Faculty

Institution

Unit

Venue

Eugenia Broude

Professor

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Eugenia Broude is currently serving as a College Of Pharmacy Professor at University of South Carolina.

Honors

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Experiences

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Education

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Eugenia Broude

University of South Carolina

Professor

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pharmacology oncology cancer research medicinal research cancer biology tumor biology cancer treatment molecular cancer enzyme inhibition tumor targeting oncogenes molecular biology cancer immunotherapy cellular therapy genetics cancer care gene expression cancer genetics anti-cancer agents cell biology leukemia drug targeting breast cancer cancer genomics cell signaling cell death cancer cells cell regulation pharmacotherapy carcinogenesis cancer growth cancer management protein science tumor suppressors apoptosis transcription regulation cancer prevention cancer imaging gene regulation cellular senescence cell cycle gene function cytokines therapeutic efficacy mitotic catastrophe molecular cell biology mammalian biology treatment development molecular regulation cellular biology tumor cells cell line triple-negative breast cancer structural chemistry molecular science treatment effects cell proliferation host-guest chemistry knockout mice oncogenic agent protein genetics cancer risk protein expression scientific visualization treatment-induced senescence terminal proliferation arrest cellular gene expression age-related diseases human p-glycoprotein inhibitor discrimination structural insight chemotherapeutic drugs human tumor cells molecular determinants terminal growth arrest chemotherapeutic agent metastasis breast oncology systems biology tumor microenvironment

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract A019: Development of Adaptive Anoikis Resistance Promotes Ovarian Cancer Metastasis That Can Be Prevented by Cdk8/19 Mediator Kinase Inhibition. Cancer Research (2024)

Mehri MonavarianResha RajkarnikarEmily Faith PageAsha KumariLiz Macias QuinteroLara Ianovsarthak SahooMohit Kumar JollyElizabeth WortheyNadine HempelAbhyudai SinghEugenia BroudeKarthikeyan Mythreye

gynecologic oncologycancer caretumor biologycancer biologyadaptive anoikis resistanceovarian cancer metastasismedicinal researchcancer preventiongynecologycancer researchcancer geneticspharmacologycancer managementovarian cancercancer treatmenthealth sciencesoncologybreast cancer

Abstract B058: Targeting Mediator Kinase Cdk8/19 Potentiates Chemotherapeutic Responses, Reverses Tumor Growth, and Prolongs Survival From Ovarian Clear Cell Carcinoma. Cancer Research (2024)

Wade BartonAsha KumariGary SchoolZachary MackLiz Macias QuinteroKarthik RangavajhulaRebecca ArendMengqian ChenEugenia V. BroudeKarthikeyan Mythreye

gynecologic oncologyanti-cancer agentsdermatologypharmacologytumor biologycell signalingcancer researchchemotherapeutic responsesradiation oncologymedicinal researchmolecular cancercellular therapyovarian cancercancer managementcancer caretumor targetingcancer growthprolongs survivalcancer genomicsoncology

Host-Derived Interleukin 1α Induces an Immunosuppressive Tumor Microenvironment via Regulating Monocyte-To-Macrophage Differentiation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Manikanda Raja Keerthi RajaGourab GuptaGrace AtkinsonKatie KathreinAlissa ArmstrongMichael GowerIgor RoninsonEugenia BroudeMenqiang ChenHao JiChang-uk LimHongjun WangDaping FanPeisheng XuJie LiGang ZhouHexin Chen

immunosuppressiononcologymonocyte-to-macrophage differentiationimmunologyimmune responsesimmunosuppressive tumor microenvironmentmedicineimmunosuppressive therapyadaptive immune systemtumor microenvironmentcytokines

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichZachary T. MackGary P. SchoolsChang-uk LimLeigh EllisXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

clinical medicineadvanced prostate cancersurgical oncologypharmacologycancer immunotherapycancer researchcancer treatmentpharmacotherapymediator kinase inhibitioncastration resistancemedicinal researchclinical investigationprostate cancerurologycancer managementcancer biologyneurologytumor targetingexperimental medicineclinical researchoncology

Suppression of Hiv-Tat and Cocaine-Induced Neurotoxicity and Inflammation by Cell Penetrable Itaconate Esters. Journal of NeuroVirology (2024)

B. Celia CuiMarina AksenovaAliaksandra SikirzhytskayaDiana OdhiamboElizaveta KorunovaVitali SikirzhytskiHao JiDiego AltomareEugenia BroudeNorma FrizzellRosemarie BoozeMichael D. WyattMichael Shtutman

neurologyvirologyhivimmunologycocaine-induced neurotoxicityneurovirologypharmacology

Abstract 5018: Protac Degraders of Cdk8/Cdk19 Mediator Kinases Potently Suppress Multiple Myeloma Proliferation. Cancer Research (2023)

Li ZhangJing LiCharles E. DowlingEugenia V. BroudeIgor B. RoninsonCampbell McInnesMengqian Chen

immunologypharmacologygeneticstumor biologycancer immunotherapycancer researchcancer geneticscancer treatmentmedicinal researchmolecular cancercellular therapyprotac degraderscancer biologyhematological malignanciesleukemiaclinical researchenzyme inhibitioncancer genomicsoncology

Abstract A043: Cdk8/19-Regulated Transcriptional Reprogramming: A Druggable Driver of Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics (2023)

Jing LiThomas HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikitzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall KerrCharles DowlingGary SchoolsChang-Uk LimEugenia BroudeGeorge WildingMichael LillyIgor RoninsonMengqian Chen

drug targetingpharmacologytumor biologycancer researchcastration-resistant prostate cancertranscription regulationcancer treatmentgene expressionpharmacotherapyoncogenesdruggable drivermedicinal researchmolecular cancerprostate cancercellular therapyurologymedicinecancer geneticscancer genomicsoncology

Abstract Pd5-10: Pd5-10 Dual Therapeutic Targeting of Cdk8/19 and Mtor in Triple Negative Breast Cancer. Cancer Research (2023)

Xiaokai DingHao JiAmanda C. SharkoJuergen LoskutovZachary MackJadyn MyersMengqian ChenElena PugachevaIgor RoninsonEugenia Broude

breast oncologyradiation oncologytumor targetingcancer biologydrug targetingcancer immunotherapymedicinal researchleukemiaradiologycancer imagingcancer researchpharmacologyclinical researchcancer treatmentenzyme inhibitioncancer careoncologybreast cancer

Anoikis Resistance and Metastasis of Ovarian Cancer Can Be Overcome by Cdk8/19 Mediator Kinase Inhibition. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Mehri MonavarianEmily Faith PageResha RajkarnikarAsha KumariLiz Quintero MaciasFelipe MassicanoNam Y LeeSarthak SahooNadine HempelMohit Kumar JollyLara IanovElizabeth WortheyAbhyudai SinghEugenia V BroudeKarthikeyan Mythreye

metastasistumor biologydevelopmental biologycancer researchpharmacologyadaptive anoikis resistancehealth sciencesoncologycancer biology

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

neurologyoncogenescancer cellstumor biologycancer treatmentmedicinal researchprostate cancercarcinogenesiscancer researchcastration-resistant prostate cancercancer growthpharmacologyurologycell regulationcancer geneticsoncologycancer biology

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Eugenia Broude

Professor

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Eugenia Broude is currently serving as a College Of Pharmacy Professor at University of South Carolina.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Eugenia Broude

University of South Carolina

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract A019: Development of Adaptive Anoikis Resistance Promotes Ovarian Cancer Metastasis That Can Be Prevented by Cdk8/19 Mediator Kinase Inhibition. Cancer Research (2024)

Mehri MonavarianResha RajkarnikarEmily Faith PageAsha KumariLiz Macias QuinteroLara Ianovsarthak SahooMohit Kumar JollyElizabeth WortheyNadine HempelAbhyudai SinghEugenia BroudeKarthikeyan Mythreye

Abstract B058: Targeting Mediator Kinase Cdk8/19 Potentiates Chemotherapeutic Responses, Reverses Tumor Growth, and Prolongs Survival From Ovarian Clear Cell Carcinoma. Cancer Research (2024)

Wade BartonAsha KumariGary SchoolZachary MackLiz Macias QuinteroKarthik RangavajhulaRebecca ArendMengqian ChenEugenia V. BroudeKarthikeyan Mythreye

Host-Derived Interleukin 1α Induces an Immunosuppressive Tumor Microenvironment via Regulating Monocyte-To-Macrophage Differentiation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Suppression of Hiv-Tat and Cocaine-Induced Neurotoxicity and Inflammation by Cell Penetrable Itaconate Esters. Journal of NeuroVirology (2024)

B. Celia CuiMarina AksenovaAliaksandra SikirzhytskayaDiana OdhiamboElizaveta KorunovaVitali SikirzhytskiHao JiDiego AltomareEugenia BroudeNorma FrizzellRosemarie BoozeMichael D. WyattMichael Shtutman

neurologyvirologyhivimmunologycocaine-induced neurotoxicityneurovirologypharmacology

Abstract 5018: Protac Degraders of Cdk8/Cdk19 Mediator Kinases Potently Suppress Multiple Myeloma Proliferation. Cancer Research (2023)

Li ZhangJing LiCharles E. DowlingEugenia V. BroudeIgor B. RoninsonCampbell McInnesMengqian Chen

Abstract A043: Cdk8/19-Regulated Transcriptional Reprogramming: A Druggable Driver of Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics (2023)

Abstract Pd5-10: Pd5-10 Dual Therapeutic Targeting of Cdk8/19 and Mtor in Triple Negative Breast Cancer. Cancer Research (2023)

Xiaokai DingHao JiAmanda C. SharkoJuergen LoskutovZachary MackJadyn MyersMengqian ChenElena PugachevaIgor RoninsonEugenia Broude

Anoikis Resistance and Metastasis of Ovarian Cancer Can Be Overcome by Cdk8/19 Mediator Kinase Inhibition. bioRxiv (Cold Spring Harbor Laboratory) (2023)

metastasistumor biologydevelopmental biologycancer researchpharmacologyadaptive anoikis resistancehealth sciencesoncologycancer biology

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

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