Faculty

Institution

Unit

Venue

Yiling Lu

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Molecular And Cellular Oncology

Yiling Lu is a High Senior Professor at The University of Texas MD Anderson Cancer Center. Her research focuses on cancer biology, molecular oncology, and cancer genomics, with particular emphasis on oncogene signaling, tumor cell survival mechanisms, and epigenetic regulation in cancer. Her recent work has identified how cancer cells evade ferroptosis induced by immune cells via fatty acid binding proteins, and she has contributed to developing DrBioRight 2.0, an LLM-powered bioinformatics chatbot for large-scale cancer functional proteomics analysis. She has also published on transcription factor BCL11A structure, histone methyltransferases MLL3/MLL4 in platelet production, and lipid homeostasis vulnerabilities in NRAS-mutant melanoma. Her research integrates structural biology, epigenetics, and functional genomics to advance understanding of cancer pathogenesis and therapeutic resistance.

Honors

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Experiences

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Yiling Lu

The University of Texas MD Anderson Cancer Center

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cancer research cell biology molecular biology oncology tumor biology cancer biology oncogenes cancer cells cancer genomics pharmacology genetics molecular cancer medicinal research gene expression cell signaling cancer genetics cancer discovery gynecologic oncology molecular cell biology signal transduction proteomics cancer treatment genomics genome biology protein science cell regulation leukemia signaling pathways tumor targeting molecular diagnostics cell death epigenetic changes clinical proteomics cellular therapy enzyme inhibition tumor suppressors anti-cancer agents cancer care breast oncology apoptosis epigenomics hematological malignancies cancer growth oncogenic agent pathway analysis melanoma molecular regulation colorectal cancer protein phosphorylation receptor tyrosine kinases protein bioinformatics non-coding rna ovarian cancer cells cancer management rna biology proteomic technologies gene function cancer genome atlas long non-coding rna chromatin remodeling translational proteomics human cancers endometrial cancer cellular biology breast cancer cells a-to-i rna pan-cancer analysis reverse-phase protein arrays human glioblastoma mouse models comprehensive molecular characterization chromatin accessibility glycogen synthase renal cell carcinoma pan-cancer proteomic perspective frequent mutation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cancer Cells Avoid Ferroptosis Induced by Immune Cells via Fatty Acid Binding Proteins. Molecular Cancer (2025)

Maria Angelica Freitas-CortezFatemeh MasrorpourHong JiangIqbal MahmudYue LuAiling HuangLisa K. DuongQi WangTiffany A. VossClaudia S. Kettlun LeytonBo WeiWai-Kin ChanKevin LinJie ZhangEfrosini TsoukoShonik GanjooHampartsoum B. BarsoumianThomas S. RiadYun HuCarola LeuschnerNahum Puebla-OsorioJing WangJian HuMichael A. DaviesVinay K. PuduvalliCyrielle BillonThomas P. BurrisPhilip L. LorenziBoyi GanJames W. Welsh

molecular cancerimmune cellscancer researchmolecular biologycancer biology

Drbioright 2.0: An Llm-Powered Bioinformatics Chatbot for Large-Scale Cancer Functional Proteomics Analysis. Nature Communications (2025)

Wei LiuJun LiYitao TangYining ZhaoChaozhong LiuMeiyi SongZhenlin JuShwetha V. KumarYiling LuRehan AkbaniGordon B. MillsHan Liang

nlp taskscientific communicationbiomedical informaticstumor biologyproteomicsdeep learningcancer imagingcancer discoverymachine learning researchprotein bioinformaticsllm-powered bioinformatics chatbotsystems biologychatbotscancer genomicsbioinformaticsproteome research

Histone Lysine Methyltransferases Mll3 and Mll4 Direct Gene Expression to Produce Platelets Efficiently. Nature Communications (2025)

chromatin remodelingepigeneticscell biologymolecular cell biologytranscription (biology)molecular biologychromatinblood plateletgene expression

Multimeric Transcription Factor Bcl11A Utilizes Two Zinc-Finger Tandem Arrays to Bind Clustered Short Sequence Motifs. Nature Communications (2025)

John R HortonMeigen YuJujun ZhouMelody TranRithvi R AnakalYue LuRobert M BlumenthalXiaotian ZhangYun HuangXing ZhangXiaodong Cheng

zinc-finger tandemsequence assemblylong non-coding rnaprotein sciencetranscription factorsfunctional genomicstranscription (biology)molecular biologysequence alignmentsequence motifsystems biologygene sequence annotationgene expressionstructural molecular biologybioinformaticsgenetics

Retraction of Deficient Lrrc8A-Dependent Volume-Regulated Anion Channel Activity is Associated With Male Infertility in Mice. JCI Insight (2025)

reproductive biologyfertilityinfertilitymale infertilityphysiologyreproductive physiologydevelopmental biologyreproductive medicinereproductive sciencesignal transductiongametes

Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in Mapk Inhibitor–Resistant Nras -Mutant Melanoma. Science Translational Medicine (2025)

receptor tyrosine kinasescell deathcell signalingcell biologymedicinal researchmolecular cancermelanomacancer researchsurvival vulnerabilitytherapeutic targetssystems biologycancer cellscell regulationcancer letterselective abrogationcancer biology

Structure-Function Relationship of Ash1L and Histone H3K36 and H3K4 Methylation. Nature Communications (2025)

Kendra R. VannRajal SharmaChih-Chao HsuMaeva DevoucouxAdam H. TencerLei ZengKevin LinLi ZhuQin LiCatherine LachanceRuben Rosas OspinaQiong TongKa Lung CheungShuai YangSoumi BiswasHongwen XuanJovylyn GatchalianLorena AlamilloJianlong WangSuk Min JangBrianna J. KleinYue LuPatricia ErnstBrian D. StrahlScott B. RothbartMartin J. WalshMichael L. ClearyJacques CôtéXiaobing ShiMing-Ming ZhouTatiana G. Kutateladze

biomolecular structureepigenetic changesbiochemistrystructure-function relationshipmolecular biologychromatinprotein structuremolecular structurestructural biologygenetics

The Landscape of Gain and Loss of Function Mutations in Melanoma. SSRN Electronic Journal (2025)

oncogenessomatic varianttumor biologymutagenesis (molecular biology technique)cell biologymelanomadermatologymolecular cancercarcinogenesisphotocarcinogenesisskin cancerfunction mutationscancer cellscancer genetics

The Zbtb24-Cdca7-Hells Axis Suppresses the Totipotent 2C-Like Reprogramming by Maintaining Dux Methylation and Repression. Nucleic Acids Research (2025)

zbtb24-cdca7-hells axischromatin remodelingnucleic acidsepigeneticstranscription factorsepigenetic changesmolecular cell biologytotipotent 2c-like reprogrammingmolecular biologychromatingene expressiongenetics

412 Synergistic Targeting of Lysine-Specific Demethylase 1 (Lsd1) and Mapk Signaling: A Mechanism-Guided Therapeutic Approach for Glioblastoma (Gbm). Journal of Clinical and Translational Science (2024)

Lea StitzleinJack AdamsMatthew LuetzenMelissa SinghXioaping SuYue LuJoy GuminFrederick LangJoya Chandra

neurosciencecancer researchsynergistic targetingpharmacotherapycancer treatmenttranslational medicinemedicinal researchcellular therapycancer biologyneurologymapk signalingtumor targetingbrain tumor researchtherapeutic approachesmedicineexperimental medicineclinical therapeuticscancer genomicsoncologyneuro-oncology

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Yiling Lu

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Molecular And Cellular Oncology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Yiling Lu

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cancer Cells Avoid Ferroptosis Induced by Immune Cells via Fatty Acid Binding Proteins. Molecular Cancer (2025)

molecular cancerimmune cellscancer researchmolecular biologycancer biology

Drbioright 2.0: An Llm-Powered Bioinformatics Chatbot for Large-Scale Cancer Functional Proteomics Analysis. Nature Communications (2025)

Wei LiuJun LiYitao TangYining ZhaoChaozhong LiuMeiyi SongZhenlin JuShwetha V. KumarYiling LuRehan AkbaniGordon B. MillsHan Liang

Histone Lysine Methyltransferases Mll3 and Mll4 Direct Gene Expression to Produce Platelets Efficiently. Nature Communications (2025)

chromatin remodelingepigeneticscell biologymolecular cell biologytranscription (biology)molecular biologychromatinblood plateletgene expression

Multimeric Transcription Factor Bcl11A Utilizes Two Zinc-Finger Tandem Arrays to Bind Clustered Short Sequence Motifs. Nature Communications (2025)

John R HortonMeigen YuJujun ZhouMelody TranRithvi R AnakalYue LuRobert M BlumenthalXiaotian ZhangYun HuangXing ZhangXiaodong Cheng

Retraction of Deficient Lrrc8A-Dependent Volume-Regulated Anion Channel Activity is Associated With Male Infertility in Mice. JCI Insight (2025)

reproductive biologyfertilityinfertilitymale infertilityphysiologyreproductive physiologydevelopmental biologyreproductive medicinereproductive sciencesignal transductiongametes

Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in Mapk Inhibitor–Resistant Nras -Mutant Melanoma. Science Translational Medicine (2025)

Structure-Function Relationship of Ash1L and Histone H3K36 and H3K4 Methylation. Nature Communications (2025)

biomolecular structureepigenetic changesbiochemistrystructure-function relationshipmolecular biologychromatinprotein structuremolecular structurestructural biologygenetics

The Landscape of Gain and Loss of Function Mutations in Melanoma. SSRN Electronic Journal (2025)

The Zbtb24-Cdca7-Hells Axis Suppresses the Totipotent 2C-Like Reprogramming by Maintaining Dux Methylation and Repression. Nucleic Acids Research (2025)

Lea StitzleinJack AdamsMatthew LuetzenMelissa SinghXioaping SuYue LuJoy GuminFrederick LangJoya Chandra

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