrovirus genome editing oncogenes aging cell virus research chromosome biology nuclear organization viral replication biology developmental cell enzyme inhibition toxins cellular biochemistry biomolecular structure experimental gerontology virus structure developmental genetics cell lineage transcriptomics technology gene function viral genetics host factors mutagenesis inhibitory activity mechanisms of action immunologic mechanisms host response innate immune system cellular immune responses dna sequencing dna analysis gene structure splicing variant ty1 gag mrna decay factors ty1 integration mouse steel gene artificial yeast chromosomes nucleosomal surface integration hotspot co-translational localization ltr-retrotransposon rna endoplasmic reticulum ty1 transpositional dormancy stress response global profiling rna post-transcriptional modifications saccharomyces cervisiae genome endogenous retrovirus spindle pole body viral assembly asymmetric inheritance

Notable Scholarly Works

Notable Federal Grants

Collaborators

Global Profiling of Rna Post-Transcriptional Modifications as an Effective Tool for Investigating the Epitranscriptomics of Stress Response. Mol. Cell. Proteomics (2016)

genome biologytranscriptometranscriptomics technologygene expressiontranscription regulationfunctional genomicsstress responserna processingtranscription (biology)systems biologygeneticsmolecular cell biologymolecular biologyglobal profilingrna post-transcriptional modificationsepigeneticsgene regulation

Paralog-Specific Functions of Rpl7A and Rpl7B Mediated by Ribosomal Protein or Snorna Dosage in Saccharomyces Cerevisiae. G3 (2016)

gene expressionyeastribosomal proteinrna processingtranscription (biology)geneticsmolecular and cellular biologyfungal geneticsmolecular cell biologyprotein synthesismolecular geneticsmolecular biologybiological chemistryparalog-specific functionsprotein biosynthesissnorna dosagenucleic acids

The Ty1 Ltr-Retrotransposon of Budding Yeast, Saccharomyces Cerevisiae. Microbiol. Spectr. (2015)

genome biologyty1 ltr-retrotransposongene expressionyeasttranscription (biology)geneticsmolecular and cellular biologymolecular cell biologymolecular geneticsmolecular biologynucleic acids

Co-Translational Localization of an Ltr-Retrotransposon Rna to the Endoplasmic Reticulum Nucleates Virus-Like Particle Assembly Sites. PLoS Genetics (2014)

virus researchgene expressionvirus structuretranscription (biology)general virologyltr-retrotransposon rnamolecular cell biologyvirologynucleic acidsmolecular biologyco-translational localizationviral replicationendoplasmic reticulumcell biology

Rna-Rna Interactions and Pre-Mrna Localization as the Drivers of Group II Intron Loss From Nuclear Genomes. Proc. Natl. Acad. Sci. USA (2014)

genome biologytranscriptomegene expressionpre-mrna localizationfunctional genomicsnuclear genomesrna processingtranscription (biology)rna-rna interactionsgeneticsmolecular cell biologymolecular biologymolecular geneticsrna biologynucleic acids

A Nucleosomal Surface Defines an Integration Hotspot for the Saccharomyces Cerevisiae Ty1 Retrotransposon. Genome Res. (2012)

genome biologyyeasttranscription (biology)geneticsmolecular cell biologymolecular geneticsmolecular biologychromosomal rearrangementschromatinchromatin remodelingnuclear organizationnucleosomal surfaceintegration hotspotnucleic acids

Host Co-Factors of the Retrovirus-Like Transposon Ty1. Mob. DNA (2012)

virus researchpathogenesisretrovirus-like transposon ty1general virologygeneticsviral geneticsvirologyhuman retrovirus

Retrotransposition is Associated With Genome Instability During Chronological Aging. Proc. Natl. Acad. Sci. USA (2011)

genome biologyageingexperimental gerontologybiogerontologyaging cellgeneticsepigeneticsgenome instability

Telomerase and Retrotransposons: Reverse Transcriptases That Shaped Genomes. Proc. Natl. Acad. Sci. USA (2011)

genomicsgenome biologygenomic mechanismsgenome structurereverse geneticsgeneticsmolecular cell biologymolecular geneticsnucleic acids

The Intra-S Phase Checkpoint Protein Tof1 Collaborates With the Helicase Rrm3 and the F-Box Protein Dia2 to Maintain Genome Stability in Saccharomyces Cerevisiae. J. Biol. Chem. (2011)

genome biologycell cyclehelicase rrm3yeastf-box protein dia2genome stabilitysystems biologymolecular and cellular biologymolecular cell biologymolecular biologydna replicationprotein sciencecell biology

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