Faculty

Institution

Unit

Venue

Dillon Cogan

Assistant Professor of Pharmacology and Pharmaceutical Sciences

University of Southern California

Affiliations

Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences

Department of Pharmacology and Pharmaceutical Sciences

Dillon Cogan is currently serving as an Alfred E. Mann School Of Pharmacy And Pharmaceutical Sciences Assistant Professor of Pharmacology and Pharmaceutical Sciences at University of Southern California.

Honors

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Experiences

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Education

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Dillon Cogan

University of Southern California

Assistant Professor of Pharmacology and Pharmaceutical Sciences

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enzymes biochemistry molecular biology biosynthesis biomolecular engineering biomolecules structural biology chemical biology biocatalysis natural product biosynthesis pharmacology protein science peptides biological chemistry enzyme inhibition peptide science structural molecular biology peptide synthesis protein biosynthesis medicinal chemistry biochemical sciences protein chemistry enzyme catalysis structure-function enzyme kinetics structural basis biochemical engineering drug discovery membrane biology antimicrobial agents protein synthesis molecular basis enzymatic modification peptide therapeutics peptide substrate antibody probes catalytic conformations structural insights organic chemistry frontier organic process research medicinal research molecular cancer cancer discovery pharmacotherapy clinical investigation catalytic synthesis molecular catalysis natural product synthesis antimicrobial chemotherapy antibiotic resistance antimicrobial compounds antimicrobial resistance genes anti-cancer agents drug targeting novel therapies clinical medicine molecular substrates key site structural composition intercellular communication gene regulation transcription regulation antibody engineering immunochemistry conformational studies bacteriology fadh2-dependent trp halogenase free trp nai-107 biosynthesis ge2270 biosynthesis final pyridine structure net dehydration reaction glutamate elimination phosphonate antibiotics phosphonic acid antibiotics proteasome inhibition competitive proteasome inhibitors biological engineering bioprospecting natural product research synthetic biology microbiology biotechnology biotechnology advance microbial cell factory signal transduction

Notable Scholarly Works

Notable Federal Grants

Collaborators

Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis. bioRxiv (Cold Spring Harbor Laboratory) (2025)

bacteriologyantimicrobial agentsenzymesnatural product biosynthesismolecular metabolismbiomoleculesbiomolecular structuremolecular microbiologysynthetic biologyprotein biosynthesisasynchronous chain elongationmolecular biologybiological chemistryantibioticsstructural molecular biologybiomolecular engineeringbiosynthesis

Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis. Nature Chemical Biology (2024)

Dillon P. CoganAlexander M. SoohooMuyuan ChenYan LiuKrystal L. BrodskyChaitan Khosla

biological engineeringkey sitestructural basisprotein sciencebiomolecular structurecell biologystructural compositionmolecular biophysicsbiotechnologymembrane biologymolecular basisassembly-line polyketide biosynthesisintercellular communicationintermodular communicationbiomolecular engineeringstructural molecular biologystructural biologybiosynthesis

Structure and Mechanisms of Assembly-Line Polyketide Synthases. Annual Review of Biochemistry (2024)

Alexander M. SoohooDillon P. CoganKrystal L. BrodskyChaitan Khosla

assembly-line polyketide synthasesenzymesbiochemical engineeringprotein scienceenzyme catalysisstructural biologybiochemistrymembrane biologybiochemical sciencesmolecular biologybiological chemistrystructure-function enzyme kineticsstructural molecular biologybiomolecular engineeringmolecular substrates

Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry (2023)

Katarina M. GuzmanDillon P. CoganKrystal L. BrodskyAlexander M. SoohooXiuyuan LiNatalia SevillanoIrimpan I. MathewsKhanh P. NguyenCharles S. CraikChaitan Khosla

enzymesimmunologyantibody probesbiochemistrypharmacologydrug discoveryimmunochemistry

In Vivo Visualization and Molecular Targeting of the Cardiac Conduction System. Journal of Clinical Investigation (2022)

William R. GoodyerBenjamin M. BeyersdorfLauren DuanNynke S. van den BergSruthi MantriFrancisco X. GaldosNazan PulucaJan W. BuikemaSoah LeeDarren SalmiElise R. RobinsonStephan RogallaDillon P. CoganChaitan KhoslaEben L. RosenthalSean M. Wu

cardiologymolecular targetingclinical medicinephysiologymedical imagingelectrophysiologyclinical investigationneurosciencebiomedical engineeringexperimental medicineclinical researchcardiac conduction systembiomedical imaging

Structure and Mechanism for Iterative Amide N -Methylation in the Biosynthesis of Channel-Forming Peptide Cytotoxins. Proceedings of the National Academy of Sciences (2022)

Dillon P. CoganAgneya BhushanReyvin ReyesLingyang ZhuJörn PielSatish K. Nair

methyl groupprotein chemistryprotein sciencepeptide therapeuticspeptide sciencemembrane proteinspeptide synthesisbiochemistrypeptidesbacterial helical peptidesmolecular biologypeptide substrateprotein structure

Structure and Mechanism of Iterative Amide N-Methylation in the Biosynthesis of Channel-Forming Peptide Cytotoxins. Proc Natl Acad Sci U S A (2022)

iterative amide n-methylationenzymespeptide engineeringbiomoleculespeptide therapeuticspeptide scienceprotein biosynthesispeptide synthesisbiochemistrypeptideschemical biologymolecular biologychannel-forming peptide cytotoxinsbiosynthesispeptide library

Mapping the Catalytic Conformations of an Assembly-Line Polyketide Synthase Module. Science (2021)

Dillon P. CoganKaiming ZhangXiuyuan LiShanshan LiGrigore D. PintilieSoung-Hun RohCharles S. CraikWah ChiuChaitan Khosla

biological engineeringcatalytic synthesisenzymesbiochemical engineeringprotein scienceenzyme catalysismolecular catalysisbiocatalysisstructural biologycatalysisprotein engineeringpharmacologybiochemical sciencescatalytic conformationsbiomolecular engineering

Mapping the Catalytic Conformations of an Assembly-Line Polyketide Synthase Module. Science (2021)

enzymesconformational studiesenzyme catalysisbiomolecular structurebiocatalysisbiochemistrymolecular biologystructure-function enzyme kineticsprotein structurecatalytic conformationsstructural molecular biologystructural biologybiosynthesis

Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society (2020)

Dillon P. CoganXiuyuan LiNatalia SevillanoIrimpan I. MathewsTsutomu MatsuiCharles S. CraikChaitan Khosla

enzymesprotein chemistryprotein scienceextended conformationantibody probesbiochemistryantibody engineeringmolecular biologypharmacologyprotein structurebiological chemistrystructural biology

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Dillon Cogan

Assistant Professor of Pharmacology and Pharmaceutical Sciences

University of Southern California

Affiliations

Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences

Department of Pharmacology and Pharmaceutical Sciences

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Dillon Cogan

University of Southern California

Assistant Professor of Pharmacology and Pharmaceutical Sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Molecular Basis for Asynchronous Chain Elongation During Rifamycin Antibiotic Biosynthesis. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis. Nature Chemical Biology (2024)

Dillon P. CoganAlexander M. SoohooMuyuan ChenYan LiuKrystal L. BrodskyChaitan Khosla

Structure and Mechanisms of Assembly-Line Polyketide Synthases. Annual Review of Biochemistry (2024)

Alexander M. SoohooDillon P. CoganKrystal L. BrodskyChaitan Khosla

Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase. Biochemistry (2023)

Katarina M. GuzmanDillon P. CoganKrystal L. BrodskyAlexander M. SoohooXiuyuan LiNatalia SevillanoIrimpan I. MathewsKhanh P. NguyenCharles S. CraikChaitan Khosla

enzymesimmunologyantibody probesbiochemistrypharmacologydrug discoveryimmunochemistry

In Vivo Visualization and Molecular Targeting of the Cardiac Conduction System. Journal of Clinical Investigation (2022)

Structure and Mechanism for Iterative Amide N -Methylation in the Biosynthesis of Channel-Forming Peptide Cytotoxins. Proceedings of the National Academy of Sciences (2022)

Dillon P. CoganAgneya BhushanReyvin ReyesLingyang ZhuJörn PielSatish K. Nair

Structure and Mechanism of Iterative Amide N-Methylation in the Biosynthesis of Channel-Forming Peptide Cytotoxins. Proc Natl Acad Sci U S A (2022)

Mapping the Catalytic Conformations of an Assembly-Line Polyketide Synthase Module. Science (2021)

Dillon P. CoganKaiming ZhangXiuyuan LiShanshan LiGrigore D. PintilieSoung-Hun RohCharles S. CraikWah ChiuChaitan Khosla

Mapping the Catalytic Conformations of an Assembly-Line Polyketide Synthase Module. Science (2021)

Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society (2020)

Dillon P. CoganXiuyuan LiNatalia SevillanoIrimpan I. MathewsTsutomu MatsuiCharles S. CraikChaitan Khosla

enzymesprotein chemistryprotein scienceextended conformationantibody probesbiochemistryantibody engineeringmolecular biologypharmacologyprotein structurebiological chemistrystructural biology

1
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3
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