Faculty

Institution

Unit

Venue

Weihang Valerie Chai

Professor

Rosalind Franklin University of Medicine and Science

Affiliations

School Of Chicago Medical

Center For Genetic Diseases

Chicago Medical School

School Of Chicago Medical

Rosalind Franklin University of Medicine and Science

Weihang Valerie Chai is currently serving as a Center For Genetic Diseases Professor at Rosalind Franklin University of Medicine And Science.

Honors

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Experiences

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Education

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Weihang Valerie Chai

Rosalind Franklin University of Medicine and Science

Professor

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molecular biology dna repair cell biology molecular cell biology genetics nucleic acids plo biology molecular genetics mutagenesis (molecular biology technique) dna replication molecular and cellular biology chromatin oncogenes gene expression genome biology cell research systems biology tumor biology molecular cancer nature method cancer cells molecular diagnostics cellular physiology vascular biology medicinal research biochemical sciences cellular biology cancer biology replication stress cell death aging cell genome instability cancer genomics cancer genetics cell physiology cell biophysics cellular senescence colorectal cancer melanoma human telomeres epigenetic changes genetic disorders fragmentation effect allometric studies rna processing cell interactions signal recognition g protein-coupled receptor lateral spread genome analysis gastrointestinal oncology chromosome biology cancer risk non-coding rna gene regulation disease susceptibility cell specialization cell proliferation radiation biology phototoxicity photocarcinogenesis stem cell exhaustion defective telomere replication telomere loss g-quadruplex dna telomere integrity different overhang sizes c-strand fill-in efficient lagging-strand synthesis origin activation replication forks nascent-strand dna dna excision repair telomere maintenance alt cancer cells cancer letter bioinformatics heredity informatics biosystems theoretical biology genome editing scientific data biomedical informatics biotechnology advance forensic genetics human biology animal biotechnology quantitative biology laboratory investigation genetic engineering medical history genomics computational biology molecular informatics human genetics genetic recombination epigenetics scientific communication bioethics synthetic biology translational research pathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2343 Deficiency of Mammalian Stn1 Induces Genome Instability in Vivo and Promotes Cancer Development in a Tissue-Specific Manner. Journal of Biological Chemistry (2026)

A Phosphorylation Switch at Mre11 Links Atm-Atr and Calcium Signaling to Safeguard Stalled Replication Fork Stability. Research Square (2026)

Stn1 Upregulation Promotes Parpi Resistance in Brca2-Deficient Cancer Cells via Replication Fork Protection and Suppression of Ssdna Gap Formation. bioRxiv (Cold Spring Harbor Laboratory) (2026)

The Nuclear Structural Protein Numa is Required for Efficient Dna Replication by Ensuring Association of Core Replication Factors to Replication Forks. bioRxiv (Cold Spring Harbor Laboratory) (2026)

mutagenesis (molecular biology technique)dna replicationgeneticsmolecular geneticsnucleic acidschromatinmolecular cell biologytranscription (biology)plo biologystructural molecular biologybiomolecular structuresystems biologyprotein sciencedna repairmolecular biologyreplicationgenome biology

Abstract 2854: The Role of Nono in Genome Stability: Implications for Rna-Dna Hybrid Accumulation, Genomic Instability, and Inflammatory Signaling. Cancer Research (2025)

inflammatory signalinggeneticsgene expressionnon-coding rnaabstract 2854gene regulationmolecular cell biologyfunctional genomicsgenome biologymolecular biologygenome stability

Dna2 and Msh2 Activity Collectively Mediate Chemically Stabilized G4 for Efficient Telomere Replication. bioRxiv (Cold Spring Harbor Laboratory) (2025)

mutagenesis (molecular biology technique)dna replicationbiochemical sciencesmolecular geneticsmolecular and cellular biologybiomolecular engineeringnucleic acidschromatinmolecular cell biologyplo biologystructural molecular biologybiological chemistrybiochemistrybiomoleculesdna repairmolecular biologygenome editing

Dna2 and Msh2 Cooperatively Repair Stabilized G4 and Allow Efficient Telomere Replication. Nature Communications (2025)

mutagenesis (molecular biology technique)dna replicationgeneticsmolecular geneticsbiochemical sciencesbiomolecular engineeringnucleic acidschromatincell divisionplo biologymolecular cell biologystructural molecular biologybiological chemistrydna repairmolecular biologygenome editinggenome biology

In Vivo Investigation of Stn1 Downregulation in Melanoma Formation in Adult Mice Following Uv Irradiation. PLoS ONE (2025)

radiation biologytumor biologydermatologycell biologycancer cellsoncogenesphototoxicityphotocarcinogenesisdna repairmelanomacarcinogenesisvivo investigationuv irradiationmelanoma formation

Conditional Depletion of Stn1 in Mouse Embryonic Fibroblasts. BIO-PROTOCOL (2024)

developmental biologycell specializationstem cellscell biologymolecular cell biologyconditional depletioncell researchcell proliferationcarcinogenesiscellular physiology

Human Cst Complex Restricts Excessive Primpol Repriming Upon Uv Induced Replication Stress by Suppressing P21. Nucleic Acids Research (2024)

mutagenesis (molecular biology technique)dna replicationgeneticsmolecular geneticsmolecular diagnosticsnucleic acidsmolecular cell biologycell biologyplo biologyoncogenesmolecular biologytranscription factorsexperimental medicinedna repairgene expressionclinical proteomicsmolecular medicine

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Weihang Valerie Chai

Professor

Rosalind Franklin University of Medicine and Science

Affiliations

School Of Chicago Medical

Center For Genetic Diseases

Chicago Medical School

School Of Chicago Medical

Rosalind Franklin University of Medicine and Science

Weihang Valerie Chai is currently serving as a Center For Genetic Diseases Professor at Rosalind Franklin University of Medicine And Science.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Weihang Valerie Chai

Rosalind Franklin University of Medicine and Science

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 2343 Deficiency of Mammalian Stn1 Induces Genome Instability in Vivo and Promotes Cancer Development in a Tissue-Specific Manner. Journal of Biological Chemistry (2026)

A Phosphorylation Switch at Mre11 Links Atm-Atr and Calcium Signaling to Safeguard Stalled Replication Fork Stability. Research Square (2026)

Stn1 Upregulation Promotes Parpi Resistance in Brca2-Deficient Cancer Cells via Replication Fork Protection and Suppression of Ssdna Gap Formation. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Abstract 2854: The Role of Nono in Genome Stability: Implications for Rna-Dna Hybrid Accumulation, Genomic Instability, and Inflammatory Signaling. Cancer Research (2025)

inflammatory signalinggeneticsgene expressionnon-coding rnaabstract 2854gene regulationmolecular cell biologyfunctional genomicsgenome biologymolecular biologygenome stability

Dna2 and Msh2 Activity Collectively Mediate Chemically Stabilized G4 for Efficient Telomere Replication. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Dna2 and Msh2 Cooperatively Repair Stabilized G4 and Allow Efficient Telomere Replication. Nature Communications (2025)

In Vivo Investigation of Stn1 Downregulation in Melanoma Formation in Adult Mice Following Uv Irradiation. PLoS ONE (2025)

radiation biologytumor biologydermatologycell biologycancer cellsoncogenesphototoxicityphotocarcinogenesisdna repairmelanomacarcinogenesisvivo investigationuv irradiationmelanoma formation

Conditional Depletion of Stn1 in Mouse Embryonic Fibroblasts. BIO-PROTOCOL (2024)

developmental biologycell specializationstem cellscell biologymolecular cell biologyconditional depletioncell researchcell proliferationcarcinogenesiscellular physiology

Human Cst Complex Restricts Excessive Primpol Repriming Upon Uv Induced Replication Stress by Suppressing P21. Nucleic Acids Research (2024)

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