Faculty

Institution

Unit

Venue

Douglas DeSimone

Ivy Pratt Distinguished Professor of Morphogenesis and Chair of Cell Biology

University of Virginia

Affiliations

School of Medicine

Department of Cell Biology

Douglas Desimone is currently serving as a Cell Biology Ivy Pratt Distinguished Professor of Morphogenesis and Chair of Cell Biology at University of Virginia.

Honors

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Experiences

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Education

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Douglas DeSimone

University of Virginia

Ivy Pratt Distinguished Professor of Morphogenesis and Chair of Cell Biology

You can click a keyword to filter the displayed items

developmental biology cell biology morphogenesis developmental cell cellular physiology molecular cell biology extracellular matrix matrix biology biology cell-matrix interactions cell adhesion cell migration embryonic development embryology cell motility cellular differentiation molecular and cellular biology developmental genetics cell signaling tissue (biology) mechanobiology cell biomechanics molecular biology developmental system molecular physiology cellular biochemistry cellular structure xenopus laevis genome biology theoretical biology mechanotransduction multicellular systems tissue development craniofacial research cell research intracellular trafficking ontogeny molecular regulation biological models developmental dynamic animal biotechnology zoology mammalian biology cell interactions cell physiology cellular neurobiology cell polarity cell fate determination signaling pathways integrin α5β1 xenopus laevis integrins collective cell migration xenopus embryos amphibian gastrulation protein science organ development bone morphogenic protein neural stem cells skeletal muscle gene function tissue morphogenesis active zones amphibian embryos marginal zone adhesive material gene characterization gene structure protein expression evolutionary developmental biology biological evolution transmembrane linkage vivo functions their fibrillogenesis cell adhesion receptors adhesive networks cx43 molecule

Notable Scholarly Works

Notable Federal Grants

Collaborators

Generative Diffusion Model Surrogates for Mechanistic Agent-Based Biological Models. Machine Learning Science and Technology (2025)

diffusion-based modelingbiological modelsmathematical biosciencetheoretical biologymathematical biologydiffusionbio-inspired computationquantitative biologybiomedical modelingsystems biologyapplied mathematics

Integrative Functional Genomics Identifies Arhgap10 in the 4Q31.2 Locus as a Novel Congenital Heart Disease and Ciliopathy Gene. bioRxiv (Cold Spring Harbor Laboratory) (2025)

cardiovascular researchgenetic disorderscell biologyfunctional genomicsgenome biologydisease gene identificationmolecular cell biologymolecular biologyciliopathy genehuman geneticsmedical geneticsgenetics

Spatial Regulation of Mitochondrial Membrane Potential by α5β1 Integrin Engagement in Collective Cell Migration. Journal of Cell Science (2025)

Gustavo G. PachecoBette J. DzambaWakako EndoBenjamin C. EdwardsMinah KhanTien ComlekogluDavid R. ShookKeri QuaseyMaureen A. BjerkeGlen D. HirshDavid F. KashatusDouglas W. DeSimone

collective cell migrationcell biologymembrane biologycellular biologymembranesmolecular biologymitochondrial functionmitochondrial membrane potentialspatial regulationcell migration

Surrogate Modeling of Cellular-Potts Agent-Based Models as a Segmentation Task Using the U-Net Neural Network Architecture. PLoS Computational Biology (2025)

Tien ComlekogluJ Quetzalcóatl Toledo-MarínTina ComlekogluDouglas W DeSimoneShayn M PeirceGeoffrey FoxJames A Glazier

cellular-potts agent-based modelssegmentation taskneural network (machine learning)biomedical modelingsystems biologysurrogate modelingmachine learning

Modeling the Roles of Cohesotaxis, Cell-Intercalation, and Tissue Geometry in Collective Cell Migration of Xenopus Mesendoderm. Biology Open (2024)

Tien ComlekogluBette J. DzambaGustavo G. PachecoDavid R. ShookT. J. SegoJames A. GlazierShayn M. PeirceDouglas W. DeSimone

collective cell migrationcell biologybiologytissue geometrycell motilitysystems biologytissue (biology)cell migration

General, Open-Source Vertex Modeling in Biological Applications Using Tissue Forge. Scientific Reports (2023)

T. J. SegoTien ComlekogluShayn M. PeirceDouglas W. DesimoneJames A. Glazier

biological engineeringcomputational biologyopen-source vertex modelingscientific computingtissue forgebiological applicationsbiomedical engineering

Characterization of Convergent Thickening, a Major Convergence Force Producing Morphogenic Movement in Amphibians. eLife (2022)

David R ShookJason WH WenAna RoloMichael O'HanlonBrian FrancicaDestiny DobbinsPaul SkoglundDouglas W DeSimoneRudolf WinklbauerRay E Keller

morphologyvertebrate paleontologyzoologyradial thickeninganatomymajor convergence forcemorphological evidencepattern formationdevelopmental biologybiologymarginal zonemorphology (biology)mechanobiologymorphogenesisbiomechanics

Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. Circulation Research (2021)

Hirofumi WatanabeBrian C. BelyeaRobert L. PaxtonMinghong LiBette J. DzambaDouglas W. DeSimoneR. Ariel GomezMaria Luisa S. Sequeira-Lopez

cell physiologycell signalingcell biologycellular physiologymechanotransductioncytoskeletonrenin cell baroreceptorsignal transduction

Extracellular Matrix (Ecm) and the Sculpting of Embryonic Tissues. Current topics in developmental biology/Current Topics in Developmental Biology (2018)

Bette J. DzambaDouglas W. DeSimone

matrix biologydevelopmental cellhuman tissuesdevelopmental biologymorphogenesisextracellular matrixtissue (biology)tissue engineering

Integrin and Ligand-Independent Pdgfr Signaling Synergistically Contribute to Directional Migration of Xenopus Mesendoderm. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Crystal M. RichardsonBette J. DzambaPooja R. SonavaneDouglas W. DeSimone

matrix biologycell-matrix interactionsdevelopmental cellcell signalingcell biologycellular physiologycell adhesiondevelopmental biologymolecular cell biologyligand-independent pdgfrsignal transductionextracellular matrixintegrin adhesioncell migrationpdgf receptor

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Douglas DeSimone

Ivy Pratt Distinguished Professor of Morphogenesis and Chair of Cell Biology

University of Virginia

Affiliations

School of Medicine

Department of Cell Biology

Douglas Desimone is currently serving as a Cell Biology Ivy Pratt Distinguished Professor of Morphogenesis and Chair of Cell Biology at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Douglas DeSimone

University of Virginia

Ivy Pratt Distinguished Professor of Morphogenesis and Chair of Cell Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Generative Diffusion Model Surrogates for Mechanistic Agent-Based Biological Models. Machine Learning Science and Technology (2025)

Integrative Functional Genomics Identifies Arhgap10 in the 4Q31.2 Locus as a Novel Congenital Heart Disease and Ciliopathy Gene. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Spatial Regulation of Mitochondrial Membrane Potential by α5β1 Integrin Engagement in Collective Cell Migration. Journal of Cell Science (2025)

Gustavo G. PachecoBette J. DzambaWakako EndoBenjamin C. EdwardsMinah KhanTien ComlekogluDavid R. ShookKeri QuaseyMaureen A. BjerkeGlen D. HirshDavid F. KashatusDouglas W. DeSimone

collective cell migrationcell biologymembrane biologycellular biologymembranesmolecular biologymitochondrial functionmitochondrial membrane potentialspatial regulationcell migration

Surrogate Modeling of Cellular-Potts Agent-Based Models as a Segmentation Task Using the U-Net Neural Network Architecture. PLoS Computational Biology (2025)

Tien ComlekogluJ Quetzalcóatl Toledo-MarínTina ComlekogluDouglas W DeSimoneShayn M PeirceGeoffrey FoxJames A Glazier

cellular-potts agent-based modelssegmentation taskneural network (machine learning)biomedical modelingsystems biologysurrogate modelingmachine learning

Modeling the Roles of Cohesotaxis, Cell-Intercalation, and Tissue Geometry in Collective Cell Migration of Xenopus Mesendoderm. Biology Open (2024)

Tien ComlekogluBette J. DzambaGustavo G. PachecoDavid R. ShookT. J. SegoJames A. GlazierShayn M. PeirceDouglas W. DeSimone

collective cell migrationcell biologybiologytissue geometrycell motilitysystems biologytissue (biology)cell migration

General, Open-Source Vertex Modeling in Biological Applications Using Tissue Forge. Scientific Reports (2023)

T. J. SegoTien ComlekogluShayn M. PeirceDouglas W. DesimoneJames A. Glazier

biological engineeringcomputational biologyopen-source vertex modelingscientific computingtissue forgebiological applicationsbiomedical engineering

Characterization of Convergent Thickening, a Major Convergence Force Producing Morphogenic Movement in Amphibians. eLife (2022)

David R ShookJason WH WenAna RoloMichael O'HanlonBrian FrancicaDestiny DobbinsPaul SkoglundDouglas W DeSimoneRudolf WinklbauerRay E Keller

Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis. Circulation Research (2021)

Hirofumi WatanabeBrian C. BelyeaRobert L. PaxtonMinghong LiBette J. DzambaDouglas W. DeSimoneR. Ariel GomezMaria Luisa S. Sequeira-Lopez

cell physiologycell signalingcell biologycellular physiologymechanotransductioncytoskeletonrenin cell baroreceptorsignal transduction

Extracellular Matrix (Ecm) and the Sculpting of Embryonic Tissues. Current topics in developmental biology/Current Topics in Developmental Biology (2018)

Bette J. DzambaDouglas W. DeSimone

matrix biologydevelopmental cellhuman tissuesdevelopmental biologymorphogenesisextracellular matrixtissue (biology)tissue engineering

Integrin and Ligand-Independent Pdgfr Signaling Synergistically Contribute to Directional Migration of Xenopus Mesendoderm. bioRxiv (Cold Spring Harbor Laboratory) (2018)

Crystal M. RichardsonBette J. DzambaPooja R. SonavaneDouglas W. DeSimone

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