Faculty

Institution

Unit

Venue

Rebecca P. Hughey

Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Microbiology and Molecular Genetics

Rebecca P. Hughey is currently serving as an Interdisciplinary Biomedical Graduate Program Professor at University of Pittsburgh.

Honors

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Experiences

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Education

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Rebecca P. Hughey

University of Pittsburgh

Professor

You can click a keyword to filter the displayed items

membrane biology cell biology physiology pharmacology nephrology protein science biochemistry biological chemistry redox biology renal function molecular physiology enzymes cell signaling signal transduction cellular physiology gene expression structural biology liver physiology protein transport cellular biochemistry mammalian biology enzyme inhibition membrane transport renal pathophysiology electrophysiology vascular biology respiratory medicine medicinal research biochemical sciences protein function glycosylation protein secretion molecular cell biology applied physiology animal physiology integrative biology epithelial sodium channel protein chemistry cancer biology functional modification molecular regulation epithelial sodium channels cell trafficking renal care insulin signaling signaling pathways cell regulation cellular biology cellular enzymology cellular neurobiology kidney research mammalian physiology intracellular trafficking proteolytic processing protein purification redox signaling veterinary physiology cell physiology respiratory neurobiology gene transfer secretory pathway cell migration cancer genetics physiological function channel activation adenovirus-mediated gene transfer epithelial cells thumb domains endoplasmic reticulum inhibitory peptide furin-dependent proteolysis prostasin-dependent release lysosomal degradation glycosylation state clathrin-mediated endocytosis rat kidney

Notable Scholarly Works

Notable Federal Grants

Collaborators

Loss of the Alpha Subunit Distal Furin Cleavage Site Blunts Enac Activation Following Na + Restriction. The Journal of Physiology (2024)

Andrew J. NickersonShaohu ShengNatalie A. CoxKennedy G. SzekelyAllison L. MarciszynTracey LamJingxin ChenSebastien GingrasOssama B. KashlanAnnet KiraboRebecca P. HugheyEvan C. RayThomas R. Kleyman

physiologymolecular biology

Influence of Glycoprotein Muc1 on Trafficking of the Ca2+-Selective Ion Channels, Trpv5 and Trpv6, and on in Vivo Calcium Homeostasis. Journal of Biological Chemistry (2023)

Mohammad M. Al-batainehCarol L. KinloughAllison MarciszynTracey LamLorena YeKendrah KiddJoseph C. MaggiorePaul A. PolandStanislav KmochAnthony BleyerDaniel J. BainNicolas MontalbettiThomas R. KleymanRebecca P. HugheyEvan C. Ray

physiologyprotein secretioncell traffickingmembrane transportmembranescell signalingprotein transportintracellular traffickingmembrane proteinsbiological chemistrysignal transductionprotein sciencemembrane biologybiochemistrycell biology

Lactating Kidneys Upregulate Expression of Cell Proliferation Genes and Trpm6 in the Distal Convoluted Tubule (Dct), Suggesting Dct Hyperplasia. Journal of the American Society of Nephrology (2023)

Lorena YeHyun Jun JungTracey LamIvy LiuAndrew GordonAllison L. MarciszynMohammad M. Al-batainehRebecca P. HugheyPaul A. WellingEvan C. Ray

neurologymedicineregenerative medicinerenal functionnephrologyurologygene functionkidney cancerhepatologycell proliferationrenal pathophysiologydct hyperplasiacancer biologytumor biologycell proliferation genes

Mice Lacking Gamma Enac Palmitoylation Sites Maintain Amiloride/Benzamil-Sensitive Na+ Transport in Vivo, Despite Markedly Reduced Open Probability of Typical Enac-Like Channels.. Physiology (2023)

Andrew NickersonShaohu ShengEvan RayOssama KashlanStephanie MutchlerMarcelo CarattinoAllison MarciszynRebecca HugheyThomas Kleyman

physiologyelectrophysiologypharmacologymembrane transportmammalian physiologyanimal physiologyredox biologyprotein transportopen probabilitymolecular physiologymembrane biologyneurophysiology

Mice Lacking γEnac Palmitoylation Sites Maintain Benzamil-Sensitive Na+ Transport Despite Reduced Channel Activity. JCI Insight (2023)

Andrew J. NickersonStephanie M. MutchlerShaohu ShengNatalie A. CoxEvan C. RayOssama B. KashlanMarcelo D. CarattinoAllison L. MarciszynAaliyah WinfreySebastien GingrasAnnet KiraboRebecca P. HugheyThomas R. Kleyman

physiologyliver physiologypharmacologycellular physiologymembrane transportprotein scienceredox biologyprotein transportneuropharmacologygenac palmitoylation sitesmembrane biologymolecular physiologyneuroscience

The Influence of Muc1 on Mg2+ Handling. Journal of the American Society of Nephrology (2023)

Tracey LamMohammad M. Al-batainehAllison L. MarciszynLorena YeAmrit SinghPaul A. PolandCarol L. KinloughDavid R. EmletEvan C. RayRebecca P. Hughey

medicinepharmacologyrenal functionnephrologyurologyrespiratory medicinerenal carerenal pathophysiology

Cloning, Expression, and Purification of Galectins for in Vitro Studies. Methods in molecular biology (2022)

Paul A. PolandCarol L. KinloughRebecca P. Hughey

molecular engineeringmolecular scienceprotein purificationbiomolecular engineeringenzymesdrug discoverymolecular biologybiological chemistrymolecular biotechnologymolecular biological methodbiochemistry

Influence of Muc1 on Trafficking of Trpv5 and Trpv6 and in Vivo Ca 2+ Homeostasis. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Mohammad M. Al-batainehCarol L. KinloughAllison MarciszynTracey LamLorena YeKendrah KiddJoseph C. MaggiorePaul A. PolandAnthony BleyerDaniel J. BainThomas R. KleymanRebecca P. HugheyEvan C. Ray

liver physiologypharmacologycell traffickingmembrane transportcell signalingintracellular traffickingbiologyprotein transportin vivo systemssignal transductionmembrane biologycell biology

Suppression of Nrf2 Activity by Hif-1α Promotes Fibrosis After Ischemic Acute Kidney Injury. Antioxidants (2022)

Corry D. BondiBrittney M. RushHannah L. HartmanJiaxuan WangMohammad M. Al-BatainehRebecca P. HugheyRoderick J. Tan

fibrosispharmacologyhematologyemergency medicineregenerative medicinenephrologyredox biologyfree radical biologyantioxidantsredox signalingrenal functionrespiratory medicinemedicinal researchacute kidney injuryrenal careoxidative stresshealth sciencesinflammation

The Role of Muc1 in Lactation‐Associated Bone Mineral Conservation. The FASEB Journal (2022)

Evan C. RayMohammad Al‐BatainehTracey LamCarol C. KinloughAllison L. MarciszynJenna BarbourIrina TourkovaHarry C. BlairThomas R. KleymanRebecca P. Hughey

physiologyliver physiologybone metabolismnutritionnutrient physiologyregenerative medicinehuman lactationbiologymolecular metabolismmineral metabolismmechanobiologynutritional biochemistrystructural biologymolecular nutritiontissue (biology)bone researchcell biology

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Rebecca P. Hughey

Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Microbiology and Molecular Genetics

Rebecca P. Hughey is currently serving as an Interdisciplinary Biomedical Graduate Program Professor at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Rebecca P. Hughey

University of Pittsburgh

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Loss of the Alpha Subunit Distal Furin Cleavage Site Blunts Enac Activation Following Na + Restriction. The Journal of Physiology (2024)

Andrew J. NickersonShaohu ShengNatalie A. CoxKennedy G. SzekelyAllison L. MarciszynTracey LamJingxin ChenSebastien GingrasOssama B. KashlanAnnet KiraboRebecca P. HugheyEvan C. RayThomas R. Kleyman

physiologymolecular biology

Influence of Glycoprotein Muc1 on Trafficking of the Ca2+-Selective Ion Channels, Trpv5 and Trpv6, and on in Vivo Calcium Homeostasis. Journal of Biological Chemistry (2023)

Lactating Kidneys Upregulate Expression of Cell Proliferation Genes and Trpm6 in the Distal Convoluted Tubule (Dct), Suggesting Dct Hyperplasia. Journal of the American Society of Nephrology (2023)

Lorena YeHyun Jun JungTracey LamIvy LiuAndrew GordonAllison L. MarciszynMohammad M. Al-batainehRebecca P. HugheyPaul A. WellingEvan C. Ray

Mice Lacking Gamma Enac Palmitoylation Sites Maintain Amiloride/Benzamil-Sensitive Na+ Transport in Vivo, Despite Markedly Reduced Open Probability of Typical Enac-Like Channels.. Physiology (2023)

Andrew NickersonShaohu ShengEvan RayOssama KashlanStephanie MutchlerMarcelo CarattinoAllison MarciszynRebecca HugheyThomas Kleyman

physiologyelectrophysiologypharmacologymembrane transportmammalian physiologyanimal physiologyredox biologyprotein transportopen probabilitymolecular physiologymembrane biologyneurophysiology

Mice Lacking γEnac Palmitoylation Sites Maintain Benzamil-Sensitive Na+ Transport Despite Reduced Channel Activity. JCI Insight (2023)

The Influence of Muc1 on Mg2+ Handling. Journal of the American Society of Nephrology (2023)

Tracey LamMohammad M. Al-batainehAllison L. MarciszynLorena YeAmrit SinghPaul A. PolandCarol L. KinloughDavid R. EmletEvan C. RayRebecca P. Hughey

medicinepharmacologyrenal functionnephrologyurologyrespiratory medicinerenal carerenal pathophysiology

Cloning, Expression, and Purification of Galectins for in Vitro Studies. Methods in molecular biology (2022)

Paul A. PolandCarol L. KinloughRebecca P. Hughey

Influence of Muc1 on Trafficking of Trpv5 and Trpv6 and in Vivo Ca 2+ Homeostasis. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Mohammad M. Al-batainehCarol L. KinloughAllison MarciszynTracey LamLorena YeKendrah KiddJoseph C. MaggiorePaul A. PolandAnthony BleyerDaniel J. BainThomas R. KleymanRebecca P. HugheyEvan C. Ray

liver physiologypharmacologycell traffickingmembrane transportcell signalingintracellular traffickingbiologyprotein transportin vivo systemssignal transductionmembrane biologycell biology

Suppression of Nrf2 Activity by Hif-1α Promotes Fibrosis After Ischemic Acute Kidney Injury. Antioxidants (2022)

Corry D. BondiBrittney M. RushHannah L. HartmanJiaxuan WangMohammad M. Al-BatainehRebecca P. HugheyRoderick J. Tan

The Role of Muc1 in Lactation‐Associated Bone Mineral Conservation. The FASEB Journal (2022)

Evan C. RayMohammad Al‐BatainehTracey LamCarol C. KinloughAllison L. MarciszynJenna BarbourIrina TourkovaHarry C. BlairThomas R. KleymanRebecca P. Hughey

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membrane protein

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