Faculty

Institution

Unit

Venue

Igor Roninson

Professor SmartState Endowed Chair Deputy Director Center for Targeted Therapeutics

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Igor Roninson is currently serving as a College Of Pharmacy Professor SmartState Endowed Chair Deputy Director Center for Targeted Therapeutics at University of South Carolina.

Honors

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Experiences

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Education

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Igor Roninson

University of South Carolina

Professor SmartState Endowed Chair Deputy Director Center for Targeted Therapeutics

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pharmacology genetics oncology molecular biology cancer research cancer biology medicinal research tumor biology gene expression cell biology cancer treatment drug resistance molecular cancer oncogenes cancer genetics enzyme inhibition cancer immunotherapy cancer genomics tumor targeting genomics cancer care leukemia anti-cancer agents cellular therapy cancer cells cell regulation drug targeting molecular genetics mammalian biology cell death pharmacotherapy genome biology protein science gene regulation cellular senescence tumor suppressors transcription regulation rna biology multidrug resistance genetic suppressor elements cancer imaging cell cycle gene function molecular regulation somatic cell genetics apoptosis cytogenetics cancer growth colorectal cancer avian biology molecular cell biology protein genetics medical genetics clinical pharmacology biogerontology nucleic acid amplification viral genetics protein expression clinical medicine gene characterization pharmacokinetics glycosylation tumor cells expression selection human leukemia cells multidrug transporter p-glycoprotein mammalian cells dna sequences multidrug-resistant human cells polymerase chain reaction gene amplification human multidrug resistance human tumor cells human mdr p-glycoprotein function drug response metastasis aging-associated diseases cancer discovery transcriptional reprogramming cancer letter pathology cancer prevention

Notable Scholarly Works

Notable Federal Grants

Collaborators

Author Response: Knockout of Cyclin Dependent Kinases 8 and 19 Leads to Depletion of Cyclin C and Suppresses Spermatogenesis and Male Fertility in Mice. (2024)

Alexandra V. BruterEkaterina A. VarlamovaNina I. StavskayaZoia G. AntyshevaVasily N. ManskikhAnna V. TvorogovaD. S. KorshunovaAlvina I. KhamidullinaMarina V. UtkinaViktor P. BogdanovAlyona I. NikiforovaEugene A. AlbertDenis O. MaksimovJing LiMengqian ChenAlexander A. ShtilIgor B. RoninsonVladislav A. MogilaYulia Y. SilaevaVictor V. Tatarskiy

neurologymale fertilityauthor responsepharmacologymammalian biologyreproductive biologyepigeneticsassisted reproductioncytogeneticsneuroscience

Host-Derived Interleukin 1α Induces an Immunosuppressive Tumor Microenvironment via Regulating Monocyte-To-Macrophage Differentiation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Manikanda Raja Keerthi RajaGourab GuptaGrace AtkinsonKatie KathreinAlissa ArmstrongMichael GowerIgor RoninsonEugenia BroudeMenqiang ChenHao JiChang-uk LimHongjun WangDaping FanPeisheng XuJie LiGang ZhouHexin Chen

immunologyimmunosuppressive therapymedicinecytokinesadaptive immune systemimmunosuppressive tumor microenvironmentoncologyimmune responsesmonocyte-to-macrophage differentiationtumor microenvironmentimmunosuppression

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichZachary T. MackGary P. SchoolsChang-uk LimLeigh EllisXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

prostate cancerneurologytumor targetingcancer managementcastration resistancecancer biologycancer researchsurgical oncologyurologycancer immunotherapycancer treatmentadvanced prostate cancerpharmacologypharmacotherapyclinical researchoncologymedicinal researchclinical investigationclinical medicinemediator kinase inhibitionexperimental medicine

Reviewer #2 (Public Review): Knockout of Cyclin Dependent Kinases 8 and 19 Leads to Depletion of Cyclin C and Suppresses Spermatogenesis and Male Fertility in Mice. (2024)

male fertilityassisted reproductioncytogeneticshuman biologyresearch evaluationhuman reproductionendocrinologyreproductive biologydermatologyreproductive medicinemammalian biologyreproductive physiologyanimal biotechnologycell regulationmutagenesis (molecular biology technique)gene expressionpharmacologygeneticspublic reviewepigenetics

Abstract 5018: Protac Degraders of Cdk8/Cdk19 Mediator Kinases Potently Suppress Multiple Myeloma Proliferation. Cancer Research (2023)

Li ZhangJing LiCharles E. DowlingEugenia V. BroudeIgor B. RoninsonCampbell McInnesMengqian Chen

hematological malignanciescancer geneticsmolecular cancercancer genomicscancer biologyprotac degradersleukemiacancer researchcancer immunotherapycancer treatmenttumor biologyimmunologyenzyme inhibitionpharmacologygeneticsoncologyclinical researchmedicinal researchcellular therapy

Abstract A043: Cdk8/19-Regulated Transcriptional Reprogramming: A Druggable Driver of Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics (2023)

Jing LiThomas HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikitzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall KerrCharles DowlingGary SchoolsChang-Uk LimEugenia BroudeGeorge WildingMichael LillyIgor RoninsonMengqian Chen

cancer geneticsprostate cancermedicinemolecular cancercancer genomicscancer researchurologycastration-resistant prostate cancerdrug targetingcancer treatmenttumor biologydruggable drivergene expressionpharmacologytranscription regulationpharmacotherapyoncologyoncogenesmedicinal researchcellular therapy

Abstract Pd5-10: Pd5-10 Dual Therapeutic Targeting of Cdk8/19 and Mtor in Triple Negative Breast Cancer. Cancer Research (2023)

Xiaokai DingHao JiAmanda C. SharkoJuergen LoskutovZachary MackJadyn MyersMengqian ChenElena PugachevaIgor RoninsonEugenia Broude

tumor targetingenzyme inhibitionradiologypharmacologycancer careleukemiaradiation oncologycancer researchcancer immunotherapycancer imagingoncologybreast cancerclinical researchmedicinal researchcancer treatmentdrug targetingcancer biologybreast oncology

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

neurologycarcinogenesispharmacologycancer geneticscell regulationcancer researchtumor biologyurologycancer growthcastration-resistant prostate canceroncologyoncogenesmedicinal researchcancer cellscancer treatmentcancer biologyprostate cancer

Cdk8/19 Inhibition Attenuates G1 Arrest Induced by Bcr-Abl Antagonists and Accelerates Death of Chronic Myelogenous Leukemia Cells. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Alvina I. KhamidullinaMargarita A. YastrebovaAlexandra V. BruterJulia V. NuzhinaNadezhda E. VorobyevaAnastasia M. KhrustalevaEkaterina A. VarlamovaAlexander V. TyakhtYaroslav E. AbramenkoEkaterina S. IvanovaMaria A. ZamkovaJing LiChang-Uk LimMengqian ChenEugenia V. BroudeIgor B. RoninsonAlexander A. ShtilVictor V. Tatarskiy

immunologyneurologyreceptorscell deathpharmacologyenzyme inhibitionhematologycancer researchcytokinescancer immunotherapyinhibitory activityapoptosisanti-cancer agentsoncologymedicinal researchtherapeutic efficacycellular therapybcr-abl antagonists

Cdk8 and Cdk19: Positive Regulators of Signal-Induced Transcription and Negative Regulators of Mediator Complex Proteins. Nucleic Acids Research (2023)

Mengqian ChenJing LiLi ZhangLili WangChen ChengHao JiSerena AltiliaXiaokai DingGuoshuai CaiDiego AltomareMichael ShtutmanStephanie D ByrumSamuel G MackintoshAlexey FeoktistovNataliya SoshnikovaVladislav A MogilaVictor TatarskiyMaksim ErokhinDarya ChetverinaAngga PrawiraYi NiStephan UrbanCampbell McInnesEugenia V BroudeIgor B Roninson

gene expressionpharmacologytranscription regulationcell signalingtranscription (biology)geneticstranscription factorsmolecular regulationsignal-induced transcriptionnegative regulatorsmolecular biologymediator complex proteinsprotein expressionpositive regulatorssignal transductionprotein sciencegene regulation

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Igor Roninson

Professor SmartState Endowed Chair Deputy Director Center for Targeted Therapeutics

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Igor Roninson is currently serving as a College Of Pharmacy Professor SmartState Endowed Chair Deputy Director Center for Targeted Therapeutics at University of South Carolina.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Igor Roninson

University of South Carolina

Professor SmartState Endowed Chair Deputy Director Center for Targeted Therapeutics

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Author Response: Knockout of Cyclin Dependent Kinases 8 and 19 Leads to Depletion of Cyclin C and Suppresses Spermatogenesis and Male Fertility in Mice. (2024)

neurologymale fertilityauthor responsepharmacologymammalian biologyreproductive biologyepigeneticsassisted reproductioncytogeneticsneuroscience

Host-Derived Interleukin 1α Induces an Immunosuppressive Tumor Microenvironment via Regulating Monocyte-To-Macrophage Differentiation. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Reviewer #2 (Public Review): Knockout of Cyclin Dependent Kinases 8 and 19 Leads to Depletion of Cyclin C and Suppresses Spermatogenesis and Male Fertility in Mice. (2024)

Abstract 5018: Protac Degraders of Cdk8/Cdk19 Mediator Kinases Potently Suppress Multiple Myeloma Proliferation. Cancer Research (2023)

Li ZhangJing LiCharles E. DowlingEugenia V. BroudeIgor B. RoninsonCampbell McInnesMengqian Chen

Abstract A043: Cdk8/19-Regulated Transcriptional Reprogramming: A Druggable Driver of Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics (2023)

Abstract Pd5-10: Pd5-10 Dual Therapeutic Targeting of Cdk8/19 and Mtor in Triple Negative Breast Cancer. Cancer Research (2023)

Xiaokai DingHao JiAmanda C. SharkoJuergen LoskutovZachary MackJadyn MyersMengqian ChenElena PugachevaIgor RoninsonEugenia Broude

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

Cdk8/19 Inhibition Attenuates G1 Arrest Induced by Bcr-Abl Antagonists and Accelerates Death of Chronic Myelogenous Leukemia Cells. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Cdk8 and Cdk19: Positive Regulators of Signal-Induced Transcription and Negative Regulators of Mediator Complex Proteins. Nucleic Acids Research (2023)

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brain tumor research

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Erica Golemis

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cancer research

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cancer letter

molecular cancer

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cancer letter

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multi-omics studies

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biomedical data science

biomedical informatics

Anthony E. Pegg

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cancer letter

toxicological mechanism