Faculty

Institution

Unit

Venue

Christopher Mack

Professor

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Pathology and Laboratory Medicine

the Graduate School

Christopher Mack is currently serving as a Pathology And Laboratory Medicine Professor at University of North Carolina At Chapel Hill.

Honors

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Experiences

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Education

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Christopher Mack

University of North Carolina at Chapel Hill

Professor

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physiology cell biology cardiology vascular biology membrane biology cardiovascular research cellular physiology gene expression pharmacology molecular physiology cell signaling signal transduction atherosclerosis thrombosis circulatory physiology cell regulation developmental biology liver physiology angiology cardiovascular physiology hematology gene regulation protein science transcription regulation focal adhesion kinase cardiovascular disease muscle function angiogenesis cell adhesion blood pressure molecular cell biology biological chemistry medicinal research gene function applied physiology signaling pathways protein expression cardiovascular function protein function smooth muscle cell mammalian biology molecular regulation human physiology hemostasis protein phosphorylation smooth muscle vascular pharmacology rna biology skeletal muscle tissue development integrative biology functional regulation cardiomyopathy vascular disease biochemical sciences cellular biochemistry genome biology embryonic development epigenetic changes biomolecular interactions redox signaling arterial disease physiological regulation myocardin-related transcription factors endogenous inhibitor actin polymerization smc differentiation selective expression smooth muscle cell-selective pressure overload-induced hypertrophy nuclear localization myocardin factors histone demethylase gtpase-activating protein bar-containing rho-gtpase-activating protein skeletal muscle differentiation matrix biology hypertension vascular adaptation cellular differentiation extracellular matrix

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Tu126: Unveiling the Role of Graf1 in Orchestrating Mitophagy and Metabolic Flexibility in Stressed Cardiomyocytes. Circulation Research (2024)

Qiang ZhuMatthew CombsChristopher MacKJoan Taylor

metabolic flexibilityoxidative stresscardiovascular functioncell biologymitophagystressed cardiomyocytesvascular biologyphysiologycardiovascular researchmolecular biologycell metabolism

Graf1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes. Cells (2024)

Qiang ZhuMatthew E. CombsDawn E. BowlesRyan T. GrossMichelle Mendiola PlaChristopher P. MackJoan M. Taylor

cell biologyneurosciencemammalian biologycardiovascular researchgene expressionmolecular and cellular biologycell regulationmitophagymembrane biologyneurologyvascular biologycell researchcell and molecular biologyprotein functiondownstream mediatorcell interactionsregenerative medicinecellular biologycellular physiology

Graf1 Deficiency Leads to Defective Brown Adipose Tissue Differentiation and Thermogenic Response. Scientific Reports (2024)

Xue BaiQiang ZhuMatthew CombsMartin WabitschChristopher P. MackJoan M. Taylor

geneticscellular differentiationadipose tissue differentiationcell biologybiochemistrymetabolic disordersgene expressionthermogenic response

Targeting Vascular Stiffness. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Christopher P. Mack

vascular stiffnessvascular agingmechanobiologyvascular surgerybiomedical engineeringvascular biologyvascular diseasecardiovascular researchvascular traumathrombosisvascular adaptationperipheral vascular disease

Graf1 Integrates Pink1-Parkin Signaling and Actin Dynamics to Mediate Cardiac Mitochondrial Homeostasis. Nature Communications (2023)

Qiang ZhuMatthew E. CombsJuan LiuXue BaiWenbo B. WangLaura E. HerringJiandong LiuJason W. LocasaleDawn E. BowlesRyan T. GrossMichelle Mendiola PlaChristopher P. MackJoan M. Taylor

cellular physiologymitochondrial functioninflammationcardiologymolecular neurosciencecardiovascular physiologycardiovascular functioncell biologyactin dynamicssystems biologymembrane biologyphysiologycardiac mitochondrial homeostasiscardiovascular researchprotein functionredox signalingcardiovascular diseasemolecular physiology

Graf1 Regulates Brown and Beige Adipose Differentiation and Function. Research Square (Research Square) (2023)

Xue BaiQiang ZhuMatthew CombsMartin WabitschChristopher P. MackJoan M. Taylor

cutaneous biologygeneticsliver physiologycell regulationendocrinologycell biologymembrane biologyphysiologysignal transductiontranscription regulationgene expressionmetabolic regulationbeige adipose differentiationcellular physiologymolecular physiology

Prdm6 Drives Ductus Arteriosus Closure by Promoting Ductus Arteriosus Smooth Muscle Cell Identity and Contractility. JCI Insight (2023)

Meng ZouKevin D. MangumJustin C. MaginHeidi H. CaoMichael T. YarboroElaine L. SheltonJoan M. TaylorJeff ReeseTerrence S. FureyChristopher P. Mack

cellular physiologyarteriosus closuremuscle functionneuroscienceangiogenesisvascular biologyphysiologytissue (biology)neurologyatherosclerosis

A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation. Frontiers in Cardiovascular Medicine (2021)

Lee StonerBethany Barone GibbsMichelle L. MeyerSimon FryerDaniel CredeurCraig PatersonKeeron StoneErik D. HansonRobert J. KowalskyMasahiro HoriuchiChristopher P. MackGaurav Dave

cardiologyphysical activitystudy designphysiologypublic healthhealth sciencescardiovascular researchcardiovascular diseasecardiovascular system

The Actin Depolymerizing Factor Destrin Serves as a Negative Feedback Inhibitor of Smooth Muscle Cell Differentiation. AJP Heart and Circulatory Physiology (2021)

Kuo An LiaoKrsna V. RangarajanXue BaiJoan M. TaylorChristopher P. Mack

negative feedback inhibitorhuman physiologypharmacologycardiovascular researchcardiovascular diseasecirculatory physiologycardiovascular physiologycardiovascular functionelectrophysiologyneurophysiologyapplied physiologyvascular biologyphysiologycardiovascular pharmacologycardiologyendocrinologydepolymerizationhealth sciencescellular physiology

Molecular Regulation of the Rhogap Graf3 and Its Capacity to Limit Blood Pressure in Vivo. Cells (2020)

Rachel A. DeeXue BaiChristopher P. MackJoan M. Taylor

cell biologyhypertensionblood pressuremembrane biologyvascular biologyphysiologymolecular biology

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Christopher Mack

Professor

University of North Carolina at Chapel Hill

Affiliations

School of Medicine

Pathology and Laboratory Medicine

the Graduate School

Christopher Mack is currently serving as a Pathology And Laboratory Medicine Professor at University of North Carolina At Chapel Hill.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Christopher Mack

University of North Carolina at Chapel Hill

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Tu126: Unveiling the Role of Graf1 in Orchestrating Mitophagy and Metabolic Flexibility in Stressed Cardiomyocytes. Circulation Research (2024)

Qiang ZhuMatthew CombsChristopher MacKJoan Taylor

metabolic flexibilityoxidative stresscardiovascular functioncell biologymitophagystressed cardiomyocytesvascular biologyphysiologycardiovascular researchmolecular biologycell metabolism

Graf1 Acts as a Downstream Mediator of Parkin to Regulate Mitophagy in Cardiomyocytes. Cells (2024)

Qiang ZhuMatthew E. CombsDawn E. BowlesRyan T. GrossMichelle Mendiola PlaChristopher P. MackJoan M. Taylor

Graf1 Deficiency Leads to Defective Brown Adipose Tissue Differentiation and Thermogenic Response. Scientific Reports (2024)

Xue BaiQiang ZhuMatthew CombsMartin WabitschChristopher P. MackJoan M. Taylor

geneticscellular differentiationadipose tissue differentiationcell biologybiochemistrymetabolic disordersgene expressionthermogenic response

Targeting Vascular Stiffness. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Christopher P. Mack

Graf1 Integrates Pink1-Parkin Signaling and Actin Dynamics to Mediate Cardiac Mitochondrial Homeostasis. Nature Communications (2023)

Qiang ZhuMatthew E. CombsJuan LiuXue BaiWenbo B. WangLaura E. HerringJiandong LiuJason W. LocasaleDawn E. BowlesRyan T. GrossMichelle Mendiola PlaChristopher P. MackJoan M. Taylor

Graf1 Regulates Brown and Beige Adipose Differentiation and Function. Research Square (Research Square) (2023)

Xue BaiQiang ZhuMatthew CombsMartin WabitschChristopher P. MackJoan M. Taylor

Prdm6 Drives Ductus Arteriosus Closure by Promoting Ductus Arteriosus Smooth Muscle Cell Identity and Contractility. JCI Insight (2023)

Meng ZouKevin D. MangumJustin C. MaginHeidi H. CaoMichael T. YarboroElaine L. SheltonJoan M. TaylorJeff ReeseTerrence S. FureyChristopher P. Mack

cellular physiologyarteriosus closuremuscle functionneuroscienceangiogenesisvascular biologyphysiologytissue (biology)neurologyatherosclerosis

A Primer on Repeated Sitting Exposure and the Cardiovascular System: Considerations for Study Design, Analysis, Interpretation, and Translation. Frontiers in Cardiovascular Medicine (2021)

Lee StonerBethany Barone GibbsMichelle L. MeyerSimon FryerDaniel CredeurCraig PatersonKeeron StoneErik D. HansonRobert J. KowalskyMasahiro HoriuchiChristopher P. MackGaurav Dave

cardiologyphysical activitystudy designphysiologypublic healthhealth sciencescardiovascular researchcardiovascular diseasecardiovascular system

The Actin Depolymerizing Factor Destrin Serves as a Negative Feedback Inhibitor of Smooth Muscle Cell Differentiation. AJP Heart and Circulatory Physiology (2021)

Kuo An LiaoKrsna V. RangarajanXue BaiJoan M. TaylorChristopher P. Mack

Molecular Regulation of the Rhogap Graf3 and Its Capacity to Limit Blood Pressure in Vivo. Cells (2020)

Rachel A. DeeXue BaiChristopher P. MackJoan M. Taylor

cell biologyhypertensionblood pressuremembrane biologyvascular biologyphysiologymolecular biology

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7
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Similar Faculty Members

Joan Taylor

Institution

University of North Carolina at Chapel Hill

health science

skeletal muscle

Lucy Liaw

Institution

Tufts University

vascular biology

physiology

Ju Chen

Institution

University of California, San Diego

naxos disease

pathology

Dolly Mehta, PhD

Institution

University of Illinois Chicago

endothelial cell biology

endothelial dysfunction

Neetu Tyagi

Institution

University of Louisville

stem cell

endothelial function

Jian-Ping Jin

Institution

Wayne State University

mechanical tension regulation

protein structure-function relationships

Joan Heller Brown

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University of California, San Diego

cam kinase

brain tumor research

Adam C. Straub

Institution

University of Pittsburgh

free radical biology

pharmacology

Brant Isakson

Institution

University of Virginia

vascular biology

physiology

Jian-Ping Jin

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University of Illinois Chicago

developmental biology

muscle cell motility