Faculty

Institution

Unit

Venue

Isabelle R. Taylor

Assistant Professor

College of William and Mary

Affiliations

Arts & Sciences

Chemistry

Isabelle R. Taylor is currently serving as an Arts & Sciences Assistant Professor at College of William And Mary.

Honors

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Experiences

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Education

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Isabelle R. Taylor

College of William and Mary

Assistant Professor

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microbiology molecular biology pharmacology molecular microbiology enzymes medicinal chemistry microbial pathogenesis drug discovery genetics protein science clinical microbiology virulence factors enzyme inhibition molecular cell biology bacteriology drug targeting drug targets biological targets virulence factor production pqse-rhlr interaction virology small molecules functional genomics tumor biology applied microbiology chemical sciences cellular physiology medicinal research cell research biological chemistry structural molecular biology microbial physiology host-microbe interactions protein synthesis microbial genetics gene regulation molecular regulation small molecule library medical microbiology mutagenesis cellular biology enzyme catalysis biocatalysis cancer treatment eukaryotic protein synthesis legionella pneumophila kinase inhibitor mimetic mutations quorum-sensing receptor rhlr protein-protein interaction rhlr dna allosteric control mechanisms high-throughput screen protein-protein interactions pqse thioesterase inhibitors pqse active site compound-bound state allosteric inhibitors local allosteric network bioprospecting antimicrobial resistance biochemistry quorum sensing

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pqse Acts as an Adaptor Protein for the Quorum-Sensing Transcription Factor Rhlr in Pseudomonas Aeruginosa. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Bilalay V. TchadiJesse J. DerringerAnna K. DetweilerIsabelle R. Taylor

microbiologypathogenic bacteriaquorum sensingmolecular microbiologymicrobial pathogenesismolecular cell biologytranscription (biology)bacteriaclinical microbiologytranscription factorsbiological chemistrystructural molecular biologybacteriologyp. aeruginosavirulence factorspqse-rhlr interactionmolecular biology

Protein Interaction Networks of Catalytically Active and Catalytically Inactive Pqse in Pseudomonas Aeruginosa. mBio (2022)

Isabelle R. TaylorLaura A. Murray-NergerTodd M. GrecoDawei LiuIleana M. CristeaBonnie L. Bassler

microbiologyenzymesbiocatalysisprotein interaction networksenzyme catalysissystems biologymolecular biology

Selective Vulnerabilities in the Proteostasis Network of Castration-Resistant Prostate Cancer. Cell chemical biology (2022)

Arielle ShkediIsabelle R. TaylorFrank EchtenkampPoornima RamkumarMohamed AlshalalfaGénesis M. Rivera-MárquezMichael A. MosesHao ShaoRobert Jeffrey KarnesLen NeckersFelix FengMartin KampmannJason E. Gestwicki

cellular physiologyurologytumor biologycancer researchproteostasis networkcastration-resistant prostate cancercell biologymolecular cell biologymedicinal researchneuroscienceselective vulnerabilitiescell researchcell and molecular biologyprostate cancercellular biologystructural biology

The Pqse Active Site as a Target for Small Molecule Antimicrobial Agents Against Pseudomonas Aeruginosa. Biochemistry (2022)

Isabelle R. TaylorPhilip D. JeffreyDina A. MoustafaJoanna B. GoldbergBonnie L. Bassler

pqse active sitemicrobiologymolecular microbiologysmall moleculesprotein scienceclinical microbiologydrug targetsbiochemistrypharmacologydrug targetingmedical microbiologybiological targetsapplied microbiology

The Pqse-Rhlr Interaction Regulates Rhlr Dna Binding to Control Virulence Factor Production in Pseudomonas Aeruginosa. Microbiology Spectrum (2022)

Kayla A. SimanekIsabelle R. TaylorErica K. RichaelErica Lasek-NesselquistBonnie L. BasslerJon E. Paczkowski

microbiologyvirologygeneticsmolecular microbiologymicrobial pathogenesisgene regulationmolecular regulationbacteriologyvirulence factor productionrhlr dnavirulence factorspqse-rhlr interactionmolecular biology

A New Target for Pseudomonas Aeruginosa Drug Discovery. (2021)

Bonnie BasslerIsabelle TaylorJon Paczkowski

medicinedrug targetsdrug targetingtherapeutic targetsdrug discoverybiological targets

Functional Genomics Screen Identifies Proteostasis Targets That Modulate Prion Protein (Prp) Stability. Cell Stress and Chaperones (2021)

Jennifer AbramsTaylor ArharSue Ann MokIsabelle R. TaylorMartin KampmannJason E. Gestwicki

cell biologyprion proteinfunctional genomics

Inhibitor Mimetic Mutations in the Pseudomonas Aeruginosa Pqse Enzyme Reveal a Protein–Protein Interaction With the Quorum-Sensing Receptor Rhlr That is Vital for Virulence Factor Production. ACS Chemical Biology (2021)

Isabelle R. TaylorJon E. PaczkowskiPhilip D. JeffreyBrad R. HenkeChari D. SmithBonnie L. Bassler

microbiologygeneticsenzymesmicrobial geneticsprotein-protein interactionmolecular microbiologymicrobial pathogenesisquorum-sensing receptor rhlrclinical microbiologyvirulence factor productioninhibitor mimetic mutationsvirulence factorsmolecular biologyenzyme inhibition

Tryptophan Scanning Mutagenesis as a Way to Mimic the Compound-Bound State and Probe the Selectivity of Allosteric Inhibitors in Cells. Chemical Science (2020)

Isabelle R. TaylorVictoria A. AssimonSzu Yu KuoSilvia RinaldiXiaokai LiZapporah T. YoungGiulia MorraKeith GreenDaniel NguyenHao ShaoSylvie Garneau-TsodikovaGiorgio ColomboJason E. Gestwicki

allosteric inhibitorschemistrymedicinal chemistrycell biologycompound-bound statechemical sciencespharmacologymutagenesisdrug discovery

A Legionella Pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host & Microbe (2019)

Steven M. MossIsabelle R. TaylorDavide RuggeroJason E. GestwickiKevan M. ShokatShaeri Mukherjee

microbiologylegionella pneumophila kinasegeneticshost-microbe interactionseukaryotic protein synthesisinfectious diseasesmicrobial pathogenesisprotein synthesismicrobial physiology

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Isabelle R. Taylor

Assistant Professor

College of William and Mary

Affiliations

Arts & Sciences

Chemistry

Isabelle R. Taylor is currently serving as an Arts & Sciences Assistant Professor at College of William And Mary.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Isabelle R. Taylor

College of William and Mary

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Pqse Acts as an Adaptor Protein for the Quorum-Sensing Transcription Factor Rhlr in Pseudomonas Aeruginosa. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Bilalay V. TchadiJesse J. DerringerAnna K. DetweilerIsabelle R. Taylor

Protein Interaction Networks of Catalytically Active and Catalytically Inactive Pqse in Pseudomonas Aeruginosa. mBio (2022)

Isabelle R. TaylorLaura A. Murray-NergerTodd M. GrecoDawei LiuIleana M. CristeaBonnie L. Bassler

microbiologyenzymesbiocatalysisprotein interaction networksenzyme catalysissystems biologymolecular biology

Selective Vulnerabilities in the Proteostasis Network of Castration-Resistant Prostate Cancer. Cell chemical biology (2022)

The Pqse Active Site as a Target for Small Molecule Antimicrobial Agents Against Pseudomonas Aeruginosa. Biochemistry (2022)

Isabelle R. TaylorPhilip D. JeffreyDina A. MoustafaJoanna B. GoldbergBonnie L. Bassler

The Pqse-Rhlr Interaction Regulates Rhlr Dna Binding to Control Virulence Factor Production in Pseudomonas Aeruginosa. Microbiology Spectrum (2022)

Kayla A. SimanekIsabelle R. TaylorErica K. RichaelErica Lasek-NesselquistBonnie L. BasslerJon E. Paczkowski

A New Target for Pseudomonas Aeruginosa Drug Discovery. (2021)

Bonnie BasslerIsabelle TaylorJon Paczkowski

medicinedrug targetsdrug targetingtherapeutic targetsdrug discoverybiological targets

Functional Genomics Screen Identifies Proteostasis Targets That Modulate Prion Protein (Prp) Stability. Cell Stress and Chaperones (2021)

Jennifer AbramsTaylor ArharSue Ann MokIsabelle R. TaylorMartin KampmannJason E. Gestwicki

cell biologyprion proteinfunctional genomics

Isabelle R. TaylorJon E. PaczkowskiPhilip D. JeffreyBrad R. HenkeChari D. SmithBonnie L. Bassler

Tryptophan Scanning Mutagenesis as a Way to Mimic the Compound-Bound State and Probe the Selectivity of Allosteric Inhibitors in Cells. Chemical Science (2020)

Isabelle R. TaylorVictoria A. AssimonSzu Yu KuoSilvia RinaldiXiaokai LiZapporah T. YoungGiulia MorraKeith GreenDaniel NguyenHao ShaoSylvie Garneau-TsodikovaGiorgio ColomboJason E. Gestwicki

allosteric inhibitorschemistrymedicinal chemistrycell biologycompound-bound statechemical sciencespharmacologymutagenesisdrug discovery

A Legionella Pneumophila Kinase Phosphorylates the Hsp70 Chaperone Family to Inhibit Eukaryotic Protein Synthesis. Cell Host & Microbe (2019)

Steven M. MossIsabelle R. TaylorDavide RuggeroJason E. GestwickiKevan M. ShokatShaeri Mukherjee

microbiologylegionella pneumophila kinasegeneticshost-microbe interactionseukaryotic protein synthesisinfectious diseasesmicrobial pathogenesisprotein synthesismicrobial physiology

1
2
10 / page

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Similar Faculty Members

Nigel Yarlett

Institution

Pace University

parasitology

microbiology

Marcos Pires

Institution

University of Virginia

biotechnology advance

synthetic biology

Yftah Tal-Gan

Institution

University of Nevada, Reno

peptide

biochemistry

Helen I. Zgurskaya

Institution

University of Oklahoma

membrane science

biomolecular engineering

Timothy Wencewicz

Institution

Washington University in St. Louis

biological chemistry

biomolecular engineering

Helen Blackwell

Institution

University of Wisconsin–Madison

bioplastic

biochemical engineering

Lindsey Les Shaw

Institution

University of South Florida

drug discovery

infectious diseases

Herman Sintim

Institution

Purdue University

antibiotic adjuvant

bio-orthogonal chemistry

Xingmin Sun

Institution

University of South Florida

infectious diseases

microbial toxin

Polikanov, Yury

Institution

University of Illinois Chicago

molecular biology

protein synthesis