Faculty

Institution

Unit

Venue

Brian N. Dominy

Associate Professor Associate Dean

Clemson University

Affiliations

College of Science

Chemistry

Brian N. Dominy is currently serving as a Chemistry Associate Professor Associate Dean at Clemson University.

Honors

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Experiences

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Education

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Brian N. Dominy

Clemson University

Associate Professor Associate Dean

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molecular biology protein science structural biology biophysics pharmacology biochemistry enzymes computational chemistry microbial pathogenesis structural molecular biology biological chemistry molecular genetics epigenetics drug resistance applied microbiology biological inorganic chemistry uracil dna glycosylase enolase inhibitors dna repair biochemical sciences enzyme inhibition clinical microbiology protein modeling molecular catalysis enzyme catalysis protein chemistry biocatalysis molecular microbiology redox biology nucleic acids hospital infections infection control medicinal research chemical sciences coordination chemistry biomedical analysis virus research molecular docking enzyme specificity molecular substrates computational biophysics pharmaceutical technology pharmaceutical biotechnology molecular recognition biochemical genetics nucleic acid amplification dna analysis gene evolution novel therapies anti-inflammatory pathogen detection fungal pathogens emerging infectious diseases tumor targeting metal toxicity metalloproteins mathematical chemistry protein evolution virus-host interactions protein function molecular virology viral evolution protein stability ionic strength thermophilic proteins electrostatic basis flexible docking search strategies physics-based potentials native-like protein structures structural mining self-consistent design deamination repair enzymes uracil-dna glycosylase conformational transitions peptide interactions computational biology rational drug design molecular mechanics theoretical biology molecular design

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cycloaddition of Phenyltriazolinedione With Carbazole-Alkynes and Yne-Carbamates to Access Diazacyclobutenes. The Journal of Organic Chemistry (2024)

Brock A. MillerChandima J. NarangodaSamuel KwainWilliam T. BridgesMonireh NooriErin E. SolomonAlexis A. BraggAlex T. SungYusuke IwaiLauren UlisseWilliam H. SchmidtColin D. McMillenBrian N. DominyDaniel C. Whitehead

organic chemistryorganic synthesis

Enolase Inhibitors as Therapeutic Leads for Naegleria Fowleri Infection. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Jillian E MilanesVictoria C YanCong-Dat PhamFlorian L MullerSamuel KwainKerrick C ReesBrian N DominyDaniel C WhiteheadSteven W MillwardMadison BolejackJan AbendrothIsabelle Q PhanBart StakerE Ashley MosemanXiang ZhangXipeng MaAudriy JebetXinmin YinJames Morris

clinical microbiologyinfectious diseasesenolase inhibitorspathogenic bacteriapathogensavian medicinepharmacologymedicinetherapeutic leadsmicrobial pathogenesis

Enolase Inhibitors as Therapeutic Leads for Naegleria Fowleri Infection. PLoS Pathogens (2024)

Jillian E. MilanesVictoria C. YanCong-Dat PhamFlorian MullerSamuel KwainKerrick C. ReesBrian N. DominyDaniel C. WhiteheadSteven W. MillwardMadison BolejackRoger ShekLogan TilleryIsabelle Q. PhanBart StakerE. Ashley MosemanXiang ZhangXipeng MaAudriy JebetXinmin YinJames C. Morris

pathologyanti-inflammatorynaegleria fowleri infectionclinical microbiologyinfectious diseasesnovel therapieshospital infectionspathogensemerging infectious diseasestherapeutic leadsinfection controlpathogen detectionenolase inhibitorspathogenic bacteriamedicinal researchmicrobiologydrug resistancemicrobial pathogenesisfungal pathogensantimicrobial resistanceenzyme inhibition

A Cathepsin C-Like Protease Mediates the Post-Translation Modification of Toxoplasma Gondii Secretory Proteins for Optimal Invasion and Egress. mBio (2023)

L. Brock ThorntonMelanie KeyChiara MicchelliAndrew J. StasicSamuel KwainKatherine FloydSilvia N.J. MorenoBrian N. DominyDaniel C. WhiteheadZhicheng Dou

immunologypost-translation modificationmicrobiologybiological invasionscathepsin c-like proteasepharmacologyoptimal invasionmicrobial pathogenesis

A Cathepsin C-Like Protease Post-Translationally Modifies Toxoplasma Gondii Secretory Proteins for Optimal Invasion and Egress. bioRxiv (Cold Spring Harbor Laboratory) (2023)

L. Brock ThorntonMelanie KeyChiara MicchelliAndrew J. StasicSamuel KwainKatherine FloydSilvia N. J. MorenoBrian N. DominyDaniel C. WhiteheadZhicheng Dou

immunologymicrobiologybiological invasionscathepsin c-like proteasemolecular biologyoptimal invasionmicrobial pathogenesis

Enolase Inhibitors as Early Lead Therapeutics Against Trypanosoma Brucei. Pathogens (2023)

Colm P. RosterDanielle LaVigneJillian E. MilanesEmily KnightHeidi D. AndersonSabrina PizarroElijah M. HardingMeredith T. MorrisVictoria C. YanCong-Dat PhamFlorian MullerSamuel KwainKerrick C. ReesBrian DominyDaniel C. WhiteheadMd Nasir UddinSteven W. MillwardJames C. Morris

trypanosoma bruceiepidemiologyinfectious diseasesenolase inhibitorspathogensearly lead therapeuticspharmacology

Exploring the Interactive Mechanism of Acarbose With the Amylase Susg in the Starch Utilization System of the Human Gut Symbiont Bacteroides Thetaiotaomicron Through Molecular Modeling. Chemical Biology & Drug Design (2023)

Samuel KwainBrian N. DominyKristi J. WhiteheadBrock A. MillerDaniel C. Whitehead

biomolecular interactionsstarch utilization systemenzymescarbohydrate-protein interactionsgastroenterologyinteractive mechanismmolecular modelingmolecular biologycarbohydrate chemistrybiocatalysisbiochemistrybiological chemistryapplied microbiologyfood chemistryprotein chemistryprotein sciencenutritional biochemistrymolecular microbiologymembrane biologymolecular pharmacologybiomolecular engineering

Glucose Metabolism in the Pathogenic Free‐Living Amoebae: Tempting Targets for Treatment Development. Chemical Biology & Drug Design (2023)

Jillian E. MilanesSamuel KwainAllyson DrawdyLaura DodsonMatthew T. MonaghanChristopher A. RiceBrian N. DominyDaniel C. WhiteheadJames C. Morris

glucose metabolismtempting targetsmedicinal chemistrymicrobiologyrational drug designchemical biologypathogenic free-living amoebaepharmacologydrug discovery

Bo XiaYinling LiuJose GuevaraJing LiCeleste JilichYe YangLiangjiang WangBrian N. DominyWeiguo Cao

uracil dna glycosylaseenzymesprotein scienceenzyme catalysismolecular catalysiscatalysismolecular geneticsmolecular biologyevolutionary biologygene evolutionmolecular evolutionstructural molecular biologystructural biologygenetics

Effects From Metal Ion in Tumor Endothelial Marker 8 and Anthrax Protective Antigen: Biolayer Interferometry Experiment and Molecular Dynamics Simulation Study. Journal of Computational Chemistry (2017)

Zhe JiaChristine AckroydTingting HanVibhor AgrawalYinling LiuKenneth ChristensenBrian Dominy

mathematical chemistryproteomicsbiomedical analysisprotective antigenimmunologydermatologymetal ionpharmacologymetalloproteinsbiological inorganic chemistrychemical sciencesbiolayer interferometry experimenttumor biologybiomarkerscomputational chemistryapplied microbiologymetastasistumor targetingprotein sciencecoordination chemistrymetal toxicity

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Brian N. Dominy

Associate Professor Associate Dean

Clemson University

Affiliations

College of Science

Chemistry

Brian N. Dominy is currently serving as a Chemistry Associate Professor Associate Dean at Clemson University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Brian N. Dominy

Clemson University

Associate Professor Associate Dean

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cycloaddition of Phenyltriazolinedione With Carbazole-Alkynes and Yne-Carbamates to Access Diazacyclobutenes. The Journal of Organic Chemistry (2024)

organic chemistryorganic synthesis

Enolase Inhibitors as Therapeutic Leads for Naegleria Fowleri Infection. bioRxiv (Cold Spring Harbor Laboratory) (2024)

clinical microbiologyinfectious diseasesenolase inhibitorspathogenic bacteriapathogensavian medicinepharmacologymedicinetherapeutic leadsmicrobial pathogenesis

Enolase Inhibitors as Therapeutic Leads for Naegleria Fowleri Infection. PLoS Pathogens (2024)

A Cathepsin C-Like Protease Mediates the Post-Translation Modification of Toxoplasma Gondii Secretory Proteins for Optimal Invasion and Egress. mBio (2023)

L. Brock ThorntonMelanie KeyChiara MicchelliAndrew J. StasicSamuel KwainKatherine FloydSilvia N.J. MorenoBrian N. DominyDaniel C. WhiteheadZhicheng Dou

immunologypost-translation modificationmicrobiologybiological invasionscathepsin c-like proteasepharmacologyoptimal invasionmicrobial pathogenesis

A Cathepsin C-Like Protease Post-Translationally Modifies Toxoplasma Gondii Secretory Proteins for Optimal Invasion and Egress. bioRxiv (Cold Spring Harbor Laboratory) (2023)

L. Brock ThorntonMelanie KeyChiara MicchelliAndrew J. StasicSamuel KwainKatherine FloydSilvia N. J. MorenoBrian N. DominyDaniel C. WhiteheadZhicheng Dou

immunologymicrobiologybiological invasionscathepsin c-like proteasemolecular biologyoptimal invasionmicrobial pathogenesis

Enolase Inhibitors as Early Lead Therapeutics Against Trypanosoma Brucei. Pathogens (2023)

trypanosoma bruceiepidemiologyinfectious diseasesenolase inhibitorspathogensearly lead therapeuticspharmacology

Samuel KwainBrian N. DominyKristi J. WhiteheadBrock A. MillerDaniel C. Whitehead

Glucose Metabolism in the Pathogenic Free‐Living Amoebae: Tempting Targets for Treatment Development. Chemical Biology & Drug Design (2023)

Jillian E. MilanesSamuel KwainAllyson DrawdyLaura DodsonMatthew T. MonaghanChristopher A. RiceBrian N. DominyDaniel C. WhiteheadJames C. Morris

glucose metabolismtempting targetsmedicinal chemistrymicrobiologyrational drug designchemical biologypathogenic free-living amoebaepharmacologydrug discovery

Bo XiaYinling LiuJose GuevaraJing LiCeleste JilichYe YangLiangjiang WangBrian N. DominyWeiguo Cao

Zhe JiaChristine AckroydTingting HanVibhor AgrawalYinling LiuKenneth ChristensenBrian Dominy

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