Faculty

Institution

Unit

Venue

David Segal

Professor

University of California, Davis

Affiliations

School of Medicine

Biochemistry and Molecular Medicine

Pharmacology

David Segal is currently serving as a Biochemistry And Molecular Medicine Professor at University of California, Davis.

Honors

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Experiences

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Education

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David Segal

University of California, Davis

Professor

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molecular biology genetics biomolecular engineering biological engineering structural biology genomics protein science gene expression epigenetics genome biology genetic engineering nucleic acids bioinformatics molecular genetics protein engineering medicinal research crispr gene editing molecular cell biology gene regulation transcription regulation rna biology angelman syndrome molecular diagnostics dna analysis cancer biology structural molecular biology epigenomics zinc fingers mammalian biology gene function nucleic acid biomarkers medical genetics dna sequences biological chemistry biomedical analysis peptides molecular design protein chemistry cell regulation molecular regulation dna sequencing molecular neurobiology zinc finger nucleases zinc finger proteins plant science biomolecular structure clinical microbiology general virology virus research genetic technologies gene recognition cellular biology viral replication virus-host interactions viral genetics molecular virology biomolecular tools opioid overdose host specificity oocytes gene transfer inhibitory activity microbial genetics molecular imprinting zinc finger set-domain-containing proteins polydactyl zinc-finger proteins artificial transcription factors direct detection cpg dinucleotides modular assembly translational outcomes full gene deletion site-directed genome modification zinc finger nuclease genome editing molecular neurodegeneration neuroscience molecular psychiatry psychiatric genetics

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Crispr-Based Split Luciferase as a Biosensor for Unique Dna Sequences in Situ. Methods in molecular biology (2024)

Nicholas G. HeathDavid J. Segal

crisprcrispr-based split luciferasegenomicsbiosensorsmolecular biologyunique dna sequencesbioinformatics

Integration of Ctcf Loops, Methylome, and Transcriptome in Differentiating Luhmes as a Model for Imprinting Dynamics of the 15Q11-Q13 Locus in Human Neurons. Human Molecular Genetics (2024)

Orangel J Gutierrez FugónOsman SharifiNicholas HeathDaniela C SotoJ Antonio GomezDag H YasuiAron Judd P MendiolaHenriette O’GeenUlrika BeitnereMarketa TomkovaViktoria HaghaniGreg DillonDavid J SegalJanine M LaSalle

ctcf loopsneurogeneticshuman neuronssystems neurosciencemolecular imprintingcentral nervous systemneurosciencemolecular neurobiologyneurodynamicsneural mechanismsmolecular biologymolecular neurosciencetranscriptomegenetics

An Aso Therapy for Angelman Syndrome That Targets an Evolutionarily Conserved Region at the Start of the Ube3A-as Transcript. Science Translational Medicine (2023)

Scott V. DindotSarah ChristianWilliam J. MurphyAllyson BerentJennifer PanagouliasAnnalise SchlaferJohnathan BallardKamelia RadevaRuth RobinsonLuke MyersThomas JeppHillary ShaheenPaul HillmanKranti KongantiAndrew HillhouseKevin R. BredemeyerLauren BlackJulie DouvilleEdwin WeeberDavid SegalAnne AndersonKevin NashJill Silverman

translational researchtranslational medicinemolecular medicinemedicinal researchaso therapypharmacologymedicineclinical researchangelman syndromegenetics

Dr.Nod: Computational Framework for Discovery of Regulatory Non-Coding Drivers in Tissue-Matched Distal Regulatory Elements. Nucleic Acids Research (2023)

Marketa TomkovaJakub TomekJulie ChowJohn D McPhersonDavid J SegalFereydoun Hormozdiari

translational bioinformaticscomputational biologygenome analysisgenomicsfunctional genomicsmachine learninggenome biologyregulatory non-coding driversmolecular regulationmolecular biologycomputational frameworksystems biologycomputational genomicsgene regulatory networksbioinformaticsgenetics

Transcriptional Reprogramming Restores Ube3A Brain-Wide and Rescues Behavioral Phenotypes in an Angelman Syndrome Mouse Model. Molecular Therapy (2023)

Henriette O’GeenUlrika BeitnereMiranda S. GarciaAnna AdhikariDavid L. CameronTimothy A. FentonNycole A. CoppingPeter DengSamantha LockJulian A.N.M. HalmaiIsaac J. VillegasJiajian LiuDanhui WangKyle D. FinkJill L. SilvermanDavid J. Segal

behavioral phenotypesneuroscienceneurogeneticsgenetics

Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome. mSystems (2023)

Ulrika BeitnereBrayan Vilanova-CuevasSarah G. ChristianClint TaylorElizabeth L. BergNycole A. CoppingScott V. DindotJill L. SilvermanMélanie G. GareauDavid J. Segal

animal modelsunique featuresgut microbiomedevelopmental biologysystems biologyangelman syndromemicrobiome

Aberrant Promoter Methylation Contributes to Lrig1 Silencing in Basal/Triple-Negative Breast Cancer. British Journal of Cancer (2022)

Maxine Umeh-GarciaHenriette O’GeenCatalina SimionMelanie Hayden GephartDavid J. SegalColleen A. Sweeney

epigenetic changesbreast canceraberrant promoter methylationgeneticsepigeneticscancer researchmolecular biologycancer cellsgene expressiononcogenesmedicinal researchmolecular cancerbiochemistrycell regulationcancer carecancer biologycancer geneticscancer genomicsoncology

An in Vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-Clinical Animal Models. Frontiers in Molecular Neuroscience (2022)

Peter DengJulian A. N. M. HalmaiUlrika BeitnereDavid CameronMichele L. MartinezCharles C. LeeJennifer J. WaldoKrista ThongphanhAnna AdhikariNycole CoppingStela P. PetkovaRuth D. LeeSamantha LockMiranda PalomaresHenriette O’GeenJasmine CarterCasiana E. GonzalezFiona K. B. BuchananJohnathan D. AndersonFernando A. FierroJan A. NoltaAlice F. TarantalJill L. SilvermanDavid J. SegalKyle D. Fink

gene deliverystem cell researchmolecular neurobiologyneurosciencecell biologytranscription factorsmolecular neurosciencegene expressionbiological engineeringgene therapycell manipulationcellular neurobiologymedicinal researchcellular therapypre-clinical animal modelscell-based drug deliveryregenerative medicinecell transplantationmolecular cell biology

Chapter 41. Stem Cell and Gene Therapy. American Psychiatric Association Publishing eBooks (2022)

Kyle D. FinkJill L. SilvermanDavid J. Segal

gene therapypsychiatrystem cell researchstem-cell therapystem cellspsychiatric research

Determinants of Heritable Gene Silencing for Krab-Dcas9 + Dnmt3 and Ezh2-Dcas9 + Dnmt3 Hit-And-Run Epigenome Editing. Nucleic Acids Research (2022)

Henriette O’GeenMarketa TomkovaJacquelyn A CombsEmma K TilleyDavid J Segal

nucleic acidsepigeneticsepigenomicsmolecular biologygeneticsgenome biology

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David Segal

Professor

University of California, Davis

Affiliations

School of Medicine

Biochemistry and Molecular Medicine

Pharmacology

David Segal is currently serving as a Biochemistry And Molecular Medicine Professor at University of California, Davis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

David Segal

University of California, Davis

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Crispr-Based Split Luciferase as a Biosensor for Unique Dna Sequences in Situ. Methods in molecular biology (2024)

Nicholas G. HeathDavid J. Segal

crisprcrispr-based split luciferasegenomicsbiosensorsmolecular biologyunique dna sequencesbioinformatics

Integration of Ctcf Loops, Methylome, and Transcriptome in Differentiating Luhmes as a Model for Imprinting Dynamics of the 15Q11-Q13 Locus in Human Neurons. Human Molecular Genetics (2024)

An Aso Therapy for Angelman Syndrome That Targets an Evolutionarily Conserved Region at the Start of the Ube3A-as Transcript. Science Translational Medicine (2023)

translational researchtranslational medicinemolecular medicinemedicinal researchaso therapypharmacologymedicineclinical researchangelman syndromegenetics

Dr.Nod: Computational Framework for Discovery of Regulatory Non-Coding Drivers in Tissue-Matched Distal Regulatory Elements. Nucleic Acids Research (2023)

Marketa TomkovaJakub TomekJulie ChowJohn D McPhersonDavid J SegalFereydoun Hormozdiari

Transcriptional Reprogramming Restores Ube3A Brain-Wide and Rescues Behavioral Phenotypes in an Angelman Syndrome Mouse Model. Molecular Therapy (2023)

behavioral phenotypesneuroscienceneurogeneticsgenetics

Unique Features of the Gut Microbiome Characterized in Animal Models of Angelman Syndrome. mSystems (2023)

Ulrika BeitnereBrayan Vilanova-CuevasSarah G. ChristianClint TaylorElizabeth L. BergNycole A. CoppingScott V. DindotJill L. SilvermanMélanie G. GareauDavid J. Segal

animal modelsunique featuresgut microbiomedevelopmental biologysystems biologyangelman syndromemicrobiome

Aberrant Promoter Methylation Contributes to Lrig1 Silencing in Basal/Triple-Negative Breast Cancer. British Journal of Cancer (2022)

Maxine Umeh-GarciaHenriette O’GeenCatalina SimionMelanie Hayden GephartDavid J. SegalColleen A. Sweeney

An in Vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-Clinical Animal Models. Frontiers in Molecular Neuroscience (2022)

Chapter 41. Stem Cell and Gene Therapy. American Psychiatric Association Publishing eBooks (2022)

Kyle D. FinkJill L. SilvermanDavid J. Segal

gene therapypsychiatrystem cell researchstem-cell therapystem cellspsychiatric research

Determinants of Heritable Gene Silencing for Krab-Dcas9 + Dnmt3 and Ezh2-Dcas9 + Dnmt3 Hit-And-Run Epigenome Editing. Nucleic Acids Research (2022)

Henriette O’GeenMarketa TomkovaJacquelyn A CombsEmma K TilleyDavid J Segal

nucleic acidsepigeneticsepigenomicsmolecular biologygeneticsgenome biology

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