Faculty

Institution

Unit

Venue

Kasper Hansen

Professor

University of Montana

Affiliations

College of Humanities and Sciences

Biochemistry

Biological Sciences

Kasper Hansen is currently serving as a Biochemistry Professor at University of Montana.

Honors

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Experiences

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Education

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Kasper Hansen

University of Montana

Professor

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pharmacology neuroscience receptors neurology neuropharmacology drug discovery medicinal chemistry molecular pharmacology neurochemistry molecular neuroscience structural biology molecular neurobiology molecular biology receptor (biochemistry) nmda receptors cell signaling medicinal research brain science protein science structural molecular biology molecular physiology pharmacotherapy neural science neurotransmission pharmacological research biological chemistry cellular neurobiology pharmacokinetics translational pharmacology pharmaceutical chemistry stereoselective synthesis pharmacological characterization triheteromeric nmda receptors subunit selectivity molecular cell biology clinical chemistry human physiology mechanisms of action drug targeting clinical pharmacology allosteric modulation pharmacological properties noncompetitive inhibition human serotonin transporter negative allosteric modulation receptor antagonist ionotropic glutamate receptors gpcr drug discovery ibotenic acid cellular physiology redox biology biological psychiatry neuropsychopharmacology experimental medicine applied pharmacology cancer care psychopharmacology protein assembly neurotransmitters inhibitory process physiological research splicing variant sensory science clinical neuroscience protein chemistry rational drug design high-throughput screening combinatorial chemistry hepatocellular carcinoma anti-cancer agents cancer treatment liver cancer mutagenesis nmda receptor function basic amino acids subunit-specific agonist activity neuropsychology neurogenetics cognitive impairment molecular neurodegeneration neuropsychiatry

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Design of ( R )-3-(5-Thienyl)Carboxamido-2-Aminopropanoic Acid Derivatives as Novel Nmda Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment Glun2 Subunit-Specific Activity. Journal of Medicinal Chemistry (2025)

Fabao ZhaoUnai AtxabalSofia MariottiniFeng YiJames S. LottiMichael S. LayeuxChandler CurrierMatthew P. MaderiaLauren E. CornelisonCarly M. AndersonEric P. SchultzZhucheng ZhangLiyang JiangZhen GaoNa LiuErica L. WoodahlLennart BunchKasper B. HansenRasmus P. Clausen

receptorsreceptor (biochemistry)pharmacologymolecular pharmacologypeptide sciencemolecular geometrymedicinal chemistryg protein-coupled receptordrug discoverypeptideschemical biologydiscrete structuresbiochemistryglycosylationmedicinal researchmolecular sciencemolecular dockingstructural molecular biologymolecular biology

Evaluation of Allosteric Nmda Receptor Modulation by Glun2A-Selective Antagonists Using Pharmacological Equilibrium Modeling. Molecular Pharmacology (2024)

James S. LottiJaron JonesJill C. FarnsworthFeng YiFabao ZhaoFrank S. MennitiRobert A. VolkmannRasmus P. ClausenKasper B. Hansen

receptorspharmacologypharmacological equilibrium modelingmolecular pharmacology

Selective Cell-Surface Expression of Triheteromeric Nmda Receptors. Methods in molecular biology (2024)

Feng YiStephen F. TraynelisKasper B. Hansen

selective cell-surface expressionreceptorsreceptor (biochemistry)molecular and cellular biologycell biologycell signalingmolecular cell biologytriheteromeric nmda receptorsmolecular biological methodmembrane biologymolecular biologystructural biologyneurology

Allosteric Modulation of Glun1/Glun3 Nmda Receptors by Glun1-Selective Competitive Antagonists. The Journal of General Physiology (2023)

Nirvan RouzbehAndrew R. RauAvery J. BentonFeng YiCarly M. AndersonMia R. JohnsLoren JensenJames S. LottiDavid C. HolleyKasper B. Hansen

receptorsneuropharmacologycardiologyallosteric modulationcell signalingelectrophysiologypharmacologyphysiologyneurology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

biophysicschemistrycrystal diffraction studycrystal engineeringcrystal researchcrystallographycrystal structuresccdc 2157502structure elucidationstructure determinationchemical structuredeposited datasetstructural chemistry

Determination of Binding Affinity and Efficacy for Nmda Receptor Agonists and Glun2A Selective Allosteric Modulators. Biophysical Journal (2022)

James LottiKasper Hansen

biophysicsreceptorsneuropharmacologymolecular neurosciencenmda receptor agonistsneurosciencepharmacologydrug discoverybiophysical chemistry

In Vitro Adme Characterization of a Very Potent 3-Acylamino-2-Aminopropionic Acid-Derived Glun2C-Nmda Receptor Agonist and Its Ester Prodrugs. Biological Chemistry (2022)

Elena BechtholdLucie GreyEmil DiamantJudith SchmidtRuben SteigerwaldFabao ZhaoKasper B. HansenLennart BunchRasmus P. ClausenBernhard Wünsch

receptorsneurosciencepharmacologytranslational pharmacologymolecular pharmacologypharmacokineticspharmacological agentsmedicinal chemistrybiological chemistrydrug discoveryclinical chemistryneuropharmacologybiochemistrymedicinal researchpharmaceutical chemistrypharmacological researchester prodrugsexperimental pharmacologypharmacotherapy

Synaptic Dysfunction by Mutations in Grin2B: Influence of Triheteromeric Nmda Receptors on Gain-Of-Function and Loss-Of-Function Mutant Classification. Brain Sciences (2022)

Marwa ElmasriJames S. LottiWajeeha AzizOliver G. SteeleEirini KarachaliouKenji SakimuraKasper B. HansenAndrew C. Penn

loss-of-function mutant classificationgeneticssynaptic dysfunctiongene expressioncellular neurobiologymolecular neurosciencebrain sciencetriheteromeric nmda receptorsneuroscienceneurogeneticsmolecular neurobiologyneurologyneuroanatomyneurophysiology

Derivatives of ( R )-3-(5-Furanyl)Carboxamido-2-Aminopropanoic Acid as Potent Nmda Receptor Glycine Site Agonists With Glun2 Subunit-Specific Activity. Journal of Medicinal Chemistry (2021)

Fabao ZhaoUnai AtxabalSofia MariottiniFeng YiJames S. LottiNirvan RouzbehNa LiuLennart BunchKasper B. HansenRasmus P. Clausen

medicinal chemistryreceptorspharmacology

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews (2021)

Kasper B. HansenLonnie P. WollmuthDerek BowieHiro FurukawaFrank S. MennitiAlexander I. SobolevskyGeoffrey T. SwansonSharon A. SwangerIngo H. GregerTerunaga NakagawaChris J. McBainVasanthi JayaramanChian-Ming LowMark L. Dell’AcquaJeffrey S. DiamondChad R. CampRiley E. PerszykHongjie YuanStephen F. Traynelis

neuropharmacologyneurosciencepharmacologyneurologystructural biology

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Kasper Hansen

Professor

University of Montana

Affiliations

College of Humanities and Sciences

Biochemistry

Biological Sciences

Kasper Hansen is currently serving as a Biochemistry Professor at University of Montana.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Kasper Hansen

University of Montana

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Evaluation of Allosteric Nmda Receptor Modulation by Glun2A-Selective Antagonists Using Pharmacological Equilibrium Modeling. Molecular Pharmacology (2024)

James S. LottiJaron JonesJill C. FarnsworthFeng YiFabao ZhaoFrank S. MennitiRobert A. VolkmannRasmus P. ClausenKasper B. Hansen

receptorspharmacologypharmacological equilibrium modelingmolecular pharmacology

Selective Cell-Surface Expression of Triheteromeric Nmda Receptors. Methods in molecular biology (2024)

Feng YiStephen F. TraynelisKasper B. Hansen

Allosteric Modulation of Glun1/Glun3 Nmda Receptors by Glun1-Selective Competitive Antagonists. The Journal of General Physiology (2023)

Nirvan RouzbehAndrew R. RauAvery J. BentonFeng YiCarly M. AndersonMia R. JohnsLoren JensenJames S. LottiDavid C. HolleyKasper B. Hansen

receptorsneuropharmacologycardiologyallosteric modulationcell signalingelectrophysiologypharmacologyphysiologyneurology

Ccdc 2157502: Experimental Crystal Structure Determination. The Cambridge Structural Database (2023)

Rao, YuPalumbo, Chad T.Venkatesh, AmritKeener, MeganStevanato, GabrieleChauvin, Anne-SophieMenzildjian, GeorgesKuzin, SergeiYulikov, MaximJeschke, GunnarLesage, AnneMazzanti, MarinellaEmsley, Lyndon

Determination of Binding Affinity and Efficacy for Nmda Receptor Agonists and Glun2A Selective Allosteric Modulators. Biophysical Journal (2022)

James LottiKasper Hansen

biophysicsreceptorsneuropharmacologymolecular neurosciencenmda receptor agonistsneurosciencepharmacologydrug discoverybiophysical chemistry

In Vitro Adme Characterization of a Very Potent 3-Acylamino-2-Aminopropionic Acid-Derived Glun2C-Nmda Receptor Agonist and Its Ester Prodrugs. Biological Chemistry (2022)

Elena BechtholdLucie GreyEmil DiamantJudith SchmidtRuben SteigerwaldFabao ZhaoKasper B. HansenLennart BunchRasmus P. ClausenBernhard Wünsch

Synaptic Dysfunction by Mutations in Grin2B: Influence of Triheteromeric Nmda Receptors on Gain-Of-Function and Loss-Of-Function Mutant Classification. Brain Sciences (2022)

Marwa ElmasriJames S. LottiWajeeha AzizOliver G. SteeleEirini KarachaliouKenji SakimuraKasper B. HansenAndrew C. Penn

Derivatives of ( R )-3-(5-Furanyl)Carboxamido-2-Aminopropanoic Acid as Potent Nmda Receptor Glycine Site Agonists With Glun2 Subunit-Specific Activity. Journal of Medicinal Chemistry (2021)

Fabao ZhaoUnai AtxabalSofia MariottiniFeng YiJames S. LottiNirvan RouzbehNa LiuLennart BunchKasper B. HansenRasmus P. Clausen

medicinal chemistryreceptorspharmacology

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. Pharmacological Reviews (2021)

neuropharmacologyneurosciencepharmacologyneurologystructural biology

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