Wayne L. Hofstetter

Wayne L. Hofstetter is a Professor of Surgery in the Department of Thoracic and Cardiovascular Surgery at The University of Texas MD Anderson Cancer Center. A surgical oncologist specializing in esophageal and gastroesophageal junction (GEJ) adenocarcinoma, his research focuses on multimodal therapy, including perioperative immunotherapy combinations, and the molecular pathology of early esophageal cancer. His recent work includes clinical trials of atezolizumab and tiragolumab, machine learning models predicting pathological complete response after trimodality therapy, and the development of patient-reported outcome instruments like the MDASI-UGI-Surg. He also investigates circulating tumor DNA as a real-time biomarker for germ cell tumors.