Faculty

Institution

Unit

Venue

Vitali Sikirzhytski

Research Assistant Professor

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Vitali Sikirzhytski is currently serving as a College Of Pharmacy Research Assistant Professor at University of South Carolina.

Honors

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Experiences

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Education

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Vitali Sikirzhytski

University of South Carolina

Research Assistant Professor

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pharmacology medicinal research oncology cancer biology cancer treatment neurology cancer research tumor biology enzyme inhibition cancer care leukemia tumor targeting cancer immunotherapy cellular therapy cancer management drug targeting centrosome amplification biophysics neuroscience therapeutic targets structural biology prostate cancer molecular models protein science cell regulation protein modeling cancer prevention anti-cancer agents cancer genomics cancer growth structural characterization lysyl oxidase aggressive breast cancers cocaine-induced neurotoxicity free radical biology cell death cancer imaging clinical investigation surgical oncology experimental medicine pharmacotherapy biopolymers animal physiology mammalian biology breast oncology cancer immunosurveillance apoptosis brain-immune interaction clinical medicine cutaneous biology mammalian physiology disease mechanisms disease physiology biomedical modeling cancer genetics cell interactions interactomics rna biology gene function chemotherapy resistance body fluid identification forensic purposes raman spectra discriminant analysis quantitative methods amyloid-like fibrils novel vulnerability microglia activation pharmacological inhibition bypasses resistance

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Po4-24-04: Identifying the Interactome of Tacc3, a Major Driver in Aggressive Cancer Cells With Centrosome Amplification. Cancer Research (2024)

Ozge SaatciOzge AkbulutMetin CetinVitali SikirzhytskiMeral UnerDeniz LengerliElizabeth C. O’QuinnMartin J. RomeoBurcu CaliskanErden BanogluSercan AksoyAysegul UnerOzgur Sahin

aggressive cancer cellscell biologyleukemiapharmacologytumor biologycancer researchoncologycancer caremembrane biologycancer treatmentcentrosome amplificationcancer genomicsmolecular cancertumor targetingmedicinal researchmajor drivercancer cellscell interactionsclinical researchhealth sciencesinteractomics

Identification of Ecohiv-Infected Cells in Microglia-Manipulated Transgenic Mice. Journal of Visualized Experiments (2024)

Hailong LiMakensie WalkerHao JiAliaksandra SikirzhytskayaMarina AksenovaMichael ShtutmanVitali SikirzhytskiCharles F. MactutusRosemarie M. Booze

infectious diseasesecohiv-infected cellsmicroglia-manipulated transgenic micehiv

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichZachary T. MackGary P. SchoolsChang-uk LimLeigh EllisXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

cancer immunotherapycastration resistancecancer biologypharmacologyclinical medicineurologyclinical investigationcancer researchoncologycancer treatmentneurologyadvanced prostate cancerclinical researchtumor targetingmedicinal researchsurgical oncologycancer managementprostate cancerexperimental medicinemediator kinase inhibitionpharmacotherapy

Single Particle Tracking of Genetically Encoded Nanoparticles: Optimizing Expression for Cytoplasmic Diffusion Studies. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Elizaveta KorunovaVitali SikirzhystkiJeffery L TwissPaula VasquezMichael Shtutman

nanoparticlesgene expressioncytoplasmic diffusion studiessingle particle trackingmolecular biology

Suppression of Hiv-Tat and Cocaine-Induced Neurotoxicity and Inflammation by Cell Penetrable Itaconate Esters. Journal of NeuroVirology (2024)

B. Celia CuiMarina AksenovaAliaksandra SikirzhytskayaDiana OdhiamboElizaveta KorunovaVitali SikirzhytskiHao JiDiego AltomareEugenia BroudeNorma FrizzellRosemarie BoozeMichael D. WyattMichael Shtutman

neurovirologyhivvirologyimmunologypharmacologycocaine-induced neurotoxicityneurology

Abstract 5728: Inhibition of Tacc3 Blocks the Growth of Highly Aggressive Breast Cancers With Centrosome Amplification. Cancer Research (2023)

Ozge SaatciOzge AkbulutMetin CetinVitali SikirzhytskiOzgur Sahin

cancer immunotherapycancer biologyleukemiaaggressive breast cancerspharmacologymetastasisoncologyimmunotherapycancer carecancer treatmentcentrosome amplificationneurologyanti-cancer agentsradiation oncologymedicinal researchcancer growthcancer cellscancer managementoncogenesclinical research

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

urologytumor biologyoncologycancer researchcancer growthcancer biologycell regulationcastration-resistant prostate cancercancer cellsoncogenespharmacologycancer treatmentprostate cancerneurologycarcinogenesiscancer geneticsmedicinal research

Rassf1 is Identified by Transcriptome Coordination Analysis as a Target of Atf4. FEBS Open Bio (2023)

Youwen ZhangKim‐Tuyen Huynh‐DamXiaokai DingVitali SikirzhytskiChang‐uk LimEugenia BroudeHippokratis Kiaris

geneticsenzymesgene expressiontranscriptome coordination analysisprotein scienceredox biologybiochemistrymembrane biologyproteomicsrna biologygene functionmolecular biology

Targeting Tacc3 Represents a Novel Vulnerability in Highly Aggressive Breast Cancers With Centrosome Amplification. Cell Death and Differentiation (2023)

Ozge SaatciOzge AkbulutMetin CetinVitali SikirzhytskiMeral UnerDeniz LengerliElizabeth C. O’QuinnMartin J. RomeoBurcu CaliskanErden BanogluSercan AksoyAysegul UnerOzgur Sahin

cancer immunotherapycancer biologyleukemiaaggressive breast cancerscancer immunosurveillancepharmacologytherapeutic targetstumor biologycellular therapyapoptosisoncologycentrosome amplificationneurologycancer genomicstumor targetingbreast cancercell deathmedicinal researchnovel vulnerabilitycancer imagingdermatology

Abstract 2572: A Novel Strategy for Plk1 Kinase Inhibition by Allosterically Targeting the Polo Box Domain. Cancer Research (2022)

Danda ChapagaiMerissa BaxterSandra CraigGuru RamamoorthyJessy StaffordSikirzhytski VitaliElmar NurmemmedovCampbell McInnesMichael D. Wyatt

cancer biologycell biologyleukemiapharmacologytumor biologycellular therapypolo box domainoncologycancer researchcancer carecancer treatmentneurologydrug discoverynovel strategytumor targetingmedicinal researchcancer managementdrug targetingenzyme inhibitionclinical research

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Vitali Sikirzhytski

Research Assistant Professor

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Vitali Sikirzhytski is currently serving as a College Of Pharmacy Research Assistant Professor at University of South Carolina.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Vitali Sikirzhytski

University of South Carolina

Research Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract Po4-24-04: Identifying the Interactome of Tacc3, a Major Driver in Aggressive Cancer Cells With Centrosome Amplification. Cancer Research (2024)

Ozge SaatciOzge AkbulutMetin CetinVitali SikirzhytskiMeral UnerDeniz LengerliElizabeth C. O’QuinnMartin J. RomeoBurcu CaliskanErden BanogluSercan AksoyAysegul UnerOzgur Sahin

Identification of Ecohiv-Infected Cells in Microglia-Manipulated Transgenic Mice. Journal of Visualized Experiments (2024)

Hailong LiMakensie WalkerHao JiAliaksandra SikirzhytskayaMarina AksenovaMichael ShtutmanVitali SikirzhytskiCharles F. MactutusRosemarie M. Booze

infectious diseasesecohiv-infected cellsmicroglia-manipulated transgenic micehiv

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Single Particle Tracking of Genetically Encoded Nanoparticles: Optimizing Expression for Cytoplasmic Diffusion Studies. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Elizaveta KorunovaVitali SikirzhystkiJeffery L TwissPaula VasquezMichael Shtutman

nanoparticlesgene expressioncytoplasmic diffusion studiessingle particle trackingmolecular biology

Suppression of Hiv-Tat and Cocaine-Induced Neurotoxicity and Inflammation by Cell Penetrable Itaconate Esters. Journal of NeuroVirology (2024)

B. Celia CuiMarina AksenovaAliaksandra SikirzhytskayaDiana OdhiamboElizaveta KorunovaVitali SikirzhytskiHao JiDiego AltomareEugenia BroudeNorma FrizzellRosemarie BoozeMichael D. WyattMichael Shtutman

neurovirologyhivvirologyimmunologypharmacologycocaine-induced neurotoxicityneurology

Abstract 5728: Inhibition of Tacc3 Blocks the Growth of Highly Aggressive Breast Cancers With Centrosome Amplification. Cancer Research (2023)

Ozge SaatciOzge AkbulutMetin CetinVitali SikirzhytskiOzgur Sahin

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

Rassf1 is Identified by Transcriptome Coordination Analysis as a Target of Atf4. FEBS Open Bio (2023)

Youwen ZhangKim‐Tuyen Huynh‐DamXiaokai DingVitali SikirzhytskiChang‐uk LimEugenia BroudeHippokratis Kiaris

geneticsenzymesgene expressiontranscriptome coordination analysisprotein scienceredox biologybiochemistrymembrane biologyproteomicsrna biologygene functionmolecular biology

Targeting Tacc3 Represents a Novel Vulnerability in Highly Aggressive Breast Cancers With Centrosome Amplification. Cell Death and Differentiation (2023)

Ozge SaatciOzge AkbulutMetin CetinVitali SikirzhytskiMeral UnerDeniz LengerliElizabeth C. O’QuinnMartin J. RomeoBurcu CaliskanErden BanogluSercan AksoyAysegul UnerOzgur Sahin

Abstract 2572: A Novel Strategy for Plk1 Kinase Inhibition by Allosterically Targeting the Polo Box Domain. Cancer Research (2022)

Danda ChapagaiMerissa BaxterSandra CraigGuru RamamoorthyJessy StaffordSikirzhytski VitaliElmar NurmemmedovCampbell McInnesMichael D. Wyatt

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drug targeting

anti-cancer agent

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future medicinal chemistry

mechanisms of action

Richard J. Pietras

Institution

University of California, Los Angeles

pharmacology

oncology

Siyuan Zhang

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single-cell analysis

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oral pathology

lung cancer

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gene therapy

cancer biology

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Duke University

pharmacology

endocrinology

Timothy Donahue

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University of California, Los Angeles

pathology

cancer cell

Julie Boerner

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novel therapeutic strategies

breast cancer

Seungpyo Hong

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biomimetic nanotechnology

biological interactions