Faculty

Institution

Unit

Venue

Jeffrey D. Winkler

Merriam Professor of Chemistry

University of Pennsylvania

Affiliations

School of Arts & Sciences

Chemistry

Jeffrey D. Winkler is currently serving as a Chemistry Merriam Professor of Chemistry at University of Pennsylvania.

Honors

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Experiences

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Education

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Jeffrey D. Winkler

University of Pennsylvania

Merriam Professor of Chemistry

You can click a keyword to filter the displayed items

organic synthesis chemistry pharmacology organic chemistry chemical synthesis medicinal chemistry cancer research tumor biology drug discovery oncology medicinal research stereoselective synthesis molecular biology cancer biology autophagy cell biology enzyme inhibition molecular cancer anti-cancer agents cancer treatment tumor targeting inside-outside stereoisomerism synthetic chemistry heterocycle chemistry cancer growth biological evaluation cancer cells pharmaceutical chemistry natural product synthesis heterocyclic intramolecular photocycloaddition clinical chemistry protein science mammalian biology drug targeting melanoma redox biology cancer care oncogenes chemical sciences structural chemistry drug targets tandem diels-alder reaction pharmacotherapy inhibitory activity molecular design drug development rational drug design cell regulation first total synthesis taxane diterpenes clinical biochemistry biological chemistry cellular senescence enzyme catalysis conformational studies cancer genetics cancer genomics selective inhibitors metal complexation solid supports single-agent antitumor activity tandem diels-alder cycloadditions later adulthood clinical case report tumor suppressors clinical pathology clinical evaluation microbial physiology biocatalysis host-guest chemistry inhibitor resistance genetic autophagy deficiency quinone oxidoreductase antimicrobial arylamide foldamers vivo activity

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Pr001: Targeting S6K2 Overcomes Resistance to Ras Inhibition in Nras-Mutant Melanoma. Cancer Research (2026)

tumor biologynras-mutant melanomaradiation oncologymolecular cancercancer biologycell biologycancer cellsmolecular cell biologyoncogenesphotocarcinogenesisabstract pr001therapeutic targetsmelanomaras inhibitionmedicinal research

Low-Dose Biliatresone Treatment of Pregnant Mice Causes Subclinical Biliary Disease in Their Offspring: Evidence for a Spectrum of Neonatal Injury. PLoS ONE (2024)

Kapish GuptaJimmy P. XuTamir DiamondIris E. M. de JongAndrew GlassJessica LlewellynNeil D. TheiseOrith Waisbourd-ZinmanJeffrey D. WinklerEdward M. BehrensClementina MesarosRebecca G. Wells

hepatologyhematologypregnant micelow-dose biliatresone treatmentneonatologyimmunologypharmacologyvascular biologymammalian biologynephrologyrespiratory medicinesubclinical biliary diseaseneonatal injuryhealth sciencescardiovascular disease

Biliatresone Treatment of Pregnant Mice Causes Changes in Bile Metabolism and Liver Inflammation in Their Offspring. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Kapish GuptaJimmy P. XuTamir DiamondIris De JongAndrew GlassJessica LlewellynNeil D. TheiseJeffrey D. WinklerEdward M. BehrensClementina MesarosRebecca G. Wells

hematologybiliatresone treatmentliver inflammationbile metabolismimmunologypharmacologyhealth sciencesmedicinal research

Chemical Methods From a Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2023)

Vito W. RebeccaMichael C. NicastriNoel McLaughlinColin FennellyQuentin McAfeeAmruta RongheMichel NofalChun-Yan LimEric WitzeCynthia I. ChudeGao ZhangGretchen M. AliceaShengfu PiaoSengottuvelan MuruganRani OjhaSamuel M. LeviZhi WeiJulie S. Barber-RotenbergMaureen E. MurphyGordon B. MillsYiling LuJoshua RabinowitzRonen MarmorsteinQin LiuShujing LiuXiaowei XuMeenhard HerlynRoberto ZoncuDonita C. BradyDavid W. SpeicherJeffrey D. WinklerRavi K. Amaravadi

chemical methodschemical biologybiochemistryphysiology

Chemical Methods From Ppt1 Promotes Tumor Growth and is the Molecular Target of Chloroquine Derivatives in Cancer. (2023)

Vito W. RebeccaMichael C. NicastriColin FennellyCynthia I. ChudeJulie S. Barber-RotenbergAmruta RongheQuentin McAfeeNoel P. McLaughlinGao ZhangAaron R. GoldmanRani OjhaShengfu PiaoEstela Noguera-OrtegaAlessandra MartorellaGretchen M. AliceaJennifer J. LeeLynn M. SchuchterXiaowei XuMeenhard HerlynRonen MarmorsteinPhyllis A. GimottyDavid W. SpeicherJeffrey D. WinklerRavi K. Amaravadi

tumor biologyanti-cancer agentschemistrycancer researchradiation oncologyoncologycancer growthmedicinal chemistrycancer biologychloroquine derivativespharmacologycancer treatmentchemical methodsdrug discoverymolecular target

Data From Atg5 Mediates a Positive Feedback Loop Between Wnt Signaling and Autophagy in Melanoma. (2023)

Abibatou NdoyeAnna Budina-KolometsCurtis H. KugelMarie R. WebsterAmanpreet KaurReeti BeheraVito W. RebeccaLing LiPatricia A. BraffordQin LiuY.N. Vashisht GopalMichael A. DaviesGordon B. MillsXiaowei XuHong WuMeenhard HerlynMichael C. NicastriJeffrey D. WinklerMaria S. SoengasRavi K. AmaravadiMaureen E. MurphyAshani T. Weeraratna

tumor biologygeneticsmelanomacancer researchoncologycancer biologydermatologyleukemiaautophagyfeedback looppositive feedback loopmolecular biologyskin cancercancer geneticsmedicinal research

Figure S1-4, Tables1, S2 From Atg5 Mediates a Positive Feedback Loop Between Wnt Signaling and Autophagy in Melanoma. (2023)

cancer biologycell signalingleukemiaautophagygene expressionmelanomatumor biologycancer researchpositive feedback loopgeneticsradiation oncologymolecular cancerfeedback loopmedicinal researchcancer growthcancer cellssignal transductionmolecular biologyskin cancer

Lysosomal Lipid Peroxidation Regulates Tumor Immunity. Journal of Clinical Investigation (2023)

Monika BhardwajJennifer J. LeeAmanda M. VersaceSandra L. HarperAaron R. GoldmanMary Ann S. CrisseyVaibhav JainMahendra Pal SinghMegane VernonAndrew E. AplinSeokwoo LeeMasao MoritaJeffrey D. WinklerQin LiuDavid W. SpeicherRavi K. Amaravadi

lipid sciencetumor biologyliver physiologyclinical lipidologyoncologycancer researchcancer biologyclinical physiologyimmunologymembrane biologypharmacologytumor immunitylysosomal lipid peroxidationclinical researchhealth sciencesmedicinal research

Supplemental Figures S1-S7 and Supplemental Table S1 From a Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2023)

liver physiologycell biologycell signalingprotein scienceautophagybiologymembrane biologyprotein functionpathology

Supplementary Figures S1-S4 From Ppt1 Promotes Tumor Growth and is the Molecular Target of Chloroquine Derivatives in Cancer. (2023)

tumor biologyanti-cancer agentscancer researchradiation oncologyoncologymolecular cancercancer growthcancer biologychloroquine derivativespharmacologymolecular target

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Jeffrey D. Winkler

Merriam Professor of Chemistry

University of Pennsylvania

Affiliations

School of Arts & Sciences

Chemistry

Jeffrey D. Winkler is currently serving as a Chemistry Merriam Professor of Chemistry at University of Pennsylvania.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jeffrey D. Winkler

University of Pennsylvania

Merriam Professor of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Pr001: Targeting S6K2 Overcomes Resistance to Ras Inhibition in Nras-Mutant Melanoma. Cancer Research (2026)

Low-Dose Biliatresone Treatment of Pregnant Mice Causes Subclinical Biliary Disease in Their Offspring: Evidence for a Spectrum of Neonatal Injury. PLoS ONE (2024)

Kapish GuptaJimmy P. XuTamir DiamondIris E. M. de JongAndrew GlassJessica LlewellynNeil D. TheiseOrith Waisbourd-ZinmanJeffrey D. WinklerEdward M. BehrensClementina MesarosRebecca G. Wells

Biliatresone Treatment of Pregnant Mice Causes Changes in Bile Metabolism and Liver Inflammation in Their Offspring. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Kapish GuptaJimmy P. XuTamir DiamondIris De JongAndrew GlassJessica LlewellynNeil D. TheiseJeffrey D. WinklerEdward M. BehrensClementina MesarosRebecca G. Wells

hematologybiliatresone treatmentliver inflammationbile metabolismimmunologypharmacologyhealth sciencesmedicinal research

Chemical Methods From a Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2023)

chemical methodschemical biologybiochemistryphysiology

Chemical Methods From Ppt1 Promotes Tumor Growth and is the Molecular Target of Chloroquine Derivatives in Cancer. (2023)

Data From Atg5 Mediates a Positive Feedback Loop Between Wnt Signaling and Autophagy in Melanoma. (2023)

tumor biologygeneticsmelanomacancer researchoncologycancer biologydermatologyleukemiaautophagyfeedback looppositive feedback loopmolecular biologyskin cancercancer geneticsmedicinal research

Figure S1-4, Tables1, S2 From Atg5 Mediates a Positive Feedback Loop Between Wnt Signaling and Autophagy in Melanoma. (2023)

Lysosomal Lipid Peroxidation Regulates Tumor Immunity. Journal of Clinical Investigation (2023)

Supplemental Figures S1-S7 and Supplemental Table S1 From a Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. (2023)

liver physiologycell biologycell signalingprotein scienceautophagybiologymembrane biologyprotein functionpathology

Supplementary Figures S1-S4 From Ppt1 Promotes Tumor Growth and is the Molecular Target of Chloroquine Derivatives in Cancer. (2023)

tumor biologyanti-cancer agentscancer researchradiation oncologyoncologymolecular cancercancer growthcancer biologychloroquine derivativespharmacologymolecular target

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2
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5
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complex synthesis

complex chemical libraries

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