Faculty

Institution

Unit

Venue

Xiaozhuo Chen

Ohio University

Affiliations

College of Arts and Sciences

Biological Sciences

Chemistry and Biochemistry

Heritage College of Osteopathic Medicine

Biomedical Sciences

NoneXiaozhuo Chen is currently serving as a Biological Sciences faculty at Ohio University.

Honors

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Experiences

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Education

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Xiaozhuo Chen

Ohio University

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pharmacology oncology cancer research cancer biology tumor biology medicinal research cell biology cancer treatment cancer care medicinal chemistry molecular cancer tumor targeting medicine molecular biology cancer cells drug discovery cancer genomics pharmacotherapy cancer growth cancer genetics extracellular atp thoracic oncology enzyme inhibition anti-cancer agents cell signaling cancer management cellular therapy diabetes drug targeting gene expression natural product research cell death therapeutic efficacy atp internalization cellular physiology insulin signaling apoptosis herbal medicine pharmaceutical chemistry cancer risk liver physiology phytotherapy research phytochemistry chemoprevention strategies epithelial-mesenchymal transition lung cancer cells nsclc cells cell metabolism complementary medicine food science nutrient physiology metabolic regulation nutritional sciences inhibitory activity pharmaceutical sciences molecular regulation cell regulation cell physiology insulin receptor small-molecule inhibitor cell-cycle arrest cancer metabolism cancer prevention treatment development human nutrition evidence-based medicine evidence-based therapies clinical evidence evidence-based practice anti-obesity activity warburg effect adipocyte differentiation-inhibitory activities active compounds insulin-mediated glucose transport dipeptide seryl-histidine structure-activity relationship study

Notable Scholarly Works

Notable Federal Grants

Collaborators

Progression of Bone-Metastatic Prostate Cancer in a Mouse Model Treated With a Novel Pan-Class I Glut Inhibitor (Drb18). Journal of Cancer Metastasis and Treatment (2025)

Nathan K. HoggardShiyu YuanMarlon R. SzczepaniakMegan M. TurnerNoriko KantakeChunmin LoZachary D. LaRussaJingwen SongNigel A. DanielsJonathan A. YoungJohn B. EcholsBlake E. Hildreth IIIStephen C. BergmeierXiaozhuo ChenThomas J. Rosol

bone-metastatic prostate cancermetastasistumor targetinganti-cancer agentsmouse modelmedicinal researchprostate cancercancer researchcancer discoverypharmacologytherapeutic targetsurologycancer treatmentoncology

Abstract 2978: Extracellular Atp Induced Senescence in Human Lung Cancer Cells. Cancer Research (2024)

Ryan A. WardArabella HuntNora AndersonXiaozhuo Chen

cell deathneurosciencethoracic oncologycell researchcell physiologytumor biologycellular senescencecell biologylung cancercancer researchsarcopeniacancer cellslongevitycancer biologyneurologyextracellular atponcologycancer imagingaging process

A Novel Pan Class-I Glucose Transporter Inhibitor Drb18 Exhibits Synergistic Effects in Vitro and in Vivo With Paclitaxel Against Human Non-Small Cell Lung Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Pratik ShriwasLindsey BachmannRyan WardSubhodip AdhicaryCorinne M NielsenYunsheng LiHaiyun ZhangJingwen SongDennis RobertsStephen BergmeierXiaozhuo Chen

oncogenestumor targetingoncologyanti-cancer agentsdrug targetingcancer immunotherapymedicinal researchsynergistic effectslung cancercancer researchcancer discoverychemoprevention strategiespharmacologymolecular biologytherapeutic targetscancer cellsenzyme inhibitionbiomolecular engineering

Diverse Temporal and Spatial Mechanisms Work, Partially Through Stanniocalcin-1, V-Atpase and Senescence, to Activate the Extracellular Atp-Mediated Drug Resistance in Human Cancer Cells. Frontiers in Oncology (2024)

Haiyun ZhangJingwen SongRyan WardYong HanArabella HuntPratik ShriwasAlexander SteedCory EdwardsYanyang CaoMilo CoXiaozhuo Chen

anti-cancer agentspharmacologyhuman cancer cellstumor biologycellular senescencecancer researchmolecular biologycancer treatmentcancer cellsspatial mechanisms workoncogenesmedicinal researchdrug resistancecancer carecancer biologytumor targetingmembrane biologymedicineenzyme inhibitiononcology

An Emerging Master Inducer and Regulator for Epithelial-Mesenchymal Transition and Tumor Metastasis: Extracellular and Intracellular Atp and Its Molecular Functions and Therapeutic Potential. Cancer Cell International (2023)

Yanyang CaoEileen ChenXuan WangJingwen SongHaiyun ZhangXiaozhuo Chen

molecular and cellular biologymolecular functionstumor metastasispharmacologytumor biologycell biologycancer researchcancer genomicsmolecular biologycancer cellsgene expressionmaster inducermedicinal researchmolecular cancercellular therapytherapeutic potentialcell regulationcancer carecancer biologyepithelial-mesenchymal transitionmitochondrial functionmolecular regulationoncology

Figure S3 From Extracellular Atp a New Player in Cancer Metabolism: Nsclc Cells Internalize Atp I in Vitro /I and I in Vivo /I Using Multiple Endocytic Mechanisms. (2023)

Yanrong QianXuan WangYunsheng LiYanyang CaoXiaozhuo Chen

nsclc cellstumor biologycell biologycancer metabolismmultiple endocytic mechanisms

First-In-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. Journal of Medicinal Chemistry (2023)

Andrea AngeliMarta FerraroniCarlotta GranchiFilippo MinutoloXiaozhuo ChenPratik ShriwasEmilio RussoAntonio LeoSilvia SelleriFabrizio CartaClaudiu T. Supuran

neurologydrug targetingdeficiency syndromemedicinal chemistryepilepsymedicinepharmacologydrug discovery

Supplementary Table 2 From a Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth I in Vitro /I and I in Vivo /I. (2023)

Yi LiuYanyan CaoWeihe ZhangStephen BergmeierYanrong QianHuzoor AkbarRobert ColvinJuan DingLingying TongShiyong WuJennifer HinesXiaozhuo Chen

tumor targetingtumor biologycell-cycle arrestanti-cancer agentsphysiologycell biologymedicinal researchsmall-molecule inhibitormedicinal chemistrypharmacologytherapeutic targetstherapeutic efficacy

Abstract 1047: Combinatorial Anticancer Therapy Strategy Using a Pan-Class I Glucose Transporter Inhibitor With Chemotherapy and Target Drugs in Vitro and in Vivo. Cancer Research (2022)

Lindsey M. BachmannPratik ShriwasRyan A. WardLiyi WangStephen C. BergmeierYunsheng LiXiaozhuo Chen

radiation oncologytumor targetingtumor biologydrug targetingcancer treatmentmedicinal researchtarget drugsmolecular cancercancer researchpharmacologytherapeutic targetscancer managementclinical researchpharmacotherapyleukemiacancer careoncologycancer biology

Abstract 405: A New Mechanism of Drug Resistance in Cancer: Extracellular Atp-Induced Resistance by Macropinocytosis-Mediated Internalization and Redox Changes. Cancer Research (2022)

Haiyun ZhangXiaozhuo Chen

macropinocytosis-mediated internalizationpharmacologytumor biologycancer researchextracellular atp-induced resistancecancer treatmentpharmacotherapymedicinal researchmolecular cancerdrug resistanceurologycancer managementcancer carecancer biologyneurologytumor targetingredox changesclinical researchenzyme inhibitioncancer genomicsoncology

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Xiaozhuo Chen

Ohio University

Affiliations

College of Arts and Sciences

Biological Sciences

Chemistry and Biochemistry

Heritage College of Osteopathic Medicine

Biomedical Sciences

NoneXiaozhuo Chen is currently serving as a Biological Sciences faculty at Ohio University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Xiaozhuo Chen

Ohio University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Progression of Bone-Metastatic Prostate Cancer in a Mouse Model Treated With a Novel Pan-Class I Glut Inhibitor (Drb18). Journal of Cancer Metastasis and Treatment (2025)

Abstract 2978: Extracellular Atp Induced Senescence in Human Lung Cancer Cells. Cancer Research (2024)

Ryan A. WardArabella HuntNora AndersonXiaozhuo Chen

Pratik ShriwasLindsey BachmannRyan WardSubhodip AdhicaryCorinne M NielsenYunsheng LiHaiyun ZhangJingwen SongDennis RobertsStephen BergmeierXiaozhuo Chen

Haiyun ZhangJingwen SongRyan WardYong HanArabella HuntPratik ShriwasAlexander SteedCory EdwardsYanyang CaoMilo CoXiaozhuo Chen

Yanyang CaoEileen ChenXuan WangJingwen SongHaiyun ZhangXiaozhuo Chen

Figure S3 From Extracellular Atp a New Player in Cancer Metabolism: Nsclc Cells Internalize Atp I in Vitro /I and I in Vivo /I Using Multiple Endocytic Mechanisms. (2023)

Yanrong QianXuan WangYunsheng LiYanyang CaoXiaozhuo Chen

nsclc cellstumor biologycell biologycancer metabolismmultiple endocytic mechanisms

First-In-Class Dual Targeting Compounds for the Management of Seizures in Glucose Transporter Type 1 Deficiency Syndrome. Journal of Medicinal Chemistry (2023)

Andrea AngeliMarta FerraroniCarlotta GranchiFilippo MinutoloXiaozhuo ChenPratik ShriwasEmilio RussoAntonio LeoSilvia SelleriFabrizio CartaClaudiu T. Supuran

neurologydrug targetingdeficiency syndromemedicinal chemistryepilepsymedicinepharmacologydrug discovery

Yi LiuYanyan CaoWeihe ZhangStephen BergmeierYanrong QianHuzoor AkbarRobert ColvinJuan DingLingying TongShiyong WuJennifer HinesXiaozhuo Chen

tumor targetingtumor biologycell-cycle arrestanti-cancer agentsphysiologycell biologymedicinal researchsmall-molecule inhibitormedicinal chemistrypharmacologytherapeutic targetstherapeutic efficacy

Abstract 1047: Combinatorial Anticancer Therapy Strategy Using a Pan-Class I Glucose Transporter Inhibitor With Chemotherapy and Target Drugs in Vitro and in Vivo. Cancer Research (2022)

Lindsey M. BachmannPratik ShriwasRyan A. WardLiyi WangStephen C. BergmeierYunsheng LiXiaozhuo Chen

Abstract 405: A New Mechanism of Drug Resistance in Cancer: Extracellular Atp-Induced Resistance by Macropinocytosis-Mediated Internalization and Redox Changes. Cancer Research (2022)

Haiyun ZhangXiaozhuo Chen

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