Faculty

Institution

Unit

Venue

Jonathan Coloff

Associate Professor

University of Illinois Chicago

Affiliations

College of Medicine

Department of Physiology and Biophysics

Jonathan Coloff is currently serving as a College Of Medicine Associate Professor at University of Illinois Chicago.

Honors

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Experiences

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Education

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Jonathan Coloff

University of Illinois Chicago

Associate Professor

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cell biology tumor biology cancer research cancer biology oncology molecular biology medicinal research molecular cancer cancer genomics genetics physiology oncogenes enzyme inhibition cancer genetics apoptosis cancer treatment membrane biology gene expression metabolism cell signaling cell death cancer growth breast oncology cell metabolism cellular therapy mammalian biology molecular and cellular biology cellular physiology molecular cell biology autophagy protein science leukemia cell research mammary gland cell regulation gene function glucose metabolism bioenergetics molecular metabolism molecular regulation host factors metabolic regulation tumor suppressors lipid science metabolic reprogramming prostate cancer cells mitochondrial function protein expression signaling pathways cellular biology cell proliferation protein function protein chemistry host response immunomodulation clinical immunology skin cancer cell physiology lipoprotein metabolism disease gene identification cellular nutrition renal pathophysiology nutrient physiology regulated process immune cell function differential glutamate metabolism glycogen synthase protein homeostasis glutathione depletion pyruvate dehydrogenase flux erk regulation non-essential amino acids diverse functions bcr-abl-mediated leukemogenesis cell stress akt-dependent glucose metabolism metabolic remodeling breast cancer pathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4155: Catabolism of Extracellular Glutathione Supplies Amino Acids to Support Tumor Growth. Cancer Research (2025)

Fabio HechtMarco ZocchiEmily TuttleNathan WardBradley SmithYun P. KangJuliana CazarinZamira G. SoaresMete Emir OzgursesHuiping ZhaoColin SheehanFatemeh AlimohammadiLila MungerDhvani TrivediGloria AsantewaaSara Blick-NitkoJason ZoellerYing ChenVasilis VasiliouBradley M. TurnerAlexander MuirJonathan L. ColoffJoshua MungerGina DeNicolaIsaac Harris

extracellular glutathione suppliesbiochemistrycancer researchcancer growthtumor growthcatabolismcancer biology

Abstract 4725: Engineering a Novel Serine-Degrading Enzyme for Targeted Cancer Therapy. Cancer Research (2025)

Ladan MashouriEbru CayirSarita BhetawalDaniel J DiazVipin RawatJonathan ColoffGeorge GeorgiouEverett Stone

enzymestargeted cancer therapybiocatalysiscancer researchnovel serine-degrading enzymebiomolecular engineering

Abstract 4757: Elucidating Novel Pro-Apoptotic Consequences of Ceramides in Endocrine Therapy-Resistant Breast Cancer. Cancer Research (2025)

breast oncologynovel pro-apoptotic consequencesradiation oncologyendocrine-related cancerstumor biologyabstract 4757anti-cancer agentsmolecular cancerpharmacologytherapeutic targetscancer treatmentcancer letteroncologybreast cancer

Abstract 5387: Modeling Physiological Lipid Availability of Tumors to Improve in Vitro Studies of Cancer Cell Lipid Metabolism. Cancer Research (2025)

Mete E. OzgursesVipin S. RawatKelly O. CongerHuiping ZhaoPatrick B. JonkerAlexander MuirJonathan L. Coloff

lipidstumor biologyphysiological lipid availabilitybiochemistrycancer researchcancer cellscancer biology

Abstract 5539: Single-Cell and Spatial Approaches of Identifying Targets in Endocrine Therapy-Resistant Breast Cancer. Cancer Research (2025)

breast oncologyradiation oncologyendocrine-related cancerstumor biologycell biologysingle-cell analysiscancer discoverytherapeutic targetsabstract 5539spatial approachescancer cellscell researchbreast cancer

Abstract P5-01-20: Elucidating Novel Pro-Apoptotic Consequences of an Altered Sphingolipidome in Endocrine Therapy-Resistance. Clinical Cancer Research (2025)

abstract p5-01-20apoptosisaltered sphingolipidomecell deathcell signalingcell biologyendocrine therapy-resistancelipid sciencepharmacologytherapeutic targetsexperimental medicineendocrinology

Ceramide-Induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

breast oncologyendocrine-related cancerscancer biologycell biologymolecular cancercancer researchtargetable vulnerabilitypharmacologytherapeutic targetscancer cellscancer letteroncologybreast cancer

Microenvironmental Arginine Restriction Sensitizes Pancreatic Cancers to Polyunsaturated Fatty Acids by Suppression of Lipid Synthesis. (2025)

Patrick B JonkerMumina SadullozodaGuillaume CognetJuan J Apiz SaabKelly H SokolViolet X WuDeepa KumariColin SheehanMete E OzgursesDarby AgovinoGrace CroleySmit A PatelAlthea Bock-HughesKay F MacleodHardik ShahJonathan L ColoffEvan C LienAlexander Muir

fatty acidsmicroenvironmental arginine restrictionbiochemistrypancreatic cancerlipid synthesistumor microenvironment

Abstract 6608: Therapeutic Enzyme Depletion of L-Serine for the Treatment of Serine Auxotrophic Tumors. Cancer Research (2024)

Vipin RawatHuiping ZhaoLadan MashouriPrarthana PrasanthKelly CongerSarita BhetawalAlessandra AraujoEverett StoneJonathan Coloff

therapeutic enzyme depletionenzyme specificityradiation oncologycancer caretumor biologyenzyme immobilizationmedicinal researchcellular therapycancer researchpharmacologycancer managementclinical researchcancer treatmentenzyme inhibitionhealth sciencesoncologycancer biologyserine auxotrophic tumors

Asct2 is a Major Contributor to Serine Uptake in Cancer Cells. Cell Reports (2024)

Kelly O. CongerChristopher ChidleyMete Emir OzgursesHuiping ZhaoYumi KimSvetlana E. SeminaPhilippa BurnsVipin RawatLina LietuvninkasRyan SheldonIssam Ben-SahraJonna FrasorPeter K. SorgerGina M. DeNicolaJonathan L. Coloff

cancer cellscell biologytumor biologycancer biology

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Jonathan Coloff

Associate Professor

University of Illinois Chicago

Affiliations

College of Medicine

Department of Physiology and Biophysics

Jonathan Coloff is currently serving as a College Of Medicine Associate Professor at University of Illinois Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jonathan Coloff

University of Illinois Chicago

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4155: Catabolism of Extracellular Glutathione Supplies Amino Acids to Support Tumor Growth. Cancer Research (2025)

extracellular glutathione suppliesbiochemistrycancer researchcancer growthtumor growthcatabolismcancer biology

Abstract 4725: Engineering a Novel Serine-Degrading Enzyme for Targeted Cancer Therapy. Cancer Research (2025)

Ladan MashouriEbru CayirSarita BhetawalDaniel J DiazVipin RawatJonathan ColoffGeorge GeorgiouEverett Stone

enzymestargeted cancer therapybiocatalysiscancer researchnovel serine-degrading enzymebiomolecular engineering

Abstract 4757: Elucidating Novel Pro-Apoptotic Consequences of Ceramides in Endocrine Therapy-Resistant Breast Cancer. Cancer Research (2025)

Abstract 5387: Modeling Physiological Lipid Availability of Tumors to Improve in Vitro Studies of Cancer Cell Lipid Metabolism. Cancer Research (2025)

Mete E. OzgursesVipin S. RawatKelly O. CongerHuiping ZhaoPatrick B. JonkerAlexander MuirJonathan L. Coloff

lipidstumor biologyphysiological lipid availabilitybiochemistrycancer researchcancer cellscancer biology

Abstract 5539: Single-Cell and Spatial Approaches of Identifying Targets in Endocrine Therapy-Resistant Breast Cancer. Cancer Research (2025)

Abstract P5-01-20: Elucidating Novel Pro-Apoptotic Consequences of an Altered Sphingolipidome in Endocrine Therapy-Resistance. Clinical Cancer Research (2025)

abstract p5-01-20apoptosisaltered sphingolipidomecell deathcell signalingcell biologyendocrine therapy-resistancelipid sciencepharmacologytherapeutic targetsexperimental medicineendocrinology

Ceramide-Induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

breast oncologyendocrine-related cancerscancer biologycell biologymolecular cancercancer researchtargetable vulnerabilitypharmacologytherapeutic targetscancer cellscancer letteroncologybreast cancer

Microenvironmental Arginine Restriction Sensitizes Pancreatic Cancers to Polyunsaturated Fatty Acids by Suppression of Lipid Synthesis. (2025)

fatty acidsmicroenvironmental arginine restrictionbiochemistrypancreatic cancerlipid synthesistumor microenvironment

Abstract 6608: Therapeutic Enzyme Depletion of L-Serine for the Treatment of Serine Auxotrophic Tumors. Cancer Research (2024)

Vipin RawatHuiping ZhaoLadan MashouriPrarthana PrasanthKelly CongerSarita BhetawalAlessandra AraujoEverett StoneJonathan Coloff

Asct2 is a Major Contributor to Serine Uptake in Cancer Cells. Cell Reports (2024)

cancer cellscell biologytumor biologycancer biology

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cancer treatment

pharmacology

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cancer biology

cancer research

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cancer risk

nf-�b family

Jeffrey C. Rathmell

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