Traver Hart

Traver Hart is an Associate Professor at The University of Texas MD Anderson Cancer Center, where his research integrates systems biology, CRISPR-based genome editing, and molecular cell biology to map cancer-relevant genetic interactions. His recent work focuses on developing computational pipelines, such as GRAPE and DKOsim, for analyzing combinatorial knockout CRISPR screens and predicting synthetic lethality in tumor biology. He has pioneered methods for identifying paralog synthetic lethality and functional modules in mammalian cells, with applications to basal breast cancer and chromosome 4p loss. His contributions include advancing gene editing platforms like in4mer enCas12a and establishing standards for CRISPR screen analysis.