Faculty

Institution

Unit

Venue

Charles C. Caldwell

Professor

University of Cincinnati

Affiliations

College of Medicine

Surgery

Charles C. Caldwell is currently serving as a College Of Medicine Professor at University of Cincinnati.

Honors

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Experiences

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Education

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Charles C. Caldwell

University of Cincinnati

Professor

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immunology sepsis inflammation pharmacology hematology emergency medicine immune responses respiratory medicine medicine regenerative medicine medicinal research adaptive immune system innate immune system mammalian biology cell signaling liver physiology cellular physiology vascular biology clinical microbiology hemostasis surgical care murine model endocrinology membrane biology intensive care cytokines cellular immune responses resuscitation chronic inflammation infection control reperfusion injury host response clinical immunology molecular physiology thrombosis animal physiology burn injury cell death treatment effects cell physiology plo biology biochemical sciences translational physiology traumatic brain injury red blood cells lymphocyte development veterinary microbiology cell regulation molecular regulation tissue injury coagulopathy hypoxia (medicine) immunosuppression host factors acute care surgery persistent inflammation medical microbiology tissue physiology inflammatory diseases anti-inflammatory disease physiology t-regulatory cell endocrine research renal function mammalian physiology critical illness septic patients immune suppression thermal injury catabolism syndrome polymicrobial sepsis acid sphingomyelinase liver recovery burn-injured mice platelet dysfunction pulmonary infection

Notable Scholarly Works

Notable Federal Grants

Collaborators

Determining Potential Immunomodulatory Drug Efficacy in Sepsis Using Elispot. Scientific Reports (2025)

Andrew H WaltonMonty B MazerKenneth E RemyDale F OsborneEthan B DavittThomas S GriffithRobert W GouldVladimir P BadovinacScott C BrakenridgeAnne M DrewryRicardo F UngaroIvanna L RochaTyler J LoftusPhilip A EfronLyle L MoldawerCharles C CaldwellRichard S Hotchkiss

immunomodulationinfectious diseasessepsisepidemiologyemergency medicine

Nanoparticles Containing Intracellular Proteins Modulate Neutrophil Functional and Phenotypic Heterogeneity. Frontiers in Immunology (2025)

nanoparticlesintracellular proteinsinflammationbiomolecular engineeringbiological macromoleculesbiomoleculesimmunologynanoparticle researchnanobiotechnologyprotein nanoparticles

Age Above All: The Impact of Storage Duration in Mice Resuscitated With Whole Blood or Packed Red Blood Cells and Plasma in a Hemorrhagic Shock Model. Surgery (2024)

Ryan C ChaeStephanie SisakChristopher Q NguyenLindsey J WattleyBernadin JosephLisa EnglandRebecca SchusterAlex B LentschCharles C CaldwellMichael D GoodmanTimothy A Pritts

resuscitationhemorrhagic shock modelsurgerywhole bloodred blood cellsstorage duration

Amitriptyline Decreases Mouse Lung Endothelial Cell Inflammatory Responses to Packed Red Blood Cell Microparticles. Journal of Surgical Research (2024)

Lindsey WattleyRyan ChaeChristopher NguyenRebecca SchusterAlex LentschCharles CaldwellMichael GoodmanTimothy A Pritts

surgeryendothelial dysfunctioninflammation

Development and Optimization of a Diluted Whole Blood Elispot Assay to Test Immune Function. Journal of Immunological Methods (2024)

Ricardo F UngaroJulie XuTamara A KucabaMahil RaoChristian B BergmannScott C BrakenridgePhilip A EfronMichael D GoodmanRobert W GouldRichard S HotchkissMuxuan LiangMonty B MazerPatrick W McGonagillLyle L MoldawerKenneth E RemyIsaiah R TurnbullCharles C CaldwellVladimir P BadovinacThomas S Griffith

hematologylaboratory medicineimmunologyimmune functionlaboratory immunologyhealth sciencesepidemiology

Functional Immunophenotyping for Precision Therapies in Sepsis. Shock (2024)

Mahil RaoPatrick W. McGonagillScott BrackenridgeKenneth E. RemyCharles C. CaldwellRichard S. HotchkissLyle L. MoldawerThomas S. GriffithVladimir P. Badovinac

intensive careimmunophenotypinginflammationinfectious diseasesprecision therapiesmolecular immunologyimmunotherapyneuroimmunologyimmunologyclinical immunologysepsiscritical careprecision medicinefunctional immunophenotypingsystem immunologymedicinal researchbiomarkers

Microvesicles From Stored Red Blood Cells Induce P-Selectin and Von Willebrand Factor Release From Endothelial Cells via a Protein Kinase C-Dependent Mechanism. Transfusion and Apheresis Science (2024)

Stephanie SisakRyan C ChaeKamala E NelsonRebecca M SchusterEmma C PerezLisa G EnglandCharles C CaldwellAlex B LentschMichael D GoodmanTimothy A Pritts

microbiologyhematologyhemostasisblood transfusiondermatologytransfusion medicineendothelial cellsregenerative medicineimmunologyvascular biologyangiogenesisextracellular microvesiclesred blood cells

Surviving Septic Patients Endotyped With a Functional Assay Demonstrate Active Immune Responses. Frontiers in Immunology (2024)

Adam D. PriceEllen R. BeckerEvan L. BarriosMonty B. MazerPatrick W. McGonagillChristian B. BergmannMichael D. GoodmanRobert W. GouldMahil RaoValerie E. PolczTamara A. KucabaAndrew H. WaltonSydney MilesJulie XuMuxuan LiangTyler J. LoftusPhilip A. EfronKenneth E. RemyScott C. BrakenridgeVladimir P. BadovinacThomas S. GriffithLyle L. MoldawerRichard S. HotchkissCharles C. Caldwell

septic patientsimmune responsesinfectious diseasesadaptive immune systemimmunologyimmunity (medicine)sepsisimmunopathology

Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by Elispot. Shock (2024)

Jacqueline UnsingerDale OsborneAndrew H. WaltonEthan HanLauren SheetsMonty B. MazerKenneth E. RemyThomas S. GriffithMahil RaoVladimir P. BadovinacScott C. BrakenridgeIsaiah TurnbullPhilip A. EfronLyle L. MoldawerCharles C. CaldwellRichard S. Hotchkiss

temporal changesinfectious diseasesimmunologysepsispublic healthadaptive immunity

Whole Blood Storage Duration Alters Fibrinogen Levels and Thrombin Formation. Journal of Trauma and Acute Care Surgery (2024)

Ryan ChaeChristopher NguyenChad ArchdeaconLindsey WattleyStephanie SisakAdam PriceEmma PerezRebecca SchusterAlex LentschCharles CaldwellMichael GoodmanTimothy Pritts

hematologyintensive caretraumamedicineresuscitationacute care surgerythrombin formationtrauma surgeryregenerative medicineemergency surgeryacute carecritical carenephrologytraumatologythrombosiscardiovascular diseaseemergency medicine

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Charles C. Caldwell

Professor

University of Cincinnati

Affiliations

College of Medicine

Surgery

Charles C. Caldwell is currently serving as a College Of Medicine Professor at University of Cincinnati.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Charles C. Caldwell

University of Cincinnati

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Determining Potential Immunomodulatory Drug Efficacy in Sepsis Using Elispot. Scientific Reports (2025)

immunomodulationinfectious diseasessepsisepidemiologyemergency medicine

Nanoparticles Containing Intracellular Proteins Modulate Neutrophil Functional and Phenotypic Heterogeneity. Frontiers in Immunology (2025)

nanoparticlesintracellular proteinsinflammationbiomolecular engineeringbiological macromoleculesbiomoleculesimmunologynanoparticle researchnanobiotechnologyprotein nanoparticles

Age Above All: The Impact of Storage Duration in Mice Resuscitated With Whole Blood or Packed Red Blood Cells and Plasma in a Hemorrhagic Shock Model. Surgery (2024)

Ryan C ChaeStephanie SisakChristopher Q NguyenLindsey J WattleyBernadin JosephLisa EnglandRebecca SchusterAlex B LentschCharles C CaldwellMichael D GoodmanTimothy A Pritts

resuscitationhemorrhagic shock modelsurgerywhole bloodred blood cellsstorage duration

Amitriptyline Decreases Mouse Lung Endothelial Cell Inflammatory Responses to Packed Red Blood Cell Microparticles. Journal of Surgical Research (2024)

Lindsey WattleyRyan ChaeChristopher NguyenRebecca SchusterAlex LentschCharles CaldwellMichael GoodmanTimothy A Pritts

surgeryendothelial dysfunctioninflammation

Development and Optimization of a Diluted Whole Blood Elispot Assay to Test Immune Function. Journal of Immunological Methods (2024)

hematologylaboratory medicineimmunologyimmune functionlaboratory immunologyhealth sciencesepidemiology

Functional Immunophenotyping for Precision Therapies in Sepsis. Shock (2024)

Mahil RaoPatrick W. McGonagillScott BrackenridgeKenneth E. RemyCharles C. CaldwellRichard S. HotchkissLyle L. MoldawerThomas S. GriffithVladimir P. Badovinac

Stephanie SisakRyan C ChaeKamala E NelsonRebecca M SchusterEmma C PerezLisa G EnglandCharles C CaldwellAlex B LentschMichael D GoodmanTimothy A Pritts

microbiologyhematologyhemostasisblood transfusiondermatologytransfusion medicineendothelial cellsregenerative medicineimmunologyvascular biologyangiogenesisextracellular microvesiclesred blood cells

Surviving Septic Patients Endotyped With a Functional Assay Demonstrate Active Immune Responses. Frontiers in Immunology (2024)

septic patientsimmune responsesinfectious diseasesadaptive immune systemimmunologyimmunity (medicine)sepsisimmunopathology

Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by Elispot. Shock (2024)

temporal changesinfectious diseasesimmunologysepsispublic healthadaptive immunity

Whole Blood Storage Duration Alters Fibrinogen Levels and Thrombin Formation. Journal of Trauma and Acute Care Surgery (2024)

Ryan ChaeChristopher NguyenChad ArchdeaconLindsey WattleyStephanie SisakAdam PriceEmma PerezRebecca SchusterAlex LentschCharles CaldwellMichael GoodmanTimothy Pritts

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Timothy A. Pritts, MD, PHD

Institution

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sepsis

biliary tract

Melanie J. Scott

Institution

University of Pittsburgh

immune mediator

innate immune responses

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Institution

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immune response

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diagnosis

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Institution

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immune mediator

cell research

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inflammation

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emergency medicine

critical care