Faculty

Institution

Unit

Venue

Robert H. Silverman

Professor

Case Western Reserve University

Affiliations

School of Medicine

Biochemistry

Molecular Biology and Microbiology

Robert H. Silverman is currently serving as a Biochemistry Professor at Case Western Reserve University.

Honors

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Experiences

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Education

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Robert H. Silverman

Case Western Reserve University

Professor

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immunology virology genetics rna biology molecular biology pharmacology virus-host interactions gene expression virus research enzymes viral genetics molecular virology general virology protein science cytokines cell signaling prostate cancer medicinal research oncology enzyme inhibition cancer research tumor biology viral replication mammalian biology medical virology cancer biology nucleic acids viral pathogenesis viral evolution cancer treatment biological chemistry virus transmission cell regulation cancer care arbovirus oligonucleotides oncogenes infection control apoptosis protein expression gene regulation protein synthesis redox biology molecular cancer cell death clinical microbiology antisense therapy cancer genetics tumor targeting cancer genomics transcription regulation viral oncology innate immune system antiviral therapy antiviral innate immunity gene vector anti-cancer agents molecular regulation double-stranded rna clinical medicine molecular immunology viral structural protein intact cells rna-dependent protein kinase adenoviral vector interferon antiviral response virus replication interferon action infectious retrovirus encephalomyocarditis virus telomerase rna mouse model viral infections rrna cleavage chronic fatigue syndrome na-dependent rnase antiviral activities cell biology antiviral research immunity (medicine)

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ascc1 Structures and Bioinformatics Reveal a Novel Helix-Clasp-Helix Rna-Binding Motif Linked to a Two-Histidine Phosphodiesterase. Journal of Biological Chemistry (2024)

Naga babu ChinnamRoopa ThaparAndrew S. ArvaiAltaf H. SarkerJennifer M. SollTanmoy PaulAleem SyedDaniel J. RosenbergMichal HammelAlbino BacollaPanagiotis KatsonisAbhishek AsthanaMiaw-Sheue TsaiIvaylo IvanovOlivier LichtargeRobert H. SilvermanNima MosammaparastSusan E. TsutakawaJohn A. Tainer

geneticsbioinformaticsrna biologystructural biologyprotein structuretwo-histidine phosphodiesterasebiochemistrymolecular biologystructural molecular biologysequence motifenzymesprotein sciencestructural bioinformatics

Initiation of a Zakα-Dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease Rnase L. Cell Reports (2024)

Jiajia XiGoda SnieckuteJosé Francisco MartínezFrederic Schrøder Wenzel ArendrupAbhishek AsthanaChristina GaughanAnders H. LundSimon Bekker-JensenRobert H. Silverman

cell biologymolecular biologyimmunologyrna biology

Rna Helicase Skiv2L Limits Antiviral Defense and Autoinflammation Elicited by the Oas-Rnase L Pathway. The EMBO Journal (2024)

Kun YangBeihua DongAbhishek AsthanaRobert H SilvermanNan Yan

molecular biology

Sars-Cov-2 Nsp15 Endoribonuclease Antagonizes Dsrna-Induced Antiviral Signaling. Proceedings of the National Academy of Sciences (2024)

Clayton J. OtterNicole BracciNicholas A. ParentiChengjin YeAbhishek AsthanaEbba K. BlomqvistLi Hui TanJessica J. PfannenstielNathaniel JacksonAnthony R. FehrRobert H. SilvermanJames M. BurkeNoam A. CohenLuis Martinez-SobridoSusan R. Weiss

geneticssars-cov-2virologymolecular biologyarbovirusimmunologymolecular virologydsrna-induced antiviral signaling

Analogs of the Catechol Derivative Dynasore Inhibit Hiv-1 Ribonuclease H, Sars-Cov-2 Nsp14 Exoribonuclease, and Virus Replication. Viruses (2023)

Abhishek AsthanaAngela CoronaWoo-Jin ShinMi-Jeong KwakChristina GaughanEnzo TramontanoJae U. JungRainer SchobertBabal Kant JhaRobert H. SilvermanBernhard Biersack

geneticsmedicinesars-cov-2virologyinfectious diseasesviral replicationviral geneticsvirus replicationhiv

Inherited Deficiency of the Oas-Rnase L Pathway in Children With Mis-C. Clinical Immunology (2023)

Danyel LeeJérémie Le PenAhmad YatimBeihua DongYann AquinoMasato OgishiRobert SilvermanShen-Ying ZhangJean-Laurent Casanova

geneticshuman geneticshereditypediatricsimmunologyselenium deficiencyclinical immunologyinherited deficiency

Supplementary Tables From I Ifnl4 /I -ΔG Allele is Associated With an Interferon Signature in Tumors and Survival of African-American Men With Prostate Cancer. (2023)

Wei TangTiffany A. WallaceMing YiCristina Magi-GalluzziTiffany H. DorseyOlusegun O. OnabajoAdeola ObajemuSymone V. JordanChristopher A. LoffredoRobert M. StephensRobert H. SilvermanGeorge R. StarkEric A. KleinLudmila Prokunina-OlssonStefan Ambs

geneticsurologyneurologygenome-wide association studiesafrican-american mengenomicscancer researchinterferon signatureoncologycancer genomicssupplementary tablesgene characterizationtumor biologyprostate cancerallelic variantmicroarray data analysis

Ablation of Sigh+ Pdcs in B6.Nba2 Mice Prevents Lupus-Like Disease Development Only If Started Before Disease is Fully Established. Lupus (2022)

Nicole O CampbellLaura M DavisonShuvojit BanerjeeJane K NguyenSarah KrafcikRobert H SilvermanTrine N Jorgensen

geneticsrheumatologymedicineimmunologymammalian biology

H3K9 Methylation Drives Resistance to Androgen Receptor–Antagonist Therapy in Prostate Cancer. Proceedings of the National Academy of Sciences (2022)

Mehdi BaratchianRitika TiwariSirvan KhalighiAnkur ChakravarthyWei YuanMichael BerkJianneng LiAmy GuerinotJohann de BonoVladimir MakarovTimothy A. ChanRobert H. SilvermanGeorge R. StarkVinay VaradanDaniel D. De CarvalhoAbhishek A. ChakrabortyNima Sharifi

tumor targetingdrug resistanceanti-cancer agentsmolecular cancercancer researchneuroscienceneurologypharmacologycancer treatmentoncologycellular therapycancer geneticsreceptor-antagonist therapyprostate cancercancer managementcancer immunotherapyoncogenesmolecular sciencemedicinal research

Inborn Errors of Oas–Rnase L in Sars-Cov-2–Related Multisystem Inflammatory Syndrome in Children. Science (2022)

Danyel LeeJérémie Le PenAhmad YatimBeihua DongYann AquinoMasato OgishiRémi PescarmonaEstelle TalouarnDarawan RinchaiPeng ZhangMagali PerretZhiyong LiuIolanda JordanSefika Elmas BozdemirGulsum Iclal BayhanCamille BeaufilsLucy BizienAurelie BisiauxWeite LeiMilena HasanJie ChenChristina GaughanAbhishek AsthanaValentina LibriJoseph M. LunaFabrice JaffréH.-Heinrich HoffmannEleftherios MichailidisMarion MoreewsYoann SeeleuthnerKaya BilguvarShrikant ManeCarlos FloresYu ZhangAndrés A. AriasRasheed BaileyAgatha SchlüterBaptiste MilisavljevicBenedetta BigioTom Le VoyerMarie MaternaAdrian GervaisMarcela Moncada-VelezFrancesca PalaTomi LazarovRomain LevyAnna-Lena NeehusJérémie RosainJessica PeelYi-Hao ChanMarie-Paule MorinRosa Maria Pino-RamirezSerkan BelkayaLazaro LorenzoJordi AntonSelket DelafontaineJulie ToubianaFanny BajolleVictoria FumadóMarta L. DeDiegoNadhira FidouhFlore RozenbergJordi Pérez-TurShuibing ChenTodd EvansFrédéric GeissmannPierre LebonSusan R. WeissDamien BonnetXavier DuvalQiang Pan-HammarströmAnna M. PlanasIsabelle MeytsFilomeen HaerynckAurora PujolVanessa Sancho-ShimizuClifford L. DalgardJacinta BustamanteAnne PuelStéphanie Boisson-DupuisBertrand BoissonTom ManiatisQian ZhangPaul BastardLuigi NotarangeloVivien BéziatRebeca Perez de DiegoCarlos Rodriguez-GallegoHelen C. SuRichard P. LiftonEmmanuelle JouanguyAurélie CobatLaia AlsinaSevgi KelesElie HaddadLaurent AbelAlexandre BelotLluis Quintana-MurciCharles M. RiceRobert H. Silverman

geneticsvaccinesviral pathogenesissars-cov-2virologyinfectious diseasesinflammationinborn errorspediatricsinflammatory diseasesvascular biologydevelopmental immunologyviral geneticsgeneral virologyinflammatory markers

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Robert H. Silverman

Professor

Case Western Reserve University

Affiliations

School of Medicine

Biochemistry

Molecular Biology and Microbiology

Robert H. Silverman is currently serving as a Biochemistry Professor at Case Western Reserve University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert H. Silverman

Case Western Reserve University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ascc1 Structures and Bioinformatics Reveal a Novel Helix-Clasp-Helix Rna-Binding Motif Linked to a Two-Histidine Phosphodiesterase. Journal of Biological Chemistry (2024)

Initiation of a Zakα-Dependent Ribotoxic Stress Response by the Innate Immunity Endoribonuclease Rnase L. Cell Reports (2024)

Jiajia XiGoda SnieckuteJosé Francisco MartínezFrederic Schrøder Wenzel ArendrupAbhishek AsthanaChristina GaughanAnders H. LundSimon Bekker-JensenRobert H. Silverman

cell biologymolecular biologyimmunologyrna biology

Rna Helicase Skiv2L Limits Antiviral Defense and Autoinflammation Elicited by the Oas-Rnase L Pathway. The EMBO Journal (2024)

Kun YangBeihua DongAbhishek AsthanaRobert H SilvermanNan Yan

molecular biology

Sars-Cov-2 Nsp15 Endoribonuclease Antagonizes Dsrna-Induced Antiviral Signaling. Proceedings of the National Academy of Sciences (2024)

geneticssars-cov-2virologymolecular biologyarbovirusimmunologymolecular virologydsrna-induced antiviral signaling

Analogs of the Catechol Derivative Dynasore Inhibit Hiv-1 Ribonuclease H, Sars-Cov-2 Nsp14 Exoribonuclease, and Virus Replication. Viruses (2023)

Abhishek AsthanaAngela CoronaWoo-Jin ShinMi-Jeong KwakChristina GaughanEnzo TramontanoJae U. JungRainer SchobertBabal Kant JhaRobert H. SilvermanBernhard Biersack

geneticsmedicinesars-cov-2virologyinfectious diseasesviral replicationviral geneticsvirus replicationhiv

Inherited Deficiency of the Oas-Rnase L Pathway in Children With Mis-C. Clinical Immunology (2023)

Danyel LeeJérémie Le PenAhmad YatimBeihua DongYann AquinoMasato OgishiRobert SilvermanShen-Ying ZhangJean-Laurent Casanova

geneticshuman geneticshereditypediatricsimmunologyselenium deficiencyclinical immunologyinherited deficiency

Supplementary Tables From I Ifnl4 /I -ΔG Allele is Associated With an Interferon Signature in Tumors and Survival of African-American Men With Prostate Cancer. (2023)

Ablation of Sigh+ Pdcs in B6.Nba2 Mice Prevents Lupus-Like Disease Development Only If Started Before Disease is Fully Established. Lupus (2022)

Nicole O CampbellLaura M DavisonShuvojit BanerjeeJane K NguyenSarah KrafcikRobert H SilvermanTrine N Jorgensen

geneticsrheumatologymedicineimmunologymammalian biology

H3K9 Methylation Drives Resistance to Androgen Receptor–Antagonist Therapy in Prostate Cancer. Proceedings of the National Academy of Sciences (2022)

Inborn Errors of Oas–Rnase L in Sars-Cov-2–Related Multisystem Inflammatory Syndrome in Children. Science (2022)

1
2
3
4
5
29
10 / page

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