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Ethan Merritt

Emeritus Research Associate Professor of Biochemistry

University of Washington

Affiliations

School of Medicine

Biochemistry

Ethan Merritt is currently serving as a Biochemistry Emeritus Research Associate Professor of Biochemistry at University of Washington.

Honors

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Experiences

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Education

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Ethan Merritt

University of Washington

Emeritus Research Associate Professor of Biochemistry

You can click a keyword to filter the displayed items

structural biology pharmacology molecular biology protein structure crystallography protein science biochemistry infectious diseases medicinal chemistry drug discovery structural molecular biology enzymes enzyme inhibition clinical microbiology biomolecular structure x-ray crystallography toxinology structural chemistry crystal structures parasitology microbial pathogenesis medicinal research protein x-ray crystallography clinical chemistry molecular structure drug targeting biological chemistry toxins receptor (biochemistry) heat-labile enterotoxin cholera toxin crystal research pharmaceutical chemistry molecular microbiology microbial toxins tropical medicine mammalian biology rna biology selective inhibitors redox biology molecular science molecular research protein chemistry medical microbiology structural genomics structural bioinformatics rational drug design crystallographic studies g protein-coupled receptor molecular epidemiology bacteriology pathway analysis clinical pharmacology structure-function enzyme kinetics antimicrobial chemotherapy molecular regulation molecular substrates structure elucidation structural morphology anisotropic displacement parameters inhibitor design cryptosporidium parvum giardia lamblia tryptophanyl-trna synthetase tls motion feedback loop default logic internet modeling model dissemination carbohydrate-protein interactions photorealistic molecular graphics multiple groups optimal description multi-group tls models multiwavelength anomalous diffraction core streptavidin protein crystallography biomolecular structure prediction methods development

Notable Scholarly Works

Notable Federal Grants

Collaborators

High-Resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design. UNC Libraries (2021)

Dantas, GautamCorrent, ColinReichow, Steve L.Havranek, James J.Eletr, Ziad M.Isern, Nancy G.Kuhlman, BrianVarani, GabrieleMerritt, Ethan A.Baker, David

biophysicsthermodynamic analysisprotein structurecomputational protein designenzymesextreme stabilizationmolecular biologystructural molecular biologymembrane biologystructural biologyprotein scienceprotein engineeringbiological engineeringhuman procarboxypeptidase

Nek8445, a Protein Kinase Required for Microtubule Regulation and Cytokinesis in Giardia Lamblia. Molecular Biology of the Cell (2020)

Kelly M. HennesseyGermain C. M. AlasIlse RogiersRenyu LiEthan A. MerrittAlexander R. Paredez

immunologymicrotubule regulationmolecular biologycell and molecular biologyprotein kinasecell biology

A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Molecular Cell (2019)

Ethan AhlerAmes C. RegisterSujata ChakrabortyLinglan FangEmily M. DieterKatherine A. SitkoRama Subba Rao VidadalaBridget M. TrevillianMartin GolkowskiHannah GelmanJason J. StephanyAlan F. RubinEthan A. MerrittDouglas M. FowlerDustin J. Maly

cell signalingmolecular regulationbiochemistrygene regulatory networkskinase activityphosphotransferase-independent functionsmolecular cell biologyenzymesprotein sciencemolecular and cellular biologyregulatory mechanismmolecular physiologycellular regulatory mechanismcell regulationcellular biochemistrygene expressionenzyme inhibitionsystems biologymolecular biologysignal transductiongene regulation

Methionyl-Trna Synthetase Inhibitor Has Potent in Vivo Activity in a Novel Giardia Lamblia Luciferase Murine Infection Model. Journal of Antimicrobial Chemotherapy (2019)

Samantha A MichaelsHan-Wei ShihBailin ZhangEdelmar D NavalunaZhongsheng ZhangRanae M RanadeJ Robert GillespieEthan A MerrittErkang FanFrederick S BucknerAlexander R ParedezKayode K Ojo

antimicrobial agentsmethionyl-trna synthetase inhibitormedicineenzyme inhibitionpharmacologyclinical microbiologyapplied microbiologypharmacotherapyenzymesvirologydrug discoveryantibacterial agentsinfectious diseasesmedical microbiologyveterinary microbiologyclinical mycologyantimicrobial chemotherapy

7 H -Pyrrolo[2,3- D ]Pyrimidin-4-Amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared With 1 H -Pyrazolo[3,4- D ]Pyrimidin-4-Amine-Based Inhibitors. ACS Infectious Diseases (2018)

Rama S. R. VidadalaMartin GolkowskiMatthew A. HulversonRyan ChoiMolly C. McCloskeyGrant R. WhitmanWenlin HuangSamuel L. M. ArnoldLynn K. BarrettErkang FanEthan A. MerrittWesley C. Van VoorhisKayode K. OjoDustin J. Maly

medicinal chemistrypharmacologypharmacokinetics

Screening of the Pathogen Box for Inhibitors With Dual Efficacy Against Giardia Lamblia and Cryptosporidium Parvum. PLoS neglected tropical diseases (2018)

Kelly M. HennesseyIlse C. RogiersHan-Wei ShihMatthew A. HulversonRyan ChoiMolly C. McCloskeyGrant R. WhitmanLynn K. BarrettEthan A. MerrittAlexander R. ParedezKayode K. Ojo

pharmacologydual efficacytropical medicineepidemiologyclinical microbiologygiardia lambliavirologyinfectious diseasespathogen boxcryptosporidium parvum

Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays. Antimicrobial Agents and Chemotherapy (2018)

Suzanne ScheeleJennifer A. GeigerAmy E. DeRocherRyan ChoiTess R. SmithMatthew A. HulversonRama Subba Rao VidadalaLynn K. BarrettDustin J. MalyEthan A. MerrittKayode K. OjoWesley C. Van VoorhisMarilyn Parsons

medicineantimicrobial resistancepharmacologyenzyme inhibitionclinical microbiologyprobing activityinfectious diseases

Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review. Experimental Parasitology (2017)

Wesley C. Van VoorhisJ. Stone DoggettMarilyn ParsonsMatthew A. HulversonRyan ChoiSamuel L.M. ArnoldMichael W. RiggsAndrew HemphillDaniel K. HoweRobert H. MealeyAudrey O.T. LauEthan A. MerrittDustin J. MalyErkang FanKayode K. Ojo

pharmacologyparasitologykinase inhibitorsglobal healthextended-spectrum antiprotozoal

Development of an Orally Available and Central Nervous System (Cns) Penetrant Toxoplasma Gondii Calcium-Dependent Protein Kinase 1 ( Tg Cdpk1) Inhibitor With Minimal Human Ether-A-Go-Go-Related Gene (Herg) Activity for the Treatment of Toxoplasmosis. Journal of Medicinal Chemistry (2016)

Rama Subba Rao VidadalaKasey L. RivasKayode K. OjoMatthew A. HulversonJennifer A. ZambriskiIgor BruzualTracey L. SchultzWenlin HuangZhongsheng ZhangSuzanne ScheeleAmy E. DeRocherRyan ChoiLynn K. BarrettLatha Kallur SiddaramaiahWim G. J. HolErkang FanEthan A. MerrittMarilyn ParsonsGail FreibergKennan MarshDale J. KempfVern B. CarruthersNina IsoherranenJ. Stone DoggettWesley C. Van VoorhisDustin J. Maly

neurologymedicineneuroinflammationpharmacologyneuropharmacologydrug discoverycentral nervous systemclinical pharmacologyinflammation

Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia Lamblia. PLoS neglected tropical diseases (2016)

Kelly M. HennesseyTess R. SmithJennifer W. XuGermain C. M. AlasKayode K. OjoEthan A. MerrittAlexander R. Paredez

medicinal chemistrymedicinepharmacologysmall-gatekeeper kinasesavian biologytropical medicinetropical insect scienceparasitologyveterinary medicineavian medicinetropical animal healthdisease ecologygiardia lamblianeglected tropical diseaseshealth sciences

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Ethan Merritt

Emeritus Research Associate Professor of Biochemistry

University of Washington

Affiliations

School of Medicine

Biochemistry

Ethan Merritt is currently serving as a Biochemistry Emeritus Research Associate Professor of Biochemistry at University of Washington.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ethan Merritt

University of Washington

Emeritus Research Associate Professor of Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

High-Resolution Structural and Thermodynamic Analysis of Extreme Stabilization of Human Procarboxypeptidase by Computational Protein Design. UNC Libraries (2021)

Dantas, GautamCorrent, ColinReichow, Steve L.Havranek, James J.Eletr, Ziad M.Isern, Nancy G.Kuhlman, BrianVarani, GabrieleMerritt, Ethan A.Baker, David

Nek8445, a Protein Kinase Required for Microtubule Regulation and Cytokinesis in Giardia Lamblia. Molecular Biology of the Cell (2020)

Kelly M. HennesseyGermain C. M. AlasIlse RogiersRenyu LiEthan A. MerrittAlexander R. Paredez

immunologymicrotubule regulationmolecular biologycell and molecular biologyprotein kinasecell biology

A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Molecular Cell (2019)

Methionyl-Trna Synthetase Inhibitor Has Potent in Vivo Activity in a Novel Giardia Lamblia Luciferase Murine Infection Model. Journal of Antimicrobial Chemotherapy (2019)

Samantha A MichaelsHan-Wei ShihBailin ZhangEdelmar D NavalunaZhongsheng ZhangRanae M RanadeJ Robert GillespieEthan A MerrittErkang FanFrederick S BucknerAlexander R ParedezKayode K Ojo

medicinal chemistrypharmacologypharmacokinetics

Screening of the Pathogen Box for Inhibitors With Dual Efficacy Against Giardia Lamblia and Cryptosporidium Parvum. PLoS neglected tropical diseases (2018)

Kelly M. HennesseyIlse C. RogiersHan-Wei ShihMatthew A. HulversonRyan ChoiMolly C. McCloskeyGrant R. WhitmanLynn K. BarrettEthan A. MerrittAlexander R. ParedezKayode K. Ojo

pharmacologydual efficacytropical medicineepidemiologyclinical microbiologygiardia lambliavirologyinfectious diseasespathogen boxcryptosporidium parvum

Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays. Antimicrobial Agents and Chemotherapy (2018)

medicineantimicrobial resistancepharmacologyenzyme inhibitionclinical microbiologyprobing activityinfectious diseases

Extended-Spectrum Antiprotozoal Bumped Kinase Inhibitors: A Review. Experimental Parasitology (2017)

pharmacologyparasitologykinase inhibitorsglobal healthextended-spectrum antiprotozoal

neurologymedicineneuroinflammationpharmacologyneuropharmacologydrug discoverycentral nervous systemclinical pharmacologyinflammation

Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia Lamblia. PLoS neglected tropical diseases (2016)

Kelly M. HennesseyTess R. SmithJennifer W. XuGermain C. M. AlasKayode K. OjoEthan A. MerrittAlexander R. Paredez

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future medicinal chemistry

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clinical infectious disease

infectious disease research

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