Faculty

Institution

Unit

Venue

Yoshikazu Takada

Professor

University of California, Davis

Affiliations

School of Medicine

Biochemistry and Molecular Medicine

Yoshikazu Takada is currently serving as a Biochemistry And Molecular Medicine Professor at University of California, Davis.

Honors

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Experiences

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Education

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Yoshikazu Takada

University of California, Davis

Professor

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pharmacology cell biology immunology biochemistry structural biology biological chemistry cell signaling gene expression tumor biology membrane biology protein science protein structure receptors medicinal research signal transduction integrative biology cancer biology vascular biology biomolecular interactions molecular cancer cellular biology cell adhesion virus-host interactions insulin signaling angiogenesis cell regulation biochemical sciences cellular physiology antibody engineering cell-matrix interactions direct binding cellular biochemistry protein function signaling pathways cancer genetics clinical biochemistry receptor (biochemistry) tumor targeting matrix biology redox biology general virology avian biology cell research cancer growth molecular regulation liver physiology cell physiology immunochemistry viral genetics cell migration protein chemistry cell interactions fibroblast growth factors molecular immunology bone research blood platelet host specificity biological inorganic chemistry protein transport in vivo systems ligand binding hla typing cell-cell interaction primary structure tissue factor cell entry vla family integrin alpha specific interaction endothelial cells plasmin-induced migration tumor cells differential regulation critical residues aiib subunit ligand recognition cell growth molecular cell biology developmental biology extracellular matrix

Notable Scholarly Works

Notable Federal Grants

Collaborators

Fgf1 Suppresses Allosteric Activation of β3 Integrins by Fgf2: A Potential Mechanism of Anti-Inflammatory and Anti-Thrombotic Action of Fgf1. Biomolecules (2024)

Yoko K. TakadaXuesong WuDavid WeiSamuel HwangYoshikazu Takada

potential mechanisminflammationanti-inflammatorythrombosisbiochemistrymolecular biologysystems biologybiomoleculesanti-thrombotic action

Fgf2 Binds to the Allosteric Site (Site 2) and Activates Integrin αIibβ3 and Fgf1 Binds to Site 2 but Suppresses Integrin Activation by Fgf2: A Potential Mechanism of Anti-Thrombotic Action of Fgf1. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Yoko K TakadaXueson WuDavid WeiSamuel HwangYoshikazu Takada

thrombosiscell regulationbiomolecular interactionshematologyprotein scienceanti-thrombotic actionfunctional modificationvenous thrombosispharmacologyreceptorspotential mechanismgene expressioninflammationfibroblast growth factorsimmunologyallosteric siteenzyme inhibitionmolecular biologyadhesion

Fgf9, a Potent Mitogen, is a New Ligand for Integrin αVβ3, and the Fgf9 Mutant Defective in Integrin Binding Acts as an Antagonist. Cells (2024)

Chih-Chieh ChangYoko K. TakadaChao-Wen ChengYukina MaekawaSeiji MoriYoshikazu Takada

geneticspharmacologymembrane biologyreceptorsgene expressioncell-matrix interactionsin vivo systemsenzyme inhibitioncellular biologycellular physiologycell interactionspotent mitogencell signalingcell biologycell and molecular biologyinhibitory activity

The Heparin-Binding Domain of Vegf165 Directly Binds to Integrin αVβ3 and Vegfr2/Kdr D1: A Potential Mechanism of Negative Regulation of Vegf165 Signaling by Αvβ3. Frontiers in Cell and Developmental Biology (2024)

Yoko K. TakadaJessica YuXiaojin YeChun-Yi WuBrunie H. FeldingMasaaki FujitaYoshikazu Takada

developmental sciencecellular physiologycell regulationcell biologygeneticsdevelopmental biologycell lineagecell researchreceptorspotential mechanismgene expressionheparin-binding domainvirus researchsignaling pathwaysmammalian biologymolecular regulationcell and molecular biologysignal transductionprotein functioncell signalingnegative regulation

Cd40L Activates Platelet Integrin αIibβ3 by Binding to the Allosteric Site (Site 2) in a Kgd-Independent Manner and Higm1 Mutations Are Clustered in the Integrin-Binding Sites of Cd40l. Cells (2023)

Yoko K. TakadaMichiko ShimodaYoshikazu Takada

cell transplantationintegrin-binding sitescellular physiologycell biologyhematologygeneticscell-matrix interactionscell interactionscell researchkgd-independent mannermolecular cell biologyblood plateletgene expressionprotein structurecellular therapyallosteric sitecellular biologyhla typingmolecular biologymembrane proteinscell signaling

Data From Optimization of Rgd-Containing Cyclic Peptides Against αVβ3 Integrin. (2023)

Yan WangWenwu XiaoYonghong ZhangLeah MezaHarry TsengYoshikazu TakadaJames B. AmesKit S. Lam

rgd-containing cyclic peptidespharmacologyreceptorsbiological engineering

Data From the Use of One-Bead One-Compound Combinatorial Library Technology to Discover High-Affinity αVβ3 Integrin and Cancer Targeting Arginine-Glycine-Aspartic Acid Ligands With a Built-in Handle. (2023)

Wenwu XiaoYan WangEdmond Y. LauJuntao LuoNianhuan YaoChangying ShiLeah MezaHarry TsengYoshiko MaedaPappanaicken KumaresanRuiwu LiuFelice C. LightstoneYoshikazu TakadaKit S. Lam

medicinal chemistrypharmacologycancer immunotherapytumor targetingdrug discoverybiostatisticsarginine-glycine-aspartic acidtumor biologyimmunologybuilt-in handletherapeutic targets

Secreted Phospholipase A2 Type Iia (Spla2-Iia) Binds to the Allosteric Site (Site 2) of Integrins and Activates Integrins in an Allosteric Manner. Elsevier eBooks (2023)

Yoshikazu TakadaMasaaki FujitaYoko K. Takada

pharmacologymembrane biologygene expressionsignal transductionprotein secretionfunctional modificationreceptor (biochemistry)enzyme inhibitionbiochemistrylocalized excited statecell signalingallosteric siteallosteric mannercell biologyenzymesprotein sciencesecretory pathway

Supplementary Tables S1-S7; Supplementary Figures S1-S2; and Supplementary Materials Methods From Optimization of Rgd-Containing Cyclic Peptides Against αVβ3 Integrin. (2023)

Yan WangWenwu XiaoYonghong ZhangLeah MezaHarry TsengYoshikazu TakadaJames B. AmesKit S. Lam

rgd-containing cyclic peptidespharmacologyreceptorssupplementary tablesbiomolecular engineeringprotein science

The C-Type Lectin Domain of Cd62P (P-Selectin) Functions as an Integrin Ligand. Life Science Alliance (2023)

Yoko K TakadaScott I SimonYoshikazu Takada

biologybiophysicsstructural biologyprotein structurec-type lectin domainintegrin ligandmolecular biologyprotein science

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Yoshikazu Takada

Professor

University of California, Davis

Affiliations

School of Medicine

Biochemistry and Molecular Medicine

Yoshikazu Takada is currently serving as a Biochemistry And Molecular Medicine Professor at University of California, Davis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Yoshikazu Takada

University of California, Davis

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Fgf1 Suppresses Allosteric Activation of β3 Integrins by Fgf2: A Potential Mechanism of Anti-Inflammatory and Anti-Thrombotic Action of Fgf1. Biomolecules (2024)

Yoko K. TakadaXuesong WuDavid WeiSamuel HwangYoshikazu Takada

potential mechanisminflammationanti-inflammatorythrombosisbiochemistrymolecular biologysystems biologybiomoleculesanti-thrombotic action

Yoko K TakadaXueson WuDavid WeiSamuel HwangYoshikazu Takada

Fgf9, a Potent Mitogen, is a New Ligand for Integrin αVβ3, and the Fgf9 Mutant Defective in Integrin Binding Acts as an Antagonist. Cells (2024)

Chih-Chieh ChangYoko K. TakadaChao-Wen ChengYukina MaekawaSeiji MoriYoshikazu Takada

Yoko K. TakadaJessica YuXiaojin YeChun-Yi WuBrunie H. FeldingMasaaki FujitaYoshikazu Takada

Yoko K. TakadaMichiko ShimodaYoshikazu Takada

Data From Optimization of Rgd-Containing Cyclic Peptides Against αVβ3 Integrin. (2023)

Yan WangWenwu XiaoYonghong ZhangLeah MezaHarry TsengYoshikazu TakadaJames B. AmesKit S. Lam

rgd-containing cyclic peptidespharmacologyreceptorsbiological engineering

Wenwu XiaoYan WangEdmond Y. LauJuntao LuoNianhuan YaoChangying ShiLeah MezaHarry TsengYoshiko MaedaPappanaicken KumaresanRuiwu LiuFelice C. LightstoneYoshikazu TakadaKit S. Lam

medicinal chemistrypharmacologycancer immunotherapytumor targetingdrug discoverybiostatisticsarginine-glycine-aspartic acidtumor biologyimmunologybuilt-in handletherapeutic targets

Secreted Phospholipase A2 Type Iia (Spla2-Iia) Binds to the Allosteric Site (Site 2) of Integrins and Activates Integrins in an Allosteric Manner. Elsevier eBooks (2023)

Yoshikazu TakadaMasaaki FujitaYoko K. Takada

Supplementary Tables S1-S7; Supplementary Figures S1-S2; and Supplementary Materials Methods From Optimization of Rgd-Containing Cyclic Peptides Against αVβ3 Integrin. (2023)

Yan WangWenwu XiaoYonghong ZhangLeah MezaHarry TsengYoshikazu TakadaJames B. AmesKit S. Lam

rgd-containing cyclic peptidespharmacologyreceptorssupplementary tablesbiomolecular engineeringprotein science

The C-Type Lectin Domain of Cd62P (P-Selectin) Functions as an Integrin Ligand. Life Science Alliance (2023)

Yoko K TakadaScott I SimonYoshikazu Takada

biologybiophysicsstructural biologyprotein structurec-type lectin domainintegrin ligandmolecular biologyprotein science

1
2
3
4
5
18
10 / page

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pharmacological research

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Steven GONIAS

Institution

University of California, San Diego

urokinase receptor

protein science

Vito Quaranta, M.D.

Institution

Vanderbilt University

biosystems

ordinary differential equations

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glycosylation

clinical proteomics

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molecular cancer

Harvey R. Herschman

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