Faculty

Institution

Unit

Venue

Uday Tak

Assistant Professor

University of Virginia

Affiliations

School of Medicine

Department of Microbiology, Immunology, and Cancer Biology

Uday Tak is currently serving as a Microbiology, Immunology, And Cancer Biology Assistant Professor at University of Virginia.

Honors

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Experiences

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Education

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Uday Tak

University of Virginia

Assistant Professor

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molecular biology microbiology microbial pathogenesis bacteria toxins biological chemistry biochemistry pathogenesis membrane proteins molecular cell biology phage biology mycobacterium tuberculosis cell biology tuberculosis immune responses enzymes pathogenic bacteria phagocytes protein transport protein secretion molecular microbiology bacteriophages toxin secretion tnt secretion phage replication autophagy cell death cellular biochemistry biomolecular structure structural molecular biology protein science biochemical sciences cell metabolism molecular metabolism enzyme inhibition clinical microbiology nucleic acids biological macromolecules mycoprotein pulmonary tuberculosis apoptosis intracellular trafficking secretory pathway enzymatic modification aldehyde dehydrogenase virulence factors pathogen characterization nucleic acid chemistry oligonucleotides molecular biological method crispr gene editing antimicrobial compounds skin pharmacology distinct enzymatic properties nadp+ glycohydrolase functional t7ss t7ss machinery gbs pathogenesis bacterial cgas-like enzymes ion channel panoptes system decoy cyclic nucleotides phage proteins minimal crispr polymerase skin pathogens

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bacterial 2′,3′-Cgamp Activates a Saved Effector to Form Membrane-Disrupting Filaments and Restrict Phage Replication. Cell Host & Microbe (2026)

microbiologybacteriophagessaved effectormembrane-disrupting filamentsphage biologymicrobial cell factoryrestrict phage replicationbacteriamembrane proteinsbiological chemistrymembrane biologymolecular biologyapplied microbiologymicroorganisms

A Minimal Crispr Polymerase Produces Decoy Cyclic Nucleotides to Detect Phage Anti-Defense Proteins. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Ashley E. SullivanAli NabhaniKate SchinkelDavid M. DinhMelissa L. DuncanEirene Marie Q. EdnacotCharlotte R.K. HoffmanDaniel S. IzrailevskyEmily M. KibbyToni A. NagyChristy M. NguyenUday TakA. Maxwell BurroughsL. AravindAaron T. WhiteleyBenjamin R. Morehouse

microbiologybacteriophagesphage replicationantiviral researchphage biologyminimal crispr polymerasemicrobial pathogenesismolecular cell biologygene editingcrisprpathogenesisbiological chemistrymolecular biologyphage proteinsgenome editingvirus research

An Antimicrobial Daptide From Human Skin Commensal Staphylococcus Hominis Protects Against Skin Pathogens. Nature Communications (2025)

antimicrobial resistancemicrobiologypathogenic bacteriaantimicrobial daptideantimicrobial agentsinfection controlantimicrobial compoundsinfectious diseasesdermatologyskin pharmacologyantibioticsinfectious diseases (medical specialty)skin pathogenspathogensdermatological treatment

The Panoptes System Uses Decoy Cyclic Nucleotides to Defend Against Phage. Nature (2025)

molecular geneticsmolecular and cellular biologynucleic acidschemical biologybiological macromoleculesphage biologymolecular cell biologynucleic acid chemistrypanoptes systemmolecular biological methodbiological chemistrybiochemistryoligonucleotidesdecoy cyclic nucleotidessynthetic biologymolecular biology

Bacterial Cgas-Like Enzymes Produce 2′,3′-Cgamp to Activate an Ion Channel That Restricts Phage Replication. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Uday TakPeace WalthAaron T. Whiteley

microbiologyenzymesphage replicationmolecular microbiologymicrobial pathogenesisbacterial cgas-like enzymesion channelbacteriabiochemistrymolecular biology

A Type VII Secretion System in Group B Streptococcus Mediates Cytotoxicity and Virulence. PLoS Pathogens (2021)

Brady L. SpencerUday TakJéssica C. MendonçaPrescilla E. NagaoMichael NiederweisKelly S. Doran

t7ss machinerymicrobiologypathogenic bacteriaimmune responsesinfectious diseasesmicrobial pathogenesisgbs pathogenesisbacteriaclinical microbiologypathogen characterizationvirulence factorspathogenesistoxinsfunctional t7ss

Pore-Forming Esx Proteins Mediate Toxin Secretion by Mycobacterium Tuberculosis. Nature Communications (2021)

Uday TakTerje DoklandMichael Niederweis

microbiologyprotein transportmycobacterium tuberculosissecretory pathwaymicrobial pathogenesisprotein scienceprotein secretionbacteriastructural molecular biologyprotein structuremembrane proteinsbiomolecular structuremolecular microbiologytoxin secretionmolecular biologytoxinstnt secretion

Toxin Secretion and Trafficking by Mycobacterium Tuberculosis. Nature Communications (2021)

David PajueloUday TakLei ZhangOlga DanilchankaAnna D. TischlerMichael Niederweis

protein transportmycobacterium tuberculosistnt secretionmicrobial pathogenesiscell biologymolecular cell biologyprotein secretiontoxin secretionmembrane proteinsmembrane biologyintracellular traffickingmolecular biologytoxinsphagocytescellular biochemistry

Nad+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium Tuberculosis. Cell Reports (2018)

David PajueloNorberto Gonzalez-JuarbeUday TakJim SunCarlos J. OrihuelaMichael Niederweis

microbiologytuberculosisimmune responsesapoptosismycobacterium tuberculosisphagocytesmicrobial pathogenesiscell biologymycoproteinautophagyimmunologypathogenesispulmonary tuberculosiscell death

The Tuberculosis Necrotizing Toxin is an Nad+ and Nadp+ Glycohydrolase With Distinct Enzymatic Properties. Journal of Biological Chemistry (2018)

Uday TakJiri VlachAcely Garza-GarciaDoreen WilliamOlga DanilchankaLuiz Pedro Sório de CarvalhoJamil S. SaadMichael Niederweis

tuberculosisbiochemical sciencesenzymesmolecular metabolismenzyme inhibitiondistinct enzymatic propertiesaldehyde dehydrogenasebiological chemistrybiochemistryglycobiologyenzymatic modificationmolecular biologycell metabolismtoxinsnadp+ glycohydrolase

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Uday Tak

Assistant Professor

University of Virginia

Affiliations

School of Medicine

Department of Microbiology, Immunology, and Cancer Biology

Uday Tak is currently serving as a Microbiology, Immunology, And Cancer Biology Assistant Professor at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Uday Tak

University of Virginia

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bacterial 2′,3′-Cgamp Activates a Saved Effector to Form Membrane-Disrupting Filaments and Restrict Phage Replication. Cell Host & Microbe (2026)

A Minimal Crispr Polymerase Produces Decoy Cyclic Nucleotides to Detect Phage Anti-Defense Proteins. bioRxiv (Cold Spring Harbor Laboratory) (2025)

An Antimicrobial Daptide From Human Skin Commensal Staphylococcus Hominis Protects Against Skin Pathogens. Nature Communications (2025)

The Panoptes System Uses Decoy Cyclic Nucleotides to Defend Against Phage. Nature (2025)

Bacterial Cgas-Like Enzymes Produce 2′,3′-Cgamp to Activate an Ion Channel That Restricts Phage Replication. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Uday TakPeace WalthAaron T. Whiteley

microbiologyenzymesphage replicationmolecular microbiologymicrobial pathogenesisbacterial cgas-like enzymesion channelbacteriabiochemistrymolecular biology

A Type VII Secretion System in Group B Streptococcus Mediates Cytotoxicity and Virulence. PLoS Pathogens (2021)

Brady L. SpencerUday TakJéssica C. MendonçaPrescilla E. NagaoMichael NiederweisKelly S. Doran

Pore-Forming Esx Proteins Mediate Toxin Secretion by Mycobacterium Tuberculosis. Nature Communications (2021)

Uday TakTerje DoklandMichael Niederweis

Toxin Secretion and Trafficking by Mycobacterium Tuberculosis. Nature Communications (2021)

David PajueloUday TakLei ZhangOlga DanilchankaAnna D. TischlerMichael Niederweis

Nad+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium Tuberculosis. Cell Reports (2018)

David PajueloNorberto Gonzalez-JuarbeUday TakJim SunCarlos J. OrihuelaMichael Niederweis

microbiologytuberculosisimmune responsesapoptosismycobacterium tuberculosisphagocytesmicrobial pathogenesiscell biologymycoproteinautophagyimmunologypathogenesispulmonary tuberculosiscell death

The Tuberculosis Necrotizing Toxin is an Nad+ and Nadp+ Glycohydrolase With Distinct Enzymatic Properties. Journal of Biological Chemistry (2018)

Uday TakJiri VlachAcely Garza-GarciaDoreen WilliamOlga DanilchankaLuiz Pedro Sório de CarvalhoJamil S. SaadMichael Niederweis

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cell biology

molecular cell biology

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Dartmouth College

immunology

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Institution

University of Illinois Urbana-Champaign

applied microbiology

gene expression

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pathogenic bacteria

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