Faculty

Institution

Unit

Venue

Wu

Professor

Wayne State University

Affiliations

School of Medicine

Oncology

Wu is currently serving as an Oncology Professor at Wayne State University.

Honors

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Experiences

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Education

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Wayne State University

Professor

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cancer research tumor biology cancer biology oncology pharmacology medicinal research cell biology cell death cancer treatment medicine oncogenes cancer genetics genetics molecular cancer apoptosis breast cancer cancer cells anti-cancer agents tumor targeting cancer genomics cancer immunotherapy cancer care gene expression enzyme inhibition cellular therapy cell signaling cell regulation ovarian cancer leukemia cell cycle cisplatin resistance gynecologic oncology biochemical sciences cancer risk cancer growth tumor suppressors molecular regulation oncogenic agent breast oncology cancer management biological chemistry molecular cell biology cellular physiology protein science transcription regulation ovarian cancer cells autophagy medical genetics protein expression cellular biology drug targeting clinical medicine biomolecular interactions death receptor apoptotic death growth arrest tnf-related apoptosis-inducing ligand host genetics integrative biology biological inorganic chemistry cell physiology biophysical aspect biochemical interaction cell lineage in vivo systems knockout mice notch signaling trail gene induction dual inactivation nuclear translocation mouse homologue molecular cloning potential role proteasome-dependent regulation rare loss-of-function mutation death receptor gene protein phosphatases cell autophagy

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure of the Smyd2-Parp1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Yingxue ZhangEid AlshammariJacob SobotaNicolas SpellmonEmerson PerryTianxin CaoThamarahansi MugunamalwaththaSheila SmithJoseph BrunzelleGensheng WuTimothy StemmlerJianping JinChunying LiZhe Yang

peptide bindingprotein structurebiochemistrymolecular biologypeptidesstructural biology

Cover Image, Volume 62, Issue 2. Molecular Carcinogenesis (2023)

Julio M. PimentelJun‐Ying ZhouGen Sheng Wu

cancer imagingcover imagecancer researchradiation oncologymolecular cancercancer biologyhealth sciences

Data From Cisplatin Resistance Associated With Parp Hyperactivation. (2023)

Judith MichelsIlio VitaleLorenzo GalluzziJulien AdamKen André OlaussenOliver KeppLaura SenovillaIbtissam TalhaouiJustine GueganDavid Pierre EnotMonique TalbotAngélique RobinPhilippe GirardCédric OréarDelphine LissaAbdul Qader SukkurwalaPauline GarciaParviz Behnam-MotlaghKimitoshi KohnoGen Sheng WuCatherine BrennerPhilippe DessenMurat SaparbaevJean-Charles SoriaMaria CastedoGuido Kroemer

parp hyperactivationcancer biologyleukemiapharmacologytumor biologycancer researchhepatologygeneticsmolecular cancerimmunologycisplatin resistancebreast cancermolecular medicinemedicinal researchcatalyst activationremedial actioncancer cellsoncogenescancer geneticshost specificity

Supplementary Table 1, Figures 1 - 8 From Cisplatin Resistance Associated With Parp Hyperactivation. (2023)

parp hyperactivationtumor biologycancer researchradiation oncologypharmacologycisplatin resistancehealth sciencesmedicinal research

The Role of the Immune Response and Inflammatory Pathways in Tnf-Related Apoptosis-Inducing Ligand (Trail) Resistance in Triple-Negative Breast Cancer Cells.. PubMed (2023)

Julio M PimentelJun-Ying ZhouSeongho KimKatherine GurdzielGen Sheng Wu

cancer immunotherapymedicinebiomedical researchpharmacologyclinical medicinetumor biologycellular therapyapoptosiscancer researchimmunotherapyadaptive immune systemimmunologytumor targetingbreast cancercell deathmedicinal researchinflammatory pathwaystnf-related apoptosis-inducing ligandcancer cellsenzyme inhibition

The Role of Trail in Apoptosis and Immunosurveillance in Cancer. Cancers (2023)

Julio M. PimentelJun-Ying ZhouGen Sheng Wu

apoptosiscancer researchoncologycancer biologyimmunologycell death

Proteomic Analysis Identifies P62/Sqstm1 as a Critical Player in Parp Inhibitor Resistance. Frontiers in Oncology (2022)

Mohammed Hafiz UddinJun-Ying ZhouJulio PimentelSteve M. PatrickSeongho KimMalathy P. ShekharGen Sheng Wu

critical playermedicineoncologycancer researchcancer biologydrug resistanceproteomicspharmacologyclinical proteomicshealth sciencesparp inhibitor resistance

Regulation of Programmed Death Ligand 1 (Pd‐L1) Expression by Tnf‐Related Apoptosis‐Inducing Ligand (Trail) in Triple‐Negative Breast Cancer Cells. Molecular Carcinogenesis (2022)

Julio M. PimentelJun‐Ying ZhouGen Sheng Wu

receptorscancer immunotherapybreast oncologypharmacologytherapeutic targetscarcinogenesisoncogenic agentcancer genomicsradiation oncologymolecular cancerimmunologydeath studiescell deathcancer growthtnf-related apoptosis-inducing ligandcancer cellsoncogenessignal transductionreceptor tyrosine kinases

Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells. Frontiers in Oncology (2021)

Ambikai GajanAshapurna SarmaSeongho KimKatherine GurdzielGen Sheng WuMalathy P. Shekhar

cancer immunotherapymedicinedrug resistanceleukemiapharmacologycellular therapyoncologycancer researchcisplatin sensitivityimmunotherapycancer carecancer treatmentcancer riskcancer genomicsanti-cancer agentsradiation oncologytumor targetingmedicinal researchcancer cells

CORRECTION: Discovery and Clinical Introduction of First-In-Class Imipridone Onc201. Oncotarget (2021)

Joshua E. AllenC. Leah B. KlineVarun V. PrabhuJessica WagnerJo IshizawaNeel MadhukarAvital LevMarie BaumeisterLanlan ZhouAmriti LullaMartin StogniewLee SchalopCyril BenesHoward L. KaufmanRichard S. PottorfB. Rao NallaganchuGary L. OlsonFahd Al-MullaMadeleine DuvicGen Sheng WuDavid T. DickerMala K. TalekarBora LimOlivier ElementoWolfgang OsterJoseph BertinoKeith FlahertyMichael L. WangGautam BorthakurMichael AndreeffMark SteinWafik S. El-Deiry

drug discoverypharmacologyclinical introductiononcology

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Wu

Professor

Wayne State University

Affiliations

School of Medicine

Oncology

Wu is currently serving as an Oncology Professor at Wayne State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Wayne State University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure of the Smyd2-Parp1 Complex Reveals Both Productive and Allosteric Modes of Peptide Binding. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Yingxue ZhangEid AlshammariJacob SobotaNicolas SpellmonEmerson PerryTianxin CaoThamarahansi MugunamalwaththaSheila SmithJoseph BrunzelleGensheng WuTimothy StemmlerJianping JinChunying LiZhe Yang

peptide bindingprotein structurebiochemistrymolecular biologypeptidesstructural biology

Cover Image, Volume 62, Issue 2. Molecular Carcinogenesis (2023)

Julio M. PimentelJun‐Ying ZhouGen Sheng Wu

cancer imagingcover imagecancer researchradiation oncologymolecular cancercancer biologyhealth sciences

Data From Cisplatin Resistance Associated With Parp Hyperactivation. (2023)

Supplementary Table 1, Figures 1 - 8 From Cisplatin Resistance Associated With Parp Hyperactivation. (2023)

parp hyperactivationtumor biologycancer researchradiation oncologypharmacologycisplatin resistancehealth sciencesmedicinal research

The Role of the Immune Response and Inflammatory Pathways in Tnf-Related Apoptosis-Inducing Ligand (Trail) Resistance in Triple-Negative Breast Cancer Cells.. PubMed (2023)

Julio M PimentelJun-Ying ZhouSeongho KimKatherine GurdzielGen Sheng Wu

The Role of Trail in Apoptosis and Immunosurveillance in Cancer. Cancers (2023)

Julio M. PimentelJun-Ying ZhouGen Sheng Wu

apoptosiscancer researchoncologycancer biologyimmunologycell death

Proteomic Analysis Identifies P62/Sqstm1 as a Critical Player in Parp Inhibitor Resistance. Frontiers in Oncology (2022)

Mohammed Hafiz UddinJun-Ying ZhouJulio PimentelSteve M. PatrickSeongho KimMalathy P. ShekharGen Sheng Wu

critical playermedicineoncologycancer researchcancer biologydrug resistanceproteomicspharmacologyclinical proteomicshealth sciencesparp inhibitor resistance

Regulation of Programmed Death Ligand 1 (Pd‐L1) Expression by Tnf‐Related Apoptosis‐Inducing Ligand (Trail) in Triple‐Negative Breast Cancer Cells. Molecular Carcinogenesis (2022)

Julio M. PimentelJun‐Ying ZhouGen Sheng Wu

Analysis of Adaptive Olaparib Resistance Effects on Cisplatin Sensitivity in Triple Negative Breast Cancer Cells. Frontiers in Oncology (2021)

Ambikai GajanAshapurna SarmaSeongho KimKatherine GurdzielGen Sheng WuMalathy P. Shekhar

CORRECTION: Discovery and Clinical Introduction of First-In-Class Imipridone Onc201. Oncotarget (2021)

drug discoverypharmacologyclinical introductiononcology

1
2
3
4
5
8
10 / page

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