Faculty

Institution

Unit

Venue

Daniel Zegarra Ruiz

Assistant Professor

University of Virginia

Affiliations

School of Medicine

Department of Microbiology, Immunology, and Cancer Biology

Daniel Zegarra Ruiz is currently serving as a Microbiology, Immunology, And Cancer Biology Assistant Professor at University of Virginia.

Honors

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Experiences

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Education

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Daniel Zegarra Ruiz

University of Virginia

Assistant Professor

You can click a keyword to filter the displayed items

immunology immune responses gut microbes mucosal immunology microbiome digestive diseases dysbiosis autoimmunity inflammation autoimmune diseases gut barrier infectious diseases inflammatory bowel disease microbiology clinical microbiology molecular gastroenterology allergy microbial pathogenesis host-microbe interactions cell death gut microbiota systemic lupus erythematosus communicable diseases immunologic diseases lupus nephritis developmental immunology ulcerative colitis inflammatory diseases t-regulatory cell cellular immune responses il-1β secretion rheumatology rheumatism clinical rheumatology reproductive immunology infection control cell research experimental medicine cell transplantation dermatological treatment cellular therapy autoantibody production gut-organ axis dietary health phagocytes cytokines dietary fibre chronic inflammation adaptive immune system innate immune system immunopathology colorectal cancer immune dysregulation vancomycin treatment commensal microbiota b cells commensal orthologs human autoantigen ro60 gut-microbiota-specific t cells microbiota manipulation colitis-associated colorectal cancer microbiota composition intestinal microbes multiple factors specific diseases lupus pathobionts

Notable Scholarly Works

Notable Federal Grants

Collaborators

Development of Microbiota-Specific T Cells During Systemic Autoimmunity 3776. The Journal of Immunology (2025)

immunologygut microbesautoimmune diseasescellular immune responsescell researchadaptive immune systemmicrobiota-specific t cellsimmune responsest-regulatory cellautoimmunityimmunity (medicine)

Dietary Lipids Induce Ppard and Bcl6 to Repress Macrophage Il-23 Induction After Intestinal Injury and Lps Exposure. Scientific Reports (2025)

Ashleigh M GilDaniel F Zegarra-RuizWan-Jung WuKendra NorwoodAdrien AssieBuck S SamuelAngela M MajorGretchen E DiehlAndrea A Hill McAlester

immunologydigestive diseasescell deathpharmacologylps exposurelipidscytokinesdietary lipidsimmune responsesmacrophage il-23 inductioninflammatory diseasesphagocytesinflammation

Dysregulated Intestinal Host–Microbe Interactions in Systemic Lupus Erythematosus: Insights From Patients and Mouse Models. Microorganisms (2025)

Miki KumeJin DinDaniel F. Zegarra-Ruiz

immunologymicrobiomegut microbesdigestive diseaseslupus pathobiontsautoimmune diseasesclinical microbiologymucosal immunologyallergyfecal microbiota transplantationimmune responsesdysbiosissystemic lupus erythematosusautoimmunitygut barrierhost-microbe interactionsinflammation

E. Coli-Activated Cellular Circuit Restrains Intestinal Inflammatory Microbiota-Specific T Cells and Protects Against Colitis. Cell Reports (2025)

immunologymicrobiomegut microbesdigestive diseasesmicrobial pathogenesisinflammatory bowel diseaseinfection controlmucosal immunologypathogenic bacteriaulcerative colitisimmune responsesdysbiosisinfectious diseasesmicrobiologyinflammation

Microbiota Regulation of Thymic Microbiota-Specific T Cell Development. The Journal of Immunology (2023)

Daniel Fernando Zegarra RuizAmanda ChenMonica AcostaDasom V. KimRyann C. CallaghanFatima B. Saldana-MoralesDean MatthewsNikketa StanfordRandy S. LongmanMatthew L. BettiniGretchen E. Diehl

immunologymicrobiota regulationimmune responses

Acute High-Fat Diet Impairs Macrophage-Supported Intestinal Damage Resolution. JCI Insight (2022)

Andrea A. HillMyunghoo KimDaniel F. Zegarra-RuizLin-Chun ChangKendra NorwoodAdrien AssiéWan-Jung H. WuMichael C. RenfroeHyo Wong SongAngela M. MajorBuck S. SamuelJoseph M. HyserRandy S. LongmanGretchen E. Diehl

health sciencesdietary health

Interleukin-1β Secretion Induced by Mucosa-Associated Gut Commensal Bacteria Promotes Intestinal Barrier Repair. Gut Microbes (2022)

Wan-Jung H. WuMyunghoo KimLin-Chun ChangAdrien AssieFatima B. Saldana-MoralesDaniel F. Zegarra-RuizKendra NorwoodBuck S. SamuelGretchen E. Diehl

immunologymicrobiomegut microbesdigestive diseasesil-1β secretioninflammatory bowel diseasemucosal immunologymolecular gastroenterologygut microbiotaimmune responsesdysbiosisinfectious diseasesgut barriermicrobiota compositioninflammation

Microbiota Manipulation to Increase Macrophage Il-10 Improves Colitis and Limits Colitis-Associated Colorectal Cancer. Gut Microbes (2022)

Daniel F. Zegarra RuizDasom V. KimKendra NorwoodFatima B. Saldana-MoralesMyunghoo KimCharles NgRyann CallaghanMaisha UddinLin-Chun ChangRandy S. LongmanGretchen E. Diehl

microbiomegut microbescolitis-associated colorectal cancermicrobiota manipulationmicrobiologyinflammatory bowel disease

Microbiota Regulation of Development of Thymic Microbiota-Specific T Cells. The Journal of Immunology (2022)

Daniel Fernando Zegarra RuizDasom V. KimFatima B. Saldana-MoralesAmanda ChenWan-Jung WuRandy S. LongmanMatthew L. BettiniGretchen E. Diehl

immunologymicrobiota regulationimmune responses

Microbiota Regulation of Intestinal Inflammation Influences Colorectal Cancer. The Journal of Immunology (2022)

Daniel Fernando Zegarra RuizDasom V. KimFatima B. Saldana-MoralesCharles NgRyann CallaghanMaisha UddinLin-Chun ChangRandy S. LongmanGretchen E. Diehl

immunologymicrobiota regulationcolorectal cancerinflammation

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Daniel Zegarra Ruiz

Assistant Professor

University of Virginia

Affiliations

School of Medicine

Department of Microbiology, Immunology, and Cancer Biology

Daniel Zegarra Ruiz is currently serving as a Microbiology, Immunology, And Cancer Biology Assistant Professor at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Daniel Zegarra Ruiz

University of Virginia

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Development of Microbiota-Specific T Cells During Systemic Autoimmunity 3776. The Journal of Immunology (2025)

immunologygut microbesautoimmune diseasescellular immune responsescell researchadaptive immune systemmicrobiota-specific t cellsimmune responsest-regulatory cellautoimmunityimmunity (medicine)

Dietary Lipids Induce Ppard and Bcl6 to Repress Macrophage Il-23 Induction After Intestinal Injury and Lps Exposure. Scientific Reports (2025)

Ashleigh M GilDaniel F Zegarra-RuizWan-Jung WuKendra NorwoodAdrien AssieBuck S SamuelAngela M MajorGretchen E DiehlAndrea A Hill McAlester

immunologydigestive diseasescell deathpharmacologylps exposurelipidscytokinesdietary lipidsimmune responsesmacrophage il-23 inductioninflammatory diseasesphagocytesinflammation

Dysregulated Intestinal Host–Microbe Interactions in Systemic Lupus Erythematosus: Insights From Patients and Mouse Models. Microorganisms (2025)

Miki KumeJin DinDaniel F. Zegarra-Ruiz

E. Coli-Activated Cellular Circuit Restrains Intestinal Inflammatory Microbiota-Specific T Cells and Protects Against Colitis. Cell Reports (2025)

Microbiota Regulation of Thymic Microbiota-Specific T Cell Development. The Journal of Immunology (2023)

Daniel Fernando Zegarra RuizAmanda ChenMonica AcostaDasom V. KimRyann C. CallaghanFatima B. Saldana-MoralesDean MatthewsNikketa StanfordRandy S. LongmanMatthew L. BettiniGretchen E. Diehl

immunologymicrobiota regulationimmune responses

Acute High-Fat Diet Impairs Macrophage-Supported Intestinal Damage Resolution. JCI Insight (2022)

health sciencesdietary health

Interleukin-1β Secretion Induced by Mucosa-Associated Gut Commensal Bacteria Promotes Intestinal Barrier Repair. Gut Microbes (2022)

Wan-Jung H. WuMyunghoo KimLin-Chun ChangAdrien AssieFatima B. Saldana-MoralesDaniel F. Zegarra-RuizKendra NorwoodBuck S. SamuelGretchen E. Diehl

Microbiota Manipulation to Increase Macrophage Il-10 Improves Colitis and Limits Colitis-Associated Colorectal Cancer. Gut Microbes (2022)

Daniel F. Zegarra RuizDasom V. KimKendra NorwoodFatima B. Saldana-MoralesMyunghoo KimCharles NgRyann CallaghanMaisha UddinLin-Chun ChangRandy S. LongmanGretchen E. Diehl

microbiomegut microbescolitis-associated colorectal cancermicrobiota manipulationmicrobiologyinflammatory bowel disease

Microbiota Regulation of Development of Thymic Microbiota-Specific T Cells. The Journal of Immunology (2022)

Daniel Fernando Zegarra RuizDasom V. KimFatima B. Saldana-MoralesAmanda ChenWan-Jung WuRandy S. LongmanMatthew L. BettiniGretchen E. Diehl

immunologymicrobiota regulationimmune responses

Microbiota Regulation of Intestinal Inflammation Influences Colorectal Cancer. The Journal of Immunology (2022)

Daniel Fernando Zegarra RuizDasom V. KimFatima B. Saldana-MoralesCharles NgRyann CallaghanMaisha UddinLin-Chun ChangRandy S. LongmanGretchen E. Diehl

immunologymicrobiota regulationcolorectal cancerinflammation

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