Faculty

Institution

Unit

Venue

Wonhwa Cho

Liberal Arts and Sciences Science Endowed Chair and UIC Distinguished Professor and Head

University of Illinois Chicago

Affiliations

College of Liberal Arts and Sciences

Chemistry

Wonhwa Cho is currently serving as a Chemistry Liberal Arts and Sciences Science Endowed Chair and UIC Distinguished Professor and Head at University of Illinois Chicago.

Honors

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Experiences

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Education

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Wonhwa Cho

University of Illinois Chicago

Liberal Arts and Sciences Science Endowed Chair and UIC Distinguished Professor and Head

You can click a keyword to filter the displayed items

biochemistry molecular biology membrane biology cell biology protein science pharmacology enzymes structural biology biological chemistry cell signaling protein structure signal transduction membrane proteins protein function gene expression redox biology lipid science structural molecular biology enzyme inhibition proteinlipid interaction liver physiology medicinal research cellular biochemistry protein phosphorylation mammalian biology protein secretion cancer biology biomolecular structure cellular physiology molecular physiology biochemical sciences molecular cell biology lipid analysis biomolecular interactions biological inorganic chemistry molecular regulation protein chemistry lipid chemistry lipoprotein metabolism protein transport enzyme specificity receptor (biochemistry) signaling pathways protein kinase c-a membrane binding clinical biochemistry molecular science cellular biology membrane transport secretory pathway enzyme catalysis cell adhesion protein expression protein purification molecular immunology membrane penetration fyve domains human eosinophils interfacial binding bacterial expression molecular basis antiviral drug development pharmaceutical chemistry drug targeting mutagenesis innate immune system mechanisms of action membrane-protein interactions phosphatidic acid structural basis membrane targeting structure-function study activation mechanisms differential subcellular localization human neutrophils lipid-binding modules chemical biology lipid biology systems biology drug discovery

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1178 a New Strategy for Inhibiting Oncogenic Progression in Inflammatory Breast Cancer: Unveiling Cholesterol-Protein Interactions and Therapeutic Potential. Journal of Biological Chemistry (2025)

immunologycholesterol-protein interactionspharmacologyabstract 1178cancer discoverytherapeutic targetsbreast canceroncogenic agentoncogenescancer cellscancer biologyinflammatory breast cancerbreast oncology

Abstract 6339: Reprogramming Srebp1-Dependent Metabolism and Inflammation in High-Risk Breast With Licochalcone a for the Prevention of Breast Cancer. Cancer Research (2025)

therapeutic targetsabstract 6339molecular metabolismbreast oncologybreast cancerchemoprevention strategiessrebp1-dependent metabolismcell biologybiochemistrycell metabolism

Abstract B063: The Cholesterol Efflux Protein, Abca1, Plays a Critical Role in Modulating Anti-Tumor Myeloid Immune Cell Functions. Cancer Immunology Research (2025)

Shruti V BendreNatalia KrawczynskaRajendra K CYu WangShaunak BhogaleErin WeisserBasel HajyousifSimon HanAvni SinghClaire P. SchaneAdam T. NelczykDhanya PradeepAnasuya Das GuptaLara KockayaHashni Epa Vidana GamageKevin Van BortleEmad TajkorshidSaurabh SinhaWendy A. WoodwardWonhwa ChoErik R Nelson

immunologymolecular cancerimmune checkpoint inhibitorscancer immunosurveillancecholesterol effluxcancer immunotherapycholesterol homeostasisoncologycholesterol efflux proteincancer cellstumor microenvironmentcancer biologytumor biologyimmunotherapycell biology

Cholesterol-Targeting Wnt–β-Catenin Signaling Inhibitors for Colorectal Cancer. Nature Chemical Biology (2025)

Ashutosh SharmaJulian ZalejskiShruti Vijay BendreSimona KavrokovaHale Siir HasdemirDefne Gorgun OzgulbasJiachen SunKoralege C PathmasiriRuicheng ShiAhmed AloulouKyli BerkleyCharles F DelisleYoung WangErin WeisserPawanthi BuwenekaDominick Pierre-JacquesSayandeb MukherjeeDiana A AbbasiDaesung LeeBo WangVladimir GevorgyanStephanie M ColognaEmad TajkhorshidErik R NelsonWonhwa Cho

pharmacologycancer researchmolecular cancercancer discoveryoncologycancer cellscolorectal cancerchemoprevention strategies

Mtor Inhibition Reprograms Cellular Lipid Homeostasis by Inducing Alternative Lipid Uptake and Promoting Cholesterol Transport. Molecular Cell (2025)

cellular lipid homeostasislipoprotein metabolismcell signalinglipidslipid synthesischolesterol transporttherapeutic targetssignal transductionmtor inhibitioncell metabolismcellular biochemistrybiochemistrycell biology

Noncanonical Pi(4,5)P2 Coordinates Lysosome Positioning Through Cholesterol Trafficking. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Ryan M LoughranGurpreet K AroraJiachen SunSophia CrabtreeAlicia LlorenteKyanh LyRen-Li HuynhWonhwa ChoBrooke M Emerling

cholesterol traffickingprotein structureprotein transportbiologyintracellular traffickingmolecular biologynoncanonical pibiochemistry

Abstract A048: The Loss of Cholesterol Efflux Pump Abca1 Skews Macrophages Towards a Pro-Tumor Phenotype and Facilitates Breast Cancer Progression. Cancer Immunology Research (2024)

Shruti BendreNatalia KrawczynskaShaunak BhogaleErin WeisserSimon HanBasel HajyousifAvni SinghRajendra KCYu WangClaire P SchaneAdam T NelczykDhanya PradeepLara KockayaHashni Epa Vidana GamageKevin VanBortleEmad TajkorshidSaurabh SinhaWendy A WoodwardWonhwa ChoErik R Nelson

breast cancer recurrenceradiation oncologymolecular cancercancer immunotherapycancer growthbreast oncologyoncologybreast cancercancer cellstumor microenvironmentcancer biologypathologytumor biologybreast cancer progressioncell biology

Licochalcone a From Licorice Reprograms Metabolic and Antioxidant Pathways in the Breast Leading to a Tumor Preventive Environment. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Atieh HajirahimkhanElizabeth T. BartomCarolina H ChungXingyu GuoKyli BerkleyOukseub LeeRuohui ChenWonhwa ChoSriram ChandrasekaranSusan E. ClareSeema A. Khan

therapeutic efficacybreast oncologycell biologycancer careantioxidantstumor preventive environmentbreast cancermembrane biologycell metabolismcancer researchremedial actionlicorice reprogramstumor biologycancer preventionantioxidant pathwayssystems biologyredox biologymitochondrial functionmolecular biologyoncologymedicinal research

Lipid Binding of Sh2 Domains. Methods in molecular biology (2023)

Wonhwa ChoKyli BerkleyAshutosh Sharma

biophysicscell signalinglipidsprotein structuremolecular biologylipid bindingstructural biologysignal transduction

Lipid‐Centric Design of Plasma Membrane‐Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery. Advanced Materials (2023)

Di NingZhi‐Gang WangLei WangYi‐Fan TianFang JingLin‐Han JiangMeng‐Qian ZhangYang‐Yang LiuDai‐Wen PangWonhwa ChoShu‐Lin Liu

membrane technologymaterials sciencedermatologynanomedicinepharmaceutical nanotechnologybiomedical engineeringlipid sciencelipid-centric designdrug deliverychemotherapeutic deliveryplasma membrane-mimicking nanocarriersadvanced materialsdrug targetingnanomaterialstherapeutic nanomaterialsnanotechnology

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Wonhwa Cho

Liberal Arts and Sciences Science Endowed Chair and UIC Distinguished Professor and Head

University of Illinois Chicago

Affiliations

College of Liberal Arts and Sciences

Chemistry

Wonhwa Cho is currently serving as a Chemistry Liberal Arts and Sciences Science Endowed Chair and UIC Distinguished Professor and Head at University of Illinois Chicago.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Wonhwa Cho

University of Illinois Chicago

Liberal Arts and Sciences Science Endowed Chair and UIC Distinguished Professor and Head

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 6339: Reprogramming Srebp1-Dependent Metabolism and Inflammation in High-Risk Breast With Licochalcone a for the Prevention of Breast Cancer. Cancer Research (2025)

therapeutic targetsabstract 6339molecular metabolismbreast oncologybreast cancerchemoprevention strategiessrebp1-dependent metabolismcell biologybiochemistrycell metabolism

Abstract B063: The Cholesterol Efflux Protein, Abca1, Plays a Critical Role in Modulating Anti-Tumor Myeloid Immune Cell Functions. Cancer Immunology Research (2025)

Cholesterol-Targeting Wnt–β-Catenin Signaling Inhibitors for Colorectal Cancer. Nature Chemical Biology (2025)

pharmacologycancer researchmolecular cancercancer discoveryoncologycancer cellscolorectal cancerchemoprevention strategies

Mtor Inhibition Reprograms Cellular Lipid Homeostasis by Inducing Alternative Lipid Uptake and Promoting Cholesterol Transport. Molecular Cell (2025)

Noncanonical Pi(4,5)P2 Coordinates Lysosome Positioning Through Cholesterol Trafficking. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Ryan M LoughranGurpreet K AroraJiachen SunSophia CrabtreeAlicia LlorenteKyanh LyRen-Li HuynhWonhwa ChoBrooke M Emerling

cholesterol traffickingprotein structureprotein transportbiologyintracellular traffickingmolecular biologynoncanonical pibiochemistry

Abstract A048: The Loss of Cholesterol Efflux Pump Abca1 Skews Macrophages Towards a Pro-Tumor Phenotype and Facilitates Breast Cancer Progression. Cancer Immunology Research (2024)

Licochalcone a From Licorice Reprograms Metabolic and Antioxidant Pathways in the Breast Leading to a Tumor Preventive Environment. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Atieh HajirahimkhanElizabeth T. BartomCarolina H ChungXingyu GuoKyli BerkleyOukseub LeeRuohui ChenWonhwa ChoSriram ChandrasekaranSusan E. ClareSeema A. Khan

Lipid Binding of Sh2 Domains. Methods in molecular biology (2023)

Wonhwa ChoKyli BerkleyAshutosh Sharma

biophysicscell signalinglipidsprotein structuremolecular biologylipid bindingstructural biologysignal transduction

Lipid‐Centric Design of Plasma Membrane‐Mimicking Nanocarriers for Targeted Chemotherapeutic Delivery. Advanced Materials (2023)

Di NingZhi‐Gang WangLei WangYi‐Fan TianFang JingLin‐Han JiangMeng‐Qian ZhangYang‐Yang LiuDai‐Wen PangWonhwa ChoShu‐Lin Liu

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University of California, Los Angeles

molecular informatics

proteomic technologies

Charles R. Sanders

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Vanderbilt University

protein misfolding

membrane protein

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Dartmouth College

autophagy

obesity

Francis Castellino

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molecular informatics

biomolecular engineering

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protein phosphorylation

lipid second messengers

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signal transduction

membrane biology