Yi Lu

Professor

UIUC

Affiliations

The Grainger College of Engineering

Bioengineering

Department of Bioengineering

Yi Lu is currently serving as a Bioengineering Professor at Uiuc.

Honors

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Experiences

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Education

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Yi Lu

UIUC

Professor

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biochemistry biomolecular engineering molecular biology chemistry nucleic acids biosensors transition metal chemistry enzymes nanoparticle research biophysical chemistry biomolecules chemical biology redox biology metalloproteins biological inorganic chemistry biological chemistry nanoparticles biomedical analysis dna nanotechnology protein structure protein science bioanalysis analytical chemistry structural molecular biology chemical sciences biomolecular structure cation sensing redox chemistry nanobiotechnology coordination chemistry nanosensors biochemical sciences nucleic acid chemistry molecular diagnostics carbonization metal nanoparticles bioactive metal chemical sensors molecular structure structural chemistry heme degradation chemical probes heme transport oligonucleotides enzyme catalysis coking type 1 nucleic acid biomarkers analytical biotechnology dna analysis single-molecule detection inorganic compounds blood glucose monitoring gold nanoparticles metal ions protein chemistry structure-function enzyme kinetics therapeutic nanomaterials biocatalysis nano-drug delivery bioelectrochemistry electroanalytical sensor oxygen reduction reaction altmetric attention score high sensitivity unnatural amino acids active site dna aptamers living cells rational design oxidase activity recent advances biological systems cytochrome c peroxidase nitric oxide reductase reduction potentials biotechnology advance pharmaceutical biotechnology biomedical engineering bioengineering model biofabrication controlled release cell engineering drug delivery

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Beyond Blue: Systematic Modulation of Electronic Structure and Redox Properties of Type 1 Copper in Azurin. Journal of the American Chemical Society (2025)

Casey Van StappenJiaqing XuYiwei LiuJacqueline Van StappenWantae KimY. Jessie ZhangYi Lu

metalloproteinsbiophysical chemistryprotein structurecoordination chemistryredox chemistrysystematic modulationbiological inorganic chemistrymolecular biologystructural chemistrychemistryinorganic chemistrytype 1chemical structureelectronic structureprotein sciencetransition metal chemistry

Contrasting Secondary Coordination Sphere Effects on Spin Density Distribution in Red vs. Blue Cu Azurin. JBIC Journal of Biological Inorganic Chemistry (2025)

Casey Van StappenEdward ReijerseSonia ChabbraAlexander SchneggYi Lu

physicsspin phenomenonphysical chemistrymagnetismblue cu azurinmolecular physicscrystal researchcondensed matterinorganic chemistry frontierapplied physicscrystallographyspintronicschemistryphase transitionsspin dynamicsspin density distributioncondensed matter physicssecondary coordinationsolid-state physics

Decoding Potassium Homeostasis in Cancer Metastasis and Drug Resistance: Insights From a Highly Selective Dnazyme-Based Intracellular K + Sensor. Journal of the American Chemical Society (2025)

Zhenglin YangXiangli ShaoYuting WuAritra RoyElijah GarciaAnnie FarrellShreestika PradhanWeijie GuoHeather GanZeynep KorkmazEmily AdamsYi Lu

chemical probesexceptional selectivitypotassium ionspotassium homeostasiscation sensingmolecular cancernucleic acid biomarkersfluorescencemolecular biologybiomedical analysismolecular diagnosticscell biologytumor biologycellular biochemistrybiochemistrymolecular imaging

Electrochemical Separation and Clean Energy Applications of Rare Earth Elements. Chemical Reviews (2025)

Bidipta GhoshHaley VapnikHee-Eun KimYonghwan KimRuchitha BirawatYongqi LuXiao SuHong Yang

rare-earth elementssustainable chemistrychemical engineeringelectrochemical engineeringelectrochemical processenergy chemistryelectrochemical energy conversionchemistryenvironmental electrochemistryrare earth elementselectrochemical separationelectrochemistry

Highly Selective Dna Aptamer Sensor for Intracellular Detection of Coenzyme A. Chemical Science (2025)

Yuan MaWhitney LewisPeng YanXiangli ShaoQuanbing MouLinggen KongWeijie GuoYi Lu

biosensorsintracellular detectionmany other moleculesbioanalysischemical biologynucleic acid biomarkersdna aptamersmolecular diagnosticsmolecular biologybiological chemistrydna analysismolecular biological methodbiochemistrynucleic acids

Mass Transfer-Reaction Modeling of Co 2 Capture Mediated by Immobilized Carbonic Anhydrase Enzyme on Multiscale Supporting Structures. Environmental Science & Technology (2025)

Yao ShenPeijing ShaoJingkai ZhaoYongqi LuShihan Zhang

sustainable chemistrycarbonizationchemical sciencesenzyme catalysisbioenergeticsbiochemistryprocess biochemistrybioproductsimmobilized enzymesbiochemical engineeringenzymeschemical reaction engineeringmultiscale supporting structurescatalysisbiocatalysismass transfer-reaction modelingcarbon capturebiomolecular engineeringenzyme immobilization

Pcr‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded Dna‐Assisted Double‐Stranded Dna Nicking by Dnazymes. Angewandte Chemie International Edition (2025)

Mingkuan LyuLinggen KongXiangli ShaoYi Lu

dna computingnucleic acid amplificationbiotechnologypcr‐free sdm methodbiomolecular engineeringmolecular biologydna repairoligonucleotidesbiomoleculesmutagenesis (molecular biology technique)dna nickingdanda systemnucleic acids

Sialic Acid Aptamer and Rna in Situ Hybridization-Mediated Proximity Ligation Assay for Spatial Imaging of Glycornas in Single Cells. Nature Protocols (2025)

Weijie GuoYuan MaQuanbing MouXiangli ShaoMingkuan LyuValeria GarciaLinggen KongWhitney LewisZhenglin YangShuya LuYi Lu

sialic acid aptamercell and molecular biologysingle cellsmolecular biological methodcell biologymolecular cell biologymolecular diagnosticsnucleic acid amplification testnucleic acidsnucleic acid amplificationtranscription (biology)glycobiologytranscriptomegene expressionspatial imagingmolecular biologybiological imagingrna biologymolecular imaging

Signal Transduction Strategies for Dnazyme-Based Sensing and Imaging of Metal Ions in Cells and in Vivo. Chemical & Biomedical Imaging (2025)

Whitney LewisAnnie FarrellShreestika PradhanYi Lu

fluorescence spectroscopybiosensorscation sensingsignal transduction strategiesnanoparticle researchbioactive metalfluorescencemolecular biologybiological chemistrybiological imagingbiomedical analysisdnazyme-based sensingmetal ionsbiochemistrymolecular imaging

Synthetic Transmembrane Dna Receptors Enable Engineered Sensing and Actuation. Nature Communications (2025)

Ze-Rui ZhouMan-Sha WuZhenglin YangYuting WuWeijie GuoDa-Wei LiRuo-Can QianYi Lu

receptorsbiological macromoleculesdna nanotechnologymolecular engineeringcell surfacebiomolecular engineeringintracellular signal transductionmolecular biologymolecular communicationdna receptorsbiomoleculessignal transductionbiofabricationsynthetic circuitssynthetic biology