Faculty

Institution

Unit

Venue

Gabriel Sosne

Associate Professor

Wayne State University

Affiliations

Graduate School

School of Medicine

Ophthalmology, Visual and Anatomical Sciences

Gabriel Sosne is currently serving as a Graduate School Associate Professor at Wayne State University.

Honors

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Experiences

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Education

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Gabriel Sosne

Wayne State University

Associate Professor

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ophthalmology pharmacology cell biology experimental ophthalmology inflammation medicine vascular biology cell signaling visual science vision research regenerative medicine wound healing ocular disease immune responses experimental medicine oral biology tumor biology molecular medicine cell and molecular biology medicinal research clinical microbiology cell death ocular surface cellular physiology apoptosis cell regulation alkali injury protein science enzyme inhibition biological therapies molecular immunology ocular tissues ocular pathology anti-inflammatory cell migration clinical immunology protein expression pseudomonas aeruginosa-induced keratitis peptides liver physiology in vivo systems experiment design corneal dystrophy cell physiology cutaneous biology endocrine research novel therapies angiogenesis severe dry eye corneal wound healing ciprofloxacin adjunctive therapy bone research peptide science cellular therapy angiology eye health chronic inflammation inflammatory diseases peptide engineering pharmaceutical biotechnology protein function inhibitory activity human exposure visual diagnosis cataracts angiogenic activity corneal nfkb multi-functional regenerative peptide clinical applications basic properties active sites short peptide sequences biological activities polymorphonuclear cell infiltration sensitizing effects tnf-a-induced nf-kb activation diagnosis dry eye disease glaucoma ophthalmology retina

Notable Scholarly Works

Notable Federal Grants

Collaborators

Activation of Pro-Resolving Pathways Mediate the Therapeutic Effects of Thymosin Beta-4 During Pseudomonas Aeruginosa-Induced Keratitis. Frontiers in Immunology (2024)

Yuxin WangLoveleen BangaAbdul Shukkur EbrahimThomas W CarionGabriel SosneElizabeth A Berger

immunologydermatologypro-resolving pathwaystherapeutic effectspharmacologypseudomonas aeruginosa-induced keratitisgene expressionclinical immunology

A Novel Combination Therapy Tβ4/Vip Protects Against Hyperglycemia-Induced Changes in Human Corneal Epithelial Cells. Biosensors (2023)

Abdul Shukkur EbrahimThomas W. CarionThanzeela EbrahimJeff WinHussein KaniYuxin WangAshten StamberskyAhmed S. IbrahimGabriel SosneElizabeth A. Berger

neurologyvascular biologyregenerative medicinebiosensorspharmacologyophthalmologyhyperglycemia-induced changes

Thymosin Beta 4: A Potential Novel Adjunct Treatment for Bacterial Keratitis. International Immunopharmacology (2023)

Gabriel SosneElizabeth A. Berger

infectious diseasesbacterial keratitisimmunologynovel therapiespharmacologytherapeutic targets

0.1% Rgn-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial. International Journal of Molecular Sciences (2022)

Gabriel SosneHynda K. KleinmanClark SpringsRobert Hollis GrossJihye SungShinwook Kang

ophthalmologypharmacologymedicinecell and molecular biology

Adjunctive Thymosin Beta-4 Treatment Influences MΦ Effector Cell Function to Improve Disease Outcome in Pseudomonas Aeruginosa-Induced Keratitis. International Journal of Molecular Sciences (2021)

Yuxin WangThomas W. CarionAbdul Shukkur EbrahimGabriel SosneElizabeth A. Berger

molecular and cellular biologydisease outcomehealth outcomesimmunologyclinical immunologyclinical microbiologycell signalingmolecular sciencemolecular biologymedicinal researchmicrobiologypseudomonas aeruginosa-induced keratitismolecular immunologyinflammationeffector cell functionmolecular medicinemolecular physiologymolecular pharmacologyhost factorsmolecular regulation

Adjunctive Thymosin Beta-4 Treatment Influences Pmn Effector Cell Function During Pseudomonas Aeruginosa-Induced Corneal Infection. Cells (2021)

Yuxin WangThomas W. CarionAbdul Shukkur EbrahimGabriel SosneElizabeth A. Berger

clinical microbiologymolecular immunologyimmunologyveterinary microbiologyimmune responsespharmacologyophthalmologymicrobial pathogenesis

Antimicrobial Effects of Adjunctive Thymosin Beta-4 Therapy in Bacterial Keratitis. Human Biology (2020)

Spandana AlluriThomas CarionEbrahim Abdul ShukkurGabriel SosneElizabeth Berger

public healthepidemiologybacterial keratitisrespiratory medicinepharmacologyveterinary medicineantimicrobial effects

Antimicrobial Effects of Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy in Pseudomonas Aeruginosa Induced Keratitis. International Journal of Molecular Sciences (2020)

Thomas W. CarionAbdul Shukkur EbrahimSpandana AlluriThanzeela EbrahimTressa ParkerJulia BurnsGabriel SosneElizabeth A. Berger

clinical microbiologyantimicrobial effectsciprofloxacin adjunctive therapyimmunologymolecular medicinepseudomonas aeruginosamedicinepharmacologyapplied microbiology

Efficacy of Rgn-259 (Thymosin β4) Relative to Approved Prescription Therapeutics in a Dry Eye Mouse Model. Investigative Ophthalmology & Visual Science (2018)

Chae Eun KimHynda K. KleinmanGabriel SosneGeorge W OuslerKyeongsoon KimSinwook KangJaeWook Yang

prescription therapeuticspharmacologytherapeutic targetsophthalmologypharmacotherapytherapeutic efficacy

Refractive Error Using Intraoperative Aberrometry Versus Traditional Measurements for Selection of Intraocular Lens Power. Investigative Ophthalmology & Visual Science (2018)

John H ZeiterFarhan HussainChaesik KimJames TodaroJustin TannirGabriel Sosne

intraoperative aberrometrytraditional measurementsintraocular lens powerophthalmologyrefractive error

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