Faculty

Institution

Unit

Venue

William Hancock

Professor

Pennsylvania State University

Affiliations

Penn State College of Engineering

Biomedical Engineering

William Hancock is currently serving as a Biomedical Engineering Professor at Pennsylvania State University.

Honors

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Experiences

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Education

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William Hancock

Pennsylvania State University

Professor

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biophysics neuroscience kinesiology cell biology biomechanics motor control membrane biology protein science structural biology experimental biophysics cytoskeleton nanotechnology protein transport biophysical modeling cell biomechanics kinematics microfluidics nanobiotechnology cell motility molecular cell biology enzyme inhibition protein function cellular physiology biophysical review microtubule growth muscle function molecular regulation nanometrology nanoscale science biomolecular interactions kinesin processivity mammalian biology molecular physiology structural molecular biology cellulose functional regulation embodied robotics magnetic devices bidirectional cargo transport kinesin molecular motors processive motility intracellular transport biological chemistry matrix biology molecular science micro technology biomedical technologies orthopedic biomechanics cardiac muscle protein assembly integrative biology membrane transport cell growth motor domains neck linker extension microtubule stability mitotic kinesins nanoparticle research developmental science developmental cell plant biotechnology molecular neurobiology molecular sorting protein expression transcription regulation cellular biology charge transport miniaturization human sciences direct observation kinesin-related protein mcak microtubule ends microtubule depolymerase atp-hydrolyzing complex inhibitory regulator motor domain bioengineering model molecular biomechanics cell engineering biomolecular engineering biomedical engineering biotechnology advance biofabrication clinical engineering

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bps2025 - a Dna Tensiometer for Studying Load-Dependent Detachment Kinetics of Kinesins 1, 2, and 3. Biophysical Journal (2025)

Crystal R. NoellTzu-Chen MaScott McKinleyWilliam O. Hancock

biophysical chemistrybiophysicsdna tensiometerload-dependent detachment kineticsbiophysical modeling

Bps2025 - Single-Molecule Tracking Reveals Dual Front Door/Back Door Inhibition of Cel7A Cellulase by Its Product Cellobiose. Biophysical Journal (2025)

Daguan NongZachary K. HavilandNerya ZexerSarah A. PfaffDaniel J. CosgroveMing TienCharles T. AndersonWilliam O. Hancock

biophysical chemistrybiophysicsproduct cellobiosecellulosebiophysical aspect

A Dna Tensiometer for Studying Detachment Kinetics of Microtubule Motors Involved in Bidirectional Transport. Biophysical Journal (2024)

Crystal R. NoellWilliam O. Hancock

molecular biophysicsbiophysicsexperimental biophysicsmicrotubule motorsdna tensiometerdetachment kineticsbidirectional transportbiomechanicsneurosciencecell biology

Author Response for"Xylan Inhibition of Cellulase Binding and Processivity Observed at Single-Molecule Resolution". (2024)

None Nerya ZexerNone Alec ParadisoNone Daguan NongNone Zachary K. HavilandNone William HancockNone Charles Anderson

structure-function enzyme kineticsmolecular pharmacologybiochemistrybiomolecular interactionskey siteenzymesstructural biologybiochemical sciencescellular enzymologyprotein sciencemembrane biologyauthor responsepeptide scienceenzyme specificityxylan inhibitionsingle-molecule resolutiongene expressionpharmacologyenzyme inhibitionredox biologycellulase bindingmolecular biology

Dna Tensiometer Reveals Catch-Bond Detachment Kinetics of Kinesin-1, -2 and -3. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Crystal R. NoellTzu-Chen MaRui JiangScott A. McKinleyWilliam O. Hancock

structural biologymolecular motorsmolecular biologybiophysics

High-Speed Tracking of Kif1A Motors by Interferometric Scattering Microscopy. Biophysical Journal (2024)

Daguan NongJeff GroppWilliam O. Hancock

physiologybiophysicsmotor drivesexperimental biophysicstracking systemsroboticsmicroscopymotor controlmotor systemsobject trackinghigh-speed trackingneuroscience

Interface-Acting Nucleotide Controls Polymerization Dynamics at Microtubule Plus- and Minus-Ends. eLife (2024)

Lauren A McCormickJoseph M ClearyWilliam O HancockLuke M Rice

biomolecular engineeringbiophysicsbiological engineeringcytoskeleton

Lignin Impairs Cel7A Degradation of in Vitro Lignified Cellulose by Impeding Enzyme Movement and Not by Acting as a Sink. Biotechnology for Biofuels and Bioproducts (2024)

Zachary K. HavilandDaguan NongNerya ZexerMing TienCharles T. AndersonWilliam O. Hancock

bioresource technologychemical biotechnologybiotechnologybiochemistrybioproductsenvironmental biotechnologybiochemical engineeringenzymesbioremediationenzyme movementcellulosebiofuelsagricultural biotechnologysoil biotechnologybiotechnology advancebiological engineeringlignin impairsligninbiomolecular engineeringenzyme immobilization

Microtubule Polymerization is Controlled by Interface-Acting Nucleotide. Biophysical Journal (2024)

Lauren A. McCormickJoseph M. ClearyWilliam O. HancockLuke M. Rice

molecular biophysicsbiophysicsinterface-acting nucleotidemicrotubule polymerizationneurosciencecell biology

Motility of Kinesin-5, Cin8-Kinesin-1 Chimera. Biophysical Journal (2024)

Himanshu PandeyTzu-Chen MaWilliam O. Hancock

physiologybiomechanicsbiophysicskinesiology

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William Hancock

Professor

Pennsylvania State University

Affiliations

Penn State College of Engineering

Biomedical Engineering

William Hancock is currently serving as a Biomedical Engineering Professor at Pennsylvania State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

William Hancock

Pennsylvania State University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bps2025 - a Dna Tensiometer for Studying Load-Dependent Detachment Kinetics of Kinesins 1, 2, and 3. Biophysical Journal (2025)

Crystal R. NoellTzu-Chen MaScott McKinleyWilliam O. Hancock

biophysical chemistrybiophysicsdna tensiometerload-dependent detachment kineticsbiophysical modeling

Bps2025 - Single-Molecule Tracking Reveals Dual Front Door/Back Door Inhibition of Cel7A Cellulase by Its Product Cellobiose. Biophysical Journal (2025)

Daguan NongZachary K. HavilandNerya ZexerSarah A. PfaffDaniel J. CosgroveMing TienCharles T. AndersonWilliam O. Hancock

biophysical chemistrybiophysicsproduct cellobiosecellulosebiophysical aspect

A Dna Tensiometer for Studying Detachment Kinetics of Microtubule Motors Involved in Bidirectional Transport. Biophysical Journal (2024)

Crystal R. NoellWilliam O. Hancock

molecular biophysicsbiophysicsexperimental biophysicsmicrotubule motorsdna tensiometerdetachment kineticsbidirectional transportbiomechanicsneurosciencecell biology

Author Response for"Xylan Inhibition of Cellulase Binding and Processivity Observed at Single-Molecule Resolution". (2024)

None Nerya ZexerNone Alec ParadisoNone Daguan NongNone Zachary K. HavilandNone William HancockNone Charles Anderson

Dna Tensiometer Reveals Catch-Bond Detachment Kinetics of Kinesin-1, -2 and -3. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Crystal R. NoellTzu-Chen MaRui JiangScott A. McKinleyWilliam O. Hancock

structural biologymolecular motorsmolecular biologybiophysics

High-Speed Tracking of Kif1A Motors by Interferometric Scattering Microscopy. Biophysical Journal (2024)

Daguan NongJeff GroppWilliam O. Hancock

physiologybiophysicsmotor drivesexperimental biophysicstracking systemsroboticsmicroscopymotor controlmotor systemsobject trackinghigh-speed trackingneuroscience

Interface-Acting Nucleotide Controls Polymerization Dynamics at Microtubule Plus- and Minus-Ends. eLife (2024)

Lauren A McCormickJoseph M ClearyWilliam O HancockLuke M Rice

biomolecular engineeringbiophysicsbiological engineeringcytoskeleton

Lignin Impairs Cel7A Degradation of in Vitro Lignified Cellulose by Impeding Enzyme Movement and Not by Acting as a Sink. Biotechnology for Biofuels and Bioproducts (2024)

Zachary K. HavilandDaguan NongNerya ZexerMing TienCharles T. AndersonWilliam O. Hancock

Microtubule Polymerization is Controlled by Interface-Acting Nucleotide. Biophysical Journal (2024)

Lauren A. McCormickJoseph M. ClearyWilliam O. HancockLuke M. Rice

molecular biophysicsbiophysicsinterface-acting nucleotidemicrotubule polymerizationneurosciencecell biology

Motility of Kinesin-5, Cin8-Kinesin-1 Chimera. Biophysical Journal (2024)

Himanshu PandeyTzu-Chen MaWilliam O. Hancock

physiologybiomechanicsbiophysicskinesiology

1
2
3
4
5
17
10 / page

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Emil Reisler

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theoretical biology

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