William M. Chilian

William M. Chilian is a Senior Professor at Northeast Ohio Medical University, where his research focuses on cardiovascular physiology, coronary microcirculation, and vascular biology. His recent work investigates exosomal NAMPT from engineered mesenchymal stem cells to mitigate aortic stenosis through metabolic and anti-inflammatory pathways, alongside studies on coronary metabolic vasodilators and microvascular dysfunction in heart failure and Takotsubo syndrome. He has contributed to advancing methodologies for isolating small extracellular vesicles from human serum for miRNA profiling and exploring early detection of chemotherapy-related cardiotoxicity via global longitudinal strain. His research integrates cell biology, pharmacology, and regenerative medicine to address cardiovascular disease mechanisms and therapeutic targets.