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Xiaolin Nan

Associate Professor of Biomedical Engineering

Oregon Health & Science University

Affiliations

Xiaolin Nan is an Associate Professor of Biomedical Engineering at Oregon Health & Science University. He earned his doctorate in biophysics, with research spanning super-resolution microscopy, molecular biology, and biomolecular engineering. His current work focuses on developing advanced imaging technologies, including photocatalytic strategies for light-driven spatial proteomics, label-free Raman spectroscopy integrated with machine learning for early cancer detection, and multiplexed DNA-PAINT nanoscopy for millimeter-scale fluorescence imaging. His recent breakthroughs include a phosphoinositide switch mediating exocyst recruitment for exosome secretion and dimeric IgA-based targeting of intracellular oncoproteins for epithelial cancer control, published in Nature Communications and Immunity, respectively. He also investigates multispectral localized surface plasmon resonance to overcome spectral heterogeneities of single gold nanoparticles for enhanced molecular sensing.

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Xiaolin Nan

Oregon Health & Science University

Associate Professor of Biomedical Engineering

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biophysics microscopy cell biology biological imaging biomedical imaging molecular biology fluorescence light microscopy super-resolution imaging membrane biology cancer research tumor biology nanoparticle research microscopy methods cancer biology novel imaging methods immunology nanotechnology cellular physiology nanomedicine protein science nanobiotechnology molecular cell biology biophysical review photomedicine tissue imaging hemostasis single-molecule detection cancer cells liver physiology thrombosis cellular biochemistry vascular biology tumor targeting therapeutic nanomaterials cellular biology microscope image processing single molecules cellular therapy medicinal research vibrational spectroscopy plo biology protein transport intracellular trafficking cell physiology nuclear organization molecular regulation electron microscopy cell regulation anti-cancer agents cancer growth lipid movement cancer genomics coherent anti-stokes raman cancer theranostics bimolecular fluorescence complementation living cell tumor suppressors host response cell motility cell biophysics disease mapping cancer genetics protein bioinformatics live fibroblast cells lipid droplets vibrational imaging mitogen-activated protein kinase ras-gtp dimers nonperturbative chemical imaging organelle transport immunogenic cell death macrophage polarization motor proteins individual steps raf multimer formation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Label-Free Raman Spectroscopy Integrated With Machine Learning for Cancer Early Detection. (2026)

label-free raman spectroscopyspectroscopic methodscancer imagingcancer early detectionbiophysicsspectroscopybiomarkersraman spectroscopybiomolecular engineeringbiomedical analysissurface-enhanced raman scattering

Light-Driven Spatial Proteomics: Photocatalytic Strategies for Mapping Protein Microenvironments. Current Opinion in Chemical Biology (2026)

biophysicsproteomicsprotein sciencechemical biologyphotobiology

A Phosphoinositide Switch Mediates Exocyst Recruitment to Multivesicular Endosomes for Exosome Secretion. Nature Communications (2023)

Di-Ao LiuKai TaoBin WuZiyan YuMalwina SzczepaniakMatthew RamesChangsong YangTatyana SvitkinaYueyao ZhuFengyuan XuXiaolin NanWei Guo

membrane biologybiochemistrymolecular biologyexosome secretioncell biology

Multiplexed and Millimeter-Scale Fluorescence Nanoscopy of Cells and Tissue Sections via Prism-Illumination and Microfluidics-Enhanced Dna-Paint. Chemical & Biomedical Imaging (2023)

Matthew J. RamesJohn P. KenisonDaniel HeineckFehmi CivitciMalwina SzczepaniakTing ZhengJulia ShangguanYujia ZhangKai TaoSadik EsenerXiaolin Nan

materials sciencenanotechnologynanobiotechnologytissue imagingnanometrologybiological imagingtissue sectionsnanomaterialsbiomedical imagingmillimeter-scale fluorescence nanoscopycell researchcell biologybiomedical engineeringdna nanotechnologyfluorescencemicrofluidics

Multispectral Localized Surface Plasmon Resonance (Mslspr) Reveals and Overcomes Spectral and Sensing Heterogeneities of Single Gold Nanoparticles. ACS Nano (2023)

Stephen PalaniJohn P. KenisonSinan SabuncuTao HuangFehmi CivitciSadik EsenerXiaolin Nan

nanoparticle researchmaterials sciencenanotechnologynanoparticlesnanomedicineplasmonicssurface nanotechnologynanomaterialsmultispectral imagingmetallic nanomaterialssingle gold nanoparticlessurface plasmon resonancesurface sciencenanobiotechnology

Targeting Intracellular Oncoproteins With Dimeric Iga Promotes Expulsion From the Cytoplasm and Immune-Mediated Control of Epithelial Cancers. Immunity (2023)

Subir BiswasGunjan MandalCarmen M AnadonRicardo A ChaurioLuis U Lopez-BailonMate Z NagyJessica A MineKay HänggiKimberly B SprengerPatrick InnamaratoCarly M HarroJohn J PowersJoseph JohnsonBin FangMostafa EyshaXiaolin NanRoger LiBradford A PerezTyler J CurielXiaoqing YuPaulo C RodriguezJose R Conejo-Garcia

tumor targetinginfection controlmedicineintracellular oncoproteinsanti-cancer agentsimmune responsescancer biologyepithelial cancerscancer researchimmune-mediated controltumor biologypharmacologycancer treatmentoncologyimmunologycancer immunosurveillancecancer carecancer immunotherapymedicinal research

An Omic and Multidimensional Spatial Atlas From Serial Biopsies of an Evolving Metastatic Breast Cancer. Cell Reports Medicine (2022)

Brett E. JohnsonAllison L. CreasonJayne M. StommelJamie M. KeckSwapnil ParmarCourtney B. BettsAurora BlucherChristopher BonifaceElmar BucherErik BurlingameTodd CampKoei ChinJennifer EngJoseph EstabrookHeidi S. FeilerMichael B. HeskettZhi HuAnnette KolodzieBen L. KongMarilyne LabrieJinho LeePatrick LeyshockSouraya MitriJanice PattersonJessica L. RiestererShamilene SivagnanamJulia SomersDamir SudarGuillaume ThibaultBenjamin R. WeederChristina ZhengXiaolin NanReid F. ThompsonLaura M. HeiserPaul T. SpellmanGeorge ThomasEmek DemirYoung Hwan ChangLisa M. CoussensAlexander R. GuimaraesChristopher CorlessJeremy GoecksRaymond BerganZahi MitriGordon B. MillsJoe W. Gray

cancer biologyhealth sciencesbreast cancermedicineserial biopsiescancer researchmultidimensional spatial atlasoncologymetastatic breast cancercell biology

A Versatile Synthetic Pathway for Producing Mesostructured Plasmonic Nanostructures. Small (2022)

plasmonsmaterials sciencenanoengineeringnanotechnologynanoparticle researchplasmonic catalysisnanostructure synthesisversatile synthetic pathwaynanomaterialsnanophotonicsadvanced functional materialsplasmonic materialsmaterial chemistrychemistry

Fast and Multiplexed Super Resolution Imaging of Fixed and Immunostained Cells With Dna‐Paint‐Ers. Current Protocols (2022)

molecular imagingtissue imagingbiological imagingsuper-resolution imagingmicroscopyconfocal microscopyimmunostained cellsbiomedical imagingnovel imaging methodscell researchimmunologycell biologybiophotonicsmedical optical imaging

Multipair FöRster Resonance Energy Transfer via Spectrally Resolved Single-Molecule Detection. The Journal of Physical Chemistry B (2022)

single moleculesmolecular spectroscopybiophysicsspectroscopysingle-molecule detectionmolecular physicsquantum chemistrymolecular structuremolecular sciencevibrational spectroscopyphotophysical propertieschemical physicsphysical chemistryexcitation energy transferchemistry

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Xiaolin Nan

Associate Professor of Biomedical Engineering

Oregon Health & Science University

Affiliations

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Xiaolin Nan

Oregon Health & Science University

Associate Professor of Biomedical Engineering

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Label-Free Raman Spectroscopy Integrated With Machine Learning for Cancer Early Detection. (2026)

Light-Driven Spatial Proteomics: Photocatalytic Strategies for Mapping Protein Microenvironments. Current Opinion in Chemical Biology (2026)

biophysicsproteomicsprotein sciencechemical biologyphotobiology

A Phosphoinositide Switch Mediates Exocyst Recruitment to Multivesicular Endosomes for Exosome Secretion. Nature Communications (2023)

Di-Ao LiuKai TaoBin WuZiyan YuMalwina SzczepaniakMatthew RamesChangsong YangTatyana SvitkinaYueyao ZhuFengyuan XuXiaolin NanWei Guo

membrane biologybiochemistrymolecular biologyexosome secretioncell biology

Multiplexed and Millimeter-Scale Fluorescence Nanoscopy of Cells and Tissue Sections via Prism-Illumination and Microfluidics-Enhanced Dna-Paint. Chemical & Biomedical Imaging (2023)

Matthew J. RamesJohn P. KenisonDaniel HeineckFehmi CivitciMalwina SzczepaniakTing ZhengJulia ShangguanYujia ZhangKai TaoSadik EsenerXiaolin Nan

Multispectral Localized Surface Plasmon Resonance (Mslspr) Reveals and Overcomes Spectral and Sensing Heterogeneities of Single Gold Nanoparticles. ACS Nano (2023)

Stephen PalaniJohn P. KenisonSinan SabuncuTao HuangFehmi CivitciSadik EsenerXiaolin Nan

Targeting Intracellular Oncoproteins With Dimeric Iga Promotes Expulsion From the Cytoplasm and Immune-Mediated Control of Epithelial Cancers. Immunity (2023)

An Omic and Multidimensional Spatial Atlas From Serial Biopsies of an Evolving Metastatic Breast Cancer. Cell Reports Medicine (2022)

cancer biologyhealth sciencesbreast cancermedicineserial biopsiescancer researchmultidimensional spatial atlasoncologymetastatic breast cancercell biology

A Versatile Synthetic Pathway for Producing Mesostructured Plasmonic Nanostructures. Small (2022)

Fast and Multiplexed Super Resolution Imaging of Fixed and Immunostained Cells With Dna‐Paint‐Ers. Current Protocols (2022)

Multipair FöRster Resonance Energy Transfer via Spectrally Resolved Single-Molecule Detection. The Journal of Physical Chemistry B (2022)

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