Faculty

Institution

Unit

Venue

Vakul Mohanty

The University of Texas MD Anderson Cancer Center

Affiliations

Metabolomics Core Facility

Department Of Bioinformatics And Computational Biology

The University of Texas MD Anderson Cancer Center

Vakul Mohanty is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research integrates cell biology, immunology, and systems biology, with a focus on tumor biology, cancer cells, and single-cell analysis. His recent work explores immunotherapeutic strategies targeting myeloid-derived suppressor cells, AI-powered immune cell knowledge graphs, and spatial immune hubs remodeled by immunotherapy. He has also investigated oncolytic virus-driven NK cell signaling, agent-based modeling of adoptive cell therapy, and the role of CREM as a regulatory checkpoint in CAR and IL-15 signaling in NK cells. His publications appear in venues including Frontiers in Immunology, npj Artificial Intelligence, Communications Biology, and Cancer Research.

Honors

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Vakul Mohanty

The University of Texas MD Anderson Cancer Center

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cell biology immunology cancer cells molecular biology tumor biology cancer research cellular therapy cancer biology single-cell analysis hematology bioinformatics medicinal research oncogenes leukemia gene expression oncology cancer immunotherapy genome biology genomics cancer genomics cellular immune responses adaptive immune system biomedical informatics cancer genetics molecular cancer hematological malignancies dermatology cell death cell transplantation single cell sequencing cancer immunosurveillance nk cells molecular diagnostics cell therapy cancer treatment myeloid neoplasia immune checkpoint inhibitors stem cell research vascular biology cancer discovery cellular physiology tumor heterogeneity tumor targeting innate immune system therapeutic efficacy cord blood gene expression profiling malignant blood disorders feature selection single-molecule detection cell metabolism novel therapies omics integration apoptosis cancer metabolism apoptotic cell death cis checkpoint deletion single-cell data bi-order multimodal integration rare cell populations gene discovery anti-cancer agents cytokines science studies brain-immune interaction cell detection viral persistence immunogenetics cytokine checkpoint glioblastoma stem cells car-nk cell therapy cytokine engineering single-cell rna-seq data metabolic fitness gmp-compliant universal antigen antitumor activity

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5194: Oncolytic Virus Infected Tumors Drive Ap-1 and Irf Signaling in Nk Cells to Sustain Anti Tumor Activity. Cancer Research (2026)

immunologyabstract 5194cell deathoncolytic viruscell signalingimmune checkpoint inhibitorsnk cellsoncogenescancer cellstumor biologyviral oncologyimmunotherapycell biology

Agent-Based Modeling of Cellular Dynamics in Adoptive Cell Therapy. Communications Biology (2026)

biomedical modelingcell engineeringadoptive cell therapycell transplantationtheoretical biologycellular therapycell biology

AI-Powered Immune Cell Knowledge Graph (Ickg) With Granular Immune Contexts Enables Immune Program Interpretation. npj Artificial Intelligence (2026)

immunologyimmunological biomarkersimmunological computingbiomedical informaticsgranular immune contextsimmune program interpretationsystems biologycell researchartificial immune systemsystem immunologyadaptive immune systemimmune responsesimmunity (medicine)immunotherapy

Spatial Immune Hubs Defined by Conserved Activated Dendritic Cells Are Remodeled by Immunotherapy. bioRxiv (Cold Spring Harbor Laboratory) (2026)

immunologyimmune mediatorsdendritic cellscellular immune responsesimmunologic mechanismssystems biologycell researchadaptive immune systemspatial immune hubsimmune responsesimmunomodulationtumor microenvironmentimmunity (medicine)cellular therapyimmunotherapycell biology

Targeting Mdscs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies. Frontiers in Immunology (2026)

molecular cancermetabolic strategiescancer immunotherapytherapeutic targetscancer cellscancer biologycell biology

Tumor Microenvironment Changes After Treatment With Avelumab and Immune- Stimulating Agent Combinations in Patients With Advanced Solid Tumors. Research Square (2026)

immunologytumor microenvironment changesradiation oncologyimmune checkpoint inhibitorscancer immunosurveillancecancer immunotherapyoncologycancer cellstumor microenvironmentmedicinal researchcancer treatmentcellular therapyimmunotherapyadvanced solid tumors

1283 “Rudimentary” Germinal Center Like-Areas Seem to Contribute to the Pathobiology of Angioimmunoblastic T Cell Lymphoma Through Enhanced Cd40: Cd40l Interactions. Laboratory Investigation (2025)

Vishal SahuKun Hee KimTania SainzNicholas DcunhaYuchen PanJuan DonosoAniruddha MundhadaHideaki MinzunoClaudia KettlunAkshay BasiJavier GomezArrate ZuberoMichael GreenJared HendersonJared BurksDeepa SampathMichael AndreeffVakul MohantyKen ChenFrancisco Vega

immunologylaboratory investigationlymphoid neoplasia

191 Tumor Microenvironment Changes After Treatment With Avelumab Combinations in Patients With Advanced Solid Tumors. Regular and Young Investigator Award Abstracts (2025)

tumor microenvironment changesradiation oncologymetronomic therapyoncologycancer cellstumor microenvironmentcancer letterjama oncologypathologycancer treatmentavelumab combinationsadvanced solid tumors

Abstract 3651: AI-Derived Immune Cell Knowledge Graphs to Advance Immunotherapy. Cancer Research (2025)

immunologyimmunological computingbiomedical informaticsabstract 3651clinical immunologyknowledge graphssystems biologycell researchcancer immunotherapyimmune responsesimmunomodulationsystem immunologyknowledge-based systemsimmunotherapy

Abstract 6396: Crem is a Regulatory Checkpoint of Car and Il-15 Signaling in Nk Cells. Cancer Research (2025)

Hind RafeiRafet BasarSunil AcharyaYu-Sung HsuPinghua LiuDeqiang ZhangQingnan LiangVakul MohantyRanjan UpadhyayPing LiPravin PhadatareMerve DedeDonghai XiongCorry JonesMay DaherAna Karen Nunez CortesMayra ShanleyBin LiuSadie M. MoseleyPatrick ZhangDexing FangPinaki BanerjeeNadima UpretyYe LiRejeena ShresthaXinhai WanHong ShenVernikka WoodsApril GilbertSeema RawalJinzhuang DouYukun TanJeong-Min ParkFrancia Reyes SilvaAlexander BiederstädtMecit KaplanXin Ru JiangInci BiederstädtSilvia TibertiMadison MooreJingling JinLuis Muniz-FelicianoPaul LinGary M. DeyterNatalie W. FowlkesAbhinav JainDavid MarinKen ChenElizabeth ShpallKatayoun Rezvani

cancer researchnk cellsregulatory checkpointcancer biology

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Vakul Mohanty

The University of Texas MD Anderson Cancer Center

Affiliations

Metabolomics Core Facility

Department Of Bioinformatics And Computational Biology

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Vakul Mohanty

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5194: Oncolytic Virus Infected Tumors Drive Ap-1 and Irf Signaling in Nk Cells to Sustain Anti Tumor Activity. Cancer Research (2026)

immunologyabstract 5194cell deathoncolytic viruscell signalingimmune checkpoint inhibitorsnk cellsoncogenescancer cellstumor biologyviral oncologyimmunotherapycell biology

Agent-Based Modeling of Cellular Dynamics in Adoptive Cell Therapy. Communications Biology (2026)

biomedical modelingcell engineeringadoptive cell therapycell transplantationtheoretical biologycellular therapycell biology

AI-Powered Immune Cell Knowledge Graph (Ickg) With Granular Immune Contexts Enables Immune Program Interpretation. npj Artificial Intelligence (2026)

Spatial Immune Hubs Defined by Conserved Activated Dendritic Cells Are Remodeled by Immunotherapy. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Targeting Mdscs in Cancer: Emerging Immunotherapeutic and Metabolic Strategies. Frontiers in Immunology (2026)

molecular cancermetabolic strategiescancer immunotherapytherapeutic targetscancer cellscancer biologycell biology

Tumor Microenvironment Changes After Treatment With Avelumab and Immune- Stimulating Agent Combinations in Patients With Advanced Solid Tumors. Research Square (2026)

immunologylaboratory investigationlymphoid neoplasia

191 Tumor Microenvironment Changes After Treatment With Avelumab Combinations in Patients With Advanced Solid Tumors. Regular and Young Investigator Award Abstracts (2025)

Abstract 3651: AI-Derived Immune Cell Knowledge Graphs to Advance Immunotherapy. Cancer Research (2025)

Abstract 6396: Crem is a Regulatory Checkpoint of Car and Il-15 Signaling in Nk Cells. Cancer Research (2025)

cancer researchnk cellsregulatory checkpointcancer biology

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