Faculty

Institution

Unit

Venue

Akiko Hata

Professor

University of California, San Francisco

Affiliations

Cardiovascular Research Institute

Akiko Hata is currently serving as a Cardiovascular Research Institute Professor at University of California, San Francisco.

Honors

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Experiences

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Education

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Akiko Hata

University of California, San Francisco

Professor

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molecular biology gene expression vascular biology cell biology systems biology genetics tumor biology cell signaling molecular and cellular biology oncogenes stem cell research microrna detection receptors signal transduction bone research bone morphogenic protein non-coding rna medicinal research molecular cell biology rna biology signaling pathways small rna cancer cells biological chemistry protein science cancer biology membrane biology cardiovascular research angiogenesis tumor microenvironment molecular cancer molecular physiology cancer genetics tumor suppressors cancer discovery thrombosis gene regulation cell regulation bone morphogenetic protein enzyme inhibition mammalian biology bone metabolism vascular disease smad proteins host specificity gene function functional regulation receptor tyrosine kinases pulmonary diseases bone homeostasis disease susceptibility pulmonary circulation microrna biogenesis long non-coding rna molecular basis receptor (biochemistry) vascular aging host factors molecular regulation cancer growth cancer genomics molecular neurobiology cellular biology drosha-mediated microrna maturation structural basis smooth muscle cells atrial natriuretic peptide therapeutic ultrasound hereditary hemorrhagic telangiectasia tgf-b signalling pathways bmp-regulated transcriptional activator mutational inactivation separate bmp-smad olf signaling pathways protein-binding zinc fingers oaz uses growth factor cellular differentiation physiology vascular homeostasis vascular adaptation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Depletion of Protein Phosphatase 1 Results in Persistent Activation of the Integrated Stress Response and Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Amit PrabhakarMeetu WadhwaPrajakta GhatpandeRahul KumarBrian B. GrahamGiorgio LagnaAkiko Hata

physiologyintegrated stress responsestress (biology)age-associated exacerbationmolecular biologypulmonary veno-occlusive disease

Mechanisms Underlying Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease. JCI Insight (2024)

Amit PrabhakarMeetu WadhwaRahul KumarPrajakta GhatpandeAneta GandjevaRubin M TuderBrian B GrahamGiorgio LagnaAkiko Hata

pulmonary diseasesage-associated exacerbationaging-associated diseasesdisease susceptibilitycritical carepulmonary veno-occlusive disease

Reply to the Letter to the Editor Entitled “Bridging the Species Divide: The Limits of Rat Models in Capturing Human Pvod Mechanisms” by Perros F. Et Al.. Pulmonary Circulation (2024)

Amit PrabhakarRahul KumarMeetu WadhwaRubin M. TuderNicholas W. MorrellBrian B. GrahamGiorgio LagnaAkiko Hata

human pvod mechanismsphysiologypulmonary circulationrespiratory medicinerat models

Reversal of Pulmonary Veno-Occlusive Disease Phenotypes by Inhibition of the Integrated Stress Response. Nature Cardiovascular Research (2024)

Amit PrabhakarRahul KumarMeetu WadhwaPrajakta GhatpandeJingkun ZhangZiwen ZhaoCarlos O. LizamaBhushan N. KharbikarStefan GräfCarmen M. TreacyNicholas W. MorrellBrian B. GrahamGiorgio LagnaAkiko Hata

cardiovascular diseaseepidemiologyimmunologypulmonary vascular diseasethoracic oncologyvascular biologyintegrated stress responsechronic obstructive pulmonary diseaseinterstitial lung diseaseoxidative stresspulmonary pharmacologypublic healthcardiologypulmonary diseasesrespiratory medicinepreventive cardiologycardiovascular researchadvanced lung diseasestress (biology)

Essential Role of the Amino-Terminal Region of Drosha for the Microprocessor Function. iScience (2023)

Amit PrabhakarSong HuJin TangPrajakta GhatpandeGiorgio LagnaXuan JiangAkiko Hata

amino-terminal regionmolecular biologymicroprocessor functionprotein structure

Development and Characterization of Type I, Type II, and Type III Lim-Kinase Chemical Probes. Journal of Medicinal Chemistry (2022)

Thomas HankeSebastian MatheaJulia WoortmanEidarus SalahBenedict-Tilman BergerAnthony TumberRisa KashimaAkiko HataBernhard KusterSusanne MüllerStefan Knapp

single-molecule detectionmolecular engineeringmolecular dockingpharmaceutical chemistryenzymespeptideschemical biologymolecular biologydrug discoverynanoparticle researchreceptor tyrosine kinasesmedicinal chemistrychemical probessystems biologytype iiprotein sciencepeptide scienceenzyme inhibitionbiomolecular engineering

Combination Therapy With Stat3 Inhibitor Enhances Serca2A-Induced Bmpr2 Expression and Inhibits Pulmonary Arterial Hypertension. International Journal of Molecular Sciences (2021)

Malik BisserierMichael G. KatzCarlos Bueno-BetiAgnieszka BrojakowskaShihong ZhangSarah GubaraErik KohlbrennerShahood FazalAnthony FargnoliPeter DorfmullerMarc HumbertAkiko HataDavid A. GoukassianYassine SassiLahouaria Hadri

cardiovascular pharmacologycardiologymolecular medicinerespiratory medicinemedicinal researchcombination therapypulmonary arterial hypertensionmolecular biologypharmacologymolecular pharmacology

Control of Ribosomal Protein Synthesis by the Microprocessor Complex. Science Signaling (2021)

Xuan JiangAmit PrabhakarStephanie M. Van der VoornPrajakta GhatpandeBarbara CelonaSrivats VenkataramananLorenzo CalvielloChuwen LinWanpeng WangBrian L. BlackStephen N. FloorGiorgio LagnaAkiko Hata

biological macromoleculescomputational biologyribosomal protein synthesismicroprocessor complexprotein sciencesynthetic biologysignaling pathwaysbiochemistryprotein assemblybiological computingprotein engineeringmolecular biologyprotein synthesisprotein structuresystems biologystructural molecular biologystructural biologyprotein biosynthesis

How Do You Mend Inactive Tumor Suppressor Mutants? You Glue Them!. Cell chemical biology (2021)

Akiko HataGiorgio Lagna

chemical biologytumor suppressorstumor biologybiochemistry

Structural Basis for Alk2/Bmpr2 Receptor Complex Signaling Through Kinase Domain Oligomerization. Nature Communications (2021)

Christopher AgnewPelin AyazRisa KashimaHanna S. LovingPrajakta GhatpandeJennifer E. KungEric S. UnderbakkeYibing ShanDavid E. ShawAkiko HataNatalia Jura

kinase domain oligomerizationstructural molecular biologycell signalingimmunologycell biologymembrane biologypharmacologyprotein structurestructural basisreceptorsstructural biology

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Akiko Hata

Professor

University of California, San Francisco

Affiliations

Cardiovascular Research Institute

Akiko Hata is currently serving as a Cardiovascular Research Institute Professor at University of California, San Francisco.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Akiko Hata

University of California, San Francisco

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Amit PrabhakarMeetu WadhwaPrajakta GhatpandeRahul KumarBrian B. GrahamGiorgio LagnaAkiko Hata

physiologyintegrated stress responsestress (biology)age-associated exacerbationmolecular biologypulmonary veno-occlusive disease

Mechanisms Underlying Age-Associated Exacerbation of Pulmonary Veno-Occlusive Disease. JCI Insight (2024)

Amit PrabhakarMeetu WadhwaRahul KumarPrajakta GhatpandeAneta GandjevaRubin M TuderBrian B GrahamGiorgio LagnaAkiko Hata

pulmonary diseasesage-associated exacerbationaging-associated diseasesdisease susceptibilitycritical carepulmonary veno-occlusive disease

Reply to the Letter to the Editor Entitled “Bridging the Species Divide: The Limits of Rat Models in Capturing Human Pvod Mechanisms” by Perros F. Et Al.. Pulmonary Circulation (2024)

Amit PrabhakarRahul KumarMeetu WadhwaRubin M. TuderNicholas W. MorrellBrian B. GrahamGiorgio LagnaAkiko Hata

human pvod mechanismsphysiologypulmonary circulationrespiratory medicinerat models

Reversal of Pulmonary Veno-Occlusive Disease Phenotypes by Inhibition of the Integrated Stress Response. Nature Cardiovascular Research (2024)

Amit PrabhakarRahul KumarMeetu WadhwaPrajakta GhatpandeJingkun ZhangZiwen ZhaoCarlos O. LizamaBhushan N. KharbikarStefan GräfCarmen M. TreacyNicholas W. MorrellBrian B. GrahamGiorgio LagnaAkiko Hata

Essential Role of the Amino-Terminal Region of Drosha for the Microprocessor Function. iScience (2023)

Amit PrabhakarSong HuJin TangPrajakta GhatpandeGiorgio LagnaXuan JiangAkiko Hata

amino-terminal regionmolecular biologymicroprocessor functionprotein structure

Development and Characterization of Type I, Type II, and Type III Lim-Kinase Chemical Probes. Journal of Medicinal Chemistry (2022)

Thomas HankeSebastian MatheaJulia WoortmanEidarus SalahBenedict-Tilman BergerAnthony TumberRisa KashimaAkiko HataBernhard KusterSusanne MüllerStefan Knapp

Combination Therapy With Stat3 Inhibitor Enhances Serca2A-Induced Bmpr2 Expression and Inhibits Pulmonary Arterial Hypertension. International Journal of Molecular Sciences (2021)

cardiovascular pharmacologycardiologymolecular medicinerespiratory medicinemedicinal researchcombination therapypulmonary arterial hypertensionmolecular biologypharmacologymolecular pharmacology

Control of Ribosomal Protein Synthesis by the Microprocessor Complex. Science Signaling (2021)

Xuan JiangAmit PrabhakarStephanie M. Van der VoornPrajakta GhatpandeBarbara CelonaSrivats VenkataramananLorenzo CalvielloChuwen LinWanpeng WangBrian L. BlackStephen N. FloorGiorgio LagnaAkiko Hata

How Do You Mend Inactive Tumor Suppressor Mutants? You Glue Them!. Cell chemical biology (2021)

Akiko HataGiorgio Lagna

chemical biologytumor suppressorstumor biologybiochemistry

Structural Basis for Alk2/Bmpr2 Receptor Complex Signaling Through Kinase Domain Oligomerization. Nature Communications (2021)

Christopher AgnewPelin AyazRisa KashimaHanna S. LovingPrajakta GhatpandeJennifer E. KungEric S. UnderbakkeYibing ShanDavid E. ShawAkiko HataNatalia Jura

kinase domain oligomerizationstructural molecular biologycell signalingimmunologycell biologymembrane biologypharmacologyprotein structurestructural basisreceptorsstructural biology

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proteome research

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