Faculty

Institution

Unit

Venue

Chad Shaw

Joint Professor

Rice University

Affiliations

George R. Brown School of Engineering

Statistics

Chad Shaw is a Professor in the Department of Genetics at Baylor College of Medicine, a Joint Professor of Statistics at Rice University, and a member of the faculty of the Neurological Research Institute at Texas Children’s Hospital. He earned his Ph.D. in Mathematical Statistics from Rice University in 2001. His research focuses on clinical exome sequencing efficacy, structural approaches to genetic heterogeneity, and the role of phase separation in variant pathogenicity. Recent work includes studies on congenital anomalies of the kidney and urinary tract, tetralogy of Fallot, and trained immunity in hematopoietic stem cells. He directs the D2K program and serves as Senior Director of Bioinformatics and Innovation at Baylor Genetics, with collaborations spanning institutions in the US, Europe, Asia, and Australia.

Honors

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Experiences

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Education

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Chad Shaw

Rice University

Joint Professor

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genetics genomics human genetics medical genetics molecular biology hematology gene expression developmental biology genome biology molecular genetics cell biology medicinal research cancer biology cardiology bioinformatics cancer genetics cytogenetics hemostasis molecular cancer thrombosis population genetics respiratory medicine mammalian biology rna biology cardiovascular research oncogenes molecular diagnostics vascular biology genetic disorders neonatology disease gene identification microarray data analysis prenatal diagnosis blood platelet cancer cells mutagenesis molecular physiology transcription regulation genome sequencing developmental genetics circulatory physiology stem cell research protein science dna sequencing gene regulation genomic medicine cell regulation epigenomics plo biology chronobiology comparative genomics genome analysis viral genetics transcriptomics technology phenotypic expansions applied genetics molecular regulation genome-wide association studies chromosomal rearrangements cardiovascular physiology genomic disorders chromosomal microarray analysis congenital diaphragmatic hernia mouse model renal function exome sequencing genomic architecture circadian clock mouse models array cgh complex rearrangements conventional cytogenetics array-comparative genomic hybridization transmission genetics genomic instability respiratory syncytial virus

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Clinical Exome Sequencing Efficacy and Phenotypic Expansions Involving Non-Isolated Congenital Anomalies of Kidney and Urinary Tract (Cakut+). European Journal of Human Genetics (2025)

urologyhuman geneticsdevelopmental anomaliesphenotypic expansionspediatric urologyurinary tracturogynecologynephrologygynecologyclinical exomeurological research

Detection of Clinically Relevant Monogenic Copy-Number Variants by a Comprehensive Genome-Wide Microarray With Exonic Coverage. Clinical Chemistry (2025)

Matthew Hoi Kin ChauStephanie A AndersonRodger SongLance CooperPatricia A WardBo YuanChad ShawPaweł StankiewiczSau Wai CheungLiesbeth VossaertYue WangNichole M OwenJanice SmithCarlos A BacinoKatharina V SchulzeWeimin Bi

geneticsbioinformaticsgenomicsclinical chemistrypopulation genomicsexonic coveragegenetic epidemiologygenome biologyclinical researchgenetic variationmolecular diagnosticscomprehensive genome-wide microarraymicroarray data analysis

Hematopoietic Stem and Progenitor Cells Confer Cross-Protective Trained Immunity in Mouse Models. iScience (2025)

Bailee N. KainBrandon T. TranPamela N. LunaRuoqiong CaoDuy T. LeMarcus A. FlorezLaure ManeixJack D. ToupsDaniel E. Morales-MantillaScott KohHyojeong HanRoman JaksikYun HuangAndre CaticChad A. ShawKatherine Y. King

health sciencesprogenitor cellsmouse modelscross-protective trained immunityimmunologyhematopoietic stemhematology

Non-Isolated Tetralogy of Fallot (Tof+): Exome Sequencing Efficacy and Phenotypic Expansions. European Journal of Human Genetics (2025)

geneticshuman geneticsfunctional genomicsmolecular geneticsgenomicsgenetic disordersphenotypic expansionsmedical geneticsdevelopmental biologynon-isolated tetralogy

Phase Separation Contributes to Pathogenicity for Nonsense Mediated Decay-Escaping Variant Alleles. medRxiv (2025)

geneticsgenetic mechanismspathogenesismolecular biologygenome biology

The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex Diseases. The American Journal of Human Genetics (2025)

geneticshuman geneticsforensic geneticsgenetic analysisgenotype-phenotype associationgenetic foundationvariant discoverybiostatisticshereditygenetic heterogeneitygenetic epidemiologygenome biologygenetic variationcomplex diseasescausal pivot

Wnt4 Deficiency Impacts Heart, Diaphragm, and Palate Development: Insights From Human Genetics, Machine Learning, and Mouse Models. Developmental Biology (2025)

geneticshuman geneticspalate developmentcongenital heart anomalycardiovascular researchmolecular medicinecongenital heart defectsmachine learningdevelopmental biology

3038 – Infection Activated Hematopoietic Stem Cells Mediate Trained Immunity. Experimental Hematology (2024)

Ruoqiong CaoBrandon TranBailee KainPamela LunaChad ShawKatherine King

immunity (medicine)infectious diseasesimmunologyimmune responseshematopoietic stem cellshematology

High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma. Investigative Ophthalmology & Visual Science (2024)

Bhavana KunisettyBailey A. Martin-GiacaloneXiaonan ZhaoPamela N. LunaBrian P. BrooksRobert B. HufnagelChad A. ShawJill A. RosenfeldA. J. AgopianPhilip J. LupoDaryl A. Scott

geneticsbioinformaticsgenomicsophthalmologytranslational bioinformaticsdna sequencingmolecular biologydiagnostic ratesmolecular diagnosticsnonisolated microphthalmia

Targeted Accurate Rna Consensus Sequencing (Tarc-Seq) Reveals Mechanisms of Replication Error Affecting Sars-Cov-2 Divergence. Nature Microbiology (2024)

Catherine C. BradleyChen WangAlasdair J. E. GordonAlice X. WenPamela N. LunaMatthew B. CookeBrendan F. KohrnScott R. KennedyVasanthi AvadhanulaPedro A. PiedraOlivier LichtargeChad A. ShawShannon E. RoncaChristophe Herman

geneticssars-cov-2microbiologyvirologybioinformaticsgenomicsmolecular geneticsviral evolutionreplication errormolecular microbiologyvirus researchmolecular biologydna sequencinggenome biologyviral replicationviral geneticsgeneral virology

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Chad Shaw

Joint Professor

Rice University

Affiliations

George R. Brown School of Engineering

Statistics

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Chad Shaw

Rice University

Joint Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Clinical Exome Sequencing Efficacy and Phenotypic Expansions Involving Non-Isolated Congenital Anomalies of Kidney and Urinary Tract (Cakut+). European Journal of Human Genetics (2025)

urologyhuman geneticsdevelopmental anomaliesphenotypic expansionspediatric urologyurinary tracturogynecologynephrologygynecologyclinical exomeurological research

Detection of Clinically Relevant Monogenic Copy-Number Variants by a Comprehensive Genome-Wide Microarray With Exonic Coverage. Clinical Chemistry (2025)

Hematopoietic Stem and Progenitor Cells Confer Cross-Protective Trained Immunity in Mouse Models. iScience (2025)

health sciencesprogenitor cellsmouse modelscross-protective trained immunityimmunologyhematopoietic stemhematology

Non-Isolated Tetralogy of Fallot (Tof+): Exome Sequencing Efficacy and Phenotypic Expansions. European Journal of Human Genetics (2025)

geneticshuman geneticsfunctional genomicsmolecular geneticsgenomicsgenetic disordersphenotypic expansionsmedical geneticsdevelopmental biologynon-isolated tetralogy

Phase Separation Contributes to Pathogenicity for Nonsense Mediated Decay-Escaping Variant Alleles. medRxiv (2025)

geneticsgenetic mechanismspathogenesismolecular biologygenome biology

The Causal Pivot: A Structural Approach to Genetic Heterogeneity and Variant Discovery in Complex Diseases. The American Journal of Human Genetics (2025)

Wnt4 Deficiency Impacts Heart, Diaphragm, and Palate Development: Insights From Human Genetics, Machine Learning, and Mouse Models. Developmental Biology (2025)

geneticshuman geneticspalate developmentcongenital heart anomalycardiovascular researchmolecular medicinecongenital heart defectsmachine learningdevelopmental biology

3038 – Infection Activated Hematopoietic Stem Cells Mediate Trained Immunity. Experimental Hematology (2024)

Ruoqiong CaoBrandon TranBailee KainPamela LunaChad ShawKatherine King

immunity (medicine)infectious diseasesimmunologyimmune responseshematopoietic stem cellshematology

High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma. Investigative Ophthalmology & Visual Science (2024)

Bhavana KunisettyBailey A. Martin-GiacaloneXiaonan ZhaoPamela N. LunaBrian P. BrooksRobert B. HufnagelChad A. ShawJill A. RosenfeldA. J. AgopianPhilip J. LupoDaryl A. Scott

geneticsbioinformaticsgenomicsophthalmologytranslational bioinformaticsdna sequencingmolecular biologydiagnostic ratesmolecular diagnosticsnonisolated microphthalmia

Targeted Accurate Rna Consensus Sequencing (Tarc-Seq) Reveals Mechanisms of Replication Error Affecting Sars-Cov-2 Divergence. Nature Microbiology (2024)

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