Faculty

Institution

Unit

Venue

Dwayne Stupack

Professor Ob/Gyn & Reproductive sciences

University of California, San Diego

Affiliations

School Of Medicine

Pathology

Dwayne Stupack is currently serving as a Pathology Professor Ob/Gyn & Reproductive sciences at University of California, San Diego.

Honors

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Experiences

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Education

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Dwayne Stupack

University of California, San Diego

Professor Ob/Gyn & Reproductive sciences

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molecular biology tumor biology cell biology cancer biology cancer research oncology oncogenes cancer cells medicinal research immunology vascular biology pharmacology tumor microenvironment cell death cell signaling gynecologic oncology cancer discovery tumor suppressors metastasis cancer treatment carcinogenesis cancer genetics virus research apoptosis angiogenesis cellular biology tumor targeting inflammation molecular cell biology cell migration cancer growth cancer genomics biological chemistry enzyme inhibition intracellular trafficking cellular therapy clinical investigation cell proliferation tumor heterogeneity cell adhesion focal adhesion kinase experimental medicine stem cell research molecular virology protein phosphorylation cell regulation anti-cancer agents cell-matrix interactions g protein-coupled receptor tumor growth thrombosis viral pathogenesis lymphocyte development neovascularization oncogenic agent signaling pathways cellular immune responses anti-inflammatory therapeutic efficacy therapy resistance cancer immunosurveillance angiology cell survival neuroblastoma metastasis adenovirus endocytosis apoptotic cues integrin-mediated death unligated integrins adherent cells distinct apoptotic stimuli vascular protection arthritic disease actin cytoskeleton reorganization rho family gtpases anticancer combination therapies homing mechanism systems biology cellular physiology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B024: Maintenance Therapy Inhibition of Ptk2 Yields Decreased Disease in Preclinical Hrp/Hrd Models of Recurrent Hgsoc. Cancer Research (2024)

Breana HillIoana BondreH Meryem SoyluJuliette AntoineXiao Lei ChenElise TahonYichi ZhangMarjaana OlajillSarah KinkelTerrie-Anne CockPratibha BinderChris BurnsDavid SchlaepferMichael McHale T. McHaleDwayne G Stupack

medicinetreatment developmentcancer researchmaintenance therapy inhibitionrecurrent hgsoc

Durable Antitumor Response via an Oncolytic Virus Encoding Decoy-Resistant Il-18. Journal for ImmunoTherapy of Cancer (2024)

Yan ChengYuanhui ZhaoYu LiuYichi ZhangDongge XuWeikang SunMengyu ZhangYuqing MiaoSusu HeYayi HouDwayne StupackErguang Li

infectious diseasesantiviral researchcancer immunosurveillanceantiviral responsesimmune responsesantiviral therapyviral oncologycancer researchoncolytic viruscancer immunotherapydurable antitumor responseimmunotherapyimmunologyvirus researchpharmacologycancer discoveryoncologyoncogenesmedicinal researchimmunomodulation

Figure 3 From Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma. (2024)

Yichi ZhangMarjaana OjalillAntonia BoyerXiao Lei ChenElise TahonGaëtan Thivolle LiouxMarvin XiaMaryam AbbasHalime Meryem SoyluDouglas B. FliederDenise C. ConnollyAlfredo A. MolinoloMichael T. McHaleDwayne G. StupackDavid D. Schlaepfer

cisplatin stressgynecologic oncologymolecular biologycancer biologytumor biologyovarian cancerovarian carcinoma

Focal Adhesion Kinase Inhibitors as Maintenance Therapy in a Homologous Recombination Repair Proficient High-Grade Serous Ovarian Cancer Murine Model. Gynecologic Oncology (2024)

Breana HillIoana BondreElise TahonHalime Meryem SoyluXiao Lei ChenMarjaana OjalillJoanna ZhangMarianne Hom-TedlaElise WilsonCheryl SaenzSteven PlaxeRamez EskanderPratibha BinderMichael McHaleDavid SchlaepferDwayne Stupack

maintenance therapycancer researchgynecologic oncologygynecologic cancersoncologycancer treatmentgynecologyovarian cancer

Focal Adhesion Kinase Signaling – Tumor Vulnerabilities and Clinical Opportunities. Journal of Cell Science (2024)

David D. SchlaepferMarjaana OjalillDwayne G. Stupack

cell signalingtherapy resistancetumor heterogeneitytumor vulnerabilitiesclinical opportunitiescell biologyvascular biologyreceptor tyrosine kinasestumor microenvironmentcellular biologybone researchtumor biologyfocal adhesion kinasesystems biologymolecular biologyoncologyoncogenescancer cellsmedicinal researchcell adhesionadhesion

Inducible Fak Deletion but Not Fak Inhibition in Endothelial Cells Activates P53 to Suppress Tumor Growth in Pyk2-Null Mice. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Xiao Lei ChenMarjaana OjalillChristine JeanIsabelle TancioniShulin JiangAntonia BoyerDuygu OzmadenciSean UryuDavid TarinJoseph SchlessingerDwayne G. StupackDavid D. Schlaepfer

inducible fak deletioncancer researchvascular biologytumor suppressorscancer growthmolecular biologyendothelial cellstumor microenvironmentcancer biologytumor biologytumor growth

Ras/Raf/Mek Mutated High-Grade Serous Ovarian Cancer Susceptible to Raf Inhibition in Vitro but Not in Vivo. Gynecologic Oncology (2024)

Ioana BondreBreana HillHalime Meryem SoyluElise WilsonAntonia BoyerElise TahonJoanna ZhangMarjaana OjalillMarianne Hom-TedlaRamez EskanderMichael McHaleSteven PlaxeCheryl SaenzPratibha BinderTerry HarrisonDavid SchlaepferDwayne Stupack

cancer geneticscancer managementradiation oncologycancer researchtumor biologygynecologic oncologycancer discoverymolecular cancerclinical radiation oncologytumor suppressorsgynecologic cancersmolecular biologyoncologyoncogenescancer cellscancer treatmentgynecologyovarian cancer

Abstract 2363: Ovarian Tumor-Intrinsic Fak-Dependent Regulation of the Matrisome. Cancer Research (2023)

Marjaana OjalillJoanna ZhangUjjwal SuwalPekka RappuJyrki HeinoDenise C. ConnollyDwayne G. StupackDavid D. Schlaepfer

cancer researchmolecular biologyovarian cancercancer biology

Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer. Cancers (2023)

Claudia ContadiniAlessandra FerriClaudia CirottiDwayne StupackDaniela Barilà

gene expressionenzyme inhibitioncancer geneticstyrosine kinasescancer researchsystems biologyenzyme specificityreceptor tyrosine kinasescancer discoverymolecular biologyoncologydangerous liaisoncancer cellscancer biologytumor biology

Caspase-8 as a Novel Mediator Linking Src Kinase Signaling to Enhanced Glioblastoma Malignancy. Cell Death and Differentiation (2022)

Claudia ContadiniAlessandra FerriMarta Di MartileClaudia CirottiDonatella Del BufaloFrancesca De NicolaMatteo PalloccaMaurizio FanciulliFrancesca SaccoGloria DonninelliAlessia CaponeElisabetta VolpeNadine KellerShunichiro MikiDaisuke KawauchiDwayne StupackFrank FurnariDaniela Barilà

signaling pathwayscell deathglioblastoma malignancygliomassystems biologycell signalingbrain tumor researchsrc kinasemolecular biologyoncologycancer cellsnovel mediatorcancer biologycellular differentiationtumor biologycell biology

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Dwayne Stupack

Professor Ob/Gyn & Reproductive sciences

University of California, San Diego

Affiliations

School Of Medicine

Pathology

Dwayne Stupack is currently serving as a Pathology Professor Ob/Gyn & Reproductive sciences at University of California, San Diego.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dwayne Stupack

University of California, San Diego

Professor Ob/Gyn & Reproductive sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B024: Maintenance Therapy Inhibition of Ptk2 Yields Decreased Disease in Preclinical Hrp/Hrd Models of Recurrent Hgsoc. Cancer Research (2024)

medicinetreatment developmentcancer researchmaintenance therapy inhibitionrecurrent hgsoc

Durable Antitumor Response via an Oncolytic Virus Encoding Decoy-Resistant Il-18. Journal for ImmunoTherapy of Cancer (2024)

Yan ChengYuanhui ZhaoYu LiuYichi ZhangDongge XuWeikang SunMengyu ZhangYuqing MiaoSusu HeYayi HouDwayne StupackErguang Li

Figure 3 From Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma. (2024)

cisplatin stressgynecologic oncologymolecular biologycancer biologytumor biologyovarian cancerovarian carcinoma

Focal Adhesion Kinase Inhibitors as Maintenance Therapy in a Homologous Recombination Repair Proficient High-Grade Serous Ovarian Cancer Murine Model. Gynecologic Oncology (2024)

maintenance therapycancer researchgynecologic oncologygynecologic cancersoncologycancer treatmentgynecologyovarian cancer

Focal Adhesion Kinase Signaling – Tumor Vulnerabilities and Clinical Opportunities. Journal of Cell Science (2024)

David D. SchlaepferMarjaana OjalillDwayne G. Stupack

Inducible Fak Deletion but Not Fak Inhibition in Endothelial Cells Activates P53 to Suppress Tumor Growth in Pyk2-Null Mice. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Xiao Lei ChenMarjaana OjalillChristine JeanIsabelle TancioniShulin JiangAntonia BoyerDuygu OzmadenciSean UryuDavid TarinJoseph SchlessingerDwayne G. StupackDavid D. Schlaepfer

inducible fak deletioncancer researchvascular biologytumor suppressorscancer growthmolecular biologyendothelial cellstumor microenvironmentcancer biologytumor biologytumor growth

Ras/Raf/Mek Mutated High-Grade Serous Ovarian Cancer Susceptible to Raf Inhibition in Vitro but Not in Vivo. Gynecologic Oncology (2024)

Abstract 2363: Ovarian Tumor-Intrinsic Fak-Dependent Regulation of the Matrisome. Cancer Research (2023)

Marjaana OjalillJoanna ZhangUjjwal SuwalPekka RappuJyrki HeinoDenise C. ConnollyDwayne G. StupackDavid D. Schlaepfer

cancer researchmolecular biologyovarian cancercancer biology

Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer. Cancers (2023)

Claudia ContadiniAlessandra FerriClaudia CirottiDwayne StupackDaniela Barilà

Caspase-8 as a Novel Mediator Linking Src Kinase Signaling to Enhanced Glioblastoma Malignancy. Cell Death and Differentiation (2022)

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receptor tyrosine kinase

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anti-cancer agent