Faculty

Institution

Unit

Venue

Brian E. Wadzinski

Associate Professor

Vanderbilt University

Affiliations

School of Medicine

Department of Pharmacology

Brian E. Wadzinski is currently serving as a Pharmacology Associate Professor at Vanderbilt University.

Honors

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Experiences

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Education

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Brian E. Wadzinski

Vanderbilt University

Associate Professor

You can click a keyword to filter the displayed items

biochemistry molecular biology signal transduction enzymes protein science cell signaling protein phosphorylation biological chemistry pharmacology neuroscience molecular regulation membrane biology enzyme inhibition molecular physiology protein function signaling pathways gene expression protein expression structural biology medicinal research cell regulation molecular neuroscience mammalian biology biochemical sciences insulin signaling redox biology tumor biology cell metabolism enzyme catalysis liver physiology molecular metabolism cellular physiology protein chemistry cell death insect molecular biology gene regulation neurochemistry biomolecular interactions molecular neurobiology transcription regulation biocatalysis cellular neurobiology apoptosis pathway analysis protein transport brain protein positive regulation oncogenes brain science functional regulation clinical neuroscience membrane transport biomolecular analysis nanobiotechnology subcellular localization developmental regulation novel subunit catalytic subunit protein phosphatases molecular cancer in vivo systems gene function cytokines enzyme specificity protein purification endocrine research antibody engineering catalytic subunits mammalian cells differential inactivation regulated complexes rat liver distinct mechanisms proapoptotic function functional complex o-glcnac transferase protein phosphatase structure-function enzyme kinetics protein structure cell biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Phosphatase Activity of the Ppp2R5D-Pp2A Holoenzyme Modulates Liprin-α1 Liquid-Liquid Phase Separation. Journal of Biological Chemistry (2025)

lipidsbiological macromoleculeslipid chemistryprotein phase separationenzymesmolecular metabolismbiomoleculesphosphatase activitybiochemistrycell metabolismppp2r5d-pp2a holoenzymemolecular biologybiological chemistrybiophysical chemistrycellular biochemistry

A Nanobody Toolbox for Recognizing Distinct Epitopes on Cas9. Journal of Molecular Biology (2024)

Jack BoylanRebecca A ShremIsabel C Vallecillo-ViejoCraig L DuvallBrian E WadzinskiBenjamin W Spiller

nanobody toolboxnanotechnologydistinct epitopesmaterials science

B56D Long-Disordered Arms Form a Dynamic Pp2A Regulation Interface Coupled With Global Allostery and Jordan’s Syndrome Mutations. Proc. Natl. Acad. Sci. U.S.A. (2024)

syndrome mutationsgenetic disordersb56d long-disordered armscell signalingdisease gene identificationglobal allosterymolecular cell biologymolecular biologysystems biologysignal transductionstructural molecular biology

Discovery of Nanosota-9 as Anti-Omicron Nanobody Therapeutic Candidate. PLoS Pathogens (2024)

Gang YeFan BuDivyasha SaxenaHailey Turner-HubbardMorgan HerbstBenjamin SpillerBrian E. WadzinskiLanying DuBin LiuJian ZhengFang Li

infectious diseasesnanoparticlesnanomedicinenanotechnologymedicinal researchtherapeutic targetsnanoparticle researchtherapeutic nanomaterialsnanobiotechnology

Discovery of Nanosota-Eb1 and -Eb2 as Novel Nanobody Inhibitors Against Ebola Virus Infection. PLoS Pathogens (2024)

Fan BuGang YeKimberly MorsheimerAlise MendozaHailey Turner-HubbardMorgan HerbstBenjamin SpillerBrian E. WadzinskiBrett EatonManu AnantpadmaGe YangBin LiuRobert DaveyFang Li

antiviral drug developmentnanotechnologypharmacologytherapeutic targetsebola virus infectioninfectious diseasesdrug discoverynanoparticle researchnanoparticlesnanomedicinemedicinal researchantiviral drugsantiviral therapytherapeutic nanomaterialsnovel nanobody inhibitorsnanobiotechnologyvirus researchantiviral researchbiomolecular engineering

Neuronal Protein Phosphatase 1β Regulates Glutamate Release, Cortical Myelination, Node of Ranvier Formation, and Action Potential Propagation in the Optic Nerve. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Cody McKeeKarl FoleyKatherine M. AndershOlivia J. MarolaBrian WadzinskiRichard T. LibbyPeter ShragerHouhui Xia

biophysicsneurologyneurochemistrysystems neuroscienceneuroanatomycellular neurobiologycognitive neuroscienceneurosciencemolecular neurobiologyranvier formationneurophysiologyoptic nerveaction potential propagationmolecular neurosciencecortical myelination

Structure-Guided in Vitro Evolution of Nanobodies Targeting New Viral Variants. PLoS Pathogens (2024)

Gang YeFan BuRuangang PanAlise MendozaGe YangBenjamin SpillerBrian E WadzinskiLanying DuStanley PerlmanBin LiuFang Li

nanotechnologymolecular biologyviral evolutionvirus research

Targeting Soluble Amyloid-Beta Oligomers With a Novel Nanobody. Scientific Reports (2024)

Justin R HaynesClayton A WhitmoreWilliam J BehofCharlotte A LandmanHenry H OngAndrew P FeldIsabelle C SueroCeleste B GreerJohn C GorePrintha WijesingheJoanne A MatsubaraBrian E WadzinskiBenjamin W SpillerWellington Pham

nanotechnologyneurosciencemolecular biologysoluble amyloid-beta oligomersnanobiotechnology

The Role of Liprin-α1 Phosphorylation in Its Liquid-Liquid Phase Separation: Regulation by Ppp2R5D/Pp2A Holoenzyme. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Abigail MayerRita DeruaElijah SpahnIris VerbinnenYang ZhangBrian WadzinskiMark R. SwingleRichard HonkanenVeerle JanssensHouhui Xia

biophysicslipidslipid chemistryenzymesprotein phosphorylationprotein scienceproteinlipid interactionmembrane proteinsbiochemistrymolecular biophysicsmolecular physiologymembrane biologylipid sciencebiochemical sciencesmolecular biologyliquid-liquid phase separationphase separation

B56δ Long-Disordered Arms Form a Dynamic Pp2A Regulation Interface Coupled With Global Allostery and Jordan’s Syndrome Mutations. Proceedings of the National Academy of Sciences (2023)

Cheng-Guo WuVijaya K. BalakrishnanRonald A. MerrillPankaj S. PariharKirill KonovolovYu-Chia ChenZhen XuHui WeiRamya SundaresanQiang CuiBrian E. WadzinskiMark R. SwingleAlla MusiyenkoWendy K. ChungRichard E. HonkanenAussie SuzukiXuhui HuangStefan StrackYongna Xing

stem cell researchdisease progressionneurosciencemolecular geneticshuman geneticsimmunogeneticsgeneticssyndrome mutationsneurogeneticstumor biologycell biologymolecular sciencemedicinal researchhistocompatibilitysomatic variantgenetic disordersprotein sciencehepatologyglobal allosterymammalian biology

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Brian E. Wadzinski

Associate Professor

Vanderbilt University

Affiliations

School of Medicine

Department of Pharmacology

Brian E. Wadzinski is currently serving as a Pharmacology Associate Professor at Vanderbilt University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Brian E. Wadzinski

Vanderbilt University

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

The Phosphatase Activity of the Ppp2R5D-Pp2A Holoenzyme Modulates Liprin-α1 Liquid-Liquid Phase Separation. Journal of Biological Chemistry (2025)

A Nanobody Toolbox for Recognizing Distinct Epitopes on Cas9. Journal of Molecular Biology (2024)

Jack BoylanRebecca A ShremIsabel C Vallecillo-ViejoCraig L DuvallBrian E WadzinskiBenjamin W Spiller

nanobody toolboxnanotechnologydistinct epitopesmaterials science

B56D Long-Disordered Arms Form a Dynamic Pp2A Regulation Interface Coupled With Global Allostery and Jordan’s Syndrome Mutations. Proc. Natl. Acad. Sci. U.S.A. (2024)

Discovery of Nanosota-9 as Anti-Omicron Nanobody Therapeutic Candidate. PLoS Pathogens (2024)

Gang YeFan BuDivyasha SaxenaHailey Turner-HubbardMorgan HerbstBenjamin SpillerBrian E. WadzinskiLanying DuBin LiuJian ZhengFang Li

infectious diseasesnanoparticlesnanomedicinenanotechnologymedicinal researchtherapeutic targetsnanoparticle researchtherapeutic nanomaterialsnanobiotechnology

Discovery of Nanosota-Eb1 and -Eb2 as Novel Nanobody Inhibitors Against Ebola Virus Infection. PLoS Pathogens (2024)

Fan BuGang YeKimberly MorsheimerAlise MendozaHailey Turner-HubbardMorgan HerbstBenjamin SpillerBrian E. WadzinskiBrett EatonManu AnantpadmaGe YangBin LiuRobert DaveyFang Li

Cody McKeeKarl FoleyKatherine M. AndershOlivia J. MarolaBrian WadzinskiRichard T. LibbyPeter ShragerHouhui Xia

Structure-Guided in Vitro Evolution of Nanobodies Targeting New Viral Variants. PLoS Pathogens (2024)

Gang YeFan BuRuangang PanAlise MendozaGe YangBenjamin SpillerBrian E WadzinskiLanying DuStanley PerlmanBin LiuFang Li

nanotechnologymolecular biologyviral evolutionvirus research

Targeting Soluble Amyloid-Beta Oligomers With a Novel Nanobody. Scientific Reports (2024)

nanotechnologyneurosciencemolecular biologysoluble amyloid-beta oligomersnanobiotechnology

The Role of Liprin-α1 Phosphorylation in Its Liquid-Liquid Phase Separation: Regulation by Ppp2R5D/Pp2A Holoenzyme. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Abigail MayerRita DeruaElijah SpahnIris VerbinnenYang ZhangBrian WadzinskiMark R. SwingleRichard HonkanenVeerle JanssensHouhui Xia

B56δ Long-Disordered Arms Form a Dynamic Pp2A Regulation Interface Coupled With Global Allostery and Jordan’s Syndrome Mutations. Proceedings of the National Academy of Sciences (2023)

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protein phosphorylation

lipid second messengers

Gary Johnson

Institution

University of North Carolina at Chapel Hill

mapk kinase

apoptosis

Palmer Taylor

Institution

University of California, San Diego

medicinal chemistry

chemistry

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huntington's disease

James R. Goldenring

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psychoneuroendocrinology

Suresh C. Tyagi

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health science

cardiovascular translational research

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molecular metabolism

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