Faculty

Institution

Unit

Venue

Huimin Zhao

Professor

UIUC

Affiliations

The Grainger College of Engineering

Bioengineering

Department of Bioengineering

College of Liberal Arts & Sciences

Department of Chemical and Biomolecular Engineering

School of Chemical Sciences

Department of Chemical and Biomolecular Engineering

Huimin Zhao is currently serving as a Bioengineering Professor at Uiuc.

Honors

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Experiences

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Education

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Huimin Zhao

UIUC

Professor

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biomolecular engineering biochemistry biotechnology molecular biology biosynthesis microbial cell factory enzymes biological engineering synthetic biology biochemical engineering metabolic engineering biomolecules pathway engineering process biochemistry genome biology biotechnology advance genome editing nucleic acids genetic engineering biocatalysis molecular metabolism natural product biosynthesis yeast enzyme catalysis biological chemistry directed evolution gene editing biochemical sciences molecular cell biology chemical biotechnology bioproducts enzyme inhibition crispr organic process research protein science fungal genetics structural molecular biology structure-function enzyme kinetics fungal cell factory synthetic circuits molecular biotechnology biotransformation microbial physiology natural product synthesis metabolic models escherichia coli metabolic networks genetic technologies molecular microbiology enzymatic modification metabolic pathway analysis protein evolution enzyme specificity sequence assembly protein biosynthesis transcription regulation cellular enzymology alcohol dehydrogenases chromatin remodeling photoredox process recent advances saccharomyces cerevisiae triacetic acid lactone dna computing biological systems crispr/cas9 system genome mining dna assembler aminopyrrolnitrin oxygenase active site directed enzyme evolution industrial biocatalysis gene deletion sickle cell disease fatty acids yeast strain multidisciplinary ai technology artificial life machine intelligence industrial artificial intelligence laboratory automation

Notable Scholarly Works

Notable Federal Grants

Collaborators

ACCFG: Accurate Functional Group Extraction and Molecular Structure Comparison. Journal of Chemical Information and Modeling (2025)

Xuan LiuSarathkrishna SwaminathanDmitry ZubarevBrandi RansomNathaniel ParkKristin SchmidtHuimin Zhao

molecular recognitionbioinformaticsmolecular structuresmall moleculesmolecular structure comparisonbiochemistryprotein bioinformaticsmolecular informaticsmolecular biologymolecular modellingfunctional groupsaccfg generates

A Generalized Platform for Artificial Intelligence-Powered Autonomous Enzyme Engineering. Nature Communications (2025)

Nilmani SinghStephan LaneTianhao YuJingxia LuAdrianna RamosHaiyang CuiHuimin Zhao

synthetic circuitsenzymesbiotechnology advancebiomolecular engineeringgeneralized platformbiotechnology

A Unified Mechanism Reveals the Evolutionary Origin of Enoyl Isomerases. ACS Catalysis (2025)

Bing ChenJinwei RenHuimin ZhaoBin Wang

molecular evolutionenzymesenoyl isomeraseschemical biologyenzyme catalysisbioorganic chemistrybiomolecular structuredirected evolutionbiological chemistrybiochemistrybiomoleculesstructure-function enzyme kineticsenzymatic modificationmolecular biology

Chemoenzymatic Synthesis Planning Guided by Synthetic Potential Score. Digital Discovery (2025)

Xuan LiuHongxiang LiHuimin Zhao

organic process researchbiomolecular engineeringchemical synthesisefficient synthesis planningmedicinal chemistrycombinatorial chemistrysynthetic chemistrybiomoleculesbiochemistrysynthetic potential scorechemoenzymatic synthesis planning

Combining Chemical Catalysis With Enzymatic Steps for the Synthesis of the Artemisinin Precursor Dihydroartemisinic Acid. ACS Synthetic Biology (2025)

Vikas UpadhyayHongxiang LiJiachen HeBlake Edward OcampoSilas CookHuimin ZhaoCostas D. Maranas

enzymesbiocatalysischemical synthesismedicinal chemistryworld health organizationbiochemistrypharmacologyorganic synthesisnatural product biosynthesisnatural product researchchemical catalysisenzyme inhibitionnatural product synthesisenzymatic steps

Decompartmentalization of the Yeast Mitochondrial Metabolism to Improve Chemical Production in Issatchenkia Orientalis. Nature Communications (2025)

Vinh G TranShih-I TanHao XuDaniel R WeilandtXi LiSarang S BhagwatZhixin ZhuJeremy S GuestJoshua D RabinowitzHuimin Zhao

metabolic pathwaysmitochondrial nadhmetabolismmolecular metabolismmicrobial cell factorybiological engineeringyeast mitochondrial metabolismbiochemical engineeringbioenergeticsbiochemistryfungal cell factoryprocess biochemistrynatural product biosynthesispathway engineeringcell metabolismmitochondrial metabolismmetabolic engineering

Design of Diverse, Functional Mitochondrial Targeting Sequences Across Eukaryotic Organisms Using Variational Autoencoder. Nature Communications (2025)

Aashutosh Girish BoobShih-I TanAirah ZaidiNilmani SinghXueyi XueShuaizhen ZhouTeresa A MartinLi-Qing ChenHuimin Zhao

bioinformaticsprotein sciencedirected evolutionmitochondrial dynamicssystems biologymolecular biologycell metabolismprotein designcomputational biologymolecular informaticsartificial peptidesproteome researchmolecular metabolismbiomolecular engineeringlocalization efficiencyvariational autoencodersynthetic biologyprotein engineeringmitochondrial biogenesis

Discovery and Characterization of Oxazolismycin, an Oxazole-Containing Natural Product With an Atypical Loading Mechanism. JACS Au (2025)

Yuwei PanGuangde JiangChunshuai HuangHuimin Zhao

oxazole-pyridine scaffoldcollismycin biosynthesispharmaceutical chemistrybiomolecular engineeringbiocatalysischemical biologypyridine-based np biosynthesisbiosynthesisbiological chemistrybiochemistrynatural product biosynthesisenzyme inhibitiondrug discoverynatural product synthesis

Discovery, Characterization, and Application of Chromosomal Integration Sites for Stable Heterologous Gene Expression in Rhodotorula Toruloides. Metabolic Engineering (2025)

Hao XuLongyuan ShiAashutosh Girish BoobWooyoung ParkShih-I TanVinh Gia TranJohn Carl SchultzHuimin Zhao

biochemical sciencesrhodotorula toruloidesgene expressionmolecular geneticsbiomolecular engineeringfungal geneticsmolecular biological methodchromosomal integration sitesmolecular biologymolecular research

Engineering Oleaginous Yeast Rhodotorula Toruloides for Production of Alkanes and Alkenes. Metabolic Engineering (2025)

Yi YuQuan YuanJing DaiHuimin ZhaoShuobo Shi

biomanufacturingbioproductsbiomolecular engineeringchemical biotechnologybioresource technologymicrobial cell factoryyeastbiological engineeringbiochemical engineeringbiosynthesisfungal cell factoryprocess biochemistrybiotechnologyoleaginous yeast rhodotorula