Faculty

Institution

Unit

Venue

Gary H. Perdew

H Thomas & Dorothy Willits Hallowell Chair of Agricultural Sciences and Director of the Center for Molecular Toxicology and Carcinogenesis

Pennsylvania State University

Affiliations

Penn State College of Medicine

Department of Biochemistry & Molecular Biology

Gary H. Perdew is currently serving as a Biochemistry & Molecular Biology H Thomas & Dorothy Willits Hallowell Chair of Agricultural Sciences and Director of the Center for Molecular Toxicology and Carcinogenesis at Pennsylvania State University.

Honors

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Experiences

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Education

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Gary H. Perdew

Pennsylvania State University

H Thomas & Dorothy Willits Hallowell Chair of Agricultural Sciences and Director of the Center for Molecular Toxicology and Carcinogenesis

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pharmacology receptors biochemistry immunology molecular biology receptor (biochemistry) protein science cell signaling toxicology membrane biology medicinal research gene expression endocrinology redox biology ah receptor biological chemistry aryl hydrocarbon receptor molecular regulation signal transduction mammalian biology biochemical sciences structural biology molecular physiology liver physiology experimental toxicology transcription regulation cancer biology heme signaling regulatory toxicology pharmacological research receptor tyrosine kinases hormonal receptor cytokines pharmacotherapy enzyme inhibition experimental pharmacology molecular cancer pharmacokinetics clinical toxicology experimental medicine redox signaling gene regulation cell regulation clinical pharmacology gene function animal physiology ecotoxicology biomolecular interactions viral hepatitis viral genetics signaling pathways rna biology functional regulation embryonic development translational pharmacology drug targeting host response aryl hydrocarbon ligand activation pathway analysis in vivo systems protein function virus-host interactions immunochemistry receptor activation chaperone proteins glucocorticoid receptor q-rich subdomain monoclonal antibodies cognate response element gastrointestinal homeostasis transactivation domain key determinant growth factor expression ligand binding ah receptor activation microbiome metabolic pathway analysis omics technologies omics metabolomic profiling drug metabolism metagenomics systems biology toxicogenomics molecular metabolism toxicological mechanism metabolic profiling microbiology

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Janus-Facedness of the Aryl Hydrocarbon Receptor Pathway Report of the 6Th International Ahr Meeting: Research, Prevention, Therapy. Biochemical Pharmacology (2025)

Thomas Haarmann-StemmannDoreen ReichertXavier CoumoulB Paige LawrenceGary H PerdewDavid H SherrHeike WeighardtKatharina M RolfesCharlotte Esser

receptorsenzyme inhibitionpharmacologydrug metabolismmolecular pharmacologytherapeutic targetsmolecular biologyclinical researchmedicinal researchexperimental pharmacologypharmacological studiesclinical pharmacologyinternational ahr meetingpharmacological researchbiochemistry

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand Tcdf on Gut Microbiota and Host Metabolic Homeostasis in C57Bl/6J Mice. Environmental Health Perspectives (2024)

Yuan TianBipin RimalJordan E. BisanzWei GuiTrenton M. WolfeImhoi KooIain A. MurrayShaneice K. NettlefordShigetoshi YokoyamaFangcong DongSergei KoshkinK. Sandeep PrabhuPeter J. TurnbaughSeth T. WalkGary H. PerdewAndrew D. Patterson

microbiomesecondary metabolismenvironmental sciencereceptor (biochemistry)gut microbiotahost responseenvironmental toxicologyenvironmental health perspectivegut microbesmolecular metabolismgut barrierhost metabolic homeostasismicrobiologyreceptorsfree radical biologygeneticsenvironmental healtharyl hydrocarbon receptorenvironmental exposuresecotoxicologymetabolic pathways

Immune Cell‐Intrinsic Ah Receptor Facilitates the Expression of Antimicrobial Reg3G in the Small Intestine. The FASEB Journal (2024)

Debopriya ChakrabortyDenise M. CosloIain A. MurrayAnitha VijayAndrew D. PattersonGary H. Perdew

cellular immune responsesclinical microbiologymucosal immunologyinfectious diseaseshost responsesmall intestineantimicrobial resistanceinnate immune systemadaptive immune systemimmune responsesinflammationantimicrobial agentsgut microbesdigestive diseasesmicrobial pathogenesisimmunologyreceptorsmedicinal researchmicrobiology

MECHANISMS: Xenobiotic Receptor-Mediated Toxicity. Elsevier eBooks (2024)

Gary H. PerdewIain A. MurrayAndrew D. PattersonJeffrey M. Peters

xenobiotic receptor-mediated toxicityreceptorspharmacologytoxicology

Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway Beyond Er Stress. International Journal of Molecular Sciences (2024)

Mallappa AnithaSupriya M. KumarImhoi KooGary H. PerdewShanthi SrinivasanAndrew D. Patterson

er stressreceptorscell deathenteric neuronscell signalingmolecular scienceneurochemistrymolecular neurobiologyceramide-induced apoptosisapoptosismolecular biologymolecular neurodegenerationsignal transductionoxidative stressneuroscienceneurodegenerative diseasesbiochemistry

Species Differences in Specific Ligand-Binding Affinity and Activation of Ahr: The Biological Basis for Calculation of Relative Effective Potencies and Toxic Equivalence Factors. Regulatory Toxicology and Pharmacology (2024)

David L. EatonTed W. SimonNorbert E. KaminskiGary H. PerdewDaniel W. Nebert

toxic equivalence factorspharmacologyspecies differencesrelative effective potenciesbiological basistoxicologyspecific ligand-binding affinityregulatory toxicology

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation. Advanced Science (2024)

Shigetoshi YokoyamaImhoi KooDaisuke AibaraYuan TianIain A. MurrayStephanie L. CollinsDenise M. CosloMari KonoJeffrey M. PetersRichard L. ProiaFrank J. GonzalezGary H. PerdewAndrew D. Patterson

receptorsgene expressionsystems biologycell signalingmolecular and cellular biologyreceptor tyrosine kinasesmolecular regulationmolecular cell biologyreceptor (biochemistry)gene functiontarget gene activationmolecular biologysignal transductionbiochemistry

The 2022 Revised Who Tefs for Dioxins and Dioxin-Like Chemicals: The Importance of Considering the Use of Species-Specific Information to Determine Relative Effective Potency for Human-Based Risk Assessment. Regulatory Toxicology and Pharmacology (2024)

David L. EatonTed W. SimonNorbert E. KaminskiGary H. PerdewDaniel W. Nebert

species-specific informationpharmacologyrelative effective potencybenchmark studiestoxicologyhuman-based risk assessmentdioxin-like chemicalsregulatory toxicology

Abstract 3710: Serum Tryptophan Metabolites Mediate Constitutive Ahr Activity in Head and Neck Squamous Cell Carcinoma Cells. Cancer Research (2023)

Dhwani PatelEthan W. MorganFangcong DongIain A. MurrayGary H. Perdew

immunologyneurologypharmacologybiomarkerscancer carecancer managementcancer researchoncologyclinical researchtoxicologyconstitutive ahr activitycancer treatmentcancer biologyserum tryptophan

Alpha-Tocopherylquinone-Mediated Activation of the Aryl Hydrocarbon Receptor Regulates the Production of Inflammation-Inducing Cytokines and Ameliorates Intestinal Inflammation. Mucosal Immunology (2023)

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangPriya ArumugamNathan Michael MorrisLeonard HarrisGregory YochumWalter KoltunGary H. PerdewMeghali NighotThomas MaPrashant Nighot

immunologyalpha-tocopherylquinone-mediated activationpharmacologycytokinesmucosal immunologyinflammation-inducing cytokinesaryl hydrocarbon receptorintestinal inflammationinflammation

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Gary H. Perdew

H Thomas & Dorothy Willits Hallowell Chair of Agricultural Sciences and Director of the Center for Molecular Toxicology and Carcinogenesis

Pennsylvania State University

Affiliations

Penn State College of Medicine

Department of Biochemistry & Molecular Biology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gary H. Perdew

Pennsylvania State University

H Thomas & Dorothy Willits Hallowell Chair of Agricultural Sciences and Director of the Center for Molecular Toxicology and Carcinogenesis

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Janus-Facedness of the Aryl Hydrocarbon Receptor Pathway Report of the 6Th International Ahr Meeting: Research, Prevention, Therapy. Biochemical Pharmacology (2025)

Thomas Haarmann-StemmannDoreen ReichertXavier CoumoulB Paige LawrenceGary H PerdewDavid H SherrHeike WeighardtKatharina M RolfesCharlotte Esser

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand Tcdf on Gut Microbiota and Host Metabolic Homeostasis in C57Bl/6J Mice. Environmental Health Perspectives (2024)

Immune Cell‐Intrinsic Ah Receptor Facilitates the Expression of Antimicrobial Reg3G in the Small Intestine. The FASEB Journal (2024)

Debopriya ChakrabortyDenise M. CosloIain A. MurrayAnitha VijayAndrew D. PattersonGary H. Perdew

MECHANISMS: Xenobiotic Receptor-Mediated Toxicity. Elsevier eBooks (2024)

Gary H. PerdewIain A. MurrayAndrew D. PattersonJeffrey M. Peters

xenobiotic receptor-mediated toxicityreceptorspharmacologytoxicology

Modulation of Ceramide-Induced Apoptosis in Enteric Neurons by Aryl Hydrocarbon Receptor Signaling: Unveiling a New Pathway Beyond Er Stress. International Journal of Molecular Sciences (2024)

Mallappa AnithaSupriya M. KumarImhoi KooGary H. PerdewShanthi SrinivasanAndrew D. Patterson

David L. EatonTed W. SimonNorbert E. KaminskiGary H. PerdewDaniel W. Nebert

toxic equivalence factorspharmacologyspecies differencesrelative effective potenciesbiological basistoxicologyspecific ligand-binding affinityregulatory toxicology

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation. Advanced Science (2024)

Shigetoshi YokoyamaImhoi KooDaisuke AibaraYuan TianIain A. MurrayStephanie L. CollinsDenise M. CosloMari KonoJeffrey M. PetersRichard L. ProiaFrank J. GonzalezGary H. PerdewAndrew D. Patterson

David L. EatonTed W. SimonNorbert E. KaminskiGary H. PerdewDaniel W. Nebert

species-specific informationpharmacologyrelative effective potencybenchmark studiestoxicologyhuman-based risk assessmentdioxin-like chemicalsregulatory toxicology

Abstract 3710: Serum Tryptophan Metabolites Mediate Constitutive Ahr Activity in Head and Neck Squamous Cell Carcinoma Cells. Cancer Research (2023)

Dhwani PatelEthan W. MorganFangcong DongIain A. MurrayGary H. Perdew

immunologyneurologypharmacologybiomarkerscancer carecancer managementcancer researchoncologyclinical researchtoxicologyconstitutive ahr activitycancer treatmentcancer biologyserum tryptophan

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangPriya ArumugamNathan Michael MorrisLeonard HarrisGregory YochumWalter KoltunGary H. PerdewMeghali NighotThomas MaPrashant Nighot

immunologyalpha-tocopherylquinone-mediated activationpharmacologycytokinesmucosal immunologyinflammation-inducing cytokinesaryl hydrocarbon receptorintestinal inflammationinflammation

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10 / page

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