Faculty

Institution

Unit

Venue

Daniel Engel

Professor

University of Virginia

Affiliations

School of Medicine

Department of Microbiology, Immunology, and Cancer Biology

Daniel Engel is currently serving as a Microbiology, Immunology, And Cancer Biology Professor at University of Virginia.

Honors

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Experiences

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Education

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Daniel Engel

University of Virginia

Professor

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virus research molecular biology virology cell biology molecular cell biology general virology gene expression transcription (biology) medical virology transcription factors viral genetics infectious diseases molecular and cellular biology viral replication viral structural protein antiviral research gene regulation molecular virology genetics influenza transcription regulation virus structure signal transduction nucleic acids molecular regulation gene function pathogenesis cellular biochemistry biological chemistry virus gene structural molecular biology antiviral drug development antiviral drugs gene activators cancer cells oncogenes genome biology protein expression molecular cancer cell regulation viral diagnostics crystal structures cyclic amp metals interface science antiviral responses antiviral compounds influenza vaccine genomic mechanisms binding site protein vii new jersey 08544 host interferon escherichia coli medicinal research protein genetics cell culture virus-host interactions rna processing biochemical genetics cellular enzymology nucleic acid amplification test nucleic acid amplification viral pathogenesis protein function cell cycle yeast transcription factor e2f glucocorticoid receptor brg1 protein ga box friedman stark sequence transcriptional repression cell lines adenovirus infection early region 4 microbiology sars-cov-2 drug discovery

Notable Scholarly Works

Notable Federal Grants

Collaborators

Co-Option of Mitochondrial Nucleic Acid–Sensing Pathways by Hsv-1 Ul12.5 for Reactivation From Latent Infection. Proceedings of the National Academy of Sciences (2025)

Patryk A. KrakowiakMatthew E. FloresSean R. CuddyAbigail L. WhitfordSara A. DochnalAleksandra BabnisTsuyoshi MiyakeMarco TiganoDaniel A. EngelAnna R. Cliffe

virus researchlatent infectionmolecular virologyviral geneticsvirologymolecular biologyinfectious diseasesmicrobiology

Cu and Cu‐30Ni Alloy as Anti‐Viral Materials for High‐Touch Surfaces: Efficacy in a Simulated Public Environment With Frequent Cleaning Practices. Advanced Materials Interfaces (2025)

materials sciencesurface treatmentscu‐30ni alloyinterface sciencesurface sciencechemical engineeringsurface engineeringinterface (matter)frequent cleaning practicesadvanced materialssimulated public environmentmetals

Host Pik3C3 Promotes Shigella Flexneri Spread From Cell to Cell Through Vacuole Formation. PLoS Pathogens (2025)

Steven J RollandZachary J LifschinErin A WeddleLauren K YumTsuyoshi MiyakeDaniel A EngelHervé F Agaisse

microbial pathogenesiscell motilitycell signalingshigella flexnerivacuole formationmolecular biologycellular differentiationmicrobiologycell biology

Interrogating the Effect of Assay Media on the Rate of Virus Inactivation of High‐Touch Copper Surfaces: A Materials Science Approach. Advanced Materials Interfaces (2022)

Carol F. GloverTsuyoshi MiyakeVictor WallemacqJamie D. HarrisJohn EmeryDaniel A. EngelStephen J. McDonnellJohn R. Scully

virus researchmaterials scienceantiviral researchinterface sciencesurface sciencemedical virologycopper surfacesgeneral virologydiagnostic virologyassay mediavirus inactivationvirologyinfectious diseasesvirus transmissionmetalsviral diagnostics

Ebola Virus Inclusion Body Formation and Rna Synthesis Are Controlled by a Novel Domain of Nucleoprotein Interacting With Vp35. Journal of Virology (2020)

Tsuyoshi MiyakeCharlotte M. FarleyBenjamin E. NeubauerThomas P. BeddowThomas HoenenDaniel A. Engel

virus researchpathogenesisvirus structureviral rna contentgeneral virologyprotein structuremolecular virologyvirologymolecular biologystructural molecular biologyinfectious diseasesstructural biologyviral replicationviral structural proteincrystal structuresvirus life cycle

Identification, Design and Synthesis of Novel Pyrazolopyridine Influenza Virus Nonstructural Protein 1 Antagonists. Bioorganic & Medicinal Chemistry Letters (2019)

Samarjit PatnaikDipanwita BasuNoel SouthallSeameen DehdashtiKanny K. WanWei ZhengMarc FerrerMercedes TaylorDaniel A. EngelJuan Jose Marugan

virus researchantiviral researchpharmacologyantiviral compoundsmedical virologyantiviral drugstherapeutic targetsbiomolecular engineeringvirologydrug discoveryinfluenzaviral structural proteinantiviral drug development

The Structure of the C-Terminal Domain of the Nucleoprotein From the Bundibugyo Strain of the Ebola Virus in Complex With a Pan-Specific Synthetic Fab. Acta Crystallographica Section D Structural Biology (2018)

Malwina J. RadwańskaMateusz JaskółowskiElena DavydovaUrszula DerewendaTsuyoshi MiyakeDaniel A. EngelAnthony A. KossiakoffZygmunt S. Derewenda

virus researchmicrobiologygeneral virologyphage biologyvirologyantibody engineeringescherichia colisandwich elisainfectious diseasesviral structural proteinsynthetic biologyphage-display technology

Crystal Structures of the Methyltransferase and Helicase From the Zika 1947 Mr766 Uganda Strain. Acta Crystallographica Section D Structural Biology (2017)

Malgorzata BukrejewskaUrszula DerewendaMalwina RadwanskaDaniel A. EngelZygmunt S. Derewenda

rna structure predictionzika 1947rna biologyprotein structurebiomolecular structureenzymesmolecular biologystructural molecular biologystructural bioinformaticsprotein x-ray crystallographymr766 uganda strainstructural biologyprotein sciencecrystal structuresbiochemistrynucleic acids

Molecular Architecture of the Nucleoprotein C-Terminal Domain From the Ebola and Marburg Viruses. Acta Crystallographica Section D Structural Biology (2015)

Laura E. BakerJeffrey F. EllenaKatarzyna B. HandingUrszula DerewendaDarkhan UtepbergenovDaniel A. EngelZygmunt S. Derewenda

virus researchvirus structuremedical virologygeneral virologyprotein structurenucleoprotein c-terminal domainviral geneticsmarburg virusesvirologymolecular biologystructural molecular biologyinfectious diseasesstructural biologyviral replicationviral structural proteinviral rna

The Crystal Structure of the C-Terminal Domain of the Ebola Virus Nucleoprotein. Acta Crystallographica Section A Foundations and Advances (2014)

Zygmunt DerewendaPaulina DziubanskaUrszula DerewendaJeffrey EllenaKrystal HaleyDaniel Engel

virus researchvirus structuremedical virologygeneral virologyprotein structurebiomolecular structurevirologymarburg npmolecular biologystructural molecular biologymarburg virusinfectious diseasesstructural biologyviral structural proteincrystal structures

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Daniel Engel

Professor

University of Virginia

Affiliations

School of Medicine

Department of Microbiology, Immunology, and Cancer Biology

Daniel Engel is currently serving as a Microbiology, Immunology, And Cancer Biology Professor at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Daniel Engel

University of Virginia

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Co-Option of Mitochondrial Nucleic Acid–Sensing Pathways by Hsv-1 Ul12.5 for Reactivation From Latent Infection. Proceedings of the National Academy of Sciences (2025)

Patryk A. KrakowiakMatthew E. FloresSean R. CuddyAbigail L. WhitfordSara A. DochnalAleksandra BabnisTsuyoshi MiyakeMarco TiganoDaniel A. EngelAnna R. Cliffe

virus researchlatent infectionmolecular virologyviral geneticsvirologymolecular biologyinfectious diseasesmicrobiology

Cu and Cu‐30Ni Alloy as Anti‐Viral Materials for High‐Touch Surfaces: Efficacy in a Simulated Public Environment With Frequent Cleaning Practices. Advanced Materials Interfaces (2025)

Host Pik3C3 Promotes Shigella Flexneri Spread From Cell to Cell Through Vacuole Formation. PLoS Pathogens (2025)

Steven J RollandZachary J LifschinErin A WeddleLauren K YumTsuyoshi MiyakeDaniel A EngelHervé F Agaisse

microbial pathogenesiscell motilitycell signalingshigella flexnerivacuole formationmolecular biologycellular differentiationmicrobiologycell biology

Interrogating the Effect of Assay Media on the Rate of Virus Inactivation of High‐Touch Copper Surfaces: A Materials Science Approach. Advanced Materials Interfaces (2022)

Carol F. GloverTsuyoshi MiyakeVictor WallemacqJamie D. HarrisJohn EmeryDaniel A. EngelStephen J. McDonnellJohn R. Scully

Ebola Virus Inclusion Body Formation and Rna Synthesis Are Controlled by a Novel Domain of Nucleoprotein Interacting With Vp35. Journal of Virology (2020)

Tsuyoshi MiyakeCharlotte M. FarleyBenjamin E. NeubauerThomas P. BeddowThomas HoenenDaniel A. Engel

Identification, Design and Synthesis of Novel Pyrazolopyridine Influenza Virus Nonstructural Protein 1 Antagonists. Bioorganic & Medicinal Chemistry Letters (2019)

Samarjit PatnaikDipanwita BasuNoel SouthallSeameen DehdashtiKanny K. WanWei ZhengMarc FerrerMercedes TaylorDaniel A. EngelJuan Jose Marugan

Malwina J. RadwańskaMateusz JaskółowskiElena DavydovaUrszula DerewendaTsuyoshi MiyakeDaniel A. EngelAnthony A. KossiakoffZygmunt S. Derewenda

virus researchmicrobiologygeneral virologyphage biologyvirologyantibody engineeringescherichia colisandwich elisainfectious diseasesviral structural proteinsynthetic biologyphage-display technology

Crystal Structures of the Methyltransferase and Helicase From the Zika 1947 Mr766 Uganda Strain. Acta Crystallographica Section D Structural Biology (2017)

Malgorzata BukrejewskaUrszula DerewendaMalwina RadwanskaDaniel A. EngelZygmunt S. Derewenda

Molecular Architecture of the Nucleoprotein C-Terminal Domain From the Ebola and Marburg Viruses. Acta Crystallographica Section D Structural Biology (2015)

Laura E. BakerJeffrey F. EllenaKatarzyna B. HandingUrszula DerewendaDarkhan UtepbergenovDaniel A. EngelZygmunt S. Derewenda

The Crystal Structure of the C-Terminal Domain of the Ebola Virus Nucleoprotein. Acta Crystallographica Section A Foundations and Advances (2014)

Zygmunt DerewendaPaulina DziubanskaUrszula DerewendaJeffrey EllenaKrystal HaleyDaniel Engel

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