Faculty

Institution

Unit

Venue

Gary Daughdrill

Professor

University of South Florida

Affiliations

College of Arts and Sciences

School of Natural Sciences and Mathematics

Department of Molecular Biosciences

Gary Daughdrill is currently serving as a College Of Arts And Sciences Professor at University of South Florida.

Honors

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Experiences

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Education

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Gary Daughdrill

University of South Florida

Professor

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molecular biology structural biology protein structure biophysics protein science biochemistry structural molecular biology protein folding biomolecular structure disordered proteins genetics tumor biology gene expression biophysical modeling biophysical review protein modeling protein evolution dna repair biomolecules protein assembly molecular cell biology nucleic acids molecular cancer molecular structure protein structure prediction molecular evolution nuclear magnetic resonance cancer discovery oncogenes biomolecular interactions cancer genetics protein misfolding molecular regulation structural ensembles secondary structure cancer cells medicinal research protein function molecular recognition molecular self-assembly mutagenesis anti-cancer agents protein x-ray crystallography c-terminal half unstructured linker domain unstructured transactivation domain rational design protein-protein interactions chemical shifts transient secondary structure virus research general virology crystal growth genetic disorders residual stress pathway analysis cancer treatment protein nmr functional selectivity molecular virology viral structural protein virus structure virus-host interactions dna analysis nuclear organization gene recognition protein bioinformatics gene function experimental biophysics cancer biology intrinsic disorder anti-sigma factor residual helicity abt-737 resistance selective mcl-1 antagonist promiscuous plasmid

Notable Scholarly Works

Notable Federal Grants

Collaborators

P53Tad Accesses a Second Pocket in Mdm2 and Mdmx for Tighter Binding. Biophysical Journal (2024)

Guy W. DayhoffPirada S. HigbeeAsokan AnbanadamSameer VarmaGary W. Daughdrill

biophysicstumor biologysecond pocketmembrane biologypharmacologymolecular biologytighter bindinggene expressiononcology

Structural Adaptation of Secondary P53 Binding Sites on Mdm2 and Mdmx. Journal of Molecular Biology (2024)

Pirada Serena HigbeeGuy W. DayhoffAsokan AnbanandamSameer VarmaGary Daughdrill

tumor biologystructural adaptationmolecular biologyprotein structurecancer geneticsstructural biologygenetics

Protein Disorder and Autoinhibition: The Role of Multivalency and Effective Concentration. Current Opinion in Structural Biology (2023)

Malissa FentonEmily GregoryGary Daughdrill

biophysicsprotein structure predictionprotein sciencebiomolecular structureprotein foldingprotein disordermolecular biologyexperimental analysisprotein structuresystems biologyeffective concentrationstructural molecular biologystructural biology

Conformational Buffering Underlies Functional Selection in Intrinsically Disordered Protein Regions. Nature Structural & Molecular Biology (2022)

Nicolás S. González-FoutelJuliana GlavinaWade M. BorcherdsMatías SafranchikSusana Barrera-VilarmauAmin SagarAlejandro EstañaAmelie BarozetNicolás A. GarroneGregorio Fernandez-BallesterClara Blanes-MiraIgnacio E. SánchezGonzalo de Prat-GayJuan CortésPau BernadóRohit V. PappuAlex S. HolehouseGary W. DaughdrillLucía B. Chemes

biophysicsfunctional selectivityprotein structurestructural molecular biologyprotein regionsstructural biology

Electrostatic and Specific Interactions Contribute to Inhibition of Dna Binding via an Intramolecular Interaction in P53. Biophysical Journal (2022)

Emily Gregory-LottMi ZhouJianfeng CaiJiandong ChenGary W. Daughdrill

biophysicsintramolecular interactiontumor biologyspecific interactionsmolecular cancermolecular biophysicsmolecular regulationmolecular biologygene expressioncancer genomicsgenetics

Molecular Gymnastics Required for Mdmx Inhibition of P53 Dna Binding Activity. SSRN Electronic Journal (2022)

Malissa FentonWade BorcherdsLihong ChenAsokan AnbanandamJiandong ChenGary Daughdrill

mdmx inhibitionstructural molecular biologymolecular gymnasticsbiochemistrymolecular biologydna repairmolecular regulationbiomolecular engineeringlate binding

Sequence Properties of an Intramolecular Interaction That Inhibits P53 Dna Binding. Biomolecules (2022)

Emily GregoryGary W. Daughdrill

intramolecular interactionbiomoleculessequence propertiesbiochemistrybiomolecular interactions

The Mdmx Acidic Domain Uses Allovalency to Bind Both P53 and Mdmx. Journal of Molecular Biology (2022)

Malissa FentonWade BorcherdsLihong ChenAsokan AnbanandamRobin LevyJiandong ChenGary Daughdrill

molecular and cellular biologytumor biologyoncologyprotein sciencestructural biologyfunctional modificationmolecular sciencebiochemistrymolecular dockingmolecular cell biologycancer discoverymolecular biologymdmx acidic domainsystems biologystructural molecular biologycancer genomicstumor microenvironment

Conformational Flexibility of P53 Transactivation Domain Controls Dna Binding Specificity and Promoter Selectivity. Biophysical Journal (2020)

Emily Gregory-LottWade M. BorcherdsFan HeMi ZhouGary W. Daughdrill

biophysicsgene regulationconformational flexibilitymolecular biologypromoter selectivitygene expression

Correction to α-Helix-Mimicking Sulfono-γ-Aapeptide Inhibitors for P53–Mdm2/Mdmx Protein–Protein Interactions. Journal of Medicinal Chemistry (2020)

Peng SangYan ShiJunhao LuLihong ChenLeixiang YangWade BorcherdsSami AbdulkadirQi LiGary DaughdrillJiandong ChenJianfeng Cai

pharmaceutical chemistrytumor biologytumor targetinganti-cancer agentsmolecular cancermedicinal chemistryrational drug designa-helix-mimicking sulfono-g-aapeptide inhibitorsmedicinepharmacologydrug discoveryenzyme inhibition

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Gary Daughdrill

Professor

University of South Florida

Affiliations

College of Arts and Sciences

School of Natural Sciences and Mathematics

Department of Molecular Biosciences

Gary Daughdrill is currently serving as a College Of Arts And Sciences Professor at University of South Florida.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gary Daughdrill

University of South Florida

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

P53Tad Accesses a Second Pocket in Mdm2 and Mdmx for Tighter Binding. Biophysical Journal (2024)

Guy W. DayhoffPirada S. HigbeeAsokan AnbanadamSameer VarmaGary W. Daughdrill

biophysicstumor biologysecond pocketmembrane biologypharmacologymolecular biologytighter bindinggene expressiononcology

Structural Adaptation of Secondary P53 Binding Sites on Mdm2 and Mdmx. Journal of Molecular Biology (2024)

Pirada Serena HigbeeGuy W. DayhoffAsokan AnbanandamSameer VarmaGary Daughdrill

tumor biologystructural adaptationmolecular biologyprotein structurecancer geneticsstructural biologygenetics

Protein Disorder and Autoinhibition: The Role of Multivalency and Effective Concentration. Current Opinion in Structural Biology (2023)

Malissa FentonEmily GregoryGary Daughdrill

Conformational Buffering Underlies Functional Selection in Intrinsically Disordered Protein Regions. Nature Structural & Molecular Biology (2022)

biophysicsfunctional selectivityprotein structurestructural molecular biologyprotein regionsstructural biology

Electrostatic and Specific Interactions Contribute to Inhibition of Dna Binding via an Intramolecular Interaction in P53. Biophysical Journal (2022)

Emily Gregory-LottMi ZhouJianfeng CaiJiandong ChenGary W. Daughdrill

biophysicsintramolecular interactiontumor biologyspecific interactionsmolecular cancermolecular biophysicsmolecular regulationmolecular biologygene expressioncancer genomicsgenetics

Molecular Gymnastics Required for Mdmx Inhibition of P53 Dna Binding Activity. SSRN Electronic Journal (2022)

Malissa FentonWade BorcherdsLihong ChenAsokan AnbanandamJiandong ChenGary Daughdrill

mdmx inhibitionstructural molecular biologymolecular gymnasticsbiochemistrymolecular biologydna repairmolecular regulationbiomolecular engineeringlate binding

Sequence Properties of an Intramolecular Interaction That Inhibits P53 Dna Binding. Biomolecules (2022)

Emily GregoryGary W. Daughdrill

intramolecular interactionbiomoleculessequence propertiesbiochemistrybiomolecular interactions

The Mdmx Acidic Domain Uses Allovalency to Bind Both P53 and Mdmx. Journal of Molecular Biology (2022)

Malissa FentonWade BorcherdsLihong ChenAsokan AnbanandamRobin LevyJiandong ChenGary Daughdrill

Conformational Flexibility of P53 Transactivation Domain Controls Dna Binding Specificity and Promoter Selectivity. Biophysical Journal (2020)

Emily Gregory-LottWade M. BorcherdsFan HeMi ZhouGary W. Daughdrill

biophysicsgene regulationconformational flexibilitymolecular biologypromoter selectivitygene expression

Correction to α-Helix-Mimicking Sulfono-γ-Aapeptide Inhibitors for P53–Mdm2/Mdmx Protein–Protein Interactions. Journal of Medicinal Chemistry (2020)

Peng SangYan ShiJunhao LuLihong ChenLeixiang YangWade BorcherdsSami AbdulkadirQi LiGary DaughdrillJiandong ChenJianfeng Cai

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