Walter J. Lukiw

Louisiana State University Health Sciences Center, New Orleans

Affiliations

School of Medicine

Center Of Eye

Center Of Neuroscience

Louisiana State University Health Sciences Center, New Orleans

Walter J. Lukiw is a High Senior Professor at Louisiana State University Health Sciences Center, New Orleans. His research focuses on molecular neurodegeneration, the neuroscience of aging, and neurodegenerative diseases, particularly Alzheimer’s disease (AD). Recent work investigates dietary fiber’s modulation of gut microbiota and lipid metabolism in 5xFAD mice, maresin-like 1’s amelioration of AD neuropathology, and microRNA complexity in AD. He also explores epigenetic inheritance in autism and ADHD, endogenous miRNA-based innate immunity against SARS-CoV-2 brain invasion, and lipopolysaccharides as neurotoxic glycolipids in AD. His publications span venues including *Scientific Reports*, *Biomedicines*, and the *International Journal of Molecular Sciences*.

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Walter J. Lukiw

Louisiana State University Health Sciences Center, New Orleans

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neuroscience molecular neurodegeneration neurodegenerative diseases alzheimer's disease cell biology neurology neuroscience of aging molecular neuroscience molecular biology molecular psychiatry gene expression neurogenetics neuroimmunology cell death degenerative pathology dementia neuroinflammation inflammation molecular cell biology aging cell microrna detection ophthalmology retina free radical biology retina molecular physiology aging-associated diseases small rna nucleic acids non-coding rna neuropsychopharmacology molecular neurobiology neurochemical biomarkers brain-immune interaction experimental medicine experimental gerontology brain pathology redox biology cellular physiology neuroprotection age-related macular degeneration molecular diagnostics cell regulation signaling pathways anti-inflammatory rna biology vision research degenerative disease neurochemistry human brain cells primary culture clinical neuroscience biological inorganic chemistry experimental ophthalmology gene function vascular dementia cytokines neurological disorders photoreceptor cells viral persistence metal toxicity virus-host interactions alzheimer ’ reperfusion injury geriatric neurology pro-inflammatory gene expression sporadic alzheimer down syndrome alzheimer disease docosahexaenoic acid pro-inflammatory signaling neurotrophic factor down-regulation genetic evidence differential regulation interleukin-1 receptor-associated kinase-1 extracellular fluid aging brain developmental system longevity translational research cell research biosystems computational biology pathology molecular informatics autophagy biochemistry human biology clinical proteomics developmental cell proteome research nature method developmental neurobiology bioinformatics cell metabolism omics functional genomics transcription (biology) molecular and cellular biology mammalian biology molecular metabolism biostatistics developmental biology huntington's disease transcriptome biomedical informatics systems biology genetics epigenetics molecular medicine

Notable Scholarly Works

Notable Federal Grants

Collaborators

Dietary Fiber Modulates Gut Microbiota and Lipid Metabolism Ameliorating Alzheimer’s Pathology in 5Xfad Mice. Scientific Reports (2025)

gut-organ axisalzheimer's diseaseneurodegenerative diseasesalzheimer ’dietary fiber modulatesmicrobiomelipid metabolismphysiologylipidsgut microbesmolecular neurodegenerationdietary fibremolecular nutritionhealth sciences

Maresin-Like 1 Ameliorates Neuropathology of Alzheimer’s Disease in Brains of a Transgenic Mouse Model. Biomedicines (2024)

brain pathologyexperimental neuropathologydegenerative pathologyneuroscience of agingneurodegenerative diseasesalzheimer's diseaseneurosciencetransgenic mouse modelameliorates neuropathologymolecular neurodegenerationneurologymaresin-like 1

Endogenous Mirna-Based Innate-Immunity Against Sars-Cov-2 Invasion of the Brain. International Journal of Molecular Sciences (2023)

neurovirologyantiviral researchmedical virologycell biologysars-cov-2neuroimmunologyimmunology

Higher Rates of Autism and Attention Deficit/Hyperactivity Disorder in American Children: Are Food Quality Issues Impacting Epigenetic Inheritance?. World Journal of Clinical Pediatrics (2023)

Renee J DufaultRaquel A CriderRichard C DethRoseanne SchnollSteven G GilbertWalter J LukiwAmanda L Hitt

pediatricsmaternal healthpediatric obesitychild psychologydevelopmental epidemiologychild healthhigher ratespublic healthpreventive pediatricschild developmentautismearly childhood developmentpsychiatric geneticschild neurologyepigenetic inheritancefood quality issuesmental healthamerican childrenchild mental healthhealth policypsychiatric epidemiologyattention disorders

Microrna (Mirna) Complexity in Alzheimer’s Disease (Ad). Biology (2023)

Alteration of Biomolecular Conformation by Aluminum-Implications for Protein Misfolding Disease. Molecules (2022)

Yuhai ZhaoAileen I. PoguePeter N. AlexandrovLeslie G. ButlerWenhong LiVivian R. JaberWalter J. Lukiw

protein sciencematerials sciencemetalloproteinsstructural chemistryprotein misfoldingmolecular biophysicsmembrane biologybiomolecular conformationmacromolecular chemistrybiological inorganic chemistryconformational studiesstructural biologybiophysicsbiomolecular engineeringcrystallographymolecular scienceprotein misfolding diseasestructural molecular biologybiomolecular structureprotein engineering

Current Advances in Our Understanding of Circular Rna (Circrna) in Alzheimer’s Disease (Ad); the Potential Utilization of Synthetic Circrnas as a Therapeutic Strategy in the Clinical Management of Ad. Frontiers in Drug Discovery (2022)

David Hunter Hubel, the ‘Circe Effect’, and Sars-Cov-2 Infection of the Human Visual System. Frontiers in Bioscience-Landmark (2022)

Downregulation of Neurofilament Light Chain Expression in Human Neuronal-Glial Cell Co-Cultures by a Microbiome-Derived Lipopolysaccharide-Induced Mirna-30B-5p. Frontiers in Neurology (2022)

optogeneticsdevelopmental neurobiologymolecular neuroscienceneurodegenerative diseasesneuronscell biologymolecular cell biologyneurosciencemolecular psychiatryneuroimmunologymolecular biologycell researchmolecular neurodegenerationgene expressionphotomedicinecellular physiologymolecular physiology

Fission Impossible: Stabilized Mirna-Based Analogs in Neurodegenerative Disease. Frontiers in Neuroscience (2022)

Walter J. Lukiw

systems neuroscienceneurodegenerative diseasesneurosciencerna biologymirna-based analogssmall rnaneuropsychopharmacologytumor biologysystems biologymolecular neurodegenerationnon-coding rnaneurologydegenerative diseaseneuroregenerationmolecular neuroscienceneuro-oncologyvascular biologyneuroscience of agingoncogenes