Faculty

Institution

Unit

Venue

David Schlaepfer

Professor Ob/Gyn & Reproductive sciences Professor

University of California, San Diego

Affiliations

School Of Medicine

Obstetrics, Gynecology & Reproductive Sciences

David Schlaepfer is currently serving as an Obstetrics, Gynecology & Reproductive Sciences Professor Ob/Gyn & Reproductive sciences Professor at University of California, San Diego.

Honors

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Experiences

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Education

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David Schlaepfer

University of California, San Diego

Professor Ob/Gyn & Reproductive sciences Professor

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cell biology molecular biology tumor biology cancer research cancer biology cell signaling focal adhesion kinase cell adhesion vascular biology biochemistry cancer cells adhesion systems biology oncogenes medicinal research cellular biology tumor microenvironment biological chemistry signaling pathways signal transduction molecular and cellular biology cancer treatment matrix biology cell motility gene expression molecular cell biology cell migration tumor suppressors cancer growth cancer genetics cancer discovery protein science cellular therapy intracellular trafficking protein phosphorylation angiogenesis cellular physiology cell research cell regulation cell-matrix interactions receptor tyrosine kinases bone research cell proliferation treatment and prevention tumor heterogeneity structural molecular biology stem cell research cell death tumor growth fak activity fibroblast growth factors biomolecular interactions cancer genomics tumor progression in vivo systems apoptosis cellular senescence embryonic development tissue development therapy resistance cell interactions disease progression pancreatic cancer genome instability tumor cell apoptosis three-dimensional environments nf-kb activation integrin-mediated signal transduction integrin-regulated fak-src signaling integrin signals clinical applications mechanistic findings integrin-stimulated cell migration differential regulation focal adhesions fak-mediated paxillin phosphorylation developmental biology focal adhesion ovarian cancer

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B024: Maintenance Therapy Inhibition of Ptk2 Yields Decreased Disease in Preclinical Hrp/Hrd Models of Recurrent Hgsoc. Cancer Research (2024)

Breana HillIoana BondreH Meryem SoyluJuliette AntoineXiao Lei ChenElise TahonYichi ZhangMarjaana OlajillSarah KinkelTerrie-Anne CockPratibha BinderChris BurnsDavid SchlaepferMichael McHale T. McHaleDwayne G Stupack

medicinerecurrent hgsoccancer researchmaintenance therapy inhibitiontreatment development

Fak, Vinculin, and Talin Control Mechanosensitive Yap Nuclear Localization. Biomaterials (2024)

Elijah N. HollandMarc A. Fernández-YagüeDennis W. ZhouEric B. O'NeillAyanna U. WoodfolkAna Mora-BozaJianping FuDavid D. SchlaepferAndrés J. García

biophysicsbiomedical engineeringmolecular biologybiomaterials

Figure 3 From Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma. (2024)

Yichi ZhangMarjaana OjalillAntonia BoyerXiao Lei ChenElise TahonGaëtan Thivolle LiouxMarvin XiaMaryam AbbasHalime Meryem SoyluDouglas B. FliederDenise C. ConnollyAlfredo A. MolinoloMichael T. McHaleDwayne G. StupackDavid D. Schlaepfer

tumor biologyovarian carcinomacisplatin stresscancer biologyovarian cancermolecular biologygynecologic oncology

Focal Adhesion Kinase Inhibitors as Maintenance Therapy in a Homologous Recombination Repair Proficient High-Grade Serous Ovarian Cancer Murine Model. Gynecologic Oncology (2024)

Breana HillIoana BondreElise TahonHalime Meryem SoyluXiao Lei ChenMarjaana OjalillJoanna ZhangMarianne Hom-TedlaElise WilsonCheryl SaenzSteven PlaxeRamez EskanderPratibha BinderMichael McHaleDavid SchlaepferDwayne Stupack

gynecologymaintenance therapygynecologic cancerscancer researchoncologyovarian cancercancer treatmentgynecologic oncology

Focal Adhesion Kinase Signaling – Tumor Vulnerabilities and Clinical Opportunities. Journal of Cell Science (2024)

David D. SchlaepferMarjaana OjalillDwayne G. Stupack

cell biologycell signalingtumor biologyoncologyadhesionmolecular biologysystems biologytumor microenvironmenttherapy resistanceclinical opportunitiesbone researchvascular biologycell adhesionmedicinal researchtumor heterogeneitytumor vulnerabilitiesfocal adhesion kinasecancer cellsoncogenesreceptor tyrosine kinasescellular biology

Inducible Fak Deletion but Not Fak Inhibition in Endothelial Cells Activates P53 to Suppress Tumor Growth in Pyk2-Null Mice. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Xiao Lei ChenMarjaana OjalillChristine JeanIsabelle TancioniShulin JiangAntonia BoyerDuygu OzmadenciSean UryuDavid TarinJoseph SchlessingerDwayne G. StupackDavid D. Schlaepfer

tumor biologyinducible fak deletioncancer researchcancer growthcancer biologytumor suppressorsendothelial cellsvascular biologytumor growthmolecular biologytumor microenvironment

Ras/Raf/Mek Mutated High-Grade Serous Ovarian Cancer Susceptible to Raf Inhibition in Vitro but Not in Vivo. Gynecologic Oncology (2024)

Ioana BondreBreana HillHalime Meryem SoyluElise WilsonAntonia BoyerElise TahonJoanna ZhangMarjaana OjalillMarianne Hom-TedlaRamez EskanderMichael McHaleSteven PlaxeCheryl SaenzPratibha BinderTerry HarrisonDavid SchlaepferDwayne Stupack

gynecologytumor biologygynecologic cancersoncologyradiation oncologycancer researchmolecular cancertumor suppressorsovarian cancercancer cellscancer managementoncogenesclinical radiation oncologycancer treatmentmolecular biologycancer discoverycancer geneticsgynecologic oncology

Abstract 2363: Ovarian Tumor-Intrinsic Fak-Dependent Regulation of the Matrisome. Cancer Research (2023)

Marjaana OjalillJoanna ZhangUjjwal SuwalPekka RappuJyrki HeinoDenise C. ConnollyDwayne G. StupackDavid D. Schlaepfer

molecular biologycancer biologyovarian cancercancer research

Author Correction: Genotype Tunes Pancreatic Ductal Adenocarcinoma Tissue Tension to Induce Matricellular Fibrosis and Tumor Progression. Nature Medicine (2023)

Hanane LaklaiYekaterina A. MiroshnikovaMichael W. PickupEric A. CollissonGrace E. KimAlex S. BarrettRyan C. HillJohnathon N. LakinsDavid D. SchlaepferJanna K. MouwValerie S. LeBleuNilotpal RoySergey V. NovitskiyJulia S. JohansenValeria PoliRaghu KalluriChristine A. Iacobuzio-DonahueLaura D. WoodMatthias HebrokKirk HansenHarold L. MosesValerie M. Weaver

medicinegenome instabilitytumor biologymatricellular fibrosisoncologycancer researchauthor correctionmatrix biologyhepatologycancer genomicsgeneticsmolecular cancertumor progressionmedical geneticsgenomicsvascular biologygenome biologymedicinal researchgenomic medicinemolecular biologycancer genetics

Tgfbi Remodels Adipose Metabolism by Regulating the Notch-1 Signaling Pathway. Experimental & Molecular Medicine (2023)

Seul Gi LeeJongbeom ChaeSeon Min WooSeung Un SeoHa-Jeong KimSang-Yeob KimDavid D. SchlaepferIn-San KimHee-Sae ParkTaeg Kyu KwonJu-Ock Nam

metabolic healthmetabolic remodelingmetabolic stategut microbesgene expressionmetabolic pathwaysstem cell researchmetabolismmolecular biologysystems biologymetabolic regulationcell metabolismbiochemistrymolecular medicinetgfbi remodelsmolecular metabolismsignal transductionexperimental medicinemetabolic control

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David Schlaepfer

Professor Ob/Gyn & Reproductive sciences Professor

University of California, San Diego

Affiliations

School Of Medicine

Obstetrics, Gynecology & Reproductive Sciences

David Schlaepfer is currently serving as an Obstetrics, Gynecology & Reproductive Sciences Professor Ob/Gyn & Reproductive sciences Professor at University of California, San Diego.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

David Schlaepfer

University of California, San Diego

Professor Ob/Gyn & Reproductive sciences Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B024: Maintenance Therapy Inhibition of Ptk2 Yields Decreased Disease in Preclinical Hrp/Hrd Models of Recurrent Hgsoc. Cancer Research (2024)

medicinerecurrent hgsoccancer researchmaintenance therapy inhibitiontreatment development

Fak, Vinculin, and Talin Control Mechanosensitive Yap Nuclear Localization. Biomaterials (2024)

Elijah N. HollandMarc A. Fernández-YagüeDennis W. ZhouEric B. O'NeillAyanna U. WoodfolkAna Mora-BozaJianping FuDavid D. SchlaepferAndrés J. García

biophysicsbiomedical engineeringmolecular biologybiomaterials

Figure 3 From Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma. (2024)

tumor biologyovarian carcinomacisplatin stresscancer biologyovarian cancermolecular biologygynecologic oncology

Focal Adhesion Kinase Inhibitors as Maintenance Therapy in a Homologous Recombination Repair Proficient High-Grade Serous Ovarian Cancer Murine Model. Gynecologic Oncology (2024)

gynecologymaintenance therapygynecologic cancerscancer researchoncologyovarian cancercancer treatmentgynecologic oncology

Focal Adhesion Kinase Signaling – Tumor Vulnerabilities and Clinical Opportunities. Journal of Cell Science (2024)

David D. SchlaepferMarjaana OjalillDwayne G. Stupack

Inducible Fak Deletion but Not Fak Inhibition in Endothelial Cells Activates P53 to Suppress Tumor Growth in Pyk2-Null Mice. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Xiao Lei ChenMarjaana OjalillChristine JeanIsabelle TancioniShulin JiangAntonia BoyerDuygu OzmadenciSean UryuDavid TarinJoseph SchlessingerDwayne G. StupackDavid D. Schlaepfer

tumor biologyinducible fak deletioncancer researchcancer growthcancer biologytumor suppressorsendothelial cellsvascular biologytumor growthmolecular biologytumor microenvironment

Ras/Raf/Mek Mutated High-Grade Serous Ovarian Cancer Susceptible to Raf Inhibition in Vitro but Not in Vivo. Gynecologic Oncology (2024)

Abstract 2363: Ovarian Tumor-Intrinsic Fak-Dependent Regulation of the Matrisome. Cancer Research (2023)

Marjaana OjalillJoanna ZhangUjjwal SuwalPekka RappuJyrki HeinoDenise C. ConnollyDwayne G. StupackDavid D. Schlaepfer

molecular biologycancer biologyovarian cancercancer research

Author Correction: Genotype Tunes Pancreatic Ductal Adenocarcinoma Tissue Tension to Induce Matricellular Fibrosis and Tumor Progression. Nature Medicine (2023)

Tgfbi Remodels Adipose Metabolism by Regulating the Notch-1 Signaling Pathway. Experimental & Molecular Medicine (2023)

Seul Gi LeeJongbeom ChaeSeon Min WooSeung Un SeoHa-Jeong KimSang-Yeob KimDavid D. SchlaepferIn-San KimHee-Sae ParkTaeg Kyu KwonJu-Ock Nam

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