Faculty

Institution

Unit

Venue

Charles Chavkin

Professor

University of Washington

Affiliations

School of Medicine

Pharmacology

Charles Chavkin is currently serving as a Pharmacology Professor at University of Washington.

Honors

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Experiences

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Education

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Charles Chavkin

University of Washington

Professor

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neuroscience pharmacology neuropharmacology neurology physiology neurophysiology cognitive neuroscience receptors neurochemistry neuroanatomy cell signaling systems neuroscience brain science signal transduction neuropsychopharmacology medicinal research protein science mammalian biology neural science pharmacokinetics biological chemistry clinical neuroscience cellular neurobiology neurotransmission receptor (biochemistry) rat hippocampus pharmacotherapy pharmacological research opioid use disorder redox biology pain research dopamine molecular neurobiology psychopharmacology animal physiology addiction biology molecular physiology xenopus oocytes affective neuroscience peptides g protein-coupled receptor receptor tyrosine kinases addiction treatment spinal cord avian biology neuroinflammation experimental pharmacology signaling pathways neuropeptides dentate gyrus guinea pig hippocampus functional regulation drug treatment biological inorganic chemistry neurotransmitters kappa opioid receptor opioid receptors tyrosine phosphorylation brain function inhibitory activity catalyst activation endogenous dynorphins kappa opioid receptors kappa-opioid receptors k-opioid receptor activation rat hippocampal slices potassium channel cognitive electrophysiology biological psychology human sciences protein phosphorylation functional selectivity translational pharmacology prodynorphin gene disruption stress-induced behavioral responses long-term potentiation drug addiction addiction pain mechanism

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

G Protein Inactivation as a Mechanism for Addiction Treatment. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Carlie NeiswangerMicaela V. RuizKandace KimballJustin D. LeeBenjamin LandAndre BerndtCharles Chavkin

substance use disordersmental healthneuropharmacologyaddiction medicinebehavioral sciencesaddiction biologysubstance useaddiction treatmentaddictionmolecular biologysubstance abuseg protein-coupled receptorsubstance addictionopioid use disorderpsychologyaddictive behaviors

Structure-Guided Engineering of a Fast Genetically Encoded Sensor for Real-Time H 2 O 2 Monitoring. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Justin Daho LeeWoojin WonKandace KimballYihan WangFred YeboahKira M. EvittsCarlie NeiswangerSelena SchattauerMichael RappleyeSamantha B BremnerChangho ChunNetta SmithDavid L. MackJessica E. YoungC. Justin LeeCharles ChavkinAndre Berndt

biological engineeringsensorsgenetic engineeringstructure-guided engineeringgenetic technologiesbiotechnologybiosensorssensor technologybiomolecular engineeringgeneticssensor design

Ultra-Fast Genetically Encoded Sensor for Precise Real-Time Monitoring of Physiological and Pathophysiological Peroxide Dynamics. Research Square (2024)

Andre BerndtJustin LeeWoojin WonKandace KimballCarlie NeiswangerSelena SchattauerYihan WangFred YeboahMicaela RuizKira EvittsMichael RappleyeSamantha BremnerChangho ChunNetta SmithDavid MackJessica YoungC. Justin LeeCharles Chavkin

sensorsphysiologyprecise real-time monitoringelectrophysiologyneurosciencereal-time monitoringbiomedical engineeringbiosensorspathophysiological peroxide dynamicsapplied physiologymachine learning

Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine Consumption. bioRxiv (Cold Spring Harbor Laboratory) (2023)

L. Gordon-FennellR.D. FareroL.M. BurgenoN.L. MurrayA.D. AbrahamM.E. SodenG.D. StuberC. ChavkinL.S. ZweifelP.E.M. Phillips

neuropharmacologyneurosciencepharmacologykappa opioid receptorsaddictioncocaine consumptionmedicinal researchneuropsychopharmacologybehavioral neurosciencemesolimbic terminalscannabis useneurologytoxicologyprotein scienceaddiction medicineaddiction biologyaddiction treatmentpharmacokineticssubstance abuse

Opioid Receptors in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

Anna BorsodiMichael BruchasGirolamo CalóCharles ChavkinMacDonald J. ChristieOlivier CivelliMark ConnorBrian M. CoxLakshmi A. DeviChristopher EvansVolker HölltGraeme HendersonStephen HusbandsEamonn KellyBrigitte KiefferIan KitchenMary-Jeanne KreekLee-Yuan Liu-ChenDavide MalfaciniDominique MassotJean-Claude MeunierPhilip S. PortogheseStefan SchulzToni S. ShippenbergEric J. SimonLawrence TollJohn R. TraynorHiroshi UedaYung H. WongNurulain ZaveriAndreas Zimmer

physiologyopioid receptorspharmacologyneuropharmacology

Optogenetic Stimulation of Dynorphinergic Neurons Within the Dorsal Raphe Activate Kappa Opioid Receptors in the Ventral Tegmental Area and Ablation of Dorsal Raphe Prodynorphin or Kappa Receptors in Dopamine Neurons Blocks Stress Potentiation of Cocaine Reward. Addiction Neuroscience (2022)

Antony D. AbrahamSanne M. CaselloBenjamin B. LandCharles Chavkin

dorsal raphecocaine rewardoptogeneticsneuropharmacologykappa opioid receptorsneuroscienceventral tegmental areadynorphinergic neurons

Release of Endogenous Dynorphin Opioids in the Prefrontal Cortex Disrupts Cognition. Neuropsychopharmacology (2021)

Antony D. AbrahamSanne M. CaselloSelena S. SchattauerBrenden A. WongGrace O. MizunoKaran MaheLin TianBenjamin B. LandCharles Chavkin

endogenous dynorphin opioidsneuropharmacologyneuropsychopharmacologycognitive neuroscienceneuroscienceneuropsychology

Stress Decreases Serotonin Tone in the Nucleus Accumbens in Male Mice to Promote Aversion and Potentiate Cocaine Preference via Decreased Stimulation of 5-Ht1B Receptors. Neuropsychopharmacology (2021)

Harrison M. FontainePhillip R. SilvaCarlie NeiswangerRachelle TranAntony D. AbrahamBenjamin B. LandJohn F. NeumaierCharles Chavkin

neurologyneuropharmacologyneuropsychopharmacologyneurosciencestress (biology)behavioral neurosciencedecreased stimulationpharmacologyclinical neurosciencepotentiate cocaine preferencemale miceneuropsychologydepression

Insidious Transmission of a Stress-Related Neuroadaptation. Frontiers in Behavioral Neuroscience (2020)

Jennifer S. StegerBenjamin B. LandJulia C. LemosCharles ChavkinPaul E. M. Phillips

behavioral neuroscienceinsidious transmissionstress-related neuroadaptationneuroscience

Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action. Molecular Pharmacology (2020)

Kathryn L. ReichardKeionna A. NewtonZeena M.G. RiveraPaulo M. Sotero de MenezesSelena S. SchattauerBenjamin B. LandCharles Chavkin

neuropharmacologyphysiologyantagonist actioncellular sitepharmacologymolecular pharmacology

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Charles Chavkin

Professor

University of Washington

Affiliations

School of Medicine

Pharmacology

Charles Chavkin is currently serving as a Pharmacology Professor at University of Washington.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Charles Chavkin

University of Washington

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

G Protein Inactivation as a Mechanism for Addiction Treatment. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Carlie NeiswangerMicaela V. RuizKandace KimballJustin D. LeeBenjamin LandAndre BerndtCharles Chavkin

Structure-Guided Engineering of a Fast Genetically Encoded Sensor for Real-Time H 2 O 2 Monitoring. bioRxiv (Cold Spring Harbor Laboratory) (2024)

biological engineeringsensorsgenetic engineeringstructure-guided engineeringgenetic technologiesbiotechnologybiosensorssensor technologybiomolecular engineeringgeneticssensor design

Ultra-Fast Genetically Encoded Sensor for Precise Real-Time Monitoring of Physiological and Pathophysiological Peroxide Dynamics. Research Square (2024)

sensorsphysiologyprecise real-time monitoringelectrophysiologyneurosciencereal-time monitoringbiomedical engineeringbiosensorspathophysiological peroxide dynamicsapplied physiologymachine learning

Kappa Opioid Receptors in Mesolimbic Terminals Mediate Escalation of Cocaine Consumption. bioRxiv (Cold Spring Harbor Laboratory) (2023)

L. Gordon-FennellR.D. FareroL.M. BurgenoN.L. MurrayA.D. AbrahamM.E. SodenG.D. StuberC. ChavkinL.S. ZweifelP.E.M. Phillips

Opioid Receptors in Gtopdb V.2023.1. IUPHAR/BPS Guide to Pharmacology CITE (2023)

physiologyopioid receptorspharmacologyneuropharmacology

Antony D. AbrahamSanne M. CaselloBenjamin B. LandCharles Chavkin

dorsal raphecocaine rewardoptogeneticsneuropharmacologykappa opioid receptorsneuroscienceventral tegmental areadynorphinergic neurons

Release of Endogenous Dynorphin Opioids in the Prefrontal Cortex Disrupts Cognition. Neuropsychopharmacology (2021)

Antony D. AbrahamSanne M. CaselloSelena S. SchattauerBrenden A. WongGrace O. MizunoKaran MaheLin TianBenjamin B. LandCharles Chavkin

endogenous dynorphin opioidsneuropharmacologyneuropsychopharmacologycognitive neuroscienceneuroscienceneuropsychology

Harrison M. FontainePhillip R. SilvaCarlie NeiswangerRachelle TranAntony D. AbrahamBenjamin B. LandJohn F. NeumaierCharles Chavkin

Insidious Transmission of a Stress-Related Neuroadaptation. Frontiers in Behavioral Neuroscience (2020)

Jennifer S. StegerBenjamin B. LandJulia C. LemosCharles ChavkinPaul E. M. Phillips

behavioral neuroscienceinsidious transmissionstress-related neuroadaptationneuroscience

Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action. Molecular Pharmacology (2020)

Kathryn L. ReichardKeionna A. NewtonZeena M.G. RiveraPaulo M. Sotero de MenezesSelena S. SchattauerBenjamin B. LandCharles Chavkin

neuropharmacologyphysiologyantagonist actioncellular sitepharmacologymolecular pharmacology

1
2
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5
22
10 / page

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