Faculty

Institution

Unit

Venue

Jeffrey L. Benovic

Thomas Eakins Endowed Professor - Cancer Biology

Thomas Jefferson University

Affiliations

Sidney Kimmel Medical College

Biochemistry & Molecular Biology

Jeffrey L. Benovic is currently serving as a Biochemistry & Molecular Biology Thomas Eakins Endowed Professor - Cancer Biology at Thomas Jefferson University.

Honors

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Experiences

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Education

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Jeffrey L. Benovic

Thomas Jefferson University

Thomas Eakins Endowed Professor - Cancer Biology

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pharmacology biochemistry receptors protein science molecular biology cell signaling neuroscience biological chemistry g protein-coupled receptor membrane biology signal transduction receptor (biochemistry) molecular pharmacology neuropharmacology molecular physiology medicinal research molecular regulation structural biology medicinal chemistry cellular physiology pharmacological research redox biology signaling pathways cellular biochemistry protein phosphorylation cell regulation pharmacokinetics mammalian biology enzyme inhibition respiratory medicine functional regulation biochemical sciences experimental pharmacology molecular cancer biomolecular interactions receptor tyrosine kinases neurochemistry cancer biology b-adrenergic receptor kinase structural molecular biology molecular neurobiology beta-adrenergic receptor kinase functional modification protein transport protein expression skin cancer clinical biochemistry molecular cell biology cellular pharmacology clinical pharmacology respiratory neurobiology uveal melanoma cellular biology cell trafficking insulin signaling respiration (physiology) protein function pulmonary pharmacology receptor kinases translational pharmacology intracellular trafficking integrative biology neurotransmission inhibitory activity lipid vesicles visual arrestin receptor phosphorylation receptor trafficking third intracellular loop g-protein-coupled receptor kinases arrestin-independent internalization selective regulation g-protein-coupled receptors agonist-induced down-regulation gtpase activity distinct mechanisms melanoma cell biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Diverse Pathways in Gpcr-Mediated Activation of Ca2+ Mobilization in Hek293 Cells. Journal of Biological Chemistry (2024)

Francesco De PascaliAsuka InoueJeffrey L Benovic

cell signalinggene expressiondiverse pathwaysmolecular and cellular biologycell regulationg protein-coupled receptorsystems biologybiological chemistrygpcr-mediated activationcell metabolismmolecular cell biologytranscription (biology)biochemistrymolecular pathwaysmedicinal researchsignaling pathwayssignal transductiontranscription regulationmolecular biologycellular physiology

Diverse Pathways in Gpcr-Mediated Activation of Ca 2+ Mobilization in Hek293 Cells. (2024)

Francesco F. De PascaliSushrut D. ShahJeffrey L. Benovic

receptorsprotein sciencecell signalingneuroscienceredox biologyimmunologypharmacologymembrane biologyprotein expressionsignal transductiongpcr-mediated activationgene expressiondiverse pathways

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent Grk5 Variant Affecting Platelets. Blood (2024)

Yanki YarmanXuefei ZhaoHyun Sook AhnHannah ThomsonMeghan RobertsDeborah L. FrenchJeffrey BenovicTimothy J. StalkerMortimer PonczPeisong Ma

clinical implicationsimmunologyblood plateletthrombotic risksmechanistic insights

Proximity Labeling Reveals a Multivalent Scaffold That Targets Grk5 to a Signaling Complex With Beta-Adrenergic Receptors. Journal of Pharmacology and Experimental Therapeutics (2024)

Konstantin KomolovSarah M. SulonDaniela K. LaurinavichyuteJeffrey L. Benovic

signaling pathwaysneuropharmacologymolecular neurosciencesignal recognitionbeta-adrenergic receptorscell signalingneuroscienceimmunologypharmacologygene expressionproximity labelingmultivalent scaffold

The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β -Cell Function and Diabetes. Pharmacological Reviews (2024)

Matthew J. VarneyJeffrey L. Benovic

receptorsmedicinediabetesreceptor (biochemistry)cell biologypancreas transplantationmolecular regulationmolecular physiologyneuropharmacologypancreatic cancerbiochemistryvascular biologymolecular medicinemedicinal researchreceptor kinasessignal transductionreceptor tyrosine kinasesenzyme inhibitioncellular biochemistry

Calcium-Dependent Regulation of G Protein-Coupled Receptor Kinases. Journal of Pharmacology and Experimental Therapeutics (2023)

Konstantin KomolovDaniela K. LaurinavichyuteAnshul BhardwajJeffrey L. Benovic

systems neuroscienceneuroscienceg protein-coupled receptormolecular regulationimmunologypharmacologycalcium-dependent regulation

Figure S6 From Igf1R Inhibition Enhances the Therapeutic Effects of G Sub Q/11 /Sub Inhibition in Metastatic Uveal Melanoma Progression. (2023)

Dominic LapadulaBao LamMizue TeraiTakahito SugaseRyota TanakaEduardo FariasRama KadambMelisa Lopez-AntonChristian C. HeineBhavik ModasiaJulio A. Aguirre-GhisoAndrew E. AplinTakami SatoJeffrey L. Benovic

metastasisurologycancer immunotherapytumor biologycellular therapytherapeutic effectsoncologyradiation oncologycancer researchmolecular cancercancer growthleukemiapharmacologytumor targetingmelanomaskin cancermedicinal researchtreatment development

How Carvedilol Does Not Activate β2-Adrenoceptors. Nature Communications (2023)

Robert J. LefkowitzHoward A. RockmanPaul J. ShimSamuel LiuSeungkirl AhnBiswaranjan PaniSudarshan RajagopalSudha K. ShenoyMichel BouvierJeffrey L. BenovicStephen B. LiggettRobert R. RuffoloMichael R. BristowMilton Packer

receptorspharmacologyneuropharmacology

Identification and Pharmacological Characterization of a Novel β-Arrestin-Biased Negative Allosteric Modulator of the Β. Journal of Pharmacology and Experimental Therapeutics (2023)

Francesco F. De PascaliMichael IppolitoNathan HopfingerKonstantin E. KomolovDaniela K. LaurinavichyuteLeon A. SakkalAjay P. NayakPoli AN. ReddyPreston S. DonoverMelvin ReichmanJoseph M. SalvinoRaymond B. PennRoger S. ArmenCharles P. ScottJeffrey L. Benovic

pharmacological characterizationdrug discoverypharmacologymolecular pharmacology

Identification of a β-Arrestin-Biased Negative Allosteric Modulator for the β 2 -Adrenergic Receptor. Proceedings of the National Academy of Sciences (2023)

Michael IppolitoFrancesco De PascaliNathan HopfingerKonstantin E. KomolovDaniela LaurinavichyutePoli Adi Narayana ReddyLeon A. SakkalKyle Z. RajkowskiAjay P. NayakJustin LeeJordan LeeGaoyuan CaoPreston S. DonoverMelvin ReichmanSteven S. AnJoseph M. SalvinoRaymond B. PennRoger S. ArmenCharles P. ScottJeffrey L. Benovic

receptorsneuropharmacologyendocrinologyneurosciencepharmacologyphysiologydrug discovery

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Jeffrey L. Benovic

Thomas Eakins Endowed Professor - Cancer Biology

Thomas Jefferson University

Affiliations

Sidney Kimmel Medical College

Biochemistry & Molecular Biology

Jeffrey L. Benovic is currently serving as a Biochemistry & Molecular Biology Thomas Eakins Endowed Professor - Cancer Biology at Thomas Jefferson University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jeffrey L. Benovic

Thomas Jefferson University

Thomas Eakins Endowed Professor - Cancer Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Diverse Pathways in Gpcr-Mediated Activation of Ca2+ Mobilization in Hek293 Cells. Journal of Biological Chemistry (2024)

Francesco De PascaliAsuka InoueJeffrey L Benovic

Diverse Pathways in Gpcr-Mediated Activation of Ca 2+ Mobilization in Hek293 Cells. (2024)

Francesco F. De PascaliSushrut D. ShahJeffrey L. Benovic

receptorsprotein sciencecell signalingneuroscienceredox biologyimmunologypharmacologymembrane biologyprotein expressionsignal transductiongpcr-mediated activationgene expressiondiverse pathways

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent Grk5 Variant Affecting Platelets. Blood (2024)

Yanki YarmanXuefei ZhaoHyun Sook AhnHannah ThomsonMeghan RobertsDeborah L. FrenchJeffrey BenovicTimothy J. StalkerMortimer PonczPeisong Ma

clinical implicationsimmunologyblood plateletthrombotic risksmechanistic insights

Proximity Labeling Reveals a Multivalent Scaffold That Targets Grk5 to a Signaling Complex With Beta-Adrenergic Receptors. Journal of Pharmacology and Experimental Therapeutics (2024)

Konstantin KomolovSarah M. SulonDaniela K. LaurinavichyuteJeffrey L. Benovic

The Role of G Protein–Coupled Receptors and Receptor Kinases in Pancreatic β -Cell Function and Diabetes. Pharmacological Reviews (2024)

Matthew J. VarneyJeffrey L. Benovic

Calcium-Dependent Regulation of G Protein-Coupled Receptor Kinases. Journal of Pharmacology and Experimental Therapeutics (2023)

Konstantin KomolovDaniela K. LaurinavichyuteAnshul BhardwajJeffrey L. Benovic

systems neuroscienceneuroscienceg protein-coupled receptormolecular regulationimmunologypharmacologycalcium-dependent regulation

Figure S6 From Igf1R Inhibition Enhances the Therapeutic Effects of G Sub Q/11 /Sub Inhibition in Metastatic Uveal Melanoma Progression. (2023)

How Carvedilol Does Not Activate β2-Adrenoceptors. Nature Communications (2023)

receptorspharmacologyneuropharmacology

Identification and Pharmacological Characterization of a Novel β-Arrestin-Biased Negative Allosteric Modulator of the Β. Journal of Pharmacology and Experimental Therapeutics (2023)

pharmacological characterizationdrug discoverypharmacologymolecular pharmacology

Identification of a β-Arrestin-Biased Negative Allosteric Modulator for the β 2 -Adrenergic Receptor. Proceedings of the National Academy of Sciences (2023)

receptorsneuropharmacologyendocrinologyneurosciencepharmacologyphysiologydrug discovery

1
2
3
4
5
32
10 / page

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